Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDV2_LEIDO

TriTrypDb:

LdBPK_281970.1 , LdCL_280024700 , LDHU3_28.2580

Length:

965

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3Q8IDV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDV2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	558	562	PF00656	0.571
CLV_NRD_NRD_1	131	133	PF00675	0.735
CLV_NRD_NRD_1	373	375	PF00675	0.493
CLV_NRD_NRD_1	391	393	PF00675	0.402
CLV_NRD_NRD_1	4	6	PF00675	0.635
CLV_NRD_NRD_1	506	508	PF00675	0.676
CLV_NRD_NRD_1	564	566	PF00675	0.770
CLV_PCSK_FUR_1	212	216	PF00082	0.513
CLV_PCSK_KEX2_1	131	133	PF00082	0.735
CLV_PCSK_KEX2_1	214	216	PF00082	0.514
CLV_PCSK_KEX2_1	26	28	PF00082	0.489
CLV_PCSK_KEX2_1	391	393	PF00082	0.582
CLV_PCSK_KEX2_1	506	508	PF00082	0.676
CLV_PCSK_KEX2_1	564	566	PF00082	0.679
CLV_PCSK_KEX2_1	6	8	PF00082	0.641
CLV_PCSK_KEX2_1	960	962	PF00082	0.427
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.497
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.489
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.643
CLV_PCSK_PC1ET2_1	960	962	PF00082	0.545
CLV_PCSK_PC7_1	127	133	PF00082	0.733
CLV_PCSK_PC7_1	2	8	PF00082	0.673
CLV_PCSK_SKI1_1	338	342	PF00082	0.427
CLV_PCSK_SKI1_1	353	357	PF00082	0.583
CLV_PCSK_SKI1_1	630	634	PF00082	0.434
CLV_PCSK_SKI1_1	657	661	PF00082	0.453
CLV_PCSK_SKI1_1	697	701	PF00082	0.335
CLV_PCSK_SKI1_1	751	755	PF00082	0.336
CLV_PCSK_SKI1_1	874	878	PF00082	0.335
CLV_PCSK_SKI1_1	884	888	PF00082	0.335
CLV_PCSK_SKI1_1	960	964	PF00082	0.583
DEG_APCC_DBOX_1	390	398	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SCF_FBW7_1	488	495	PF00400	0.666
DEG_SCF_FBW7_1	69	76	PF00400	0.555
DOC_ANK_TNKS_1	676	683	PF00023	0.335
DOC_CKS1_1	149	154	PF01111	0.663
DOC_CKS1_1	70	75	PF01111	0.559
DOC_CYCLIN_RxL_1	881	888	PF00134	0.335
DOC_MAPK_FxFP_2	548	551	PF00069	0.633
DOC_MAPK_gen_1	372	382	PF00069	0.598
DOC_MAPK_gen_1	410	418	PF00069	0.502
DOC_MAPK_gen_1	848	857	PF00069	0.453
DOC_MAPK_gen_1	874	882	PF00069	0.335
DOC_MAPK_gen_1	920	930	PF00069	0.335
DOC_MAPK_MEF2A_6	923	930	PF00069	0.335
DOC_PP2B_LxvP_1	139	142	PF13499	0.704
DOC_PP2B_LxvP_1	622	625	PF13499	0.476
DOC_PP4_FxxP_1	548	551	PF00568	0.633
DOC_USP7_MATH_1	108	112	PF00917	0.657
DOC_USP7_MATH_1	198	202	PF00917	0.714
