PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDU9_LEIDO

TriTrypDb:

LdBPK_281110.1 , LdCL_280015700 , LDHU3_28.1360

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.696
CLV_C14_Caspase3-7	368	372	PF00656	0.565
CLV_NRD_NRD_1	163	165	PF00675	0.536
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	258	260	PF00675	0.419
CLV_NRD_NRD_1	264	266	PF00675	0.407
CLV_NRD_NRD_1	28	30	PF00675	0.464
CLV_NRD_NRD_1	426	428	PF00675	0.496
CLV_NRD_NRD_1	455	457	PF00675	0.454
CLV_NRD_NRD_1	541	543	PF00675	0.492
CLV_NRD_NRD_1	92	94	PF00675	0.517
CLV_PCSK_KEX2_1	163	165	PF00082	0.536
CLV_PCSK_KEX2_1	198	200	PF00082	0.577
CLV_PCSK_KEX2_1	258	260	PF00082	0.408
CLV_PCSK_KEX2_1	28	30	PF00082	0.464
CLV_PCSK_KEX2_1	426	428	PF00082	0.496
CLV_PCSK_KEX2_1	455	457	PF00082	0.454
CLV_PCSK_KEX2_1	540	542	PF00082	0.445
CLV_PCSK_KEX2_1	547	549	PF00082	0.476
CLV_PCSK_KEX2_1	92	94	PF00082	0.508
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.546
CLV_PCSK_SKI1_1	154	158	PF00082	0.382
CLV_PCSK_SKI1_1	248	252	PF00082	0.413
CLV_PCSK_SKI1_1	28	32	PF00082	0.491
CLV_PCSK_SKI1_1	346	350	PF00082	0.484
CLV_PCSK_SKI1_1	4	8	PF00082	0.466
CLV_PCSK_SKI1_1	416	420	PF00082	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.595
DOC_CYCLIN_yCln2_LP_2	304	307	PF00134	0.389
DOC_MAPK_DCC_7	265	275	PF00069	0.436
DOC_MAPK_gen_1	375	384	PF00069	0.397
DOC_MAPK_gen_1	98	106	PF00069	0.368
DOC_MAPK_MEF2A_6	286	294	PF00069	0.424
DOC_MAPK_MEF2A_6	378	386	PF00069	0.443
DOC_PP1_SILK_1	292	297	PF00149	0.450
DOC_PP2B_LxvP_1	304	307	PF13499	0.389
DOC_PP4_FxxP_1	556	559	PF00568	0.386
DOC_USP7_MATH_1	194	198	PF00917	0.729
DOC_USP7_MATH_1	440	444	PF00917	0.407
DOC_USP7_MATH_2	211	217	PF00917	0.566
DOC_WW_Pin1_4	197	202	PF00397	0.671
DOC_WW_Pin1_4	242	247	PF00397	0.553
DOC_WW_Pin1_4	268	273	PF00397	0.403
DOC_WW_Pin1_4	620	625	PF00397	0.651
LIG_14-3-3_CanoR_1	360	366	PF00244	0.609
LIG_14-3-3_CanoR_1	378	383	PF00244	0.415
LIG_14-3-3_CanoR_1	430	435	PF00244	0.495
LIG_14-3-3_CanoR_1	459	464	PF00244	0.494
LIG_Actin_WH2_2	141	156	PF00022	0.457
LIG_APCC_ABBA_1	549	554	PF00400	0.436
LIG_APCC_ABBAyCdc20_2	548	554	PF00400	0.459
LIG_BRCT_BRCA1_1	191	195	PF00533	0.645
LIG_BRCT_BRCA1_1	622	626	PF00533	0.638
LIG_deltaCOP1_diTrp_1	486	490	PF00928	0.393
LIG_eIF4E_1	506	512	PF01652	0.445
LIG_FHA_1	148	154	PF00498	0.381
