Ysine_decarboxylase-like_protein/GeneDB:LmjF.17.0 735

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ysine decarboxylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDZ9_LEIDO

TriTrypDb:

LdBPK_170880.1 , LdCL_170014800 , LDHU3_17.1290

Length:

322

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Ysine decarboxylase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDZ9

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009308	amine metabolic process	4	9
GO:0009690	cytokinin metabolic process	3	9
GO:0009691	cytokinin biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0010817	regulation of hormone levels	3	9
GO:0042445	hormone metabolic process	2	9
GO:0042446	hormone biosynthetic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.349
CLV_PCSK_SKI1_1	127	131	PF00082	0.449
DOC_MAPK_gen_1	254	262	PF00069	0.548
DOC_PP1_RVXF_1	216	223	PF00149	0.548
DOC_PP2B_PxIxI_1	254	260	PF00149	0.599
DOC_PP4_FxxP_1	265	268	PF00568	0.547
DOC_PP4_FxxP_1	306	309	PF00568	0.490
DOC_USP7_MATH_1	107	111	PF00917	0.813
DOC_USP7_MATH_1	212	216	PF00917	0.593
DOC_USP7_UBL2_3	148	152	PF12436	0.509
DOC_WW_Pin1_4	308	313	PF00397	0.568
LIG_14-3-3_CanoR_1	207	214	PF00244	0.564
LIG_14-3-3_CanoR_1	62	67	PF00244	0.636
LIG_AP2alpha_1	20	24	PF02296	0.616
LIG_AP2alpha_1	265	269	PF02296	0.556
LIG_AP2alpha_2	267	269	PF02296	0.547
LIG_BRCT_BRCA1_1	218	222	PF00533	0.548
LIG_FHA_1	166	172	PF00498	0.441
LIG_FHA_1	38	44	PF00498	0.573
LIG_FHA_1	6	12	PF00498	0.573
LIG_FHA_2	211	217	PF00498	0.559
LIG_FHA_2	235	241	PF00498	0.548
LIG_FHA_2	293	299	PF00498	0.548
LIG_GSK3_LRP6_1	308	314	PF00069	0.600
LIG_LIR_Apic_2	263	268	PF02991	0.547
LIG_LIR_Apic_2	305	309	PF02991	0.499
LIG_LIR_Gen_1	237	245	PF02991	0.551
LIG_LIR_Gen_1	267	277	PF02991	0.576
LIG_LIR_Gen_1	284	294	PF02991	0.603
LIG_LIR_Gen_1	61	69	PF02991	0.616
LIG_LIR_Gen_1	97	107	PF02991	0.682
LIG_LIR_Nem_3	22	27	PF02991	0.574
LIG_LIR_Nem_3	237	241	PF02991	0.551
LIG_LIR_Nem_3	263	269	PF02991	0.573
LIG_LIR_Nem_3	284	290	PF02991	0.613
LIG_LIR_Nem_3	68	72	PF02991	0.633
LIG_LIR_Nem_3	97	102	PF02991	0.604
LIG_Pex14_2	20	24	PF04695	0.573
LIG_Pex14_2	265	269	PF04695	0.550
LIG_SH2_CRK	99	103	PF00017	0.627
LIG_SH2_GRB2like	99	102	PF00017	0.596
LIG_SH2_NCK_1	209	213	PF00017	0.599
LIG_SH2_NCK_1	99	103	PF00017	0.627
LIG_SH2_STAP1	143	147	PF00017	0.481
LIG_SH2_STAP1	99	103	PF00017	0.627
LIG_SH2_STAT5	143	146	PF00017	0.469
LIG_SH2_STAT5	153	156	PF00017	0.407
LIG_SH2_STAT5	209	212	PF00017	0.599
LIG_SH2_STAT5	57	60	PF00017	0.574
LIG_SH3_3	196	202	PF00018	0.509
LIG_SH3_3	226	232	PF00018	0.548
LIG_SH3_3	288	294	PF00018	0.548
LIG_SH3_3	304	310	PF00018	0.604
LIG_SUMO_SIM_anti_2	239	246	PF11976	0.548
LIG_SUMO_SIM_anti_2	295	302	PF11976	0.534
LIG_SUMO_SIM_par_1	239	246	PF11976	0.548
LIG_TRAF2_1	90	93	PF00917	0.596
LIG_TYR_ITIM	55	60	PF00017	0.564
LIG_TYR_ITSM	95	102	PF00017	0.596
LIG_WRC_WIRS_1	235	240	PF05994	0.573
LIG_WRC_WIRS_1	303	308	PF05994	0.521
MOD_CK1_1	197	203	PF00069	0.565
MOD_CK1_1	311	317	PF00069	0.641
MOD_CK2_1	192	198	PF00069	0.672
MOD_CK2_1	210	216	PF00069	0.481
MOD_CK2_1	234	240	PF00069	0.554
MOD_CK2_1	292	298	PF00069	0.548
MOD_GlcNHglycan	136	139	PF01048	0.597
MOD_GlcNHglycan	198	202	PF01048	0.373
MOD_GlcNHglycan	75	78	PF01048	0.503
MOD_GSK3_1	113	120	PF00069	0.710
MOD_GSK3_1	208	215	PF00069	0.564
MOD_GSK3_1	308	315	PF00069	0.615
MOD_GSK3_1	97	104	PF00069	0.677
MOD_NEK2_1	316	321	PF00069	0.690
MOD_NEK2_2	5	10	PF00069	0.595
MOD_PIKK_1	101	107	PF00454	0.698
MOD_PIKK_1	141	147	PF00454	0.519
MOD_PK_1	185	191	PF00069	0.616
MOD_PKA_2	216	222	PF00069	0.556
MOD_PKA_2	61	67	PF00069	0.575
MOD_Plk_2-3	117	123	PF00069	0.568
MOD_Plk_4	216	222	PF00069	0.585
MOD_Plk_4	224	230	PF00069	0.565
MOD_Plk_4	302	308	PF00069	0.642
MOD_Plk_4	312	318	PF00069	0.628
MOD_Plk_4	94	100	PF00069	0.583
MOD_ProDKin_1	308	314	PF00069	0.574
MOD_SUMO_rev_2	156	161	PF00179	0.531
MOD_SUMO_rev_2	215	220	PF00179	0.555
MOD_SUMO_rev_2	279	287	PF00179	0.552
MOD_SUMO_rev_2	92	97	PF00179	0.643
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.675
TRG_ENDOCYTIC_2	57	60	PF00928	0.616
TRG_ENDOCYTIC_2	63	66	PF00928	0.616
TRG_ENDOCYTIC_2	99	102	PF00928	0.682
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC81	Leptomonas seymouri	70%	100%
A0A1X0NSV2	Trypanosomatidae	46%	94%
A0A422MP54	Trypanosoma rangeli	48%	100%
A4H924	Leishmania braziliensis	86%	100%
A4HXF6	Leishmania infantum	100%	100%
E9AR51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEB2	Leishmania major	95%	100%