LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IDW2_LEIDO
TriTrypDb:
LdBPK_282130.1 , LdCL_280026300 , LDHU3_28.2860
Length:
109

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3Q8IDW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDW2

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_CKS1_1 84 89 PF01111 0.625
DOC_MAPK_DCC_7 72 82 PF00069 0.608
DOC_MAPK_MEF2A_6 74 82 PF00069 0.610
DOC_PP2B_LxvP_1 29 32 PF13499 0.498
DOC_PP4_FxxP_1 101 104 PF00568 0.621
DOC_PP4_FxxP_1 84 87 PF00568 0.625
DOC_WW_Pin1_4 83 88 PF00397 0.651
LIG_BIR_II_1 1 5 PF00653 0.634
LIG_BRCT_BRCA1_1 97 101 PF00533 0.606
LIG_EH1_1 22 30 PF00400 0.258
LIG_eIF4E_1 34 40 PF01652 0.300
LIG_LIR_Apic_2 98 104 PF02991 0.622
LIG_LIR_LC3C_4 58 63 PF02991 0.586
LIG_LIR_Nem_3 50 56 PF02991 0.490
LIG_SH2_CRK 34 38 PF00017 0.257
LIG_SH2_PTP2 14 17 PF00017 0.335
LIG_SH2_STAP1 48 52 PF00017 0.313
LIG_SH2_STAT5 14 17 PF00017 0.313
LIG_SH2_STAT5 23 26 PF00017 0.266
LIG_SH3_3 77 83 PF00018 0.644
LIG_SH3_3 91 97 PF00018 0.728
LIG_TYR_ITIM 12 17 PF00017 0.421
MOD_GlcNHglycan 50 53 PF01048 0.374
MOD_GlcNHglycan 9 12 PF01048 0.359
MOD_GlcNHglycan 98 101 PF01048 0.472
MOD_GSK3_1 43 50 PF00069 0.378
MOD_GSK3_1 92 99 PF00069 0.602
MOD_NEK2_1 47 52 PF00069 0.340
MOD_NEK2_2 43 48 PF00069 0.327
MOD_Plk_4 43 49 PF00069 0.382
MOD_ProDKin_1 83 89 PF00069 0.565
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.517
TRG_ENDOCYTIC_2 14 17 PF00928 0.313
TRG_ENDOCYTIC_2 23 26 PF00928 0.293
TRG_ENDOCYTIC_2 34 37 PF00928 0.508
TRG_Pf-PMV_PEXEL_1 54 59 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8F0 Leptomonas seymouri 51% 98%
A4HGQ0 Leishmania braziliensis 73% 100%
A4I3S7 Leishmania infantum 100% 100%
C9ZNQ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9ADK1 Leishmania major 94% 100%
E9B019 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS