Magnesium-dependent phosphatase-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

magnesium-dependent phosphatase-1/HAD phosphatase, family IIIC, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDV7_LEIDO

TriTrypDb:

LdBPK_332280.1 , LdCL_330029800 , LDHU3_33.3300

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.286
CLV_NRD_NRD_1	194	196	PF00675	0.467
CLV_PCSK_KEX2_1	194	196	PF00082	0.447
CLV_PCSK_SKI1_1	67	71	PF00082	0.398
CLV_PCSK_SKI1_1	97	101	PF00082	0.545
DEG_APCC_DBOX_1	66	74	PF00400	0.398
DEG_SPOP_SBC_1	85	89	PF00917	0.398
DOC_CKS1_1	28	33	PF01111	0.545
DOC_MAPK_gen_1	130	138	PF00069	0.530
DOC_MAPK_gen_1	43	53	PF00069	0.506
DOC_MAPK_MEF2A_6	46	53	PF00069	0.506
DOC_PP1_RVXF_1	16	23	PF00149	0.414
DOC_PP2B_PxIxI_1	48	54	PF00149	0.506
DOC_USP7_MATH_1	114	118	PF00917	0.467
DOC_USP7_MATH_1	146	150	PF00917	0.545
DOC_USP7_MATH_1	85	89	PF00917	0.385
DOC_WW_Pin1_4	27	32	PF00397	0.463
LIG_BIR_II_1	1	5	PF00653	0.817
LIG_CaM_NSCaTE_8	95	102	PF13499	0.467
LIG_CSL_BTD_1	28	31	PF09270	0.483
LIG_FHA_1	159	165	PF00498	0.390
LIG_FHA_1	87	93	PF00498	0.518
LIG_GBD_Chelix_1	20	28	PF00786	0.398
LIG_LIR_Apic_2	173	178	PF02991	0.448
LIG_LIR_Gen_1	149	157	PF02991	0.411
LIG_LIR_Nem_3	82	86	PF02991	0.488
LIG_Pex14_1	79	83	PF04695	0.483
LIG_SH2_STAP1	151	155	PF00017	0.545
LIG_SH2_STAT5	176	179	PF00017	0.423
LIG_SH2_STAT5	83	86	PF00017	0.483
LIG_SH3_2	41	46	PF14604	0.518
LIG_SH3_3	38	44	PF00018	0.456
LIG_SH3_4	43	50	PF00018	0.545
LIG_WRC_WIRS_1	100	105	PF05994	0.467
MOD_CK1_1	179	185	PF00069	0.476
MOD_CK1_1	2	8	PF00069	0.779
MOD_CK2_1	144	150	PF00069	0.509
MOD_CK2_1	53	59	PF00069	0.518
MOD_GlcNHglycan	167	170	PF01048	0.499
MOD_GlcNHglycan	178	181	PF01048	0.371
MOD_GlcNHglycan	54	58	PF01048	0.509
MOD_GSK3_1	99	106	PF00069	0.554
MOD_N-GLC_1	158	163	PF02516	0.414
MOD_NEK2_1	24	29	PF00069	0.398
MOD_NEK2_1	84	89	PF00069	0.399
MOD_NEK2_2	114	119	PF00069	0.410
MOD_PKA_2	2	8	PF00069	0.792
MOD_Plk_4	11	17	PF00069	0.535
MOD_Plk_4	114	120	PF00069	0.377
MOD_Plk_4	171	177	PF00069	0.393
MOD_Plk_4	24	30	PF00069	0.398
MOD_Plk_4	47	53	PF00069	0.518
MOD_Plk_4	79	85	PF00069	0.456
MOD_ProDKin_1	27	33	PF00069	0.463
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.483
TRG_ENDOCYTIC_2	151	154	PF00928	0.545
TRG_ENDOCYTIC_2	83	86	PF00928	0.483
TRG_ER_diArg_1	193	195	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.403
TRG_PTS1	198	201	PF00515	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R9	Leptomonas seymouri	74%	100%
A0A0S4J859	Bodo saltans	46%	100%
A0A1X0P3P5	Trypanosomatidae	59%	99%
A0A3S5IR86	Trypanosoma rangeli	61%	100%
A4HLS8	Leishmania braziliensis	83%	100%
A4I987	Leishmania infantum	100%	100%
D0A698	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B454	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94279	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q86V88	Homo sapiens	32%	100%
Q9D967	Mus musculus	31%	100%
Q9GRN1	Leishmania major	95%	100%
V5B8Q4	Trypanosoma cruzi	60%	81%