DOC_USP7_MATH_1	32	36	PF00917	0.679
DOC_USP7_MATH_1	417	421	PF00917	0.663
DOC_USP7_MATH_1	437	441	PF00917	0.462
DOC_USP7_MATH_1	45	49	PF00917	0.568
DOC_USP7_MATH_1	471	475	PF00917	0.720
DOC_USP7_MATH_1	487	491	PF00917	0.571
DOC_USP7_MATH_1	526	530	PF00917	0.734
DOC_USP7_MATH_1	587	591	PF00917	0.585
DOC_USP7_MATH_1	603	607	PF00917	0.515
DOC_USP7_MATH_1	73	77	PF00917	0.637
DOC_USP7_MATH_1	772	776	PF00917	0.383
DOC_USP7_MATH_1	937	941	PF00917	0.453
DOC_USP7_UBL2_3	57	61	PF12436	0.622
DOC_WW_Pin1_4	148	153	PF00397	0.692
DOC_WW_Pin1_4	178	183	PF00397	0.746
DOC_WW_Pin1_4	191	196	PF00397	0.636
DOC_WW_Pin1_4	36	41	PF00397	0.684
DOC_WW_Pin1_4	488	493	PF00397	0.671
DOC_WW_Pin1_4	62	67	PF00397	0.679
DOC_WW_Pin1_4	69	74	PF00397	0.586
DOC_WW_Pin1_4	712	717	PF00397	0.380
LIG_14-3-3_CanoR_1	260	266	PF00244	0.444
LIG_14-3-3_CanoR_1	292	300	PF00244	0.600
LIG_14-3-3_CanoR_1	338	343	PF00244	0.571
LIG_14-3-3_CanoR_1	515	525	PF00244	0.674
LIG_14-3-3_CanoR_1	638	646	PF00244	0.385
LIG_14-3-3_CanoR_1	799	805	PF00244	0.511
LIG_14-3-3_CanoR_1	818	825	PF00244	0.210
LIG_14-3-3_CanoR_1	848	857	PF00244	0.460
LIG_14-3-3_CterR_2	961	965	PF00244	0.564
LIG_Actin_WH2_2	882	899	PF00022	0.335
LIG_APCC_ABBA_1	743	748	PF00400	0.349
LIG_BIR_III_2	197	201	PF00653	0.665
LIG_BRCT_BRCA1_1	738	742	PF00533	0.335
LIG_BRCT_BRCA1_1	942	946	PF00533	0.335
LIG_FHA_1	234	240	PF00498	0.639
LIG_FHA_1	354	360	PF00498	0.470
LIG_FHA_1	525	531	PF00498	0.764
LIG_FHA_1	792	798	PF00498	0.404
LIG_FHA_1	835	841	PF00498	0.335
LIG_FHA_1	908	914	PF00498	0.349
LIG_FHA_2	208	214	PF00498	0.655
LIG_FHA_2	246	252	PF00498	0.496
LIG_FHA_2	293	299	PF00498	0.639
LIG_FHA_2	332	338	PF00498	0.448
LIG_FHA_2	425	431	PF00498	0.633
LIG_FHA_2	537	543	PF00498	0.695
LIG_FHA_2	739	745	PF00498	0.335
LIG_IRF3_LxIS_1	835	841	PF10401	0.453
LIG_LIR_Apic_2	35	40	PF02991	0.609
LIG_LIR_Gen_1	652	663	PF02991	0.335
LIG_LIR_Gen_1	739	750	PF02991	0.335
LIG_LIR_Gen_1	758	765	PF02991	0.335
LIG_LIR_Gen_1	805	815	PF02991	0.464
LIG_LIR_Nem_3	652	658	PF02991	0.335
LIG_LIR_Nem_3	666	672	PF02991	0.348
LIG_LIR_Nem_3	739	745	PF02991	0.343
LIG_LIR_Nem_3	805	810	PF02991	0.352
LIG_MYND_1	596	600	PF01753	0.678
LIG_NRBOX	908	914	PF00104	0.349
LIG_PCNA_yPIPBox_3	240	254	PF02747	0.641
LIG_PCNA_yPIPBox_3	747	760	PF02747	0.335
