Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY5_LEIDO

TriTrypDb:

LdBPK_261840.1 , LdCL_260024000 , LDHU3_26.2410

Length:

987

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.686
CLV_C14_Caspase3-7	959	963	PF00656	0.517
CLV_NRD_NRD_1	203	205	PF00675	0.589
CLV_NRD_NRD_1	426	428	PF00675	0.600
CLV_NRD_NRD_1	513	515	PF00675	0.586
CLV_NRD_NRD_1	53	55	PF00675	0.664
CLV_NRD_NRD_1	762	764	PF00675	0.633
CLV_NRD_NRD_1	774	776	PF00675	0.550
CLV_NRD_NRD_1	908	910	PF00675	0.620
CLV_PCSK_KEX2_1	426	428	PF00082	0.597
CLV_PCSK_KEX2_1	53	55	PF00082	0.664
CLV_PCSK_KEX2_1	762	764	PF00082	0.633
CLV_PCSK_KEX2_1	774	776	PF00082	0.550
CLV_PCSK_KEX2_1	908	910	PF00082	0.620
CLV_PCSK_SKI1_1	178	182	PF00082	0.684
CLV_PCSK_SKI1_1	208	212	PF00082	0.721
CLV_PCSK_SKI1_1	303	307	PF00082	0.722
CLV_PCSK_SKI1_1	412	416	PF00082	0.513
CLV_PCSK_SKI1_1	514	518	PF00082	0.594
CLV_PCSK_SKI1_1	606	610	PF00082	0.607
CLV_PCSK_SKI1_1	775	779	PF00082	0.676
DEG_Nend_UBRbox_2	1	3	PF02207	0.446
DEG_ODPH_VHL_1	517	530	PF01847	0.545
DEG_SCF_FBW7_2	942	949	PF00400	0.713
DEG_SPOP_SBC_1	104	108	PF00917	0.543
DEG_SPOP_SBC_1	209	213	PF00917	0.544
DEG_SPOP_SBC_1	428	432	PF00917	0.636
DEG_SPOP_SBC_1	460	464	PF00917	0.635
DEG_SPOP_SBC_1	856	860	PF00917	0.657
DOC_ANK_TNKS_1	338	345	PF00023	0.671
DOC_CDC14_PxL_1	948	956	PF14671	0.537
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	524	530	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	890	896	PF00134	0.542
DOC_MAPK_MEF2A_6	397	406	PF00069	0.534
DOC_MAPK_MEF2A_6	496	505	PF00069	0.519
DOC_MAPK_MEF2A_6	742	749	PF00069	0.516
DOC_PP1_RVXF_1	410	416	PF00149	0.517
DOC_PP2B_LxvP_1	289	292	PF13499	0.686
DOC_PP2B_LxvP_1	528	531	PF13499	0.599
DOC_PP2B_LxvP_1	80	83	PF13499	0.658
DOC_PP2B_PxIxI_1	863	869	PF00149	0.686
DOC_PP4_FxxP_1	628	631	PF00568	0.671
DOC_USP7_MATH_1	209	213	PF00917	0.737
DOC_USP7_MATH_1	247	251	PF00917	0.725
DOC_USP7_MATH_1	26	30	PF00917	0.488
DOC_USP7_MATH_1	283	287	PF00917	0.787
DOC_USP7_MATH_1	298	302	PF00917	0.680
DOC_USP7_MATH_1	367	371	PF00917	0.708
DOC_USP7_MATH_1	428	432	PF00917	0.581
DOC_USP7_MATH_1	459	463	PF00917	0.690
DOC_USP7_MATH_1	52	56	PF00917	0.715
DOC_USP7_MATH_1	563	567	PF00917	0.643
DOC_USP7_MATH_1	577	581	PF00917	0.556
DOC_USP7_MATH_1	601	605	PF00917	0.640
DOC_USP7_MATH_1	670	674	PF00917	0.634
DOC_USP7_MATH_1	684	688	PF00917	0.518
DOC_USP7_MATH_1	702	706	PF00917	0.615
DOC_USP7_MATH_1	729	733	PF00917	0.599
DOC_USP7_MATH_1	832	836	PF00917	0.672
DOC_USP7_MATH_1	839	843	PF00917	0.708
DOC_USP7_MATH_1	84	88	PF00917	0.770
DOC_USP7_MATH_1	856	860	PF00917	0.576
DOC_WW_Pin1_4	120	125	PF00397	0.717
DOC_WW_Pin1_4	186	191	PF00397	0.730
DOC_WW_Pin1_4	256	261	PF00397	0.742
DOC_WW_Pin1_4	368	373	PF00397	0.724
DOC_WW_Pin1_4	429	434	PF00397	0.719
DOC_WW_Pin1_4	487	492	PF00397	0.613
DOC_WW_Pin1_4	559	564	PF00397	0.590
DOC_WW_Pin1_4	581	586	PF00397	0.663
DOC_WW_Pin1_4	627	632	PF00397	0.684
DOC_WW_Pin1_4	780	785	PF00397	0.649
DOC_WW_Pin1_4	811	816	PF00397	0.660
DOC_WW_Pin1_4	824	829	PF00397	0.652
DOC_WW_Pin1_4	830	835	PF00397	0.605
DOC_WW_Pin1_4	89	94	PF00397	0.618
DOC_WW_Pin1_4	942	947	PF00397	0.623
LIG_14-3-3_CanoR_1	178	183	PF00244	0.669
LIG_14-3-3_CanoR_1	208	217	PF00244	0.684
LIG_14-3-3_CanoR_1	335	343	PF00244	0.695
LIG_14-3-3_CanoR_1	426	436	PF00244	0.653
LIG_14-3-3_CanoR_1	663	672	PF00244	0.675
LIG_14-3-3_CanoR_1	699	705	PF00244	0.626
LIG_14-3-3_CanoR_1	774	784	PF00244	0.681
LIG_14-3-3_CanoR_1	94	98	PF00244	0.556
LIG_14-3-3_CanoR_1	967	971	PF00244	0.539
LIG_Actin_WH2_2	761	776	PF00022	0.519
LIG_APCC_ABBAyCdc20_2	303	309	PF00400	0.715
LIG_BRCT_BRCA1_1	658	662	PF00533	0.657
LIG_BRCT_BRCA1_1	936	940	PF00533	0.638
LIG_deltaCOP1_diTrp_1	971	981	PF00928	0.617
LIG_EVH1_1	289	293	PF00568	0.684
LIG_FHA_1	137	143	PF00498	0.611
LIG_FHA_1	249	255	PF00498	0.568
LIG_FHA_1	351	357	PF00498	0.621
LIG_FHA_1	66	72	PF00498	0.486
LIG_FHA_1	680	686	PF00498	0.594
LIG_FHA_1	884	890	PF00498	0.468
LIG_FHA_1	898	904	PF00498	0.537
LIG_FHA_1	921	927	PF00498	0.551
LIG_FHA_1	943	949	PF00498	0.664
LIG_FHA_2	31	37	PF00498	0.462
LIG_FHA_2	540	546	PF00498	0.721
LIG_FHA_2	738	744	PF00498	0.566
LIG_FHA_2	776	782	PF00498	0.688
LIG_FHA_2	835	841	PF00498	0.624
LIG_FHA_2	858	864	PF00498	0.609
LIG_FHA_2	966	972	PF00498	0.566
LIG_Integrin_isoDGR_2	410	412	PF01839	0.527
LIG_LIR_Gen_1	225	235	PF02991	0.495
LIG_LIR_Gen_1	793	801	PF02991	0.691
LIG_LIR_LC3C_4	744	749	PF02991	0.607
LIG_LIR_Nem_3	100	104	PF02991	0.619
LIG_LIR_Nem_3	192	197	PF02991	0.590
LIG_LIR_Nem_3	2	7	PF02991	0.416
LIG_LIR_Nem_3	225	231	PF02991	0.489
LIG_LIR_Nem_3	416	420	PF02991	0.527
LIG_LIR_Nem_3	724	730	PF02991	0.662
LIG_LIR_Nem_3	793	797	PF02991	0.722
LIG_LIR_Nem_3	900	904	PF02991	0.592
LIG_PDZ_Class_2	982	987	PF00595	0.456
LIG_Pex14_1	981	985	PF04695	0.441
LIG_SH2_CRK	483	487	PF00017	0.659
