Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 2

Species:

Leishmania donovani

UniProt:

A0A3Q8IDW3_LEIDO

TriTrypDb:

LdBPK_261860.1 , LdCL_260024200 , LDHU3_26.2430

Length:

548

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 2 (POMP2) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3Q8IDW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.503
CLV_MEL_PAP_1	257	263	PF00089	0.551
CLV_NRD_NRD_1	158	160	PF00675	0.731
CLV_NRD_NRD_1	339	341	PF00675	0.590
CLV_NRD_NRD_1	391	393	PF00675	0.498
CLV_PCSK_KEX2_1	325	327	PF00082	0.546
CLV_PCSK_KEX2_1	374	376	PF00082	0.662
CLV_PCSK_KEX2_1	393	395	PF00082	0.405
CLV_PCSK_KEX2_1	504	506	PF00082	0.774
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.548
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.674
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.415
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.774
CLV_PCSK_SKI1_1	152	156	PF00082	0.689
CLV_PCSK_SKI1_1	209	213	PF00082	0.671
CLV_PCSK_SKI1_1	223	227	PF00082	0.519
CLV_PCSK_SKI1_1	341	345	PF00082	0.584
CLV_PCSK_SKI1_1	366	370	PF00082	0.479
DEG_APCC_DBOX_1	393	401	PF00400	0.278
DOC_CKS1_1	32	37	PF01111	0.480
DOC_CKS1_1	491	496	PF01111	0.408
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.407
DOC_MAPK_DCC_7	247	257	PF00069	0.312
DOC_MAPK_gen_1	159	166	PF00069	0.538
DOC_MAPK_gen_1	337	346	PF00069	0.300
DOC_MAPK_JIP1_4	160	166	PF00069	0.534
DOC_MAPK_MEF2A_6	249	257	PF00069	0.312
DOC_MAPK_RevD_3	530	546	PF00069	0.371
DOC_PP2B_LxvP_1	275	278	PF13499	0.330
DOC_PP2B_LxvP_1	4	7	PF13499	0.556
DOC_PP2B_PxIxI_1	252	258	PF00149	0.315
DOC_PP4_FxxP_1	240	243	PF00568	0.290
DOC_SPAK_OSR1_1	427	431	PF12202	0.253
DOC_USP7_MATH_1	102	106	PF00917	0.502
DOC_USP7_MATH_1	150	154	PF00917	0.449
DOC_USP7_MATH_1	17	21	PF00917	0.606
DOC_USP7_MATH_1	22	26	PF00917	0.622
DOC_USP7_MATH_1	309	313	PF00917	0.364
DOC_USP7_MATH_1	36	40	PF00917	0.581
DOC_USP7_MATH_1	456	460	PF00917	0.346
DOC_USP7_MATH_1	513	517	PF00917	0.537
DOC_USP7_MATH_1	533	537	PF00917	0.469
DOC_USP7_UBL2_3	205	209	PF12436	0.475
DOC_WW_Pin1_4	132	137	PF00397	0.476
DOC_WW_Pin1_4	138	143	PF00397	0.438
DOC_WW_Pin1_4	235	240	PF00397	0.313
DOC_WW_Pin1_4	27	32	PF00397	0.525
DOC_WW_Pin1_4	490	495	PF00397	0.409
DOC_WW_Pin1_4	523	528	PF00397	0.201
LIG_14-3-3_CanoR_1	159	165	PF00244	0.534
LIG_14-3-3_CanoR_1	483	491	PF00244	0.524
LIG_14-3-3_CanoR_1	505	510	PF00244	0.518
LIG_Actin_WH2_2	361	376	PF00022	0.394
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.412
LIG_FHA_1	161	167	PF00498	0.518
LIG_FHA_1	367	373	PF00498	0.281
LIG_FHA_1	382	388	PF00498	0.286
LIG_FHA_1	524	530	PF00498	0.289
LIG_FHA_1	536	542	PF00498	0.288
LIG_FHA_2	57	63	PF00498	0.497
LIG_GBD_Chelix_1	364	372	PF00786	0.571
LIG_LIR_Apic_2	238	243	PF02991	0.290
LIG_LIR_Gen_1	302	311	PF02991	0.279
LIG_LIR_Gen_1	402	411	PF02991	0.285
LIG_LIR_Gen_1	449	458	PF02991	0.425
LIG_LIR_Gen_1	520	530	PF02991	0.366
LIG_LIR_Nem_3	302	306	PF02991	0.268
LIG_LIR_Nem_3	323	327	PF02991	0.421
LIG_LIR_Nem_3	396	401	PF02991	0.286
LIG_LIR_Nem_3	402	407	PF02991	0.263
LIG_LIR_Nem_3	449	455	PF02991	0.378
LIG_LIR_Nem_3	520	525	PF02991	0.505
LIG_LIR_Nem_3	75	81	PF02991	0.363
LIG_Pex14_1	74	78	PF04695	0.364
LIG_Pex14_2	299	303	PF04695	0.272
