Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP41

Species:

Leishmania donovani

UniProt:

A0A3Q8IDW0_LEIDO

TriTrypDb:

LdBPK_210580.1 , LdCL_210010600 , LDHU3_21.0620

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IDW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.685
CLV_C14_Caspase3-7	94	98	PF00656	0.613
CLV_NRD_NRD_1	111	113	PF00675	0.417
CLV_NRD_NRD_1	3	5	PF00675	0.584
CLV_NRD_NRD_1	317	319	PF00675	0.612
CLV_NRD_NRD_1	34	36	PF00675	0.503
CLV_PCSK_KEX2_1	111	113	PF00082	0.417
CLV_PCSK_KEX2_1	3	5	PF00082	0.584
CLV_PCSK_KEX2_1	317	319	PF00082	0.612
CLV_PCSK_SKI1_1	218	222	PF00082	0.441
CLV_PCSK_SKI1_1	236	240	PF00082	0.227
CLV_PCSK_SKI1_1	298	302	PF00082	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SPOP_SBC_1	135	139	PF00917	0.573
DOC_CKS1_1	340	345	PF01111	0.567
DOC_MAPK_gen_1	111	117	PF00069	0.479
DOC_MAPK_gen_1	33	43	PF00069	0.518
DOC_PP2B_LxvP_1	239	242	PF13499	0.556
DOC_PP2B_LxvP_1	347	350	PF13499	0.392
DOC_USP7_MATH_1	144	148	PF00917	0.675
DOC_USP7_MATH_1	158	162	PF00917	0.553
DOC_USP7_MATH_1	183	187	PF00917	0.711
DOC_USP7_MATH_1	263	267	PF00917	0.551
DOC_USP7_MATH_1	269	273	PF00917	0.579
DOC_USP7_MATH_1	334	338	PF00917	0.586
DOC_USP7_MATH_1	406	410	PF00917	0.581
DOC_USP7_MATH_1	433	437	PF00917	0.400
DOC_USP7_MATH_1	70	74	PF00917	0.487
DOC_WW_Pin1_4	189	194	PF00397	0.666
DOC_WW_Pin1_4	339	344	PF00397	0.525
DOC_WW_Pin1_4	36	41	PF00397	0.570
LIG_14-3-3_CanoR_1	157	167	PF00244	0.502
LIG_14-3-3_CanoR_1	271	275	PF00244	0.532
LIG_14-3-3_CanoR_1	318	328	PF00244	0.570
LIG_14-3-3_CanoR_1	33	43	PF00244	0.514
LIG_14-3-3_CanoR_1	4	10	PF00244	0.528
LIG_Actin_WH2_2	252	267	PF00022	0.498
LIG_BIR_III_4	359	363	PF00653	0.515
LIG_BRCT_BRCA1_1	38	42	PF00533	0.620
LIG_EH1_1	232	240	PF00400	0.510
LIG_FHA_1	104	110	PF00498	0.441
LIG_FHA_1	222	228	PF00498	0.399
LIG_FHA_1	242	248	PF00498	0.246
LIG_FHA_1	351	357	PF00498	0.471
LIG_FHA_2	415	421	PF00498	0.660
LIG_FHA_2	42	48	PF00498	0.541
LIG_FHA_2	94	100	PF00498	0.626
LIG_LIR_Apic_2	222	228	PF02991	0.528
LIG_LIR_Gen_1	166	175	PF02991	0.545
LIG_LIR_Gen_1	429	435	PF02991	0.523
LIG_LIR_Gen_1	85	93	PF02991	0.496
LIG_LIR_Nem_3	166	170	PF02991	0.496
LIG_LIR_Nem_3	281	287	PF02991	0.425
LIG_LIR_Nem_3	345	351	PF02991	0.498
LIG_LIR_Nem_3	39	45	PF02991	0.571
LIG_LIR_Nem_3	429	434	PF02991	0.528
LIG_LIR_Nem_3	85	90	PF02991	0.493
LIG_SH2_CRK	152	156	PF00017	0.417
LIG_SH2_CRK	7	11	PF00017	0.584
LIG_SH2_PTP2	87	90	PF00017	0.488
LIG_SH2_SRC	87	90	PF00017	0.482
LIG_SH2_STAT3	110	113	PF00017	0.550
LIG_SH2_STAT5	108	111	PF00017	0.410
LIG_SH2_STAT5	444	447	PF00017	0.508
LIG_SH2_STAT5	7	10	PF00017	0.449
LIG_SH2_STAT5	87	90	PF00017	0.449
LIG_SH3_3	410	416	PF00018	0.588
LIG_SH3_3	60	66	PF00018	0.462
