Separase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

eukaryotic translation initiation factor 3 subunit a

Species:

Leishmania donovani

UniProt:

A0A3Q8IDU4_LEIDO

TriTrypDb:

LdBPK_170010.1 , LdCL_170005000 , LDHU3_17.0020

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043614	multi-eIF complex	3	1
GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e	3	1
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A0A3Q8IDU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDU4

Function

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Biological processes
Term	Name	Level	Count
GO:0001732	formation of cytoplasmic translation initiation complex	7	1
GO:0002183	cytoplasmic translational initiation	4	1
GO:0002188	translation reinitiation	5	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.586
CLV_C14_Caspase3-7	490	494	PF00656	0.669
CLV_NRD_NRD_1	151	153	PF00675	0.639
CLV_NRD_NRD_1	590	592	PF00675	0.732
CLV_NRD_NRD_1	606	608	PF00675	0.546
CLV_NRD_NRD_1	626	628	PF00675	0.369
CLV_NRD_NRD_1	663	665	PF00675	0.663
CLV_NRD_NRD_1	669	671	PF00675	0.678
CLV_NRD_NRD_1	690	692	PF00675	0.643
CLV_NRD_NRD_1	718	720	PF00675	0.616

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGW0	Leptomonas seymouri	76%	100%
A0A0S4IU09	Bodo saltans	23%	95%
A0A1X0NTC2	Trypanosomatidae	34%	100%
A0A422NFC9	Trypanosoma rangeli	33%	100%
A4H8U7	Leishmania braziliensis	93%	100%
A4HX65	Leishmania infantum	100%	100%
C9ZTS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ARC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QEJ8	Leishmania major	99%	100%
V5D8P7	Trypanosoma cruzi	32%	100%

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