LIG_SH2_CRK	794	798	PF00017	0.695
LIG_SH2_CRK	911	915	PF00017	0.599
LIG_SH2_GRB2like	521	524	PF00017	0.698
LIG_SH2_SRC	167	170	PF00017	0.583
LIG_SH2_SRC	23	26	PF00017	0.369
LIG_SH2_STAP1	906	910	PF00017	0.501
LIG_SH2_STAT5	167	170	PF00017	0.662
LIG_SH2_STAT5	521	524	PF00017	0.591
LIG_SH3_1	257	263	PF00018	0.694
LIG_SH3_1	287	293	PF00018	0.691
LIG_SH3_3	126	132	PF00018	0.680
LIG_SH3_3	166	172	PF00018	0.554
LIG_SH3_3	257	263	PF00018	0.742
LIG_SH3_3	287	293	PF00018	0.762
LIG_SH3_3	375	381	PF00018	0.724
LIG_SH3_3	39	45	PF00018	0.585
LIG_SH3_3	534	540	PF00018	0.614
LIG_SH3_3	579	585	PF00018	0.623
LIG_SH3_3	597	603	PF00018	0.502
LIG_SH3_3	893	899	PF00018	0.524
LIG_SH3_3	911	917	PF00018	0.608
LIG_Sin3_3	194	201	PF02671	0.510
LIG_Sin3_3	28	35	PF02671	0.492
LIG_SUMO_SIM_anti_2	886	892	PF11976	0.483
LIG_SUMO_SIM_par_1	400	405	PF11976	0.636
LIG_SUMO_SIM_par_1	526	532	PF11976	0.551
LIG_TRAF2_1	842	845	PF00917	0.735
LIG_TRFH_1	235	239	PF08558	0.516
LIG_TYR_ITIM	305	310	PF00017	0.601
MOD_CDC14_SPxK_1	432	435	PF00782	0.675
MOD_CDC14_SPxK_1	838	841	PF00782	0.586
MOD_CDK_SPK_2	89	94	PF00069	0.557
MOD_CDK_SPxK_1	429	435	PF00069	0.673
MOD_CDK_SPxK_1	835	841	PF00069	0.589
MOD_CDK_SPxxK_3	120	127	PF00069	0.691
MOD_CK1_1	105	111	PF00069	0.513
MOD_CK1_1	114	120	PF00069	0.753
MOD_CK1_1	136	142	PF00069	0.620
MOD_CK1_1	145	151	PF00069	0.668
MOD_CK1_1	163	169	PF00069	0.721
MOD_CK1_1	265	271	PF00069	0.750
MOD_CK1_1	322	328	PF00069	0.579
MOD_CK1_1	359	365	PF00069	0.724
MOD_CK1_1	455	461	PF00069	0.736
MOD_CK1_1	489	495	PF00069	0.590
MOD_CK1_1	566	572	PF00069	0.637
MOD_CK1_1	584	590	PF00069	0.507
MOD_CK1_1	621	627	PF00069	0.609
MOD_CK1_1	668	674	PF00069	0.725
MOD_CK1_1	687	693	PF00069	0.768
MOD_CK1_1	705	711	PF00069	0.486
MOD_CK1_1	714	720	PF00069	0.599
MOD_CK1_1	803	809	PF00069	0.645
MOD_CK1_1	835	841	PF00069	0.639
MOD_CK1_1	89	95	PF00069	0.643
MOD_CK1_1	933	939	PF00069	0.646
MOD_CK2_1	186	192	PF00069	0.612
MOD_CK2_1	261	267	PF00069	0.683
MOD_CK2_1	30	36	PF00069	0.463
MOD_CK2_1	52	58	PF00069	0.591
MOD_CK2_1	737	743	PF00069	0.578
MOD_CK2_1	775	781	PF00069	0.708
MOD_CK2_1	824	830	PF00069	0.700
MOD_CK2_1	834	840	PF00069	0.655
MOD_CK2_1	965	971	PF00069	0.571
MOD_CMANNOS	495	498	PF00535	0.690
MOD_GlcNHglycan	108	111	PF01048	0.466
MOD_GlcNHglycan	136	139	PF01048	0.609
MOD_GlcNHglycan	163	166	PF01048	0.723
MOD_GlcNHglycan	363	366	PF01048	0.677
MOD_GlcNHglycan	378	381	PF01048	0.588
