Translation initiation factor eIF-2B subunit epsilon, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF-2B subunit epsilon, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY2_LEIDO

TriTrypDb:

LdBPK_282460.1 , LdCL_280029600 , LDHU3_28.3320

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3Q8IDY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003743	translation initiation factor activity	4	4
GO:0005488	binding	1	4
GO:0008135	translation factor activity, RNA binding	3	4
GO:0045182	translation regulator activity	1	4
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005515	protein binding	2	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031369	translation initiation factor binding	3	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.553
CLV_NRD_NRD_1	125	127	PF00675	0.512
CLV_NRD_NRD_1	174	176	PF00675	0.525
CLV_NRD_NRD_1	370	372	PF00675	0.481
CLV_NRD_NRD_1	459	461	PF00675	0.548
CLV_NRD_NRD_1	607	609	PF00675	0.551
CLV_NRD_NRD_1	7	9	PF00675	0.558
CLV_NRD_NRD_1	761	763	PF00675	0.571
CLV_PCSK_KEX2_1	125	127	PF00082	0.512
CLV_PCSK_KEX2_1	370	372	PF00082	0.481
CLV_PCSK_KEX2_1	459	461	PF00082	0.548
CLV_PCSK_KEX2_1	607	609	PF00082	0.551
CLV_PCSK_KEX2_1	7	9	PF00082	0.591
CLV_PCSK_KEX2_1	761	763	PF00082	0.571
CLV_PCSK_SKI1_1	190	194	PF00082	0.500
CLV_PCSK_SKI1_1	370	374	PF00082	0.440
CLV_PCSK_SKI1_1	460	464	PF00082	0.539
CLV_PCSK_SKI1_1	488	492	PF00082	0.546
CLV_PCSK_SKI1_1	552	556	PF00082	0.649
CLV_PCSK_SKI1_1	674	678	PF00082	0.569
CLV_PCSK_SKI1_1	762	766	PF00082	0.569
CLV_PCSK_SKI1_1	830	834	PF00082	0.672
CLV_Separin_Metazoa	236	240	PF03568	0.699
DEG_APCC_DBOX_1	487	495	PF00400	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SPOP_SBC_1	284	288	PF00917	0.648
DEG_SPOP_SBC_1	389	393	PF00917	0.579
DOC_CYCLIN_RxL_1	367	376	PF00134	0.476
DOC_MAPK_FxFP_2	640	643	PF00069	0.520
DOC_MAPK_gen_1	250	257	PF00069	0.575
DOC_PP2B_LxvP_1	150	153	PF13499	0.405
DOC_PP4_FxxP_1	640	643	PF00568	0.520
DOC_USP7_MATH_1	284	288	PF00917	0.542
DOC_USP7_MATH_1	345	349	PF00917	0.504
DOC_USP7_MATH_1	353	357	PF00917	0.408
DOC_USP7_MATH_1	389	393	PF00917	0.502
DOC_USP7_MATH_1	406	410	PF00917	0.437
DOC_USP7_MATH_1	585	589	PF00917	0.745
DOC_WW_Pin1_4	212	217	PF00397	0.601
DOC_WW_Pin1_4	44	49	PF00397	0.491
DOC_WW_Pin1_4	62	67	PF00397	0.243
DOC_WW_Pin1_4	662	667	PF00397	0.646
LIG_14-3-3_CanoR_1	125	131	PF00244	0.497
LIG_14-3-3_CanoR_1	198	202	PF00244	0.608
LIG_14-3-3_CanoR_1	232	240	PF00244	0.651
LIG_14-3-3_CanoR_1	241	246	PF00244	0.633
LIG_14-3-3_CanoR_1	252	256	PF00244	0.480
LIG_14-3-3_CanoR_1	39	43	PF00244	0.569