LIG_FHA_1	269	275	PF00498	0.390
LIG_FHA_1	322	328	PF00498	0.340
LIG_FHA_2	202	208	PF00498	0.660
LIG_FHA_2	232	238	PF00498	0.623
LIG_FHA_2	534	540	PF00498	0.423
LIG_FHA_2	604	610	PF00498	0.602
LIG_FHA_2	620	626	PF00498	0.526
LIG_LIR_Apic_2	401	405	PF02991	0.324
LIG_LIR_Apic_2	553	559	PF02991	0.421
LIG_LIR_Gen_1	252	261	PF02991	0.421
LIG_LIR_Gen_1	385	395	PF02991	0.401
LIG_LIR_Gen_1	417	425	PF02991	0.495
LIG_LIR_Gen_1	449	458	PF02991	0.475
LIG_LIR_Gen_1	504	513	PF02991	0.369
LIG_LIR_Gen_1	520	530	PF02991	0.351
LIG_LIR_Nem_3	252	257	PF02991	0.399
LIG_LIR_Nem_3	385	390	PF02991	0.438
LIG_LIR_Nem_3	417	422	PF02991	0.474
LIG_LIR_Nem_3	449	454	PF02991	0.561
LIG_LIR_Nem_3	486	490	PF02991	0.441
LIG_LIR_Nem_3	520	525	PF02991	0.401
LIG_LIR_Nem_3	89	94	PF02991	0.485
LIG_Pex14_1	415	419	PF04695	0.438
LIG_SH2_CRK	522	526	PF00017	0.438
LIG_SH2_CRK	91	95	PF00017	0.433
LIG_SH2_PTP2	87	90	PF00017	0.430
LIG_SH2_STAP1	310	314	PF00017	0.369
LIG_SH2_STAP1	437	441	PF00017	0.416
LIG_SH2_STAP1	552	556	PF00017	0.523
LIG_SH2_STAP1	613	617	PF00017	0.581
LIG_SH2_STAT3	318	321	PF00017	0.404
LIG_SH2_STAT5	152	155	PF00017	0.340
LIG_SH2_STAT5	474	477	PF00017	0.406
LIG_SH2_STAT5	517	520	PF00017	0.391
LIG_SH2_STAT5	87	90	PF00017	0.400
LIG_SH3_3	429	435	PF00018	0.517
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.457
LIG_SUMO_SIM_par_1	271	277	PF11976	0.410
LIG_TRAF2_1	167	170	PF00917	0.654
LIG_TRAF2_1	204	207	PF00917	0.649
LIG_TRAF2_1	250	253	PF00917	0.427
LIG_TRAF2_1	351	354	PF00917	0.360
LIG_TRAF2_1	356	359	PF00917	0.379
LIG_TRFH_1	556	560	PF08558	0.447
MOD_CDC14_SPxK_1	245	248	PF00782	0.344
MOD_CDK_SPxK_1	242	248	PF00069	0.392
MOD_CK1_1	189	195	PF00069	0.703
MOD_CK1_1	197	203	PF00069	0.701
MOD_CK2_1	164	170	PF00069	0.692
MOD_CK2_1	187	193	PF00069	0.814
MOD_CK2_1	201	207	PF00069	0.696
MOD_CK2_1	353	359	PF00069	0.394
MOD_CK2_1	440	446	PF00069	0.343
MOD_CK2_1	459	465	PF00069	0.365
MOD_CK2_1	533	539	PF00069	0.414
MOD_CK2_1	619	625	PF00069	0.677
MOD_Cter_Amidation	161	164	PF01082	0.500
MOD_GlcNHglycan	166	169	PF01048	0.672
MOD_GlcNHglycan	189	192	PF01048	0.750
MOD_GlcNHglycan	353	358	PF01048	0.409
MOD_GlcNHglycan	367	370	PF01048	0.632
MOD_GlcNHglycan	432	435	PF01048	0.504
MOD_GlcNHglycan	595	598	PF01048	0.554
MOD_GSK3_1	183	190	PF00069	0.734
MOD_GSK3_1	197	204	PF00069	0.578
