Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDU7_LEIDO

TriTrypDb:

LdBPK_292110.1 , LdCL_290027000 , LDHU3_29.3010

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.633
CLV_NRD_NRD_1	121	123	PF00675	0.728
CLV_NRD_NRD_1	370	372	PF00675	0.662
CLV_NRD_NRD_1	42	44	PF00675	0.709
CLV_NRD_NRD_1	97	99	PF00675	0.708
CLV_PCSK_FUR_1	40	44	PF00082	0.707
CLV_PCSK_KEX2_1	121	123	PF00082	0.723
CLV_PCSK_KEX2_1	343	345	PF00082	0.720
CLV_PCSK_KEX2_1	370	372	PF00082	0.662
CLV_PCSK_KEX2_1	42	44	PF00082	0.709
CLV_PCSK_KEX2_1	97	99	PF00082	0.708
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.720
DEG_SPOP_SBC_1	348	352	PF00917	0.746
DOC_ANK_TNKS_1	451	458	PF00023	0.748
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.810
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.615
DOC_PP2B_LxvP_1	189	192	PF13499	0.670
DOC_PP2B_LxvP_1	273	276	PF13499	0.507
DOC_PP4_FxxP_1	150	153	PF00568	0.812
DOC_SPAK_OSR1_1	238	242	PF12202	0.713
DOC_USP7_MATH_1	161	165	PF00917	0.844
DOC_USP7_MATH_1	198	202	PF00917	0.727
DOC_USP7_MATH_1	223	227	PF00917	0.550
DOC_USP7_MATH_1	348	352	PF00917	0.746
DOC_USP7_MATH_1	438	442	PF00917	0.800
DOC_USP7_MATH_1	66	70	PF00917	0.749
DOC_WW_Pin1_4	127	132	PF00397	0.727
DOC_WW_Pin1_4	165	170	PF00397	0.732
DOC_WW_Pin1_4	172	177	PF00397	0.684
DOC_WW_Pin1_4	255	260	PF00397	0.604
DOC_WW_Pin1_4	41	46	PF00397	0.747
DOC_WW_Pin1_4	434	439	PF00397	0.836
DOC_WW_Pin1_4	6	11	PF00397	0.804
LIG_14-3-3_CanoR_1	238	242	PF00244	0.588
LIG_14-3-3_CanoR_1	370	377	PF00244	0.677
LIG_14-3-3_CanoR_1	394	402	PF00244	0.595
LIG_14-3-3_CanoR_1	439	447	PF00244	0.633
LIG_14-3-3_CanoR_1	64	74	PF00244	0.727
LIG_14-3-3_CanoR_1	97	107	PF00244	0.688
LIG_APCC_ABBA_1	241	246	PF00400	0.465
LIG_APCC_ABBA_1	90	95	PF00400	0.764
LIG_BIR_II_1	1	5	PF00653	0.810
LIG_BIR_III_4	421	425	PF00653	0.717
LIG_BIR_III_4	429	433	PF00653	0.629
LIG_BIR_III_4	480	484	PF00653	0.738
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.692
LIG_deltaCOP1_diTrp_1	373	380	PF00928	0.608
LIG_FHA_1	166	172	PF00498	0.771
LIG_FHA_1	34	40	PF00498	0.762
LIG_FHA_1	370	376	PF00498	0.689
LIG_FHA_1	386	392	PF00498	0.579
LIG_FHA_1	397	403	PF00498	0.616
LIG_FHA_1	42	48	PF00498	0.721
LIG_FHA_1	448	454	PF00498	0.677
LIG_FHA_2	410	416	PF00498	0.741
LIG_LIR_Gen_1	132	142	PF02991	0.664
LIG_LIR_Gen_1	521	530	PF02991	0.755
LIG_LIR_Nem_3	13	18	PF02991	0.783
LIG_LIR_Nem_3	132	137	PF02991	0.744
LIG_LIR_Nem_3	140	145	PF02991	0.647
LIG_LIR_Nem_3	374	380	PF02991	0.602
LIG_LIR_Nem_3	521	526	PF02991	0.758
LIG_LIR_Nem_3	91	96	PF02991	0.695
LIG_PCNA_PIPBox_1	498	507	PF02747	0.692
LIG_SH2_CRK	134	138	PF00017	0.745
LIG_SH2_PTP2	270	273	PF00017	0.547
LIG_SH2_STAP1	134	138	PF00017	0.745
LIG_SH2_STAT3	282	285	PF00017	0.615
LIG_SH2_STAT3	324	327	PF00017	0.626
LIG_SH2_STAT5	181	184	PF00017	0.608
LIG_SH2_STAT5	270	273	PF00017	0.569
LIG_SH2_STAT5	33	36	PF00017	0.730
LIG_SH3_3	101	107	PF00018	0.616
LIG_SH3_3	146	152	PF00018	0.743
LIG_SH3_3	166	172	PF00018	0.576
LIG_SH3_3	295	301	PF00018	0.680
LIG_SH3_3	441	447	PF00018	0.751
