Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDW5_LEIDO

TriTrypDb:

LdBPK_170280.1 , LdCL_170008300 , LDHU3_17.0520

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A0A3Q8IDW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDW5

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	2
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.804
CLV_NRD_NRD_1	170	172	PF00675	0.581
CLV_NRD_NRD_1	250	252	PF00675	0.688
CLV_NRD_NRD_1	293	295	PF00675	0.659
CLV_PCSK_KEX2_1	170	172	PF00082	0.581
CLV_PCSK_KEX2_1	518	520	PF00082	0.533
CLV_PCSK_KEX2_1	54	56	PF00082	0.563
CLV_PCSK_KEX2_1	89	91	PF00082	0.728
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.533
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.563
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.714
CLV_PCSK_SKI1_1	105	109	PF00082	0.629
CLV_PCSK_SKI1_1	311	315	PF00082	0.704
CLV_PCSK_SKI1_1	359	363	PF00082	0.704
CLV_PCSK_SKI1_1	480	484	PF00082	0.495
CLV_PCSK_SKI1_1	641	645	PF00082	0.548
CLV_PCSK_SKI1_1	682	686	PF00082	0.470
DEG_SCF_TRCP1_1	306	312	PF00400	0.601
DOC_CDC14_PxL_1	139	147	PF14671	0.624
DOC_CKS1_1	351	356	PF01111	0.674
DOC_CYCLIN_RxL_1	477	484	PF00134	0.502
DOC_MAPK_DCC_7	606	614	PF00069	0.425
DOC_MAPK_gen_1	170	180	PF00069	0.537
DOC_MAPK_MEF2A_6	259	267	PF00069	0.482
DOC_PP1_RVXF_1	624	630	PF00149	0.469
DOC_PP2B_LxvP_1	199	202	PF13499	0.616
DOC_PP4_FxxP_1	485	488	PF00568	0.551
DOC_USP7_MATH_1	121	125	PF00917	0.616
DOC_USP7_MATH_1	130	134	PF00917	0.610
DOC_USP7_MATH_1	146	150	PF00917	0.803
DOC_USP7_MATH_1	153	157	PF00917	0.733
DOC_USP7_MATH_1	230	234	PF00917	0.743
DOC_USP7_MATH_1	391	395	PF00917	0.606
DOC_USP7_MATH_1	420	424	PF00917	0.426
DOC_USP7_MATH_1	463	467	PF00917	0.510
DOC_USP7_MATH_1	550	554	PF00917	0.553
DOC_USP7_UBL2_3	355	359	PF12436	0.627
DOC_WW_Pin1_4	151	156	PF00397	0.665
DOC_WW_Pin1_4	158	163	PF00397	0.590
DOC_WW_Pin1_4	226	231	PF00397	0.736
DOC_WW_Pin1_4	236	241	PF00397	0.632
DOC_WW_Pin1_4	332	337	PF00397	0.616
DOC_WW_Pin1_4	35	40	PF00397	0.543
DOC_WW_Pin1_4	350	355	PF00397	0.610
DOC_WW_Pin1_4	410	415	PF00397	0.429
DOC_WW_Pin1_4	453	458	PF00397	0.530
DOC_WW_Pin1_4	536	541	PF00397	0.486
DOC_WW_Pin1_4	607	612	PF00397	0.514
DOC_WW_Pin1_4	75	80	PF00397	0.534
DOC_WW_Pin1_4	97	102	PF00397	0.608
LIG_14-3-3_CanoR_1	12	17	PF00244	0.613
LIG_14-3-3_CanoR_1	170	180	PF00244	0.662
LIG_14-3-3_CanoR_1	390	396	PF00244	0.549
LIG_14-3-3_CanoR_1	55	65	PF00244	0.641
LIG_14-3-3_CanoR_1	90	95	PF00244	0.629
LIG_AP2alpha_1	685	689	PF02296	0.449
LIG_APCC_ABBA_1	271	276	PF00400	0.491
LIG_BIR_III_2	152	156	PF00653	0.567
LIG_BRCT_BRCA1_1	202	206	PF00533	0.714
LIG_BRCT_BRCA1_1	451	455	PF00533	0.492
LIG_EH_1	116	120	PF12763	0.591
LIG_EH1_1	394	402	PF00400	0.470
LIG_FHA_1	15	21	PF00498	0.585
LIG_FHA_1	229	235	PF00498	0.640
LIG_FHA_1	468	474	PF00498	0.500
LIG_FHA_1	476	482	PF00498	0.463
LIG_FHA_1	638	644	PF00498	0.399
LIG_FHA_1	91	97	PF00498	0.686
LIG_FHA_2	347	353	PF00498	0.543
LIG_FHA_2	525	531	PF00498	0.403
LIG_FHA_2	57	63	PF00498	0.802
LIG_FHA_2	657	663	PF00498	0.452
LIG_FXI_DFP_1	319	323	PF00024	0.670
LIG_LIR_Apic_2	484	488	PF02991	0.551
LIG_LIR_Gen_1	203	211	PF02991	0.552
LIG_LIR_Gen_1	257	267	PF02991	0.480
LIG_LIR_Gen_1	318	326	PF02991	0.668
LIG_LIR_Gen_1	564	574	PF02991	0.392
LIG_LIR_Gen_1	638	646	PF02991	0.506
LIG_LIR_Nem_3	257	263	PF02991	0.488
LIG_LIR_Nem_3	318	322	PF02991	0.668
LIG_LIR_Nem_3	328	334	PF02991	0.701
LIG_LIR_Nem_3	522	526	PF02991	0.503
LIG_LIR_Nem_3	564	569	PF02991	0.453
LIG_LIR_Nem_3	638	642	PF02991	0.543
LIG_LIR_Nem_3	687	692	PF02991	0.376
LIG_MAD2	480	488	PF02301	0.341
LIG_PCNA_PIPBox_1	508	517	PF02747	0.511
LIG_PCNA_yPIPBox_3	501	515	PF02747	0.486
LIG_Pex14_2	685	689	PF04695	0.449
LIG_SH2_CRK	260	264	PF00017	0.499
LIG_SH2_CRK	28	32	PF00017	0.568
LIG_SH2_SRC	274	277	PF00017	0.510
LIG_SH2_STAP1	126	130	PF00017	0.583
LIG_SH2_STAP1	274	278	PF00017	0.499
LIG_SH2_STAT5	461	464	PF00017	0.511
LIG_SH2_STAT5	526	529	PF00017	0.497
LIG_SH2_STAT5	544	547	PF00017	0.589
LIG_SH2_STAT5	580	583	PF00017	0.428
LIG_SH2_STAT5	653	656	PF00017	0.432
LIG_SH2_STAT5	673	676	PF00017	0.423
LIG_SH2_STAT5	693	696	PF00017	0.399
LIG_SH3_3	115	121	PF00018	0.677
LIG_SH3_3	190	196	PF00018	0.649
LIG_SH3_3	330	336	PF00018	0.616
LIG_SH3_3	7	13	PF00018	0.687
LIG_SH3_3	71	77	PF00018	0.561
LIG_SUMO_SIM_par_1	174	181	PF11976	0.601
LIG_SUMO_SIM_par_1	653	659	PF11976	0.361
LIG_TRAF2_1	266	269	PF00917	0.545
LIG_WRC_WIRS_1	316	321	PF05994	0.675
LIG_WRC_WIRS_1	392	397	PF05994	0.572
LIG_WRC_WIRS_1	482	487	PF05994	0.422
MOD_CDK_SPK_2	158	163	PF00069	0.563
MOD_CDK_SPK_2	350	355	PF00069	0.621
MOD_CDK_SPxxK_3	453	460	PF00069	0.367
MOD_CK1_1	100	106	PF00069	0.703
MOD_CK1_1	124	130	PF00069	0.711
MOD_CK1_1	15	21	PF00069	0.713
MOD_CK1_1	176	182	PF00069	0.617
MOD_CK1_1	215	221	PF00069	0.629
MOD_CK1_1	225	231	PF00069	0.616
MOD_CK1_1	304	310	PF00069	0.681
MOD_CK1_1	335	341	PF00069	0.672
MOD_CK1_1	35	41	PF00069	0.582
MOD_CK1_1	46	52	PF00069	0.691
MOD_CK1_1	558	564	PF00069	0.425
MOD_CK1_1	579	585	PF00069	0.398
MOD_CK2_1	129	135	PF00069	0.727
MOD_CK2_1	263	269	PF00069	0.568
MOD_CK2_1	277	283	PF00069	0.567
MOD_CK2_1	346	352	PF00069	0.616
MOD_CK2_1	410	416	PF00069	0.428
MOD_CK2_1	42	48	PF00069	0.635
MOD_CK2_1	463	469	PF00069	0.341
MOD_CK2_1	524	530	PF00069	0.399
MOD_CK2_1	586	592	PF00069	0.422
MOD_CK2_1	607	613	PF00069	0.436
MOD_CK2_1	656	662	PF00069	0.408
MOD_CK2_1	75	81	PF00069	0.766
MOD_CK2_1	96	102	PF00069	0.617
MOD_Cter_Amidation	292	295	PF01082	0.677
MOD_GlcNHglycan	148	151	PF01048	0.754
MOD_GlcNHglycan	155	158	PF01048	0.674
MOD_GlcNHglycan	180	183	PF01048	0.729
MOD_GlcNHglycan	219	223	PF01048	0.679
MOD_GlcNHglycan	246	249	PF01048	0.524
MOD_GlcNHglycan	306	309	PF01048	0.801
MOD_GlcNHglycan	33	37	PF01048	0.601
MOD_GlcNHglycan	451	454	PF01048	0.439
MOD_GlcNHglycan	504	507	PF01048	0.391
MOD_GlcNHglycan	546	549	PF01048	0.361
MOD_GlcNHglycan	557	560	PF01048	0.431
MOD_GlcNHglycan	598	601	PF01048	0.473
MOD_GlcNHglycan	632	635	PF01048	0.468