LIG_PDZ_Class_1	960	965	PF00595	0.532
LIG_Pex14_2	649	653	PF04695	0.496
LIG_RPA_C_Fungi	273	285	PF08784	0.541
LIG_RPA_C_Fungi	292	304	PF08784	0.405
LIG_SH2_CRK	37	41	PF00017	0.607
LIG_SH2_CRK	408	412	PF00017	0.394
LIG_SH2_CRK	655	659	PF00017	0.335
LIG_SH2_CRK	781	785	PF00017	0.335
LIG_SH2_GRB2like	90	93	PF00017	0.682
LIG_SH2_NCK_1	37	41	PF00017	0.607
LIG_SH2_NCK_1	655	659	PF00017	0.335
LIG_SH2_STAP1	228	232	PF00017	0.646
LIG_SH2_STAP1	655	659	PF00017	0.335
LIG_SH2_STAP1	761	765	PF00017	0.335
LIG_SH2_STAT3	911	914	PF00017	0.453
LIG_SH2_STAT5	408	411	PF00017	0.380
LIG_SH2_STAT5	839	842	PF00017	0.276
LIG_SH2_STAT5	911	914	PF00017	0.489
LIG_SH2_STAT5	916	919	PF00017	0.433
LIG_SH2_STAT5	954	957	PF00017	0.556
LIG_SH3_1	132	138	PF00018	0.648
LIG_SH3_2	135	140	PF14604	0.744
LIG_SH3_3	132	138	PF00018	0.648
LIG_SH3_3	146	152	PF00018	0.643
LIG_SH3_3	455	461	PF00018	0.614
LIG_SH3_3	63	69	PF00018	0.623
LIG_SH3_3	82	88	PF00018	0.711
LIG_SUMO_SIM_par_1	484	491	PF11976	0.743
LIG_SUMO_SIM_par_1	923	929	PF11976	0.349
LIG_SxIP_EBH_1	37	49	PF03271	0.630
LIG_TRAF2_1	277	280	PF00917	0.515
LIG_TRAF2_1	606	609	PF00917	0.667
LIG_TRAF2_1	663	666	PF00917	0.330
LIG_TRAF2_1	803	806	PF00917	0.389
LIG_UBA3_1	886	891	PF00899	0.335
LIG_WRC_WIRS_1	646	651	PF05994	0.453
MOD_CDK_SPK_2	148	153	PF00069	0.692
MOD_CDK_SPK_2	712	717	PF00069	0.335
MOD_CK1_1	111	117	PF00069	0.637
MOD_CK1_1	120	126	PF00069	0.618
MOD_CK1_1	181	187	PF00069	0.745
MOD_CK1_1	296	302	PF00069	0.602
MOD_CK1_1	330	336	PF00069	0.412
MOD_CK1_1	35	41	PF00069	0.622
MOD_CK1_1	384	390	PF00069	0.501
MOD_CK1_1	424	430	PF00069	0.646
MOD_CK1_1	476	482	PF00069	0.627
MOD_CK1_1	490	496	PF00069	0.601
MOD_CK1_1	516	522	PF00069	0.635
MOD_CK1_1	524	530	PF00069	0.643
MOD_CK1_1	55	61	PF00069	0.755
MOD_CK1_1	639	645	PF00069	0.320
MOD_CK1_1	65	71	PF00069	0.584
MOD_CK1_1	695	701	PF00069	0.349
MOD_CK1_1	829	835	PF00069	0.335
MOD_CK1_1	940	946	PF00069	0.455
MOD_CK2_1	198	204	PF00069	0.728
MOD_CK2_1	207	213	PF00069	0.567
MOD_CK2_1	245	251	PF00069	0.515
MOD_CK2_1	292	298	PF00069	0.482
MOD_CK2_1	331	337	PF00069	0.446
MOD_CK2_1	393	399	PF00069	0.555
MOD_CK2_1	536	542	PF00069	0.699
MOD_CK2_1	603	609	PF00069	0.601
MOD_CK2_1	645	651	PF00069	0.447
MOD_CK2_1	738	744	PF00069	0.349
MOD_CK2_1	800	806	PF00069	0.453
