R3H domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IE01_LEIDO

TriTrypDb:

LdBPK_282710.1 , LdCL_280032200 , LDHU3_28.3670

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IE01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IE01

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.759
CLV_C14_Caspase3-7	72	76	PF00656	0.674
CLV_MEL_PAP_1	173	179	PF00089	0.545
CLV_NRD_NRD_1	218	220	PF00675	0.516
CLV_NRD_NRD_1	381	383	PF00675	0.704
CLV_NRD_NRD_1	398	400	PF00675	0.655
CLV_NRD_NRD_1	491	493	PF00675	0.615
CLV_NRD_NRD_1	630	632	PF00675	0.640
CLV_PCSK_FUR_1	216	220	PF00082	0.644
CLV_PCSK_FUR_1	396	400	PF00082	0.700
CLV_PCSK_KEX2_1	218	220	PF00082	0.516
CLV_PCSK_KEX2_1	379	381	PF00082	0.700
CLV_PCSK_KEX2_1	396	398	PF00082	0.693
CLV_PCSK_KEX2_1	491	493	PF00082	0.615
CLV_PCSK_KEX2_1	630	632	PF00082	0.640
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.700
CLV_PCSK_SKI1_1	101	105	PF00082	0.317
CLV_PCSK_SKI1_1	154	158	PF00082	0.472
CLV_PCSK_SKI1_1	218	222	PF00082	0.648
CLV_PCSK_SKI1_1	225	229	PF00082	0.677
CLV_PCSK_SKI1_1	28	32	PF00082	0.736
CLV_PCSK_SKI1_1	524	528	PF00082	0.472
CLV_PCSK_SKI1_1	617	621	PF00082	0.516
CLV_PCSK_SKI1_1	8	12	PF00082	0.621
DEG_APCC_DBOX_1	100	108	PF00400	0.562
DEG_APCC_KENBOX_2	88	92	PF00400	0.573
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DEG_SPOP_SBC_1	270	274	PF00917	0.704
DEG_SPOP_SBC_1	285	289	PF00917	0.558
DEG_SPOP_SBC_1	293	297	PF00917	0.692
DOC_CKS1_1	52	57	PF01111	0.804
DOC_CYCLIN_RxL_1	521	530	PF00134	0.502
DOC_CYCLIN_RxL_1	97	108	PF00134	0.564
DOC_MAPK_DCC_7	593	602	PF00069	0.605
DOC_MAPK_gen_1	110	117	PF00069	0.440
DOC_MAPK_gen_1	153	159	PF00069	0.656
DOC_MAPK_gen_1	510	519	PF00069	0.439
DOC_MAPK_gen_1	94	104	PF00069	0.352
DOC_MAPK_HePTP_8	507	519	PF00069	0.518
DOC_MAPK_MEF2A_6	510	519	PF00069	0.492
DOC_MAPK_MEF2A_6	593	602	PF00069	0.605
DOC_MAPK_MEF2A_6	97	106	PF00069	0.586
DOC_PP1_RVXF_1	152	159	PF00149	0.649
DOC_PP1_RVXF_1	174	180	PF00149	0.606
DOC_PP2B_LxvP_1	115	118	PF13499	0.482
DOC_PP4_FxxP_1	159	162	PF00568	0.606
DOC_USP7_MATH_1	14	18	PF00917	0.638
DOC_USP7_MATH_1	270	274	PF00917	0.745
DOC_USP7_MATH_1	285	289	PF00917	0.727
DOC_USP7_MATH_1	293	297	PF00917	0.751
DOC_USP7_MATH_1	3	7	PF00917	0.546
DOC_USP7_MATH_1	41	45	PF00917	0.763
DOC_USP7_MATH_1	437	441	PF00917	0.652
DOC_USP7_MATH_1	497	501	PF00917	0.669
DOC_USP7_MATH_1	53	57	PF00917	0.636
DOC_USP7_MATH_1	621	625	PF00917	0.528
DOC_USP7_MATH_1	632	636	PF00917	0.576
DOC_USP7_UBL2_3	28	32	PF12436	0.737
DOC_WW_Pin1_4	272	277	PF00397	0.732
DOC_WW_Pin1_4	286	291	PF00397	0.597
DOC_WW_Pin1_4	341	346	PF00397	0.575
DOC_WW_Pin1_4	51	56	PF00397	0.809
DOC_WW_Pin1_4	634	639	PF00397	0.574
LIG_14-3-3_CanoR_1	176	180	PF00244	0.638
LIG_14-3-3_CanoR_1	187	197	PF00244	0.620
LIG_14-3-3_CanoR_1	225	232	PF00244	0.658
LIG_14-3-3_CanoR_1	4	8	PF00244	0.694
LIG_14-3-3_CanoR_1	545	550	PF00244	0.659
LIG_14-3-3_CanoR_1	593	598	PF00244	0.556
LIG_deltaCOP1_diTrp_1	456	463	PF00928	0.455
LIG_eIF4E_1	232	238	PF01652	0.551
LIG_FHA_1	273	279	PF00498	0.735
LIG_FHA_1	296	302	PF00498	0.731
LIG_FHA_1	466	472	PF00498	0.536
LIG_FHA_1	578	584	PF00498	0.462
LIG_FHA_1	620	626	PF00498	0.558
LIG_FHA_2	231	237	PF00498	0.609
LIG_FHA_2	34	40	PF00498	0.806
LIG_FHA_2	437	443	PF00498	0.480
LIG_FHA_2	516	522	PF00498	0.436
LIG_FHA_2	528	534	PF00498	0.446
LIG_FHA_2	70	76	PF00498	0.754
LIG_LIR_Gen_1	529	539	PF02991	0.450
LIG_LIR_Nem_3	325	331	PF02991	0.542
LIG_LIR_Nem_3	480	484	PF02991	0.433
LIG_LIR_Nem_3	502	508	PF02991	0.425
LIG_LIR_Nem_3	529	534	PF02991	0.550
LIG_Pex14_1	459	463	PF04695	0.432
LIG_Pex14_2	477	481	PF04695	0.445
LIG_PTB_Apo_2	525	532	PF02174	0.516
LIG_Rb_LxCxE_1	358	373	PF01857	0.645
LIG_RPA_C_Fungi	302	314	PF08784	0.721
LIG_SH2_CRK	99	103	PF00017	0.449
LIG_SH2_PTP2	506	509	PF00017	0.484
LIG_SH2_SRC	328	331	PF00017	0.466
LIG_SH2_STAP1	113	117	PF00017	0.447
LIG_SH2_STAT3	232	235	PF00017	0.635
LIG_SH2_STAT5	188	191	PF00017	0.649
LIG_SH2_STAT5	232	235	PF00017	0.616
LIG_SH2_STAT5	353	356	PF00017	0.463
LIG_SH2_STAT5	506	509	PF00017	0.448
LIG_SH3_2	598	603	PF14604	0.422
LIG_SH3_3	287	293	PF00018	0.710
LIG_SH3_3	52	58	PF00018	0.794
LIG_SH3_3	595	601	PF00018	0.580
LIG_TRAF2_1	233	236	PF00917	0.574
LIG_TRAF2_1	403	406	PF00917	0.712
LIG_TRAF2_1	429	432	PF00917	0.784
LIG_TRAF2_1	624	627	PF00917	0.574
LIG_TYR_ITIM	326	331	PF00017	0.542
LIG_UBA3_1	103	112	PF00899	0.428
MOD_CK1_1	138	144	PF00069	0.324
MOD_CK1_1	295	301	PF00069	0.700
MOD_CK1_1	308	314	PF00069	0.446
MOD_CK1_1	40	46	PF00069	0.816
MOD_CK1_1	425	431	PF00069	0.764
MOD_CK1_1	465	471	PF00069	0.525
MOD_CK2_1	108	114	PF00069	0.342
MOD_CK2_1	175	181	PF00069	0.561
MOD_CK2_1	230	236	PF00069	0.562
MOD_CK2_1	383	389	PF00069	0.740
MOD_CK2_1	425	431	PF00069	0.776
MOD_CK2_1	621	627	PF00069	0.498
MOD_Cter_Amidation	394	397	PF01082	0.774
MOD_GlcNHglycan	12	15	PF01048	0.684
MOD_GlcNHglycan	140	143	PF01048	0.407
MOD_GlcNHglycan	190	193	PF01048	0.625
MOD_GlcNHglycan	259	262	PF01048	0.657
MOD_GlcNHglycan	38	42	PF01048	0.734
MOD_GlcNHglycan	386	389	PF01048	0.756
MOD_GlcNHglycan	393	396	PF01048	0.790
MOD_GlcNHglycan	420	423	PF01048	0.786
MOD_GlcNHglycan	428	431	PF01048	0.773
MOD_GlcNHglycan	451	455	PF01048	0.520
MOD_GlcNHglycan	535	538	PF01048	0.705
MOD_GlcNHglycan	547	550	PF01048	0.728
MOD_GSK3_1	10	17	PF00069	0.677
MOD_GSK3_1	175	182	PF00069	0.562
MOD_GSK3_1	265	272	PF00069	0.715
MOD_GSK3_1	292	299	PF00069	0.681
MOD_GSK3_1	33	40	PF00069	0.782
MOD_GSK3_1	418	425	PF00069	0.765
MOD_GSK3_1	446	453	PF00069	0.572
MOD_GSK3_1	47	54	PF00069	0.771
MOD_GSK3_1	513	520	PF00069	0.532
MOD_GSK3_1	573	580	PF00069	0.506
