Isocitrate dehydrogenase [NADP]

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

isocitrate dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY7_LEIDO

TriTrypDb:

LdBPK_332680.1 , LdCL_330033900 , LDHU3_33.3800

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY7

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006081	cellular aldehyde metabolic process	3	7
GO:0006082	organic acid metabolic process	3	7
GO:0006097	glyoxylate cycle	4	7
GO:0006099	tricarboxylic acid cycle	3	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0043436	oxoacid metabolic process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0004448	isocitrate dehydrogenase [NAD(P)+] activity	5	7
GO:0004450	isocitrate dehydrogenase (NADP+) activity	6	7
GO:0005488	binding	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	7
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	7
GO:0036094	small molecule binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.471
CLV_NRD_NRD_1	52	54	PF00675	0.241
CLV_PCSK_KEX2_1	52	54	PF00082	0.169
CLV_PCSK_SKI1_1	121	125	PF00082	0.248
CLV_PCSK_SKI1_1	30	34	PF00082	0.248
CLV_PCSK_SKI1_1	9	13	PF00082	0.395
DEG_SCF_FBW7_2	91	98	PF00400	0.448
DOC_CKS1_1	156	161	PF01111	0.463
DOC_CKS1_1	92	97	PF01111	0.448
DOC_MAPK_gen_1	108	115	PF00069	0.494

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ7	Leptomonas seymouri	81%	100%
A0PPY6	Mycobacterium ulcerans (strain Agy99)	30%	100%
A0QJC2	Mycobacterium avium (strain 104)	30%	100%
A1KMY9	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	32%	100%
A1T6Z4	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	29%	100%
A1UE98	Mycobacterium sp. (strain KMS)	29%	100%
A3PXQ2	Mycobacterium sp. (strain JLS)	29%	100%
A4FMQ2	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	31%	100%
A4HLW5	Leishmania braziliensis	90%	100%
A4I994	Leishmania infantum	100%	100%

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