MOD_CMANNOS	208	211	PF00535	0.688
MOD_Cter_Amidation	59	62	PF01082	0.664
MOD_GlcNHglycan	116	119	PF01048	0.668
MOD_GlcNHglycan	153	156	PF01048	0.714
MOD_GlcNHglycan	329	332	PF01048	0.552
MOD_GlcNHglycan	359	362	PF01048	0.479
MOD_GlcNHglycan	413	416	PF01048	0.520
MOD_GlcNHglycan	473	476	PF01048	0.692
MOD_GlcNHglycan	481	484	PF01048	0.590
MOD_GlcNHglycan	515	518	PF01048	0.692
MOD_GlcNHglycan	58	61	PF01048	0.746
MOD_GlcNHglycan	584	587	PF01048	0.691
MOD_GlcNHglycan	589	592	PF01048	0.673
MOD_GlcNHglycan	694	697	PF01048	0.349
MOD_GlcNHglycan	755	758	PF01048	0.338
MOD_GlcNHglycan	776	779	PF01048	0.394
MOD_GlcNHglycan	786	789	PF01048	0.282
MOD_GlcNHglycan	840	843	PF01048	0.453
MOD_GlcNHglycan	868	871	PF01048	0.335
MOD_GSK3_1	108	115	PF00069	0.660
MOD_GSK3_1	117	124	PF00069	0.615
MOD_GSK3_1	174	181	PF00069	0.588
MOD_GSK3_1	196	203	PF00069	0.659
MOD_GSK3_1	292	299	PF00069	0.501
MOD_GSK3_1	32	39	PF00069	0.626
MOD_GSK3_1	327	334	PF00069	0.477
MOD_GSK3_1	353	360	PF00069	0.489
MOD_GSK3_1	417	424	PF00069	0.666
MOD_GSK3_1	465	472	PF00069	0.649
MOD_GSK3_1	473	480	PF00069	0.605
MOD_GSK3_1	487	494	PF00069	0.589
MOD_GSK3_1	513	520	PF00069	0.704
MOD_GSK3_1	52	59	PF00069	0.638
MOD_GSK3_1	521	528	PF00069	0.805
MOD_GSK3_1	599	606	PF00069	0.580
MOD_GSK3_1	61	68	PF00069	0.616
MOD_GSK3_1	624	631	PF00069	0.540
MOD_GSK3_1	636	643	PF00069	0.308
MOD_GSK3_1	645	652	PF00069	0.385
MOD_GSK3_1	69	76	PF00069	0.533
MOD_GSK3_1	732	739	PF00069	0.349
MOD_GSK3_1	770	777	PF00069	0.402
MOD_GSK3_1	780	787	PF00069	0.266
MOD_GSK3_1	816	823	PF00069	0.498
MOD_GSK3_1	834	841	PF00069	0.212
MOD_GSK3_1	950	957	PF00069	0.417
MOD_N-GLC_1	108	113	PF02516	0.520
MOD_N-GLC_1	639	644	PF02516	0.335
MOD_N-GLC_1	843	848	PF02516	0.321
MOD_N-GLC_1	866	871	PF02516	0.338
MOD_N-GLC_1	882	887	PF02516	0.402
MOD_N-GLC_1	91	96	PF02516	0.735
MOD_NEK2_1	143	148	PF00069	0.754
MOD_NEK2_1	207	212	PF00069	0.571
MOD_NEK2_1	401	406	PF00069	0.423
MOD_NEK2_1	477	482	PF00069	0.648
MOD_NEK2_1	525	530	PF00069	0.588
MOD_NEK2_1	649	654	PF00069	0.453
MOD_NEK2_1	738	743	PF00069	0.338
MOD_NEK2_1	753	758	PF00069	0.335
MOD_NEK2_1	816	821	PF00069	0.491
MOD_NEK2_1	838	843	PF00069	0.337
MOD_NEK2_1	926	931	PF00069	0.349
MOD_NEK2_2	108	113	PF00069	0.579
MOD_NEK2_2	834	839	PF00069	0.335