LIG_Pex14_2	404	408	PF04695	0.273
LIG_Rb_pABgroove_1	395	403	PF01858	0.275
LIG_SH2_CRK	327	331	PF00017	0.293
LIG_SH2_GRB2like	147	150	PF00017	0.457
LIG_SH2_NCK_1	327	331	PF00017	0.293
LIG_SH2_SRC	147	150	PF00017	0.457
LIG_SH2_SRC	53	56	PF00017	0.505
LIG_SH2_STAP1	147	151	PF00017	0.513
LIG_SH2_STAP1	301	305	PF00017	0.356
LIG_SH2_STAP1	360	364	PF00017	0.345
LIG_SH2_STAP1	401	405	PF00017	0.364
LIG_SH2_STAT5	331	334	PF00017	0.265
LIG_SH2_STAT5	53	56	PF00017	0.464
LIG_SH3_3	10	16	PF00018	0.581
LIG_SUMO_SIM_anti_2	538	543	PF11976	0.417
LIG_SUMO_SIM_par_1	442	449	PF11976	0.420
LIG_TYR_ITIM	329	334	PF00017	0.311
MOD_CK1_1	168	174	PF00069	0.494
MOD_CK1_1	39	45	PF00069	0.472
MOD_CK1_1	423	429	PF00069	0.321
MOD_CK1_1	56	62	PF00069	0.502
MOD_CK2_1	22	28	PF00069	0.500
MOD_CK2_1	351	357	PF00069	0.419
MOD_CK2_1	383	389	PF00069	0.418
MOD_GlcNHglycan	105	108	PF01048	0.724
MOD_GlcNHglycan	109	112	PF01048	0.732
MOD_GlcNHglycan	152	155	PF01048	0.665
MOD_GlcNHglycan	19	22	PF01048	0.713
MOD_GlcNHglycan	24	27	PF01048	0.725
MOD_GlcNHglycan	263	266	PF01048	0.654
MOD_GlcNHglycan	311	314	PF01048	0.493
MOD_GlcNHglycan	38	41	PF01048	0.661
MOD_GlcNHglycan	422	425	PF01048	0.538
MOD_GlcNHglycan	469	472	PF01048	0.692
MOD_GlcNHglycan	515	518	PF01048	0.694
MOD_GlcNHglycan	535	538	PF01048	0.150
MOD_GSK3_1	103	110	PF00069	0.513
MOD_GSK3_1	128	135	PF00069	0.474
MOD_GSK3_1	189	196	PF00069	0.511
MOD_GSK3_1	27	34	PF00069	0.512
MOD_GSK3_1	403	410	PF00069	0.361
MOD_GSK3_1	416	423	PF00069	0.332
MOD_GSK3_1	49	56	PF00069	0.516
MOD_GSK3_1	513	520	PF00069	0.506
MOD_LATS_1	207	213	PF00433	0.523
MOD_NEK2_1	126	131	PF00069	0.470
MOD_NEK2_1	195	200	PF00069	0.573
MOD_NEK2_1	233	238	PF00069	0.321
MOD_NEK2_1	261	266	PF00069	0.433
MOD_NEK2_1	381	386	PF00069	0.392
MOD_NEK2_1	521	526	PF00069	0.405
MOD_NEK2_1	82	87	PF00069	0.479
MOD_NEK2_2	403	408	PF00069	0.328
MOD_PIKK_1	218	224	PF00454	0.450
MOD_PIKK_1	483	489	PF00454	0.594
MOD_PKA_1	159	165	PF00069	0.488
MOD_PKA_1	209	215	PF00069	0.430
MOD_PKA_1	504	510	PF00069	0.564
MOD_PKA_2	504	510	PF00069	0.564
MOD_Plk_1	189	195	PF00069	0.473
MOD_Plk_1	456	462	PF00069	0.417
MOD_Plk_2-3	383	389	PF00069	0.345
MOD_Plk_4	383	389	PF00069	0.315
MOD_Plk_4	403	409	PF00069	0.187
MOD_Plk_4	49	55	PF00069	0.476
MOD_Plk_4	517	523	PF00069	0.485
MOD_ProDKin_1	132	138	PF00069	0.477
MOD_ProDKin_1	235	241	PF00069	0.307
MOD_ProDKin_1	27	33	PF00069	0.524
MOD_ProDKin_1	490	496	PF00069	0.408
MOD_ProDKin_1	523	529	PF00069	0.201
MOD_SUMO_rev_2	73	81	PF00179	0.388
TRG_DiLeu_BaEn_1	77	82	PF01217	0.442
TRG_ENDOCYTIC_2	331	334	PF00928	0.325
TRG_ENDOCYTIC_2	401	404	PF00928	0.299
TRG_ER_diArg_1	283	286	PF00400	0.340
TRG_ER_diArg_1	391	394	PF00400	0.308
TRG_ER_diLys_1	545	548	PF00400	0.689
TRG_NES_CRM1_1	295	308	PF08389	0.363
TRG_NES_CRM1_1	377	389	PF08389	0.364
TRG_NES_CRM1_1	453	464	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG5	Leptomonas seymouri	64%	96%
A0A0S4IT25	Bodo saltans	45%	80%
A0A1X0P7G8	Trypanosomatidae	45%	88%
A0A422NQN2	Trypanosoma rangeli	47%	91%
A4HF31	Leishmania braziliensis	88%	100%
A4I274	Leishmania infantum	100%	100%
C9ZX99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	90%
E9AYG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
Q4Q906	Leishmania major	96%	100%