LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IDW7_LEIDO
TriTrypDb:
LdBPK_262670.1 , LdCL_260032600 , LDHU3_26.3460
Length:
384

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IDW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDW7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 236 240 PF00656 0.339
CLV_NRD_NRD_1 3 5 PF00675 0.444
CLV_NRD_NRD_1 320 322 PF00675 0.391
CLV_PCSK_KEX2_1 3 5 PF00082 0.431
CLV_PCSK_KEX2_1 361 363 PF00082 0.417
CLV_PCSK_PC1ET2_1 361 363 PF00082 0.417
CLV_PCSK_SKI1_1 248 252 PF00082 0.328
CLV_PCSK_SKI1_1 55 59 PF00082 0.439
CLV_PCSK_SKI1_1 73 77 PF00082 0.271
CLV_PCSK_SKI1_1 78 82 PF00082 0.371
DEG_Nend_Nbox_1 1 3 PF02207 0.487
DEG_ODPH_VHL_1 10 21 PF01847 0.336
DEG_SPOP_SBC_1 158 162 PF00917 0.482
DOC_CKS1_1 125 130 PF01111 0.648
DOC_MAPK_gen_1 321 329 PF00069 0.526
DOC_PP1_RVXF_1 110 116 PF00149 0.332
DOC_PP1_RVXF_1 228 235 PF00149 0.340
DOC_PP2B_LxvP_1 156 159 PF13499 0.482
DOC_PP4_FxxP_1 125 128 PF00568 0.528
DOC_PP4_FxxP_1 270 273 PF00568 0.530
DOC_USP7_MATH_1 189 193 PF00917 0.603
DOC_USP7_MATH_1 259 263 PF00917 0.565
DOC_USP7_MATH_1 32 36 PF00917 0.423
DOC_USP7_UBL2_3 37 41 PF12436 0.328
DOC_WW_Pin1_4 124 129 PF00397 0.519
DOC_WW_Pin1_4 289 294 PF00397 0.720
LIG_BRCT_BRCA1_1 266 270 PF00533 0.542
LIG_FHA_1 199 205 PF00498 0.505
LIG_FHA_1 215 221 PF00498 0.390
LIG_FHA_1 222 228 PF00498 0.315
LIG_FHA_1 269 275 PF00498 0.647
LIG_FHA_1 28 34 PF00498 0.297
LIG_FHA_1 56 62 PF00498 0.472
LIG_FHA_1 98 104 PF00498 0.381
LIG_LIR_Apic_2 267 273 PF02991 0.647
LIG_LIR_Nem_3 365 369 PF02991 0.344
LIG_LYPXL_yS_3 366 369 PF13949 0.306
LIG_PDZ_Class_2 379 384 PF00595 0.411
LIG_PTB_Apo_2 310 317 PF02174 0.495
LIG_PTB_Phospho_1 310 316 PF10480 0.497
LIG_SH2_CRK 364 368 PF00017 0.313
LIG_SH2_SRC 364 367 PF00017 0.319
LIG_SH2_STAT3 294 297 PF00017 0.560
LIG_SH2_STAT3 59 62 PF00017 0.341
LIG_SH3_3 139 145 PF00018 0.504
LIG_SH3_3 203 209 PF00018 0.498
LIG_SH3_3 278 284 PF00018 0.580
LIG_SUMO_SIM_par_1 200 205 PF11976 0.514
LIG_TRAF2_1 192 195 PF00917 0.503
LIG_TRAF2_1 209 212 PF00917 0.532
MOD_CK1_1 157 163 PF00069 0.728
MOD_CK1_1 262 268 PF00069 0.562
MOD_CK1_1 309 315 PF00069 0.496
MOD_CK1_1 368 374 PF00069 0.419
MOD_CK2_1 189 195 PF00069 0.574
MOD_CK2_1 32 38 PF00069 0.424
MOD_GlcNHglycan 156 159 PF01048 0.634
MOD_GlcNHglycan 187 190 PF01048 0.578
MOD_GlcNHglycan 21 24 PF01048 0.376
MOD_GlcNHglycan 251 254 PF01048 0.403
MOD_GlcNHglycan 264 267 PF01048 0.501
MOD_GlcNHglycan 285 288 PF01048 0.497
MOD_GlcNHglycan 308 311 PF01048 0.524
MOD_GlcNHglycan 351 354 PF01048 0.286
MOD_GlcNHglycan 67 70 PF01048 0.458
MOD_GlcNHglycan 82 85 PF01048 0.236
MOD_GSK3_1 154 161 PF00069 0.531
MOD_GSK3_1 185 192 PF00069 0.580
MOD_GSK3_1 214 221 PF00069 0.430
MOD_GSK3_1 260 267 PF00069 0.521
MOD_GSK3_1 268 275 PF00069 0.551
MOD_GSK3_1 27 34 PF00069 0.333
MOD_GSK3_1 78 85 PF00069 0.303
MOD_N-GLC_1 232 237 PF02516 0.336
MOD_N-GLC_1 259 264 PF02516 0.555
MOD_N-GLC_1 97 102 PF02516 0.445
MOD_NEK2_1 183 188 PF00069 0.550
MOD_NEK2_1 82 87 PF00069 0.293
MOD_NEK2_2 214 219 PF00069 0.424
MOD_NEK2_2 32 37 PF00069 0.449
MOD_Plk_1 152 158 PF00069 0.491
MOD_Plk_2-3 198 204 PF00069 0.498
MOD_ProDKin_1 124 130 PF00069 0.520
MOD_ProDKin_1 289 295 PF00069 0.720
MOD_SUMO_for_1 333 336 PF00179 0.282
MOD_SUMO_for_1 36 39 PF00179 0.322
MOD_SUMO_rev_2 358 363 PF00179 0.332
MOD_SUMO_rev_2 68 75 PF00179 0.424
TRG_ENDOCYTIC_2 247 250 PF00928 0.302
TRG_ENDOCYTIC_2 366 369 PF00928 0.306
TRG_ER_diArg_1 2 4 PF00400 0.446
TRG_ER_diArg_1 243 246 PF00400 0.301
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.707
TRG_Pf-PMV_PEXEL_1 225 229 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 241 245 PF00026 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1E9 Leptomonas seymouri 71% 100%
A0A0S4IIA8 Bodo saltans 48% 93%
A0A1X0P7H1 Trypanosomatidae 52% 100%
A0A422N3I7 Trypanosoma rangeli 52% 100%
A4HFA8 Leishmania braziliensis 85% 100%
A4I2I5 Leishmania infantum 100% 100%
C9ZWZ6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 88%
E9AYP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q8S7 Leishmania major 97% 100%
V5BC49 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS