Putative N6-adenine methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Probable N6-adenine methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDX6_LEIDO

TriTrypDb:

LdBPK_170470.1 , LdCL_170010200 , LDHU3_17.0760

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IDX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDX6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016278	lysine N-methyltransferase activity	6	12
GO:0016279	protein-lysine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.537
CLV_NRD_NRD_1	246	248	PF00675	0.601
CLV_NRD_NRD_1	519	521	PF00675	0.468
CLV_NRD_NRD_1	77	79	PF00675	0.354
CLV_NRD_NRD_1	93	95	PF00675	0.307
CLV_PCSK_KEX2_1	248	250	PF00082	0.645
CLV_PCSK_KEX2_1	519	521	PF00082	0.573
CLV_PCSK_KEX2_1	77	79	PF00082	0.354
CLV_PCSK_KEX2_1	93	95	PF00082	0.307
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.684
CLV_PCSK_SKI1_1	147	151	PF00082	0.275
CLV_PCSK_SKI1_1	153	157	PF00082	0.257
CLV_PCSK_SKI1_1	161	165	PF00082	0.241
CLV_PCSK_SKI1_1	180	184	PF00082	0.354
CLV_PCSK_SKI1_1	381	385	PF00082	0.594
CLV_PCSK_SKI1_1	519	523	PF00082	0.549
CLV_PCSK_SKI1_1	530	534	PF00082	0.281
CLV_PCSK_SKI1_1	537	541	PF00082	0.452
DOC_CKS1_1	65	70	PF01111	0.478
DOC_CYCLIN_RxL_1	147	158	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.485
DOC_MAPK_FxFP_2	521	524	PF00069	0.542
DOC_MAPK_gen_1	371	379	PF00069	0.573
DOC_MAPK_gen_1	422	431	PF00069	0.561
DOC_MAPK_RevD_3	63	78	PF00069	0.554
DOC_PIKK_1	169	177	PF02985	0.554
DOC_PP1_RVXF_1	159	165	PF00149	0.471
DOC_PP4_FxxP_1	116	119	PF00568	0.471
DOC_PP4_FxxP_1	521	524	PF00568	0.537
DOC_USP7_MATH_1	24	28	PF00917	0.537
DOC_USP7_MATH_1	334	338	PF00917	0.588
DOC_USP7_MATH_1	354	358	PF00917	0.442
DOC_USP7_MATH_1	397	401	PF00917	0.630
DOC_USP7_MATH_1	471	475	PF00917	0.784
DOC_USP7_UBL2_3	153	157	PF12436	0.506
DOC_USP7_UBL2_3	387	391	PF12436	0.658
DOC_WW_Pin1_4	452	457	PF00397	0.721
DOC_WW_Pin1_4	475	480	PF00397	0.649
DOC_WW_Pin1_4	64	69	PF00397	0.478
LIG_14-3-3_CanoR_1	147	156	PF00244	0.505
LIG_14-3-3_CanoR_1	234	242	PF00244	0.586
LIG_14-3-3_CanoR_1	26	30	PF00244	0.549
LIG_Actin_WH2_2	220	236	PF00022	0.486
LIG_APCC_ABBA_1	302	307	PF00400	0.680
LIG_BIR_III_4	472	476	PF00653	0.530
LIG_BRCT_BRCA1_1	68	72	PF00533	0.460
LIG_BRCT_BRCA1_1	95	99	PF00533	0.460
LIG_FHA_1	139	145	PF00498	0.460
LIG_FHA_1	149	155	PF00498	0.460
LIG_FHA_1	163	169	PF00498	0.442
LIG_FHA_1	285	291	PF00498	0.696
LIG_FHA_1	410	416	PF00498	0.474
LIG_FHA_1	65	71	PF00498	0.478
LIG_FHA_2	164	170	PF00498	0.471
LIG_FHA_2	321	327	PF00498	0.785
LIG_FHA_2	80	86	PF00498	0.553
LIG_Integrin_RGD_1	78	80	PF01839	0.340
LIG_LIR_Apic_2	115	119	PF02991	0.460
LIG_LIR_Apic_2	483	488	PF02991	0.566
LIG_LIR_Apic_2	518	524	PF02991	0.432
LIG_LIR_Gen_1	195	206	PF02991	0.460
LIG_LIR_Nem_3	108	114	PF02991	0.460
LIG_LIR_Nem_3	143	148	PF02991	0.470
LIG_LIR_Nem_3	186	191	PF02991	0.484
LIG_LIR_Nem_3	195	201	PF02991	0.441
LIG_LIR_Nem_3	294	298	PF02991	0.691
LIG_LIR_Nem_3	37	41	PF02991	0.471
LIG_LIR_Nem_3	483	489	PF02991	0.595
LIG_LIR_Nem_3	69	74	PF02991	0.460
LIG_LYPXL_S_1	187	191	PF13949	0.354
LIG_LYPXL_yS_3	188	191	PF13949	0.554
LIG_MLH1_MIPbox_1	68	72	PF16413	0.460
LIG_NRBOX	173	179	PF00104	0.485
LIG_NRP_CendR_1	540	543	PF00754	0.634
LIG_Pex14_2	183	187	PF04695	0.471
LIG_Pex14_2	38	42	PF04695	0.471
LIG_SH2_CRK	196	200	PF00017	0.471
LIG_SH2_SRC	196	199	PF00017	0.460
LIG_SH2_STAP1	101	105	PF00017	0.554
LIG_SH2_STAP1	342	346	PF00017	0.411
LIG_SH2_STAP1	489	493	PF00017	0.501
LIG_SH2_STAT3	101	104	PF00017	0.523
LIG_SH2_STAT5	111	114	PF00017	0.525
LIG_SH2_STAT5	132	135	PF00017	0.489
LIG_SH2_STAT5	148	151	PF00017	0.491
LIG_SH2_STAT5	198	201	PF00017	0.468
LIG_SH3_3	131	137	PF00018	0.505
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.435
LIG_TRAF2_1	509	512	PF00917	0.578
LIG_TYR_ITIM	194	199	PF00017	0.471
LIG_TYR_ITSM	184	191	PF00017	0.420
LIG_UBA3_1	532	540	PF00899	0.434
LIG_WRC_WIRS_1	184	189	PF05994	0.505
MOD_CK1_1	22	28	PF00069	0.604
MOD_CK1_1	321	327	PF00069	0.693
MOD_CK1_1	399	405	PF00069	0.593
MOD_CK1_1	44	50	PF00069	0.470
MOD_CK1_1	452	458	PF00069	0.725
MOD_CK1_1	480	486	PF00069	0.679
MOD_CK1_1	66	72	PF00069	0.460
MOD_CK2_1	163	169	PF00069	0.460
MOD_CK2_1	233	239	PF00069	0.476
MOD_CK2_1	399	405	PF00069	0.602
MOD_GlcNHglycan	10	13	PF01048	0.741
MOD_GlcNHglycan	14	17	PF01048	0.695
MOD_GlcNHglycan	21	24	PF01048	0.582
MOD_GlcNHglycan	320	323	PF01048	0.711
MOD_GlcNHglycan	399	402	PF01048	0.563
MOD_GlcNHglycan	452	455	PF01048	0.731
MOD_GlcNHglycan	472	476	PF01048	0.745
MOD_GlcNHglycan	479	482	PF01048	0.648
MOD_GlcNHglycan	512	516	PF01048	0.411
MOD_GSK3_1	200	207	PF00069	0.529
MOD_GSK3_1	377	384	PF00069	0.540
MOD_GSK3_1	393	400	PF00069	0.614
MOD_GSK3_1	471	478	PF00069	0.760
MOD_GSK3_1	511	518	PF00069	0.403
MOD_GSK3_1	8	15	PF00069	0.689
MOD_N-GLC_1	169	174	PF02516	0.271
MOD_NEK2_1	162	167	PF00069	0.460
MOD_NEK2_1	183	188	PF00069	0.449
MOD_PIKK_1	1	7	PF00454	0.796
MOD_PIKK_1	87	93	PF00454	0.507
MOD_PKA_1	93	99	PF00069	0.544
MOD_PKA_2	233	239	PF00069	0.441
MOD_PKA_2	25	31	PF00069	0.554
MOD_PKA_2	44	50	PF00069	0.589
MOD_PKA_2	93	99	PF00069	0.525
MOD_Plk_1	169	175	PF00069	0.471
MOD_Plk_1	381	387	PF00069	0.588
MOD_Plk_2-3	169	175	PF00069	0.463
MOD_Plk_4	163	169	PF00069	0.449
MOD_Plk_4	183	189	PF00069	0.496
MOD_Plk_4	300	306	PF00069	0.602
MOD_Plk_4	381	387	PF00069	0.501
MOD_Plk_4	480	486	PF00069	0.548
MOD_Plk_4	66	72	PF00069	0.461
MOD_ProDKin_1	452	458	PF00069	0.726
MOD_ProDKin_1	475	481	PF00069	0.646
MOD_ProDKin_1	64	70	PF00069	0.478
MOD_SUMO_for_1	34	37	PF00179	0.539
MOD_SUMO_rev_2	215	224	PF00179	0.446
TRG_DiLeu_BaEn_1	158	163	PF01217	0.554
TRG_ENDOCYTIC_2	188	191	PF00928	0.483
TRG_ENDOCYTIC_2	196	199	PF00928	0.440
TRG_ENDOCYTIC_2	500	503	PF00928	0.407
TRG_ER_diArg_1	346	349	PF00400	0.563
TRG_ER_diArg_1	519	521	PF00400	0.573
TRG_ER_diArg_1	92	94	PF00400	0.514
TRG_NES_CRM1_1	360	375	PF08389	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR6	Leptomonas seymouri	65%	100%
A0A0S4KEA9	Bodo saltans	39%	100%
A0A1X0NT88	Trypanosomatidae	43%	100%
A0A422NXL8	Trypanosoma rangeli	45%	100%
A4H8Y5	Leishmania braziliensis	79%	99%
A4HXB5	Leishmania infantum	99%	100%
C9ZU02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AR11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEF2	Leishmania major	92%	100%
V5BAJ7	Trypanosoma cruzi	42%	87%