PQ loop repeat, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDX3_LEIDO

TriTrypDb:

LdBPK_262040.1 , LdCL_260026000 , LDHU3_26.2670

Length:

368

Annotations

LeishMANIAdb annotations

Shows homology to LAAT transporters found in mammals (SLC66 family).. Localization: Lysosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005768	endosome	7	1
GO:0005802	trans-Golgi network	4	1
GO:0005829	cytosol	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0031984	organelle subcompartment	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A0A3Q8IDX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDX3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0009987	cellular process	1	1
GO:0015748	organophosphate ester transport	5	1
GO:0015914	phospholipid transport	6	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0034204	lipid translocation	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0045332	phospholipid translocation	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071702	organic substance transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097035	regulation of membrane lipid distribution	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.321
CLV_PCSK_KEX2_1	268	270	PF00082	0.258
CLV_PCSK_KEX2_1	329	331	PF00082	0.391
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.397
CLV_PCSK_PC7_1	265	271	PF00082	0.321
CLV_PCSK_PC7_1	325	331	PF00082	0.412
CLV_PCSK_SKI1_1	298	302	PF00082	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.392
DEG_SPOP_SBC_1	118	122	PF00917	0.658
DEG_SPOP_SBC_1	158	162	PF00917	0.747
DOC_MAPK_gen_1	329	336	PF00069	0.597
DOC_MAPK_MEF2A_6	5	14	PF00069	0.334
DOC_MAPK_RevD_3	316	330	PF00069	0.443
DOC_PP1_RVXF_1	288	295	PF00149	0.385
DOC_PP1_RVXF_1	3	9	PF00149	0.308
DOC_PP2B_LxvP_1	258	261	PF13499	0.291
DOC_USP7_MATH_1	119	123	PF00917	0.719
DOC_USP7_MATH_1	158	162	PF00917	0.701
DOC_USP7_MATH_1	356	360	PF00917	0.579
DOC_USP7_MATH_1	38	42	PF00917	0.298
DOC_WW_Pin1_4	111	116	PF00397	0.702
DOC_WW_Pin1_4	143	148	PF00397	0.667
DOC_WW_Pin1_4	207	212	PF00397	0.512
DOC_WW_Pin1_4	34	39	PF00397	0.479
LIG_14-3-3_CanoR_1	268	278	PF00244	0.454
LIG_Actin_WH2_2	195	210	PF00022	0.513
LIG_Actin_WH2_2	250	267	PF00022	0.385
LIG_APCC_ABBA_1	309	314	PF00400	0.319
LIG_Clathr_ClatBox_1	195	199	PF01394	0.544
LIG_CtBP_PxDLS_1	175	179	PF00389	0.656
LIG_FHA_1	112	118	PF00498	0.725
LIG_FHA_1	221	227	PF00498	0.246
LIG_FHA_1	270	276	PF00498	0.454
LIG_FHA_1	28	34	PF00498	0.533
LIG_FHA_1	47	53	PF00498	0.385
LIG_GBD_Chelix_1	62	70	PF00786	0.356
LIG_HP1_1	38	42	PF01393	0.325
LIG_LIR_Gen_1	188	198	PF02991	0.538
LIG_LIR_LC3C_4	223	228	PF02991	0.234
LIG_LIR_Nem_3	188	194	PF02991	0.573
LIG_LIR_Nem_3	34	39	PF02991	0.453
LIG_MYND_1	176	180	PF01753	0.610
LIG_NBox_RRM_1	8	18	PF00076	0.343
