Protein_kinase_putative/GeneDB:LmjF.29.2490

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDY1_LEIDO

TriTrypDb:

LdBPK_292600.1 , LdCL_290032100 , LDHU3_29.3850

Length:

447

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005964	phosphorylase kinase complex	7	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IDY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDY1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0000271	polysaccharide biosynthetic process	5	1
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0005978	glycogen biosynthetic process	7	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009250	glucan biosynthetic process	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0033692	obsolete cellular polysaccharide biosynthetic process	5	1
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0044042	glucan metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044264	obsolete cellular polysaccharide metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0004689	phosphorylase kinase activity	6	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.423
CLV_NRD_NRD_1	256	258	PF00675	0.335
CLV_NRD_NRD_1	325	327	PF00675	0.311
CLV_NRD_NRD_1	39	41	PF00675	0.487
CLV_NRD_NRD_1	398	400	PF00675	0.255
CLV_NRD_NRD_1	62	64	PF00675	0.361
CLV_PCSK_FUR_1	60	64	PF00082	0.354
CLV_PCSK_KEX2_1	324	326	PF00082	0.326
CLV_PCSK_KEX2_1	390	392	PF00082	0.258
CLV_PCSK_KEX2_1	398	400	PF00082	0.320
CLV_PCSK_KEX2_1	62	64	PF00082	0.361
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.396
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.258
CLV_PCSK_SKI1_1	162	166	PF00082	0.517
CLV_PCSK_SKI1_1	258	262	PF00082	0.376
CLV_PCSK_SKI1_1	289	293	PF00082	0.353
DOC_CYCLIN_RxL_1	157	168	PF00134	0.526
DOC_MAPK_gen_1	255	265	PF00069	0.390
DOC_MAPK_gen_1	289	299	PF00069	0.309
DOC_MAPK_gen_1	40	47	PF00069	0.347
DOC_MAPK_MEF2A_6	232	241	PF00069	0.299
DOC_MAPK_MEF2A_6	264	272	PF00069	0.265
DOC_MAPK_MEF2A_6	40	47	PF00069	0.391
DOC_PP2B_LxvP_1	128	131	PF13499	0.493
DOC_PP2B_LxvP_1	139	142	PF13499	0.665
DOC_USP7_MATH_1	131	135	PF00917	0.562
DOC_USP7_MATH_1	155	159	PF00917	0.579
DOC_WW_Pin1_4	134	139	PF00397	0.593
DOC_WW_Pin1_4	326	331	PF00397	0.257
DOC_WW_Pin1_4	382	387	PF00397	0.309
DOC_WW_Pin1_4	47	52	PF00397	0.419
LIG_14-3-3_CanoR_1	257	265	PF00244	0.392
LIG_14-3-3_CanoR_1	3	9	PF00244	0.469
LIG_14-3-3_CanoR_1	40	44	PF00244	0.353
LIG_14-3-3_CanoR_1	402	412	PF00244	0.323
LIG_14-3-3_CanoR_1	62	68	PF00244	0.579
LIG_APCC_ABBAyCdc20_2	192	198	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	405	409	PF00533	0.343
LIG_Clathr_ClatBox_1	307	311	PF01394	0.265
LIG_FHA_1	313	319	PF00498	0.379
LIG_FHA_2	200	206	PF00498	0.375
LIG_FHA_2	344	350	PF00498	0.280
LIG_FHA_2	360	366	PF00498	0.218
LIG_FHA_2	402	408	PF00498	0.427
LIG_FHA_2	48	54	PF00498	0.403
LIG_FHA_2	88	94	PF00498	0.414
LIG_FXI_DFP_1	363	367	PF00024	0.302
LIG_GBD_Chelix_1	268	276	PF00786	0.343
LIG_LIR_Apic_2	331	337	PF02991	0.237
LIG_LIR_Gen_1	406	417	PF02991	0.392
LIG_LIR_Gen_1	71	81	PF02991	0.390
LIG_LIR_Nem_3	158	164	PF02991	0.402
LIG_LIR_Nem_3	365	369	PF02991	0.250
LIG_LIR_Nem_3	406	412	PF02991	0.392
LIG_LIR_Nem_3	66	70	PF02991	0.458
LIG_SH2_CRK	161	165	PF00017	0.399
LIG_SH2_SRC	225	228	PF00017	0.265
LIG_SH2_STAP1	332	336	PF00017	0.411
LIG_SH2_STAP1	405	409	PF00017	0.265
