Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDV0_LEIDO

TriTrypDb:

LdBPK_332050.1 , LdCL_330027400 , LDHU3_33.2970

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A0A3Q8IDV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.731
CLV_C14_Caspase3-7	197	201	PF00656	0.707
CLV_C14_Caspase3-7	454	458	PF00656	0.450
CLV_C14_Caspase3-7	635	639	PF00656	0.567
CLV_C14_Caspase3-7	91	95	PF00656	0.606
CLV_NRD_NRD_1	13	15	PF00675	0.543
CLV_NRD_NRD_1	30	32	PF00675	0.454
CLV_NRD_NRD_1	339	341	PF00675	0.477
CLV_NRD_NRD_1	626	628	PF00675	0.502
CLV_PCSK_FUR_1	375	379	PF00082	0.388
CLV_PCSK_KEX2_1	13	15	PF00082	0.543
CLV_PCSK_KEX2_1	231	233	PF00082	0.379
CLV_PCSK_KEX2_1	30	32	PF00082	0.454
CLV_PCSK_KEX2_1	339	341	PF00082	0.371
CLV_PCSK_KEX2_1	377	379	PF00082	0.319
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.269
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.360
CLV_PCSK_SKI1_1	169	173	PF00082	0.420
CLV_PCSK_SKI1_1	31	35	PF00082	0.482
CLV_PCSK_SKI1_1	378	382	PF00082	0.357
CLV_PCSK_SKI1_1	631	635	PF00082	0.484
DEG_MDM2_SWIB_1	312	320	PF02201	0.239
DEG_SCF_TRCP1_1	638	643	PF00400	0.580
DOC_MAPK_FxFP_2	400	403	PF00069	0.239
DOC_MAPK_gen_1	372	381	PF00069	0.513
DOC_MAPK_gen_1	423	432	PF00069	0.263
DOC_MAPK_MEF2A_6	423	431	PF00069	0.264
DOC_MAPK_RevD_3	362	378	PF00069	0.524
DOC_PP1_RVXF_1	542	548	PF00149	0.428
DOC_PP1_RVXF_1	573	580	PF00149	0.435
DOC_PP1_RVXF_1	618	624	PF00149	0.658
DOC_PP2B_LxvP_1	346	349	PF13499	0.559
DOC_PP4_FxxP_1	215	218	PF00568	0.523
DOC_PP4_FxxP_1	400	403	PF00568	0.357
DOC_PP4_FxxP_1	57	60	PF00568	0.800
DOC_USP7_MATH_1	143	147	PF00917	0.507
DOC_USP7_MATH_1	18	22	PF00917	0.684
DOC_USP7_MATH_1	252	256	PF00917	0.490
DOC_USP7_MATH_1	48	52	PF00917	0.782
DOC_USP7_MATH_1	645	649	PF00917	0.744
DOC_USP7_MATH_1	82	86	PF00917	0.721
DOC_WW_Pin1_4	12	17	PF00397	0.648
DOC_WW_Pin1_4	128	133	PF00397	0.501
DOC_WW_Pin1_4	347	352	PF00397	0.485
LIG_14-3-3_CanoR_1	126	132	PF00244	0.475
LIG_14-3-3_CanoR_1	17	23	PF00244	0.675
LIG_14-3-3_CanoR_1	221	230	PF00244	0.612
LIG_14-3-3_CanoR_1	300	305	PF00244	0.426
LIG_14-3-3_CanoR_1	475	483	PF00244	0.461
LIG_14-3-3_CanoR_1	511	520	PF00244	0.207
LIG_14-3-3_CanoR_1	544	554	PF00244	0.493
LIG_14-3-3_CanoR_1	77	84	PF00244	0.711
LIG_Actin_WH2_2	215	233	PF00022	0.564
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BIR_III_2	47	51	PF00653	0.631
LIG_Clathr_ClatBox_1	63	67	PF01394	0.610
LIG_CORNRBOX	391	399	PF00104	0.215
LIG_CtBP_PxDLS_1	60	64	PF00389	0.621
LIG_deltaCOP1_diTrp_1	421	426	PF00928	0.292
LIG_EH1_1	165	173	PF00400	0.478
LIG_eIF4E_1	304	310	PF01652	0.239
LIG_eIF4E_1	593	599	PF01652	0.418
LIG_FHA_1	306	312	PF00498	0.279
LIG_FHA_1	514	520	PF00498	0.256
LIG_FHA_1	540	546	PF00498	0.551
LIG_FHA_1	6	12	PF00498	0.786
LIG_FHA_1	632	638	PF00498	0.556
LIG_FHA_1	644	650	PF00498	0.549
LIG_FHA_1	68	74	PF00498	0.678
LIG_FHA_2	174	180	PF00498	0.491
LIG_FHA_2	189	195	PF00498	0.491
LIG_FHA_2	5	11	PF00498	0.628
LIG_FHA_2	89	95	PF00498	0.726
LIG_GBD_Chelix_1	479	487	PF00786	0.239
LIG_HP1_1	427	431	PF01393	0.196
LIG_IBAR_NPY_1	164	166	PF08397	0.459
LIG_LIR_Apic_2	212	218	PF02991	0.522
LIG_LIR_Apic_2	54	60	PF02991	0.793
LIG_LIR_Gen_1	225	235	PF02991	0.558
LIG_LIR_Gen_1	236	242	PF02991	0.468
LIG_LIR_Gen_1	250	258	PF02991	0.565
LIG_LIR_Gen_1	278	289	PF02991	0.427
LIG_LIR_Gen_1	342	353	PF02991	0.630
LIG_LIR_Gen_1	363	373	PF02991	0.537
LIG_LIR_Gen_1	493	503	PF02991	0.306
LIG_LIR_Gen_1	530	540	PF02991	0.336
LIG_LIR_Gen_1	546	555	PF02991	0.434
LIG_LIR_Gen_1	573	584	PF02991	0.331
LIG_LIR_LC3C_4	62	65	PF02991	0.617
LIG_LIR_Nem_3	133	139	PF02991	0.539
LIG_LIR_Nem_3	225	230	PF02991	0.551
LIG_LIR_Nem_3	233	238	PF02991	0.516
LIG_LIR_Nem_3	250	256	PF02991	0.608
LIG_LIR_Nem_3	278	284	PF02991	0.364
LIG_LIR_Nem_3	303	307	PF02991	0.264
LIG_LIR_Nem_3	342	348	PF02991	0.623
LIG_LIR_Nem_3	350	355	PF02991	0.609
LIG_LIR_Nem_3	363	368	PF02991	0.459
LIG_LIR_Nem_3	493	499	PF02991	0.370
LIG_LIR_Nem_3	530	535	PF02991	0.336
LIG_LIR_Nem_3	546	550	PF02991	0.345
LIG_LIR_Nem_3	573	579	PF02991	0.318
LIG_LIR_Nem_3	582	588	PF02991	0.225
LIG_LIR_Nem_3	589	593	PF02991	0.232
LIG_PCNA_PIPBox_1	189	198	PF02747	0.499
LIG_PCNA_yPIPBox_3	186	196	PF02747	0.552
LIG_PCNA_yPIPBox_3	199	211	PF02747	0.535
LIG_Pex14_1	590	594	PF04695	0.393
LIG_Pex14_1	607	611	PF04695	0.506
LIG_Pex14_2	215	219	PF04695	0.522
LIG_Pex14_2	312	316	PF04695	0.447
LIG_Pex14_2	444	448	PF04695	0.393
LIG_Pex14_2	579	583	PF04695	0.400
LIG_PTB_Apo_2	265	272	PF02174	0.413
LIG_Rb_pABgroove_1	236	244	PF01858	0.445
LIG_REV1ctd_RIR_1	212	217	PF16727	0.441
LIG_SH2_CRK	227	231	PF00017	0.609
LIG_SH2_CRK	307	311	PF00017	0.301
LIG_SH2_GRB2like	410	413	PF00017	0.363
LIG_SH2_GRB2like	512	515	PF00017	0.248
LIG_SH2_PTP2	237	240	PF00017	0.524
LIG_SH2_PTP2	352	355	PF00017	0.472
LIG_SH2_PTP2	428	431	PF00017	0.459
LIG_SH2_PTP2	532	535	PF00017	0.216
LIG_SH2_SRC	532	535	PF00017	0.198
LIG_SH2_STAP1	307	311	PF00017	0.277
LIG_SH2_STAP1	370	374	PF00017	0.601
LIG_SH2_STAP1	446	450	PF00017	0.413
LIG_SH2_STAT3	242	245	PF00017	0.469
LIG_SH2_STAT5	117	120	PF00017	0.675
LIG_SH2_STAT5	166	169	PF00017	0.473
LIG_SH2_STAT5	210	213	PF00017	0.474
LIG_SH2_STAT5	237	240	PF00017	0.515
LIG_SH2_STAT5	307	310	PF00017	0.315
LIG_SH2_STAT5	345	348	PF00017	0.483
LIG_SH2_STAT5	352	355	PF00017	0.483
LIG_SH2_STAT5	410	413	PF00017	0.268
LIG_SH2_STAT5	428	431	PF00017	0.323
LIG_SH2_STAT5	485	488	PF00017	0.318
LIG_SH2_STAT5	527	530	PF00017	0.423
LIG_SH2_STAT5	532	535	PF00017	0.410
LIG_SH2_STAT5	576	579	PF00017	0.335
LIG_SH2_STAT5	587	590	PF00017	0.239
LIG_SH2_STAT5	593	596	PF00017	0.203
LIG_SH3_3	129	135	PF00018	0.629
LIG_SH3_3	246	252	PF00018	0.520
LIG_SH3_3	30	36	PF00018	0.663
LIG_SH3_3	345	351	PF00018	0.517
LIG_SH3_3	354	360	PF00018	0.508
LIG_SH3_3	62	68	PF00018	0.613
LIG_SUMO_SIM_anti_2	515	521	PF11976	0.385
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.612
LIG_SUMO_SIM_par_1	117	123	PF11976	0.624
LIG_SUMO_SIM_par_1	515	521	PF11976	0.365
LIG_SUMO_SIM_par_1	532	539	PF11976	0.275
LIG_SUMO_SIM_par_1	557	564	PF11976	0.371
LIG_SUMO_SIM_par_1	62	67	PF11976	0.612
LIG_UBA3_1	621	628	PF00899	0.559
LIG_WRC_WIRS_1	211	216	PF05994	0.440
LIG_WRC_WIRS_1	83	88	PF05994	0.598
MOD_CDK_SPK_2	12	17	PF00069	0.680
MOD_CK1_1	130	136	PF00069	0.631
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK1_1	21	27	PF00069	0.674
MOD_CK1_1	389	395	PF00069	0.239
MOD_CK1_1	506	512	PF00069	0.339
MOD_CK1_1	521	527	PF00069	0.257
MOD_CK1_1	53	59	PF00069	0.783
MOD_CK2_1	128	134	PF00069	0.550
MOD_CK2_1	173	179	PF00069	0.529
MOD_CK2_1	188	194	PF00069	0.469
MOD_CK2_1	230	236	PF00069	0.449
MOD_CK2_1	48	54	PF00069	0.756
MOD_CK2_1	486	492	PF00069	0.441
MOD_CK2_1	636	642	PF00069	0.737
MOD_GlcNHglycan	102	105	PF01048	0.578
MOD_GlcNHglycan	122	125	PF01048	0.342
MOD_GlcNHglycan	173	176	PF01048	0.339
MOD_GlcNHglycan	2	5	PF01048	0.565
MOD_GlcNHglycan	232	235	PF01048	0.305
MOD_GlcNHglycan	391	394	PF01048	0.215
MOD_GlcNHglycan	476	479	PF01048	0.291
MOD_GlcNHglycan	505	508	PF01048	0.596
MOD_GlcNHglycan	520	523	PF01048	0.282
MOD_GlcNHglycan	638	641	PF01048	0.563
MOD_GSK3_1	17	24	PF00069	0.661
MOD_GSK3_1	173	180	PF00069	0.643
MOD_GSK3_1	195	202	PF00069	0.606
MOD_GSK3_1	275	282	PF00069	0.391
MOD_GSK3_1	486	493	PF00069	0.437
MOD_GSK3_1	535	542	PF00069	0.469
MOD_GSK3_1	627	634	PF00069	0.554
MOD_GSK3_1	636	643	PF00069	0.580
MOD_GSK3_1	88	95	PF00069	0.734
MOD_N-GLC_1	100	105	PF02516	0.355
MOD_N-GLC_1	258	263	PF02516	0.385
MOD_N-GLC_1	37	42	PF02516	0.517
MOD_N-GLC_1	513	518	PF02516	0.554
MOD_N-GLC_1	75	80	PF02516	0.467
MOD_N-GLC_1	92	97	PF02516	0.422
MOD_NEK2_1	22	27	PF00069	0.738
MOD_NEK2_1	222	227	PF00069	0.575
MOD_NEK2_1	230	235	PF00069	0.529
MOD_NEK2_1	279	284	PF00069	0.319
MOD_NEK2_1	498	503	PF00069	0.359
MOD_NEK2_1	505	510	PF00069	0.330
MOD_NEK2_1	579	584	PF00069	0.365
MOD_NEK2_1	632	637	PF00069	0.676
MOD_NEK2_1	92	97	PF00069	0.622
MOD_NEK2_2	210	215	PF00069	0.461
MOD_NEK2_2	527	532	PF00069	0.353
MOD_NEK2_2	592	597	PF00069	0.432
MOD_PIKK_1	222	228	PF00454	0.579
MOD_PIKK_1	404	410	PF00454	0.476
MOD_PIKK_1	434	440	PF00454	0.454
MOD_PKA_1	627	633	PF00069	0.565
MOD_PKA_2	220	226	PF00069	0.607
MOD_PKA_2	389	395	PF00069	0.405
MOD_PKA_2	474	480	PF00069	0.542
MOD_PKA_2	503	509	PF00069	0.434
MOD_PKA_2	543	549	PF00069	0.501
MOD_PKA_2	579	585	PF00069	0.275
MOD_PKA_2	76	82	PF00069	0.769
MOD_Plk_1	38	44	PF00069	0.781
MOD_Plk_1	414	420	PF00069	0.453
MOD_Plk_1	513	519	PF00069	0.322
MOD_Plk_1	538	544	PF00069	0.588
MOD_Plk_1	640	646	PF00069	0.579
MOD_Plk_1	92	98	PF00069	0.729
MOD_Plk_2-3	173	179	PF00069	0.657
MOD_Plk_4	210	216	PF00069	0.483
MOD_Plk_4	252	258	PF00069	0.546
MOD_Plk_4	275	281	PF00069	0.267
MOD_Plk_4	305	311	PF00069	0.402
MOD_Plk_4	486	492	PF00069	0.320
MOD_Plk_4	513	519	PF00069	0.222
MOD_Plk_4	527	533	PF00069	0.322
MOD_Plk_4	579	585	PF00069	0.337
MOD_Plk_4	82	88	PF00069	0.795
MOD_Plk_4	92	98	PF00069	0.785
MOD_ProDKin_1	12	18	PF00069	0.647
MOD_ProDKin_1	128	134	PF00069	0.505
MOD_ProDKin_1	347	353	PF00069	0.484
MOD_SUMO_rev_2	337	346	PF00179	0.545
TRG_DiLeu_BaEn_1	236	241	PF01217	0.445
TRG_DiLeu_BaEn_2	491	497	PF01217	0.393
TRG_DiLeu_BaEn_4	569	575	PF01217	0.268
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.441
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.540
TRG_ENDOCYTIC_2	208	211	PF00928	0.462
TRG_ENDOCYTIC_2	227	230	PF00928	0.528
TRG_ENDOCYTIC_2	237	240	PF00928	0.510
TRG_ENDOCYTIC_2	307	310	PF00928	0.312
TRG_ENDOCYTIC_2	345	348	PF00928	0.573
TRG_ENDOCYTIC_2	352	355	PF00928	0.608
TRG_ENDOCYTIC_2	428	431	PF00928	0.337
TRG_ENDOCYTIC_2	446	449	PF00928	0.287
TRG_ENDOCYTIC_2	532	535	PF00928	0.249
TRG_ENDOCYTIC_2	576	579	PF00928	0.302
TRG_ENDOCYTIC_2	593	596	PF00928	0.257
TRG_ER_diArg_1	327	330	PF00400	0.612
TRG_ER_diArg_1	338	340	PF00400	0.671
TRG_ER_diArg_1	422	425	PF00400	0.308
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIV3	Bodo saltans	24%	85%
A0A0S4IZJ9	Bodo saltans	27%	68%
A0A1X0NUP0	Trypanosomatidae	20%	100%
A0A1X0P3P0	Trypanosomatidae	36%	95%
A0A3R7R847	Trypanosoma rangeli	31%	98%
A0A3S7X5M8	Leishmania donovani	22%	100%
A0A422MY34	Trypanosoma rangeli	23%	100%
A4HKK2	Leishmania braziliensis	22%	100%
A4HLQ6	Leishmania braziliensis	77%	100%
A4I834	Leishmania infantum	22%	100%
A4I956	Leishmania infantum	100%	100%
D0A6B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q3Z3	Leishmania major	91%	100%
Q4Q564	Leishmania major	22%	100%
V5B8R5	Trypanosoma cruzi	32%	98%
V5BBK9	Trypanosoma cruzi	24%	100%