LIG_14-3-3_CanoR_1	404	413	PF00244	0.595
LIG_14-3-3_CanoR_1	567	574	PF00244	0.644
LIG_BRCT_BRCA1_1	575	579	PF00533	0.626
LIG_BRCT_BRCA1_1	636	640	PF00533	0.589
LIG_Clathr_ClatBox_1	151	155	PF01394	0.517
LIG_Clathr_ClatBox_1	751	755	PF01394	0.553
LIG_eIF4E_1	70	76	PF01652	0.398
LIG_FHA_1	242	248	PF00498	0.683
LIG_FHA_1	252	258	PF00498	0.425
LIG_FHA_1	260	266	PF00498	0.346
LIG_FHA_1	324	330	PF00498	0.481
LIG_FHA_1	394	400	PF00498	0.464
LIG_FHA_1	548	554	PF00498	0.608
LIG_FHA_1	573	579	PF00498	0.588
LIG_FHA_1	63	69	PF00498	0.354
LIG_FHA_1	631	637	PF00498	0.574
LIG_FHA_1	648	654	PF00498	0.498
LIG_FHA_1	82	88	PF00498	0.376
LIG_FHA_2	117	123	PF00498	0.499
LIG_FHA_2	127	133	PF00498	0.548
LIG_FHA_2	167	173	PF00498	0.486
LIG_FHA_2	516	522	PF00498	0.664
LIG_FHA_2	658	664	PF00498	0.666
LIG_GBD_Chelix_1	193	201	PF00786	0.559
LIG_GBD_Chelix_1	22	30	PF00786	0.516
LIG_Integrin_isoDGR_2	558	560	PF01839	0.569
LIG_Integrin_RGD_1	525	527	PF01839	0.737
LIG_LIR_Apic_2	637	643	PF02991	0.530
LIG_LIR_Apic_2	679	683	PF02991	0.493
LIG_LIR_Gen_1	148	157	PF02991	0.413
LIG_LIR_Gen_1	159	167	PF02991	0.428
LIG_LIR_Gen_1	319	329	PF02991	0.473
LIG_LIR_Gen_1	479	490	PF02991	0.510
LIG_LIR_Gen_1	740	751	PF02991	0.580
LIG_LIR_Nem_3	148	152	PF02991	0.372
LIG_LIR_Nem_3	159	163	PF02991	0.400
LIG_LIR_Nem_3	319	324	PF02991	0.456
LIG_LIR_Nem_3	332	338	PF02991	0.408
LIG_LIR_Nem_3	479	485	PF02991	0.508
LIG_LIR_Nem_3	740	746	PF02991	0.595
LIG_LYPXL_yS_3	642	645	PF13949	0.520
LIG_PCNA_yPIPBox_3	691	701	PF02747	0.620
LIG_Pex14_1	680	684	PF04695	0.477
LIG_Pex14_2	684	688	PF04695	0.488
LIG_SH2_CRK	243	247	PF00017	0.649
LIG_SH2_CRK	321	325	PF00017	0.441
LIG_SH2_CRK	335	339	PF00017	0.520
LIG_SH2_CRK	743	747	PF00017	0.593
LIG_SH2_GRB2like	685	688	PF00017	0.485
LIG_SH2_PTP2	482	485	PF00017	0.453
LIG_SH2_STAP1	180	184	PF00017	0.367
LIG_SH2_STAP1	568	572	PF00017	0.636
LIG_SH2_STAP1	685	689	PF00017	0.521
LIG_SH2_STAT3	721	724	PF00017	0.590
LIG_SH2_STAT5	243	246	PF00017	0.699
LIG_SH2_STAT5	360	363	PF00017	0.379
LIG_SH2_STAT5	398	401	PF00017	0.430
LIG_SH2_STAT5	482	485	PF00017	0.453
LIG_SH2_STAT5	70	73	PF00017	0.365
LIG_SH2_STAT5	743	746	PF00017	0.602
LIG_SH2_STAT5	768	771	PF00017	0.620
LIG_SH3_1	243	249	PF00018	0.648
LIG_SH3_3	213	219	PF00018	0.731
LIG_SH3_3	243	249	PF00018	0.600
LIG_SH3_3	275	281	PF00018	0.632
LIG_SH3_3	347	353	PF00018	0.424
LIG_SH3_3	39	45	PF00018	0.500
LIG_SH3_3	418	424	PF00018	0.438
LIG_SH3_3	50	56	PF00018	0.393
LIG_SH3_3	581	587	PF00018	0.772
LIG_SH3_5	66	70	PF00018	0.396
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.474