LIG_SH2_STAT3	432	435	PF00017	0.294
LIG_SH2_STAT5	225	228	PF00017	0.250
LIG_SH2_STAT5	278	281	PF00017	0.246
LIG_SH2_STAT5	403	406	PF00017	0.440
LIG_SH3_3	236	242	PF00018	0.284
LIG_SH3_3	361	367	PF00018	0.343
LIG_SH3_3	415	421	PF00018	0.402
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.392
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.265
LIG_SUMO_SIM_anti_2	302	309	PF11976	0.265
LIG_SUMO_SIM_par_1	187	193	PF11976	0.417
LIG_SUMO_SIM_par_1	314	319	PF11976	0.203
LIG_TYR_ITIM	223	228	PF00017	0.250
LIG_TYR_ITIM	65	70	PF00017	0.442
LIG_WW_1	51	54	PF00397	0.422
MOD_CK1_1	134	140	PF00069	0.542
MOD_CK1_1	382	388	PF00069	0.278
MOD_CK1_1	88	94	PF00069	0.533
MOD_CK2_1	199	205	PF00069	0.461
MOD_CK2_1	401	407	PF00069	0.427
MOD_CK2_1	87	93	PF00069	0.493
MOD_GlcNHglycan	134	137	PF01048	0.557
MOD_GlcNHglycan	372	375	PF01048	0.392
MOD_GlcNHglycan	379	382	PF01048	0.392
MOD_GlcNHglycan	426	429	PF01048	0.286
MOD_GlcNHglycan	87	90	PF01048	0.574
MOD_GSK3_1	312	319	PF00069	0.268
MOD_GSK3_1	339	346	PF00069	0.284
MOD_GSK3_1	81	88	PF00069	0.463
MOD_N-GLC_1	196	201	PF02516	0.392
MOD_N-GLC_2	19	21	PF02516	0.368
MOD_NEK2_1	132	137	PF00069	0.519
MOD_NEK2_1	226	231	PF00069	0.386
MOD_NEK2_1	339	344	PF00069	0.265
MOD_NEK2_1	377	382	PF00069	0.343
MOD_NEK2_1	97	102	PF00069	0.432
MOD_PIKK_1	105	111	PF00454	0.518
MOD_PK_1	264	270	PF00069	0.265
MOD_PKA_2	39	45	PF00069	0.361
MOD_PKA_2	401	407	PF00069	0.258
MOD_PKA_2	423	429	PF00069	0.315
MOD_Plk_1	199	205	PF00069	0.378
MOD_Plk_1	226	232	PF00069	0.302
MOD_Plk_4	264	270	PF00069	0.262
MOD_Plk_4	318	324	PF00069	0.356
MOD_ProDKin_1	134	140	PF00069	0.598
MOD_ProDKin_1	326	332	PF00069	0.257
MOD_ProDKin_1	382	388	PF00069	0.309
MOD_ProDKin_1	47	53	PF00069	0.431
MOD_SUMO_for_1	291	294	PF00179	0.284
MOD_SUMO_rev_2	245	252	PF00179	0.353
MOD_SUMO_rev_2	340	348	PF00179	0.297
TRG_DiLeu_BaEn_1	294	299	PF01217	0.289
TRG_DiLeu_BaEn_1	302	307	PF01217	0.237
TRG_DiLeu_BaEn_1	408	413	PF01217	0.309
TRG_ENDOCYTIC_2	161	164	PF00928	0.379
TRG_ENDOCYTIC_2	225	228	PF00928	0.314
TRG_ENDOCYTIC_2	67	70	PF00928	0.464
TRG_ER_diArg_1	397	399	PF00400	0.276
TRG_ER_diArg_1	60	63	PF00400	0.353
TRG_NES_CRM1_1	408	420	PF08389	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X9	Leptomonas seymouri	26%	100%
A0A0N1HT76	Leptomonas seymouri	74%	100%
A0A0N1PCH4	Leptomonas seymouri	25%	100%
A0A0S4IXR9	Bodo saltans	28%	97%
A0A0S4JWD5	Bodo saltans	29%	100%
A0A0S4JZV2	Bodo saltans	24%	100%
A0A0S4KN74	Bodo saltans	27%	100%
A0A1X0P9C1	Trypanosomatidae	28%	100%
A0A1X0PA19	Trypanosomatidae	47%	90%
A0A3R7K1T4	Trypanosoma rangeli	47%	89%
A0A3R7M848	Trypanosoma rangeli	28%	96%
A2BD05	Sus scrofa	27%	100%
A4HHP8	Leishmania braziliensis	83%	100%
A4HHS9	Leishmania braziliensis	25%	100%
A4I4W3	Leishmania infantum	100%	100%
A5GFW1	Sus scrofa	26%	100%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	89%
E9ACA4	Leishmania major	28%	84%
E9AEB1	Leishmania major	97%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q2V419	Arabidopsis thaliana	26%	100%
Q40532	Nicotiana tabacum	26%	100%
Q7YRC6	Bos taurus	26%	100%
Q8LF80	Arabidopsis thaliana	25%	100%
Q9M1Z9	Arabidopsis thaliana	27%	71%
Q9NI63	Drosophila melanogaster	26%	84%
Q9STF0	Arabidopsis thaliana	28%	100%
Q9XBQ0	Myxococcus xanthus	27%	82%
V5BPJ0	Trypanosoma cruzi	26%	90%
V5BSK0	Trypanosoma cruzi	49%	90%