MOD_GlcNHglycan	39	42	PF01048	0.490
MOD_GlcNHglycan	407	410	PF01048	0.600
MOD_GlcNHglycan	457	460	PF01048	0.748
MOD_GlcNHglycan	531	534	PF01048	0.716
MOD_GlcNHglycan	54	57	PF01048	0.552
MOD_GlcNHglycan	556	560	PF01048	0.634
MOD_GlcNHglycan	563	566	PF01048	0.597
MOD_GlcNHglycan	568	571	PF01048	0.557
MOD_GlcNHglycan	603	606	PF01048	0.683
MOD_GlcNHglycan	658	661	PF01048	0.621
MOD_GlcNHglycan	667	670	PF01048	0.672
MOD_GlcNHglycan	672	675	PF01048	0.790
MOD_GlcNHglycan	713	716	PF01048	0.664
MOD_GlcNHglycan	775	778	PF01048	0.672
MOD_GlcNHglycan	88	91	PF01048	0.663
MOD_GlcNHglycan	918	921	PF01048	0.544
MOD_GSK3_1	102	109	PF00069	0.518
MOD_GSK3_1	133	140	PF00069	0.628
MOD_GSK3_1	145	152	PF00069	0.733
MOD_GSK3_1	153	160	PF00069	0.473
MOD_GSK3_1	258	265	PF00069	0.744
MOD_GSK3_1	26	33	PF00069	0.413
MOD_GSK3_1	293	300	PF00069	0.694
MOD_GSK3_1	319	326	PF00069	0.577
MOD_GSK3_1	356	363	PF00069	0.675
MOD_GSK3_1	376	383	PF00069	0.516
MOD_GSK3_1	449	456	PF00069	0.665
MOD_GSK3_1	460	467	PF00069	0.521
MOD_GSK3_1	486	493	PF00069	0.510
MOD_GSK3_1	555	562	PF00069	0.589
MOD_GSK3_1	566	573	PF00069	0.619
MOD_GSK3_1	577	584	PF00069	0.578
MOD_GSK3_1	658	665	PF00069	0.596
MOD_GSK3_1	668	675	PF00069	0.692
MOD_GSK3_1	707	714	PF00069	0.600
MOD_GSK3_1	775	782	PF00069	0.649
MOD_GSK3_1	830	837	PF00069	0.743
MOD_GSK3_1	85	92	PF00069	0.791
MOD_GSK3_1	916	923	PF00069	0.631
MOD_GSK3_1	926	933	PF00069	0.513
MOD_GSK3_1	93	100	PF00069	0.564
MOD_GSK3_1	934	941	PF00069	0.578
MOD_GSK3_1	965	972	PF00069	0.557
MOD_LATS_1	333	339	PF00433	0.652
MOD_N-GLC_1	102	107	PF02516	0.567
MOD_N-GLC_1	142	147	PF02516	0.679
MOD_N-GLC_1	149	154	PF02516	0.624
MOD_N-GLC_1	376	381	PF02516	0.639
MOD_N-GLC_1	621	626	PF02516	0.607
MOD_N-GLC_1	679	684	PF02516	0.617
MOD_N-GLC_1	847	852	PF02516	0.606
MOD_NEK2_1	142	147	PF00069	0.692
MOD_NEK2_1	161	166	PF00069	0.727
MOD_NEK2_1	30	35	PF00069	0.493
MOD_NEK2_1	323	328	PF00069	0.662
MOD_NEK2_1	453	458	PF00069	0.685
MOD_NEK2_1	486	491	PF00069	0.497
MOD_NEK2_1	549	554	PF00069	0.668
MOD_NEK2_1	640	645	PF00069	0.637
MOD_NEK2_1	66	71	PF00069	0.630
MOD_NEK2_1	662	667	PF00069	0.653
MOD_NEK2_1	679	684	PF00069	0.523
MOD_NEK2_1	773	778	PF00069	0.733
MOD_NEK2_1	85	90	PF00069	0.471
MOD_NEK2_1	857	862	PF00069	0.658
MOD_NEK2_1	925	930	PF00069	0.562
MOD_NEK2_1	965	970	PF00069	0.572
MOD_NEK2_1	97	102	PF00069	0.532
MOD_PIKK_1	211	217	PF00454	0.674
MOD_PIKK_1	465	471	PF00454	0.598