MOD_PIKK_1	223	229	PF00454	0.538
MOD_PIKK_1	233	239	PF00454	0.509
MOD_PIKK_1	298	304	PF00454	0.523
MOD_PIKK_1	307	313	PF00454	0.429
MOD_PIKK_1	417	423	PF00454	0.667
MOD_PKA_1	61	67	PF00069	0.664
MOD_PKA_2	112	118	PF00069	0.662
MOD_PKA_2	293	299	PF00069	0.590
MOD_PKA_2	438	444	PF00069	0.633
MOD_PKA_2	521	527	PF00069	0.639
MOD_PKA_2	817	823	PF00069	0.335
MOD_Plk_1	108	114	PF00069	0.580
MOD_Plk_1	353	359	PF00069	0.472
MOD_Plk_1	788	794	PF00069	0.335
MOD_Plk_1	843	849	PF00069	0.313
MOD_Plk_1	882	888	PF00069	0.349
MOD_Plk_2-3	381	387	PF00069	0.579
MOD_Plk_2-3	393	399	PF00069	0.397
MOD_Plk_2-3	651	657	PF00069	0.335
MOD_Plk_2-3	732	738	PF00069	0.319
MOD_Plk_4	454	460	PF00069	0.662
MOD_Plk_4	526	532	PF00069	0.732
MOD_Plk_4	718	724	PF00069	0.335
MOD_Plk_4	738	744	PF00069	0.230
MOD_Plk_4	907	913	PF00069	0.340
MOD_Plk_4	950	956	PF00069	0.409
MOD_ProDKin_1	148	154	PF00069	0.694
MOD_ProDKin_1	178	184	PF00069	0.749
MOD_ProDKin_1	191	197	PF00069	0.632
MOD_ProDKin_1	36	42	PF00069	0.684
MOD_ProDKin_1	488	494	PF00069	0.671
MOD_ProDKin_1	62	68	PF00069	0.678
MOD_ProDKin_1	69	75	PF00069	0.587
MOD_ProDKin_1	712	718	PF00069	0.380
MOD_SUMO_rev_2	360	366	PF00179	0.514
MOD_SUMO_rev_2	396	404	PF00179	0.447
TRG_DiLeu_BaEn_1	362	367	PF01217	0.446
TRG_DiLeu_BaEn_1	567	572	PF01217	0.685
TRG_DiLeu_BaEn_4	608	614	PF01217	0.592
TRG_DiLeu_BaEn_4	805	811	PF01217	0.389
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.733
TRG_ENDOCYTIC_2	268	271	PF00928	0.497
TRG_ENDOCYTIC_2	408	411	PF00928	0.380
TRG_ENDOCYTIC_2	655	658	PF00928	0.335
TRG_ENDOCYTIC_2	669	672	PF00928	0.335
TRG_ENDOCYTIC_2	746	749	PF00928	0.335
TRG_ENDOCYTIC_2	761	764	PF00928	0.335
TRG_ENDOCYTIC_2	781	784	PF00928	0.335
TRG_ER_diArg_1	130	132	PF00400	0.710
TRG_ER_diArg_1	168	171	PF00400	0.627
TRG_ER_diArg_1	254	257	PF00400	0.543
TRG_ER_diArg_1	275	278	PF00400	0.483
TRG_ER_diArg_1	572	575	PF00400	0.695
TRG_ER_diArg_1	705	708	PF00400	0.374
TRG_ER_diArg_1	847	850	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	884	888	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP4	Leptomonas seymouri	56%	100%
A4HGN8	Leishmania braziliensis	78%	100%
A4I3R1	Leishmania infantum	100%	100%
E9B004	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q881	Leishmania major	93%	100%