Aminoacyl-tRNA editing domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY4_LEIDO

TriTrypDb:

LdBPK_211150.1 , LdCL_210016500 , LDHU3_21.1350

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0004812	aminoacyl-tRNA ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.359
CLV_NRD_NRD_1	88	90	PF00675	0.481
CLV_PCSK_FUR_1	86	90	PF00082	0.383
CLV_PCSK_KEX2_1	116	118	PF00082	0.359
CLV_PCSK_KEX2_1	88	90	PF00082	0.488
CLV_PCSK_SKI1_1	117	121	PF00082	0.378
CLV_PCSK_SKI1_1	130	134	PF00082	0.228
DEG_SCF_TRCP1_1	93	99	PF00400	0.368
DOC_ANK_TNKS_1	39	46	PF00023	0.525
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.483
DOC_PP2B_LxvP_1	102	105	PF13499	0.508
DOC_PP2B_LxvP_1	120	123	PF13499	0.301
DOC_PP2B_LxvP_1	225	228	PF13499	0.462
DOC_SPAK_OSR1_1	24	28	PF12202	0.424
DOC_USP7_MATH_1	51	55	PF00917	0.675
DOC_USP7_MATH_1	9	13	PF00917	0.619
LIG_14-3-3_CanoR_1	60	68	PF00244	0.461
LIG_Actin_WH2_2	25	42	PF00022	0.524
LIG_BRCT_BRCA1_1	97	101	PF00533	0.324
LIG_CSL_BTD_1	102	105	PF09270	0.423
LIG_FHA_1	227	233	PF00498	0.532
LIG_FHA_1	97	103	PF00498	0.466
LIG_FHA_2	138	144	PF00498	0.452
LIG_FHA_2	262	268	PF00498	0.466
LIG_LIR_Gen_1	150	160	PF02991	0.437
LIG_LIR_Gen_1	247	256	PF02991	0.467
LIG_LIR_Gen_1	98	109	PF02991	0.486
LIG_LIR_Nem_3	150	156	PF02991	0.437
LIG_LIR_Nem_3	247	251	PF02991	0.435
LIG_LIR_Nem_3	98	104	PF02991	0.337
LIG_MYND_1	72	76	PF01753	0.557
LIG_SH2_SRC	157	160	PF00017	0.472
LIG_SH2_STAT5	153	156	PF00017	0.437
LIG_SH2_STAT5	159	162	PF00017	0.437
LIG_SH2_STAT5	231	234	PF00017	0.507
LIG_SH3_3	75	81	PF00018	0.619
LIG_SUMO_SIM_par_1	214	219	PF11976	0.443
LIG_TRAF2_1	171	174	PF00917	0.461
LIG_TRAF2_1	264	267	PF00917	0.390
LIG_TYR_ITIM	155	160	PF00017	0.539
MOD_CK1_1	54	60	PF00069	0.683
MOD_CK2_1	261	267	PF00069	0.404
MOD_Cter_Amidation	179	182	PF01082	0.237
MOD_GlcNHglycan	201	204	PF01048	0.353
MOD_GlcNHglycan	29	32	PF01048	0.465
MOD_GlcNHglycan	93	96	PF01048	0.373
MOD_GSK3_1	195	202	PF00069	0.531
MOD_GSK3_1	216	223	PF00069	0.522
MOD_GSK3_1	257	264	PF00069	0.387
MOD_GSK3_1	50	57	PF00069	0.671
MOD_GSK3_1	91	98	PF00069	0.311
MOD_N-GLC_1	147	152	PF02516	0.257
MOD_NEK2_1	128	133	PF00069	0.437
MOD_NEK2_1	134	139	PF00069	0.437
MOD_PKA_2	249	255	PF00069	0.613
MOD_PKA_2	59	65	PF00069	0.629
MOD_Plk_1	147	153	PF00069	0.432
MOD_Plk_1	54	60	PF00069	0.693
MOD_Plk_4	128	134	PF00069	0.444
MOD_Plk_4	226	232	PF00069	0.440
TRG_ENDOCYTIC_2	152	155	PF00928	0.438
TRG_ENDOCYTIC_2	157	160	PF00928	0.436
TRG_ER_diArg_1	115	117	PF00400	0.351
TRG_ER_diArg_1	86	89	PF00400	0.476
TRG_NES_CRM1_1	16	29	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I030	Leptomonas seymouri	72%	100%
A0A0S4IHR6	Bodo saltans	46%	100%
A0A1X0NXR2	Trypanosomatidae	47%	100%
A0A422NWD3	Trypanosoma rangeli	50%	100%
A4HK97	Leishmania braziliensis	79%	100%
D0A1C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AGV9	Leishmania infantum	97%	100%
E9AV75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCA6	Leishmania major	90%	100%
V5B6I0	Trypanosoma cruzi	48%	100%