LIG_SUMO_SIM_par_1	340	348	PF11976	0.470
LIG_SUMO_SIM_par_1	81	91	PF11976	0.525
LIG_SUMO_SIM_par_1	816	821	PF11976	0.606
LIG_TRAF2_1	596	599	PF00917	0.730
LIG_TRAF2_2	587	592	PF00917	0.558
LIG_TRFH_1	149	153	PF08558	0.506
LIG_TYR_ITIM	480	485	PF00017	0.531
LIG_UBA3_1	255	260	PF00899	0.540
LIG_WRC_WIRS_1	157	162	PF05994	0.478
LIG_WRC_WIRS_1	320	325	PF05994	0.466
MOD_CDK_SPK_2	49	54	PF00069	0.521
MOD_CDK_SPxxK_3	47	54	PF00069	0.521
MOD_CK1_1	188	194	PF00069	0.388
MOD_CK1_1	212	218	PF00069	0.689
MOD_CK1_1	322	328	PF00069	0.447
MOD_CK1_1	445	451	PF00069	0.488
MOD_CK1_1	47	53	PF00069	0.526
MOD_CK1_1	533	539	PF00069	0.728
MOD_CK1_1	747	753	PF00069	0.660
MOD_CK1_1	786	792	PF00069	0.748
MOD_CK1_1	793	799	PF00069	0.790
MOD_CK2_1	116	122	PF00069	0.501
MOD_CK2_1	166	172	PF00069	0.437
MOD_CK2_1	308	314	PF00069	0.426
MOD_CK2_1	389	395	PF00069	0.502
MOD_CK2_1	537	543	PF00069	0.724
MOD_CK2_1	587	593	PF00069	0.745
MOD_CK2_1	619	625	PF00069	0.569
MOD_Cter_Amidation	457	460	PF01082	0.538
MOD_GlcNHglycan	190	193	PF01048	0.463
MOD_GlcNHglycan	222	225	PF01048	0.738
MOD_GlcNHglycan	287	290	PF01048	0.565
MOD_GlcNHglycan	347	350	PF01048	0.514
MOD_GlcNHglycan	355	358	PF01048	0.459
MOD_GlcNHglycan	496	499	PF01048	0.567
MOD_GlcNHglycan	513	518	PF01048	0.665
MOD_GlcNHglycan	575	578	PF01048	0.615
MOD_GlcNHglycan	637	640	PF01048	0.531
MOD_GlcNHglycan	746	749	PF01048	0.669
MOD_GlcNHglycan	800	803	PF01048	0.633
MOD_GlcNHglycan	90	93	PF01048	0.450
MOD_GSK3_1	112	119	PF00069	0.474
MOD_GSK3_1	227	234	PF00069	0.692
MOD_GSK3_1	259	266	PF00069	0.476
MOD_GSK3_1	285	292	PF00069	0.530
MOD_GSK3_1	319	326	PF00069	0.444
MOD_GSK3_1	389	396	PF00069	0.478
MOD_GSK3_1	419	426	PF00069	0.459
MOD_GSK3_1	530	537	PF00069	0.708
MOD_GSK3_1	573	580	PF00069	0.625
MOD_GSK3_1	619	626	PF00069	0.556
MOD_GSK3_1	630	637	PF00069	0.380
MOD_GSK3_1	683	690	PF00069	0.519
MOD_GSK3_1	782	789	PF00069	0.742
MOD_GSK3_1	790	797	PF00069	0.780
MOD_GSK3_1	88	95	PF00069	0.459
MOD_GSK3_1	97	104	PF00069	0.451
MOD_N-GLC_1	116	121	PF02516	0.520
MOD_N-GLC_1	145	150	PF02516	0.487
MOD_N-GLC_1	241	246	PF02516	0.606
MOD_N-GLC_1	87	92	PF02516	0.402
MOD_NEK2_1	112	117	PF00069	0.533
MOD_NEK2_1	185	190	PF00069	0.469
MOD_NEK2_1	197	202	PF00069	0.515
MOD_NEK2_1	285	290	PF00069	0.530
MOD_NEK2_1	323	328	PF00069	0.468
MOD_NEK2_1	399	404	PF00069	0.462
MOD_NEK2_1	429	434	PF00069	0.475
MOD_NEK2_1	606	611	PF00069	0.523
MOD_NEK2_1	657	662	PF00069	0.602
MOD_NEK2_1	676	681	PF00069	0.544
MOD_NEK2_1	784	789	PF00069	0.557
MOD_NEK2_1	86	91	PF00069	0.455