MOD_PK_1	149	155	PF00069	0.663
MOD_PKA_2	334	340	PF00069	0.684
MOD_PKA_2	359	365	PF00069	0.654
MOD_PKA_2	434	440	PF00069	0.601
MOD_PKA_2	52	58	PF00069	0.663
MOD_PKA_2	640	646	PF00069	0.565
MOD_PKA_2	662	668	PF00069	0.692
MOD_PKA_2	773	779	PF00069	0.585
MOD_PKA_2	93	99	PF00069	0.545
MOD_PKA_2	966	972	PF00069	0.542
MOD_PKB_1	147	155	PF00069	0.663
MOD_Plk_1	308	314	PF00069	0.672
MOD_Plk_1	549	555	PF00069	0.666
MOD_Plk_1	621	627	PF00069	0.609
MOD_Plk_1	66	72	PF00069	0.663
MOD_Plk_1	847	853	PF00069	0.604
MOD_Plk_1	952	958	PF00069	0.749
MOD_Plk_1	970	976	PF00069	0.478
MOD_Plk_4	163	169	PF00069	0.673
MOD_Plk_4	26	32	PF00069	0.491
MOD_Plk_4	439	445	PF00069	0.711
MOD_Plk_4	490	496	PF00069	0.596
MOD_Plk_4	549	555	PF00069	0.755
MOD_Plk_4	66	72	PF00069	0.488
MOD_Plk_4	97	103	PF00069	0.594
MOD_Plk_4	970	976	PF00069	0.628
MOD_ProDKin_1	120	126	PF00069	0.716
MOD_ProDKin_1	186	192	PF00069	0.728
MOD_ProDKin_1	256	262	PF00069	0.744
MOD_ProDKin_1	368	374	PF00069	0.723
MOD_ProDKin_1	429	435	PF00069	0.721
MOD_ProDKin_1	487	493	PF00069	0.615
MOD_ProDKin_1	559	565	PF00069	0.591
MOD_ProDKin_1	581	587	PF00069	0.662
MOD_ProDKin_1	627	633	PF00069	0.682
MOD_ProDKin_1	780	786	PF00069	0.650
MOD_ProDKin_1	811	817	PF00069	0.655
MOD_ProDKin_1	824	830	PF00069	0.654
MOD_ProDKin_1	835	841	PF00069	0.635
MOD_ProDKin_1	89	95	PF00069	0.618
MOD_ProDKin_1	942	948	PF00069	0.623
TRG_DiLeu_BaEn_1	439	444	PF01217	0.664
TRG_DiLeu_BaEn_1	743	748	PF01217	0.510
TRG_DiLeu_BaEn_1	921	926	PF01217	0.650
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.522
TRG_DiLeu_LyEn_5	734	739	PF01217	0.653
TRG_ENDOCYTIC_2	307	310	PF00928	0.599
TRG_ENDOCYTIC_2	483	486	PF00928	0.659
TRG_ENDOCYTIC_2	521	524	PF00928	0.591
TRG_ENDOCYTIC_2	727	730	PF00928	0.609
TRG_ENDOCYTIC_2	794	797	PF00928	0.699
TRG_ENDOCYTIC_2	911	914	PF00928	0.597
TRG_ER_diArg_1	426	428	PF00400	0.585
TRG_ER_diArg_1	509	512	PF00400	0.564
TRG_ER_diArg_1	718	721	PF00400	0.639
TRG_ER_diArg_1	761	763	PF00400	0.620
TRG_ER_diArg_1	773	775	PF00400	0.538
TRG_ER_diArg_1	908	910	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	606	611	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	762	766	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFF4	Leptomonas seymouri	43%	100%
A4HF29	Leishmania braziliensis	65%	99%
A4I2B7	Leishmania infantum	99%	100%
E9AYG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q908	Leishmania major	87%	100%