LIG_NRBOX	274	280	PF00104	0.367
LIG_NRBOX	60	66	PF00104	0.308
LIG_SH2_CRK	249	253	PF00017	0.355
LIG_SH2_CRK	324	328	PF00017	0.655
LIG_SH2_CRK	36	40	PF00017	0.291
LIG_SH2_NCK_1	218	222	PF00017	0.234
LIG_SH2_PTP2	233	236	PF00017	0.521
LIG_SH2_SRC	218	221	PF00017	0.307
LIG_SH2_STAP1	218	222	PF00017	0.354
LIG_SH2_STAP1	296	300	PF00017	0.321
LIG_SH2_STAT3	20	23	PF00017	0.330
LIG_SH2_STAT3	296	299	PF00017	0.321
LIG_SH2_STAT5	20	23	PF00017	0.365
LIG_SH2_STAT5	233	236	PF00017	0.421
LIG_SH2_STAT5	249	252	PF00017	0.330
LIG_SH2_STAT5	293	296	PF00017	0.293
LIG_SH2_STAT5	55	58	PF00017	0.319
LIG_SH3_3	10	16	PF00018	0.325
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.325
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.305
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.356
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.291
LIG_SUMO_SIM_par_1	276	282	PF11976	0.325
LIG_SUMO_SIM_par_1	41	47	PF11976	0.322
LIG_TYR_ITIM	231	236	PF00017	0.270
LIG_TYR_ITIM	247	252	PF00017	0.298
LIG_TYR_ITIM	321	326	PF00017	0.459
MOD_CK1_1	146	152	PF00069	0.723
MOD_GlcNHglycan	100	105	PF01048	0.391
MOD_GlcNHglycan	121	124	PF01048	0.530
MOD_GlcNHglycan	125	128	PF01048	0.486
MOD_GlcNHglycan	161	164	PF01048	0.566
MOD_GlcNHglycan	169	173	PF01048	0.437
MOD_GlcNHglycan	180	183	PF01048	0.336
MOD_GSK3_1	113	120	PF00069	0.764
MOD_GSK3_1	174	181	PF00069	0.701
MOD_GSK3_1	269	276	PF00069	0.457
MOD_GSK3_1	34	41	PF00069	0.498
MOD_NEK2_1	279	284	PF00069	0.291
MOD_NEK2_1	44	49	PF00069	0.342
MOD_PIKK_1	27	33	PF00454	0.528
MOD_PIKK_1	356	362	PF00454	0.580
MOD_PK_1	29	35	PF00069	0.570
MOD_PKA_1	268	274	PF00069	0.479
MOD_PKA_1	329	335	PF00069	0.577
MOD_PKA_2	268	274	PF00069	0.479
MOD_PKA_2	329	335	PF00069	0.577
MOD_PKA_2	93	99	PF00069	0.536
MOD_Plk_1	202	208	PF00069	0.514
MOD_Plk_4	202	208	PF00069	0.507
MOD_Plk_4	273	279	PF00069	0.460
MOD_Plk_4	38	44	PF00069	0.317
MOD_ProDKin_1	111	117	PF00069	0.704
MOD_ProDKin_1	143	149	PF00069	0.669
MOD_ProDKin_1	207	213	PF00069	0.513
MOD_ProDKin_1	34	40	PF00069	0.479
MOD_SUMO_for_1	328	331	PF00179	0.593
TRG_DiLeu_BaEn_1	331	336	PF01217	0.561
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.405
TRG_ENDOCYTIC_2	233	236	PF00928	0.344
TRG_ENDOCYTIC_2	249	252	PF00928	0.357
TRG_ENDOCYTIC_2	323	326	PF00928	0.538
TRG_ENDOCYTIC_2	36	39	PF00928	0.291
TRG_ENDOCYTIC_2	53	56	PF00928	0.370
TRG_ER_diArg_1	268	270	PF00400	0.521
TRG_NES_CRM1_1	299	314	PF08389	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE3	Leptomonas seymouri	51%	100%
A0A422N3F4	Trypanosoma rangeli	40%	100%
A4HF48	Leishmania braziliensis	71%	100%
A4I2D2	Leishmania infantum	99%	100%
C9ZX76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9AYI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8Y8	Leishmania major	90%	100%