LIG_SH3_3	514	520	PF00018	0.689
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.649
LIG_TRAF2_1	416	419	PF00917	0.626
LIG_UBA3_1	379	387	PF00899	0.644
MOD_CDK_SPK_2	41	46	PF00069	0.747
MOD_CDK_SPK_2	434	439	PF00069	0.622
MOD_CK1_1	126	132	PF00069	0.803
MOD_CK1_1	365	371	PF00069	0.708
MOD_CK1_1	413	419	PF00069	0.813
MOD_CK1_1	437	443	PF00069	0.747
MOD_CK1_1	53	59	PF00069	0.829
MOD_CK1_1	68	74	PF00069	0.572
MOD_CK2_1	334	340	PF00069	0.742
MOD_CK2_1	349	355	PF00069	0.808
MOD_CK2_1	409	415	PF00069	0.729
MOD_Cter_Amidation	119	122	PF01082	0.611
MOD_GlcNHglycan	202	205	PF01048	0.678
MOD_GlcNHglycan	218	222	PF01048	0.562
MOD_GlcNHglycan	252	255	PF01048	0.605
MOD_GlcNHglycan	29	32	PF01048	0.681
MOD_GlcNHglycan	328	331	PF01048	0.552
MOD_GlcNHglycan	351	354	PF01048	0.739
MOD_GlcNHglycan	412	415	PF01048	0.834
MOD_GlcNHglycan	52	55	PF01048	0.808
MOD_GlcNHglycan	70	73	PF01048	0.534
MOD_GlcNHglycan	86	90	PF01048	0.501
MOD_GSK3_1	122	129	PF00069	0.822
MOD_GSK3_1	161	168	PF00069	0.660
MOD_GSK3_1	223	230	PF00069	0.586
MOD_GSK3_1	334	341	PF00069	0.753
MOD_GSK3_1	343	350	PF00069	0.625
MOD_GSK3_1	365	372	PF00069	0.723
MOD_GSK3_1	405	412	PF00069	0.684
MOD_GSK3_1	41	48	PF00069	0.784
MOD_GSK3_1	434	441	PF00069	0.814
MOD_GSK3_1	50	57	PF00069	0.708
MOD_GSK3_1	6	13	PF00069	0.745
MOD_N-GLC_1	405	410	PF02516	0.759
MOD_N-GLC_1	66	71	PF02516	0.747
MOD_NEK2_1	113	118	PF00069	0.754
MOD_NEK2_1	137	142	PF00069	0.678
MOD_NEK2_1	217	222	PF00069	0.679
MOD_NEK2_1	326	331	PF00069	0.730
MOD_NEK2_1	349	354	PF00069	0.696
MOD_NEK2_1	380	385	PF00069	0.719
MOD_NEK2_2	59	64	PF00069	0.614
MOD_PIKK_1	114	120	PF00454	0.749
MOD_PIKK_1	33	39	PF00454	0.697
MOD_PIKK_1	405	411	PF00454	0.802
MOD_PK_1	280	286	PF00069	0.726
MOD_PKA_1	343	349	PF00069	0.728
MOD_PKA_2	237	243	PF00069	0.625
MOD_PKA_2	333	339	PF00069	0.714
MOD_PKA_2	343	349	PF00069	0.672
MOD_PKA_2	369	375	PF00069	0.727
MOD_PKA_2	438	444	PF00069	0.678
MOD_PKA_2	45	51	PF00069	0.811
MOD_Plk_1	280	286	PF00069	0.698
MOD_Plk_1	334	340	PF00069	0.786
MOD_Plk_1	85	91	PF00069	0.742
MOD_Plk_2-3	369	375	PF00069	0.649
MOD_Plk_4	380	386	PF00069	0.719
MOD_Plk_4	387	393	PF00069	0.566
MOD_Plk_4	440	446	PF00069	0.713
MOD_ProDKin_1	127	133	PF00069	0.725
MOD_ProDKin_1	165	171	PF00069	0.730
MOD_ProDKin_1	172	178	PF00069	0.676
MOD_ProDKin_1	255	261	PF00069	0.604
MOD_ProDKin_1	41	47	PF00069	0.749
MOD_ProDKin_1	434	440	PF00069	0.837
MOD_ProDKin_1	6	12	PF00069	0.804
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.751
TRG_ENDOCYTIC_2	134	137	PF00928	0.721
TRG_ENDOCYTIC_2	270	273	PF00928	0.569
TRG_ENDOCYTIC_2	523	526	PF00928	0.645
TRG_ENDOCYTIC_2	93	96	PF00928	0.677
TRG_ER_diArg_1	121	123	PF00400	0.725
TRG_ER_diArg_1	41	43	PF00400	0.709
TRG_ER_diArg_1	96	98	PF00400	0.697
TRG_NES_CRM1_1	456	469	PF08389	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXW3	Leptomonas seymouri	26%	92%
A4HHJ8	Leishmania braziliensis	68%	100%
A4I4Q7	Leishmania infantum	99%	100%
E9AE60	Leishmania major	88%	100%
E9ALM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%