Acyl CoA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY9_LEIDO

TriTrypDb:

LdBPK_170670.1 , LdCL_170012100 , LDHU3_17.0970

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	7
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0033218	amide binding	2	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0120227	acyl-CoA binding	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:1901567	fatty acid derivative binding	3	7
GO:1901681	sulfur compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.614
CLV_C14_Caspase3-7	41	45	PF00656	0.399
CLV_NRD_NRD_1	100	102	PF00675	0.339
CLV_NRD_NRD_1	123	125	PF00675	0.472
CLV_NRD_NRD_1	326	328	PF00675	0.711
CLV_NRD_NRD_1	338	340	PF00675	0.682
CLV_NRD_NRD_1	47	49	PF00675	0.466
CLV_NRD_NRD_1	8	10	PF00675	0.575
CLV_PCSK_FUR_1	327	331	PF00082	0.720
CLV_PCSK_KEX2_1	227	229	PF00082	0.352
CLV_PCSK_KEX2_1	268	270	PF00082	0.626
CLV_PCSK_KEX2_1	329	331	PF00082	0.603
CLV_PCSK_KEX2_1	337	339	PF00082	0.429
CLV_PCSK_KEX2_1	494	496	PF00082	0.639
CLV_PCSK_KEX2_1	8	10	PF00082	0.584
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.339
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.626
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.605
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.429
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.634
CLV_PCSK_SKI1_1	104	108	PF00082	0.466
CLV_PCSK_SKI1_1	173	177	PF00082	0.317
CLV_PCSK_SKI1_1	232	236	PF00082	0.430
CLV_PCSK_SKI1_1	264	268	PF00082	0.598
CLV_PCSK_SKI1_1	494	498	PF00082	0.613
CLV_PCSK_SKI1_1	71	75	PF00082	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.716
DEG_SPOP_SBC_1	432	436	PF00917	0.670
DOC_CKS1_1	184	189	PF01111	0.466
DOC_MAPK_gen_1	108	116	PF00069	0.316
DOC_MAPK_gen_1	465	472	PF00069	0.590
DOC_MAPK_MEF2A_6	110	118	PF00069	0.369
DOC_MAPK_MEF2A_6	465	472	PF00069	0.590
DOC_PP1_RVXF_1	137	144	PF00149	0.458
DOC_PP1_RVXF_1	61	67	PF00149	0.339
DOC_PP4_FxxP_1	29	32	PF00568	0.522
DOC_USP7_MATH_1	305	309	PF00917	0.514
DOC_USP7_MATH_1	408	412	PF00917	0.574
DOC_USP7_MATH_1	450	454	PF00917	0.761
DOC_USP7_MATH_1	457	461	PF00917	0.697
DOC_USP7_MATH_1	477	481	PF00917	0.616
DOC_USP7_UBL2_3	232	236	PF12436	0.557
DOC_USP7_UBL2_3	264	268	PF12436	0.725
DOC_USP7_UBL2_3	329	333	PF12436	0.665
DOC_USP7_UBL2_3	471	475	PF12436	0.716
DOC_USP7_UBL2_3	484	488	PF12436	0.670
DOC_WW_Pin1_4	183	188	PF00397	0.466
DOC_WW_Pin1_4	433	438	PF00397	0.715
LIG_14-3-3_CanoR_1	124	130	PF00244	0.656
LIG_BIR_III_4	292	296	PF00653	0.626
LIG_BRCT_BRCA1_1	21	25	PF00533	0.634
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.478
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.339
LIG_FHA_2	268	274	PF00498	0.650
LIG_FHA_2	284	290	PF00498	0.459
LIG_FHA_2	308	314	PF00498	0.620
LIG_FHA_2	364	370	PF00498	0.774
LIG_FHA_2	387	393	PF00498	0.630
LIG_FHA_2	72	78	PF00498	0.339
LIG_KLC1_Yacidic_2	113	117	PF13176	0.279
LIG_LIR_Apic_2	128	134	PF02991	0.670
LIG_LIR_Apic_2	28	32	PF02991	0.527
LIG_LIR_Gen_1	113	123	PF02991	0.339
LIG_LIR_Gen_1	137	147	PF02991	0.467
LIG_LIR_Gen_1	213	221	PF02991	0.353
LIG_LIR_Gen_1	344	353	PF02991	0.564
LIG_LIR_Nem_3	11	17	PF02991	0.633
LIG_LIR_Nem_3	113	118	PF02991	0.339