MOD_GSK3_1	632	639	PF00069	0.633
MOD_GSK3_1	77	84	PF00069	0.687
MOD_N-GLC_1	118	123	PF02516	0.424
MOD_N-GLC_1	135	140	PF02516	0.227
MOD_N-GLC_1	527	532	PF02516	0.342
MOD_N-GLC_1	573	578	PF02516	0.483
MOD_NEK2_1	230	235	PF00069	0.678
MOD_NEK2_1	294	299	PF00069	0.705
MOD_NEK2_1	305	310	PF00069	0.706
MOD_NEK2_1	37	42	PF00069	0.812
MOD_NEK2_1	515	520	PF00069	0.485
MOD_NEK2_1	527	532	PF00069	0.480
MOD_NEK2_2	14	19	PF00069	0.663
MOD_NEK2_2	3	8	PF00069	0.616
MOD_NEK2_2	573	578	PF00069	0.483
MOD_PIKK_1	230	236	PF00454	0.562
MOD_PIKK_1	619	625	PF00454	0.540
MOD_PK_1	593	599	PF00069	0.582
MOD_PKA_1	218	224	PF00069	0.643
MOD_PKA_2	14	20	PF00069	0.630
MOD_PKA_2	175	181	PF00069	0.637
MOD_PKA_2	218	224	PF00069	0.549
MOD_PKA_2	3	9	PF00069	0.692
MOD_PKA_2	348	354	PF00069	0.608
MOD_PKA_2	358	364	PF00069	0.551
MOD_PKA_2	383	389	PF00069	0.595
MOD_PKA_2	418	424	PF00069	0.789
MOD_PKA_2	425	431	PF00069	0.694
MOD_PKA_2	465	471	PF00069	0.556
MOD_PKA_2	544	550	PF00069	0.655
MOD_PKB_1	216	224	PF00069	0.644
MOD_PKB_1	382	390	PF00069	0.720
MOD_PKB_1	424	432	PF00069	0.680
MOD_Plk_1	118	124	PF00069	0.441
MOD_Plk_1	513	519	PF00069	0.553
MOD_Plk_1	527	533	PF00069	0.476
MOD_Plk_1	573	579	PF00069	0.484
MOD_Plk_1	81	87	PF00069	0.607
MOD_Plk_2-3	175	181	PF00069	0.559
MOD_Plk_2-3	201	207	PF00069	0.659
MOD_Plk_2-3	71	77	PF00069	0.676
MOD_Plk_4	26	32	PF00069	0.605
MOD_Plk_4	322	328	PF00069	0.614
MOD_Plk_4	358	364	PF00069	0.460
MOD_Plk_4	527	533	PF00069	0.409
MOD_Plk_4	573	579	PF00069	0.484
MOD_ProDKin_1	272	278	PF00069	0.735
MOD_ProDKin_1	286	292	PF00069	0.593
MOD_ProDKin_1	341	347	PF00069	0.579
MOD_ProDKin_1	51	57	PF00069	0.808
MOD_ProDKin_1	634	640	PF00069	0.586
MOD_SUMO_for_1	244	247	PF00179	0.699
MOD_SUMO_for_1	370	373	PF00179	0.693
MOD_SUMO_rev_2	175	184	PF00179	0.630
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.447
TRG_ENDOCYTIC_2	328	331	PF00928	0.442
TRG_ENDOCYTIC_2	506	509	PF00928	0.484
TRG_ENDOCYTIC_2	99	102	PF00928	0.447
TRG_ER_diArg_1	18	21	PF00400	0.582
TRG_ER_diArg_1	217	219	PF00400	0.524
TRG_ER_diArg_1	338	341	PF00400	0.499
TRG_ER_diArg_1	380	382	PF00400	0.819
TRG_ER_diArg_1	396	399	PF00400	0.554
TRG_ER_diArg_1	490	492	PF00400	0.626
TRG_ER_diArg_1	610	613	PF00400	0.557
TRG_ER_diArg_1	629	631	PF00400	0.548
TRG_NES_CRM1_1	360	373	PF08389	0.601
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.808
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I070	Leptomonas seymouri	62%	100%
A0A1X0NQY1	Trypanosomatidae	33%	100%
A0A3R7KGE8	Trypanosoma rangeli	32%	100%
A4HGV4	Leishmania braziliensis	79%	100%
A4I3Y4	Leishmania infantum	99%	100%
D0A955	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B074	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q811	Leishmania major	94%	100%
V5BGS0	Trypanosoma cruzi	31%	100%