C-8 sterol isomerase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-8 sterol isomerase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDV8_LEIDO

TriTrypDb:

LdBPK_292250.1 , LdCL_290028600 , LDHU3_29.3330

Length:

223

Annotations

LeishMANIAdb annotations

Homologous to fungal ERG2 sterol isomerase and the mammalian sigma receptor 1. A lipid modifying enzyme family. Related to fungal C-8 sterol isomerases, but the catalytic activity of animal orthologs is unclear. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A3Q8IDV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDV8

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	216	220	PF00082	0.360
CLV_PCSK_SKI1_1	60	64	PF00082	0.514
CLV_PCSK_SKI1_1	68	72	PF00082	0.502
DOC_MAPK_MEF2A_6	5	14	PF00069	0.428
DOC_USP7_MATH_1	159	163	PF00917	0.173
DOC_USP7_MATH_1	42	46	PF00917	0.215
DOC_USP7_MATH_1	92	96	PF00917	0.236
DOC_USP7_UBL2_3	56	60	PF12436	0.183
LIG_AP2alpha_1	190	194	PF02296	0.233
LIG_BIR_II_1	1	5	PF00653	0.630

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I584	Leptomonas seymouri	82%	100%
A0A1D8PCB9	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0P040	Trypanosomatidae	65%	100%
A0A3R7RKQ2	Trypanosoma rangeli	66%	100%
A4HHL4	Leishmania braziliensis	85%	100%
A4I4S3	Leishmania infantum	100%	100%
C9ZLG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AE76	Leishmania major	93%	100%
E9ALK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
I1RT23	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	45%	95%

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