LIG_LIR_Nem_3	137	143	PF02991	0.478
LIG_LIR_Nem_3	192	198	PF02991	0.341
LIG_LIR_Nem_3	213	218	PF02991	0.514
LIG_LIR_Nem_3	344	348	PF02991	0.556
LIG_LIR_Nem_3	90	94	PF02991	0.339
LIG_MAD2	454	462	PF02301	0.661
LIG_MYND_3	440	444	PF01753	0.627
LIG_Pex14_2	25	29	PF04695	0.576
LIG_Pex14_2	66	70	PF04695	0.466
LIG_REV1ctd_RIR_1	3	11	PF16727	0.577
LIG_SH2_NCK_1	36	40	PF00017	0.466
LIG_SH2_PTP2	115	118	PF00017	0.310
LIG_SH2_PTP2	345	348	PF00017	0.556
LIG_SH2_STAP1	212	216	PF00017	0.339
LIG_SH2_STAP1	36	40	PF00017	0.466
LIG_SH2_STAT5	115	118	PF00017	0.339
LIG_SH2_STAT5	159	162	PF00017	0.317
LIG_SH2_STAT5	230	233	PF00017	0.339
LIG_SH2_STAT5	243	246	PF00017	0.511
LIG_SH2_STAT5	345	348	PF00017	0.556
LIG_SH2_STAT5	46	49	PF00017	0.339
LIG_SH3_3	14	20	PF00018	0.568
LIG_SH3_3	241	247	PF00018	0.507
LIG_SH3_3	29	35	PF00018	0.429
LIG_SH3_3	351	357	PF00018	0.578
LIG_SH3_3	79	85	PF00018	0.356
LIG_TRAF2_1	286	289	PF00917	0.699
LIG_TRAF2_1	320	323	PF00917	0.657
LIG_TRAF2_1	39	42	PF00917	0.399
LIG_UBA3_1	149	155	PF00899	0.466
LIG_ULM_U2AF65_1	193	198	PF00076	0.316
LIG_WRC_WIRS_1	2	7	PF05994	0.578
LIG_WRC_WIRS_1	306	311	PF05994	0.675
MOD_CDK_SPxxK_3	435	442	PF00069	0.585
MOD_CK1_1	200	206	PF00069	0.366
MOD_CK1_1	262	268	PF00069	0.745
MOD_CK1_1	359	365	PF00069	0.672
MOD_CK2_1	283	289	PF00069	0.707
MOD_CK2_1	296	302	PF00069	0.530
MOD_CK2_1	307	313	PF00069	0.556
MOD_CK2_1	363	369	PF00069	0.762
MOD_CK2_1	455	461	PF00069	0.714
MOD_Cter_Amidation	325	328	PF01082	0.648
MOD_Cter_Amidation	6	9	PF01082	0.711
MOD_GlcNHglycan	134	137	PF01048	0.581
MOD_GlcNHglycan	236	239	PF01048	0.514
MOD_GlcNHglycan	261	264	PF01048	0.594
MOD_GlcNHglycan	410	413	PF01048	0.674
MOD_GlcNHglycan	419	422	PF01048	0.815
MOD_GlcNHglycan	444	448	PF01048	0.698
MOD_GSK3_1	258	265	PF00069	0.732
MOD_GSK3_1	356	363	PF00069	0.734
MOD_GSK3_1	428	435	PF00069	0.727
MOD_N-GLC_1	178	183	PF02516	0.366
MOD_N-GLC_2	398	400	PF02516	0.678
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	443	448	PF00069	0.727
MOD_PKA_1	267	273	PF00069	0.616
MOD_PKA_2	200	206	PF00069	0.371
MOD_Plk_1	363	369	PF00069	0.725
MOD_Plk_1	428	434	PF00069	0.660
MOD_Plk_4	1	7	PF00069	0.562
MOD_Plk_4	125	131	PF00069	0.658
MOD_Plk_4	19	25	PF00069	0.464
MOD_Plk_4	296	302	PF00069	0.657
MOD_Plk_4	341	347	PF00069	0.563
MOD_Plk_4	65	71	PF00069	0.339
MOD_Plk_4	83	89	PF00069	0.339
MOD_ProDKin_1	183	189	PF00069	0.466
MOD_ProDKin_1	433	439	PF00069	0.716
MOD_SUMO_for_1	357	360	PF00179	0.703
MOD_SUMO_for_1	441	444	PF00179	0.659
MOD_SUMO_for_1	464	467	PF00179	0.672
MOD_SUMO_rev_2	11	17	PF00179	0.627
MOD_SUMO_rev_2	75	85	PF00179	0.417
TRG_ENDOCYTIC_2	115	118	PF00928	0.339
TRG_ENDOCYTIC_2	195	198	PF00928	0.339
TRG_ENDOCYTIC_2	345	348	PF00928	0.556
TRG_ENDOCYTIC_2	67	70	PF00928	0.481
TRG_ENDOCYTIC_2	94	97	PF00928	0.466
TRG_ER_diArg_1	198	201	PF00400	0.339
TRG_NES_CRM1_1	289	302	PF08389	0.606
TRG_NLS_Bipartite_1	327	341	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F7	Leptomonas seymouri	46%	100%
A4H904	Leishmania braziliensis	69%	99%
A4HXD5	Leishmania infantum	100%	100%
E9AR30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QED3	Leishmania major	91%	100%