MOD_GSK3_1	11	18	PF00069	0.719
MOD_GSK3_1	120	127	PF00069	0.761
MOD_GSK3_1	172	179	PF00069	0.718
MOD_GSK3_1	218	225	PF00069	0.633
MOD_GSK3_1	226	233	PF00069	0.643
MOD_GSK3_1	302	309	PF00069	0.661
MOD_GSK3_1	346	353	PF00069	0.663
MOD_GSK3_1	359	366	PF00069	0.652
MOD_GSK3_1	410	417	PF00069	0.406
MOD_GSK3_1	42	49	PF00069	0.729
MOD_GSK3_1	449	456	PF00069	0.403
MOD_GSK3_1	463	470	PF00069	0.299
MOD_GSK3_1	546	553	PF00069	0.439
MOD_GSK3_1	557	564	PF00069	0.425
MOD_GSK3_1	574	581	PF00069	0.395
MOD_GSK3_1	586	593	PF00069	0.389
MOD_GSK3_1	601	608	PF00069	0.373
MOD_GSK3_1	614	621	PF00069	0.699
MOD_GSK3_1	96	103	PF00069	0.769
MOD_LATS_1	198	204	PF00433	0.618
MOD_N-GLC_1	364	369	PF02516	0.607
MOD_N-GLC_1	524	529	PF02516	0.315
MOD_NEK2_1	145	150	PF00069	0.753
MOD_NEK2_1	172	177	PF00069	0.606
MOD_NEK2_1	32	37	PF00069	0.630
MOD_NEK2_1	378	383	PF00069	0.718
MOD_NEK2_1	4	9	PF00069	0.540
MOD_NEK2_1	514	519	PF00069	0.443
MOD_NEK2_1	576	581	PF00069	0.385
MOD_NEK2_1	627	632	PF00069	0.447
MOD_NEK2_1	685	690	PF00069	0.428
MOD_NEK2_1	96	101	PF00069	0.642
MOD_NEK2_2	121	126	PF00069	0.611
MOD_NEK2_2	550	555	PF00069	0.367
MOD_NMyristoyl	1	7	PF02799	0.678
MOD_PIKK_1	19	25	PF00454	0.496
MOD_PK_1	173	179	PF00069	0.600
MOD_PKA_2	11	17	PF00069	0.690
MOD_PKA_2	172	178	PF00069	0.679
MOD_PKA_2	212	218	PF00069	0.745
MOD_PKA_2	346	352	PF00069	0.581
MOD_PKA_2	56	62	PF00069	0.625
MOD_PKB_1	171	179	PF00069	0.536
MOD_Plk_1	425	431	PF00069	0.429
MOD_Plk_1	467	473	PF00069	0.334
MOD_Plk_1	550	556	PF00069	0.332
MOD_Plk_1	590	596	PF00069	0.500
MOD_Plk_4	121	127	PF00069	0.547
MOD_Plk_4	137	143	PF00069	0.554
MOD_Plk_4	15	21	PF00069	0.552
MOD_Plk_4	173	179	PF00069	0.687
MOD_Plk_4	212	218	PF00069	0.704
MOD_Plk_4	346	352	PF00069	0.683
MOD_Plk_4	446	452	PF00069	0.384
MOD_Plk_4	467	473	PF00069	0.308
MOD_Plk_4	5	11	PF00069	0.606
MOD_Plk_4	590	596	PF00069	0.500
MOD_ProDKin_1	151	157	PF00069	0.666
MOD_ProDKin_1	158	164	PF00069	0.591
MOD_ProDKin_1	226	232	PF00069	0.739
MOD_ProDKin_1	236	242	PF00069	0.632
MOD_ProDKin_1	332	338	PF00069	0.617
MOD_ProDKin_1	35	41	PF00069	0.546
MOD_ProDKin_1	350	356	PF00069	0.611
MOD_ProDKin_1	410	416	PF00069	0.428
MOD_ProDKin_1	453	459	PF00069	0.393
MOD_ProDKin_1	536	542	PF00069	0.332
MOD_ProDKin_1	607	613	PF00069	0.523
MOD_ProDKin_1	75	81	PF00069	0.536
MOD_ProDKin_1	97	103	PF00069	0.607
MOD_SPalmitoyl_4	1	7	PF01529	0.539
MOD_SUMO_rev_2	452	462	PF00179	0.347
TRG_DiLeu_BaEn_2	267	273	PF01217	0.538
TRG_ENDOCYTIC_2	260	263	PF00928	0.664
TRG_ENDOCYTIC_2	274	277	PF00928	0.520
TRG_ENDOCYTIC_2	28	31	PF00928	0.593
TRG_ER_diArg_1	170	173	PF00400	0.580
TRG_NLS_MonoExtN_4	51	58	PF00514	0.547
TRG_NLS_MonoExtN_4	86	93	PF00514	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	68%	98%
A0A1X0NT03	Trypanosomatidae	48%	100%
A0A3Q8IGX5	Leishmania donovani	28%	100%
A4H8W6	Leishmania braziliensis	65%	100%
A4HX90	Leishmania infantum	100%	100%
A4ICS7	Leishmania infantum	27%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QEH1	Leishmania major	92%	100%