MOD_GSK3_1	349	356	PF00069	0.449
MOD_GSK3_1	361	368	PF00069	0.484
MOD_GSK3_1	378	385	PF00069	0.511
MOD_GSK3_1	40	47	PF00069	0.436
MOD_GSK3_1	593	600	PF00069	0.601
MOD_LATS_1	134	140	PF00433	0.532
MOD_N-GLC_1	136	141	PF02516	0.552
MOD_N-GLC_1	533	538	PF02516	0.475
MOD_NEK2_1	10	15	PF00069	0.450
MOD_NEK2_1	157	162	PF00069	0.435
MOD_NEK2_1	274	279	PF00069	0.411
MOD_NEK2_1	290	295	PF00069	0.317
MOD_NEK2_1	333	338	PF00069	0.448
MOD_NEK2_1	365	370	PF00069	0.637
MOD_NEK2_1	382	387	PF00069	0.369
MOD_NEK2_1	458	463	PF00069	0.509
MOD_NEK2_2	310	315	PF00069	0.376
MOD_PIKK_1	183	189	PF00454	0.731
MOD_PIKK_1	276	282	PF00454	0.436
MOD_PIKK_1	321	327	PF00454	0.342
MOD_PIKK_1	40	46	PF00454	0.434
MOD_PIKK_1	533	539	PF00454	0.445
MOD_PIKK_1	611	617	PF00454	0.611
MOD_PKA_2	10	16	PF00069	0.510
MOD_PKA_2	213	219	PF00069	0.689
MOD_PKA_2	458	464	PF00069	0.491
MOD_PKA_2	593	599	PF00069	0.529
MOD_Plk_1	310	316	PF00069	0.360
MOD_Plk_1	341	347	PF00069	0.384
MOD_Plk_1	533	539	PF00069	0.451
MOD_Plk_4	290	296	PF00069	0.442
MOD_Plk_4	382	388	PF00069	0.374
MOD_Plk_4	466	472	PF00069	0.436
MOD_Plk_4	521	527	PF00069	0.455
MOD_ProDKin_1	197	203	PF00069	0.671
MOD_ProDKin_1	242	248	PF00069	0.546
MOD_ProDKin_1	268	274	PF00069	0.395
MOD_ProDKin_1	620	626	PF00069	0.657
MOD_SUMO_rev_2	539	549	PF00179	0.536
TRG_AP2beta_CARGO_1	417	426	PF09066	0.452
TRG_DiLeu_BaEn_4	252	258	PF01217	0.432
TRG_DiLeu_BaEn_4	553	559	PF01217	0.470
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.378
TRG_DiLeu_LyEn_5	269	274	PF01217	0.492
TRG_ENDOCYTIC_2	506	509	PF00928	0.400
TRG_ENDOCYTIC_2	522	525	PF00928	0.468
TRG_ENDOCYTIC_2	87	90	PF00928	0.371
TRG_ENDOCYTIC_2	91	94	PF00928	0.384
TRG_ER_diArg_1	163	165	PF00400	0.536
TRG_ER_diArg_1	257	259	PF00400	0.385
TRG_ER_diArg_1	425	427	PF00400	0.440
TRG_ER_diArg_1	454	456	PF00400	0.447
TRG_ER_diArg_1	482	485	PF00400	0.492
TRG_ER_diArg_1	540	542	PF00400	0.503
TRG_ER_diArg_1	548	551	PF00400	0.528
TRG_ER_diArg_1	91	93	PF00400	0.459
TRG_ER_diArg_1	96	99	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P278	Leptomonas seymouri	66%	100%
A0A0S4IQ65	Bodo saltans	31%	88%
A0A1X0NYR6	Trypanosomatidae	46%	100%
A4HGE6	Leishmania braziliensis	85%	100%
A4I3J2	Leishmania infantum	99%	100%
E9AZR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8G5	Leishmania major	95%	100%