LIG_SH3_3	8	14	PF00018	0.426
LIG_Sin3_3	74	81	PF02671	0.445
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.466
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.395
LIG_SUMO_SIM_par_1	113	122	PF11976	0.549
LIG_TRFH_1	7	11	PF08558	0.584
LIG_TYR_ITIM	150	155	PF00017	0.406
LIG_TYR_ITIM	5	10	PF00017	0.596
MOD_CK1_1	104	110	PF00069	0.431
MOD_CK1_1	139	145	PF00069	0.694
MOD_CK1_1	163	169	PF00069	0.524
MOD_CK1_1	272	278	PF00069	0.568
MOD_CK2_1	252	258	PF00069	0.452
MOD_CK2_1	41	47	PF00069	0.550
MOD_CK2_1	414	420	PF00069	0.669
MOD_CK2_1	93	99	PF00069	0.539
MOD_GlcNHglycan	138	141	PF01048	0.661
MOD_GlcNHglycan	160	163	PF01048	0.580
MOD_GlcNHglycan	200	203	PF01048	0.576
MOD_GlcNHglycan	23	26	PF01048	0.483
MOD_GlcNHglycan	261	264	PF01048	0.497
MOD_GlcNHglycan	265	268	PF01048	0.528
MOD_GlcNHglycan	336	339	PF01048	0.567
MOD_GlcNHglycan	359	363	PF01048	0.515
MOD_GlcNHglycan	396	399	PF01048	0.722
MOD_GlcNHglycan	72	75	PF01048	0.491
MOD_GlcNHglycan	79	82	PF01048	0.487
MOD_GSK3_1	135	142	PF00069	0.670
MOD_GSK3_1	178	185	PF00069	0.736
MOD_GSK3_1	198	205	PF00069	0.554
MOD_GSK3_1	237	244	PF00069	0.483
MOD_GSK3_1	259	266	PF00069	0.536
MOD_GSK3_1	350	357	PF00069	0.440
MOD_N-GLC_1	259	264	PF02516	0.529
MOD_NEK2_1	20	25	PF00069	0.551
MOD_NEK2_1	214	219	PF00069	0.420
MOD_NEK2_1	221	226	PF00069	0.395
MOD_NEK2_1	394	399	PF00069	0.694
MOD_NEK2_1	41	46	PF00069	0.467
MOD_PIKK_1	241	247	PF00454	0.548
MOD_PIKK_1	400	406	PF00454	0.668
MOD_PKA_1	317	323	PF00069	0.599
MOD_PKA_1	35	41	PF00069	0.549
MOD_PKA_2	270	276	PF00069	0.581
MOD_PKA_2	317	323	PF00069	0.561
MOD_PKA_2	34	40	PF00069	0.499
MOD_PKB_1	33	41	PF00069	0.529
MOD_Plk_1	221	227	PF00069	0.468
MOD_Plk_1	259	265	PF00069	0.516
MOD_Plk_4	104	110	PF00069	0.417
MOD_Plk_4	252	258	PF00069	0.406
MOD_Plk_4	5	11	PF00069	0.517
MOD_ProDKin_1	189	195	PF00069	0.649
MOD_ProDKin_1	339	345	PF00069	0.520
MOD_ProDKin_1	36	42	PF00069	0.560
MOD_SUMO_rev_2	337	343	PF00179	0.379
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.546
TRG_ENDOCYTIC_2	152	155	PF00928	0.409
TRG_ENDOCYTIC_2	7	10	PF00928	0.472
TRG_ENDOCYTIC_2	87	90	PF00928	0.449
TRG_ER_diArg_1	110	112	PF00400	0.400
TRG_ER_diArg_1	149	152	PF00400	0.534
TRG_ER_diArg_1	2	4	PF00400	0.572
TRG_ER_diArg_1	316	318	PF00400	0.578
TRG_ER_diArg_1	407	410	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P853	Leptomonas seymouri	53%	88%
A0A1X0NY38	Trypanosomatidae	30%	100%
A0A422NBK7	Trypanosoma rangeli	31%	100%
A4HBP9	Leishmania braziliensis	87%	99%
A4HZ51	Leishmania infantum	100%	100%
D0A1Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AV19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCG3	Leishmania major	96%	100%
V5BQ65	Trypanosoma cruzi	27%	100%