Cytochrome_c_oxidase_subunit_V_putative/GeneDB:Lm jF.26.1710

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase subunit V, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDX4_LEIDO

TriTrypDb:

LdBPK_261690.1 , LdCL_260022500 , LDHU3_26.2110

Length:

196

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase subunit V

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IDX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDX4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016491	oxidoreductase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.589
CLV_NRD_NRD_1	36	38	PF00675	0.433
CLV_NRD_NRD_1	62	64	PF00675	0.459
CLV_PCSK_KEX2_1	2	4	PF00082	0.533
CLV_PCSK_KEX2_1	62	64	PF00082	0.456
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.533
CLV_PCSK_SKI1_1	143	147	PF00082	0.361
CLV_PCSK_SKI1_1	16	20	PF00082	0.567
CLV_PCSK_SKI1_1	76	80	PF00082	0.473
CLV_PCSK_SKI1_1	88	92	PF00082	0.423
DEG_APCC_KENBOX_2	68	72	PF00400	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CDC14_PxL_1	95	103	PF14671	0.386
DOC_CKS1_1	176	181	PF01111	0.534
DOC_CYCLIN_RxL_1	140	148	PF00134	0.359
DOC_MAPK_DCC_7	2	11	PF00069	0.464
DOC_MAPK_gen_1	69	79	PF00069	0.468
DOC_MAPK_MEF2A_6	104	112	PF00069	0.424
DOC_MAPK_MEF2A_6	2	11	PF00069	0.464
DOC_MAPK_MEF2A_6	72	79	PF00069	0.475
DOC_PP4_FxxP_1	120	123	PF00568	0.386
DOC_PP4_FxxP_1	176	179	PF00568	0.531
DOC_PP4_FxxP_1	4	7	PF00568	0.578
DOC_PP4_FxxP_1	78	81	PF00568	0.427
DOC_SPAK_OSR1_1	3	7	PF12202	0.638
DOC_USP7_UBL2_3	189	193	PF12436	0.559
DOC_WW_Pin1_4	151	156	PF00397	0.398
DOC_WW_Pin1_4	175	180	PF00397	0.524
LIG_14-3-3_CanoR_1	156	162	PF00244	0.380
LIG_14-3-3_CanoR_1	44	53	PF00244	0.487
LIG_APCC_ABBA_1	131	136	PF00400	0.394
LIG_eIF4E_1	140	146	PF01652	0.460
LIG_FHA_1	176	182	PF00498	0.536
LIG_FHA_1	6	12	PF00498	0.550
LIG_GBD_Chelix_1	137	145	PF00786	0.345
LIG_LIR_Apic_2	118	123	PF02991	0.383
LIG_LIR_Apic_2	173	179	PF02991	0.520
LIG_LIR_Gen_1	124	135	PF02991	0.416
LIG_LIR_Gen_1	29	39	PF02991	0.402
LIG_LIR_Gen_1	73	81	PF02991	0.444
LIG_LIR_Nem_3	124	130	PF02991	0.435
LIG_LIR_Nem_3	73	77	PF02991	0.458
LIG_LYPXL_yS_3	98	101	PF13949	0.391
LIG_Pex14_2	14	18	PF04695	0.557
LIG_Pex14_2	19	23	PF04695	0.495
LIG_Pex14_2	74	78	PF04695	0.492
LIG_REV1ctd_RIR_1	16	25	PF16727	0.490
LIG_SH2_CRK	127	131	PF00017	0.414
LIG_SH2_STAP1	127	131	PF00017	0.414
LIG_SH2_STAP1	32	36	PF00017	0.499
LIG_SH2_STAP1	49	53	PF00017	0.454
LIG_SH2_STAP1	93	97	PF00017	0.361
LIG_SH2_STAT5	140	143	PF00017	0.464
LIG_SH3_3	127	133	PF00018	0.407
LIG_SH3_3	74	80	PF00018	0.449
LIG_SH3_5	123	127	PF00018	0.448
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.494
LIG_UBA3_1	145	150	PF00899	0.389
MOD_CDK_SPK_2	151	156	PF00069	0.398
MOD_CK1_1	5	11	PF00069	0.459
MOD_CK2_1	141	147	PF00069	0.351
MOD_CK2_1	157	163	PF00069	0.382
MOD_GSK3_1	141	148	PF00069	0.358
MOD_GSK3_1	157	164	PF00069	0.387
MOD_GSK3_1	27	34	PF00069	0.569
MOD_GSK3_1	44	51	PF00069	0.510
MOD_N-GLC_1	70	75	PF02516	0.439
MOD_NEK2_1	14	19	PF00069	0.608
MOD_NEK2_1	141	146	PF00069	0.340
MOD_NEK2_1	161	166	PF00069	0.277
MOD_NEK2_2	27	32	PF00069	0.431
MOD_PIKK_1	44	50	PF00454	0.444
MOD_PK_1	2	8	PF00069	0.466
MOD_PKA_1	2	8	PF00069	0.466
MOD_PKA_2	2	8	PF00069	0.466
MOD_Plk_1	70	76	PF00069	0.445
MOD_Plk_4	141	147	PF00069	0.351
MOD_Plk_4	157	163	PF00069	0.382
MOD_Plk_4	27	33	PF00069	0.387
MOD_Plk_4	70	76	PF00069	0.445
MOD_Plk_4	91	97	PF00069	0.389
MOD_ProDKin_1	151	157	PF00069	0.391
MOD_ProDKin_1	175	181	PF00069	0.528
MOD_SUMO_for_1	108	111	PF00179	0.473
MOD_SUMO_for_1	149	152	PF00179	0.414
MOD_SUMO_rev_2	66	74	PF00179	0.449
TRG_DiLeu_BaEn_2	69	75	PF01217	0.463
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.358
TRG_ENDOCYTIC_2	127	130	PF00928	0.420
TRG_ENDOCYTIC_2	32	35	PF00928	0.507
TRG_ENDOCYTIC_2	93	96	PF00928	0.378
TRG_ENDOCYTIC_2	98	101	PF00928	0.444
TRG_ER_diArg_1	61	63	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C4	Leptomonas seymouri	91%	100%
A0A1X0NHI2	Trypanosomatidae	90%	100%
A0A3R7N5B2	Trypanosoma rangeli	87%	100%
A4HD57	Leishmania braziliensis	94%	100%
A4I2A3	Leishmania infantum	100%	100%
C9ZXD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AYF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q922	Leishmania major	97%	100%