MOD_NEK2_2	227	232	PF00069	0.625
MOD_PIKK_1	210	216	PF00454	0.650
MOD_PIKK_1	259	265	PF00454	0.492
MOD_PIKK_1	585	591	PF00454	0.713
MOD_PKA_1	125	131	PF00069	0.476
MOD_PKA_1	175	181	PF00069	0.510
MOD_PKA_2	125	131	PF00069	0.476
MOD_PKA_2	197	203	PF00069	0.606
MOD_PKA_2	231	237	PF00069	0.629
MOD_PKA_2	251	257	PF00069	0.466
MOD_PKA_2	376	382	PF00069	0.440
MOD_PKA_2	38	44	PF00069	0.563
MOD_PKA_2	566	572	PF00069	0.707
MOD_PKA_2	585	591	PF00069	0.736
MOD_PKA_2	606	612	PF00069	0.527
MOD_PKA_2	766	772	PF00069	0.626
MOD_PKA_2	782	788	PF00069	0.718
MOD_PKB_1	173	181	PF00069	0.556
MOD_PKB_1	239	247	PF00069	0.599
MOD_Plk_1	116	122	PF00069	0.462
MOD_Plk_1	419	425	PF00069	0.569
MOD_Plk_1	442	448	PF00069	0.497
MOD_Plk_1	478	484	PF00069	0.442
MOD_Plk_1	624	630	PF00069	0.532
MOD_Plk_1	81	87	PF00069	0.450
MOD_Plk_2-3	308	314	PF00069	0.474
MOD_Plk_2-3	625	631	PF00069	0.527
MOD_Plk_4	116	122	PF00069	0.455
MOD_Plk_4	145	151	PF00069	0.417
MOD_Plk_4	180	186	PF00069	0.366
MOD_Plk_4	197	203	PF00069	0.478
MOD_Plk_4	251	257	PF00069	0.464
MOD_Plk_4	263	269	PF00069	0.436
MOD_Plk_4	308	314	PF00069	0.392
MOD_Plk_4	319	325	PF00069	0.380
MOD_Plk_4	38	44	PF00069	0.594
MOD_Plk_4	393	399	PF00069	0.413
MOD_Plk_4	406	412	PF00069	0.476
MOD_Plk_4	429	435	PF00069	0.455
MOD_Plk_4	478	484	PF00069	0.506
MOD_Plk_4	747	753	PF00069	0.660
MOD_Plk_4	81	87	PF00069	0.450
MOD_ProDKin_1	212	218	PF00069	0.606
MOD_ProDKin_1	44	50	PF00069	0.487
MOD_ProDKin_1	62	68	PF00069	0.241
MOD_ProDKin_1	662	668	PF00069	0.644
MOD_SUMO_rev_2	807	817	PF00179	0.630
TRG_DiLeu_BaEn_1	308	313	PF01217	0.471
TRG_DiLeu_BaEn_1	813	818	PF01217	0.604
TRG_DiLeu_BaEn_1	82	87	PF01217	0.456
TRG_DiLeu_BaEn_4	805	811	PF01217	0.649
TRG_ENDOCYTIC_2	321	324	PF00928	0.461
TRG_ENDOCYTIC_2	335	338	PF00928	0.495
TRG_ENDOCYTIC_2	482	485	PF00928	0.531
TRG_ENDOCYTIC_2	642	645	PF00928	0.520
TRG_ENDOCYTIC_2	685	688	PF00928	0.547
TRG_ENDOCYTIC_2	743	746	PF00928	0.602
TRG_ENDOCYTIC_2	768	771	PF00928	0.620
TRG_ER_diArg_1	125	127	PF00400	0.512
TRG_ER_diArg_1	238	241	PF00400	0.585
TRG_ER_diArg_1	370	372	PF00400	0.481
TRG_ER_diArg_1	6	8	PF00400	0.660
TRG_ER_diArg_1	606	608	PF00400	0.548
TRG_NES_CRM1_1	644	655	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B8	Leptomonas seymouri	69%	100%
A0A0S4IRE8	Bodo saltans	31%	100%
A4HGT3	Leishmania braziliensis	85%	97%
A4I3W0	Leishmania infantum	100%	100%
D0A928	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B050	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P56287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q4Q835	Leishmania major	98%	100%