DUF3342 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3342), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDU2_LEIDO

TriTrypDb:

LdBPK_281760.1 , LdCL_280022500 , LDHU3_28.2290

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.501
CLV_C14_Caspase3-7	389	393	PF00656	0.572
CLV_NRD_NRD_1	365	367	PF00675	0.468
CLV_NRD_NRD_1	385	387	PF00675	0.355
CLV_NRD_NRD_1	536	538	PF00675	0.642
CLV_PCSK_KEX2_1	365	367	PF00082	0.468
CLV_PCSK_KEX2_1	536	538	PF00082	0.642
CLV_PCSK_SKI1_1	33	37	PF00082	0.440
CLV_Separin_Metazoa	383	387	PF03568	0.474
DEG_APCC_DBOX_1	32	40	PF00400	0.390
DEG_COP1_1	434	442	PF00400	0.601
DEG_SPOP_SBC_1	568	572	PF00917	0.768
DEG_SPOP_SBC_1	66	70	PF00917	0.385
DOC_CYCLIN_yClb5_NLxxxL_5	141	150	PF00134	0.546
DOC_MAPK_gen_1	365	373	PF00069	0.438
DOC_PP2B_LxvP_1	236	239	PF13499	0.524
DOC_PP2B_LxvP_1	320	323	PF13499	0.576
DOC_PP4_FxxP_1	388	391	PF00568	0.496
DOC_USP7_MATH_1	202	206	PF00917	0.658
DOC_USP7_MATH_1	212	216	PF00917	0.760
DOC_USP7_MATH_1	230	234	PF00917	0.483
DOC_USP7_MATH_1	274	278	PF00917	0.608
DOC_USP7_MATH_1	457	461	PF00917	0.752
DOC_USP7_MATH_1	476	480	PF00917	0.754
DOC_USP7_MATH_1	576	580	PF00917	0.686
DOC_USP7_MATH_1	613	617	PF00917	0.727
DOC_USP7_MATH_1	66	70	PF00917	0.459
DOC_USP7_MATH_2	65	71	PF00917	0.385
DOC_WW_Pin1_4	221	226	PF00397	0.641
DOC_WW_Pin1_4	313	318	PF00397	0.600
DOC_WW_Pin1_4	387	392	PF00397	0.504
DOC_WW_Pin1_4	418	423	PF00397	0.528
DOC_WW_Pin1_4	487	492	PF00397	0.714
DOC_WW_Pin1_4	549	554	PF00397	0.676
DOC_WW_Pin1_4	570	575	PF00397	0.727
DOC_WW_Pin1_4	60	65	PF00397	0.440
DOC_WW_Pin1_4	609	614	PF00397	0.737
LIG_14-3-3_CanoR_1	153	161	PF00244	0.417
LIG_14-3-3_CanoR_1	261	271	PF00244	0.508
LIG_14-3-3_CanoR_1	313	317	PF00244	0.677
LIG_14-3-3_CanoR_1	386	391	PF00244	0.550
LIG_14-3-3_CanoR_1	536	544	PF00244	0.657
LIG_Actin_WH2_2	139	155	PF00022	0.512
LIG_APCC_ABBA_1	168	173	PF00400	0.595
LIG_BRCT_BRCA1_1	111	115	PF00533	0.376
LIG_CaM_NSCaTE_8	351	358	PF13499	0.454
LIG_CSL_BTD_1	222	225	PF09270	0.738
LIG_deltaCOP1_diTrp_1	349	353	PF00928	0.409
LIG_FHA_1	146	152	PF00498	0.468
LIG_FHA_1	239	245	PF00498	0.565
LIG_FHA_1	263	269	PF00498	0.656
LIG_FHA_1	313	319	PF00498	0.683
LIG_FHA_1	343	349	PF00498	0.561
LIG_FHA_1	4	10	PF00498	0.747
LIG_FHA_1	470	476	PF00498	0.679
LIG_FHA_2	21	27	PF00498	0.402
LIG_FHA_2	250	256	PF00498	0.447
LIG_FHA_2	454	460	PF00498	0.602
LIG_FHA_2	5	11	PF00498	0.741
LIG_IRF3_LxIS_1	546	552	PF10401	0.618
LIG_LIR_Gen_1	112	121	PF02991	0.376
LIG_LIR_Gen_1	484	491	PF02991	0.563
LIG_LIR_Gen_1	6	15	PF02991	0.691
LIG_LIR_Gen_1	86	94	PF02991	0.378
LIG_LIR_Nem_3	396	401	PF02991	0.514
LIG_LIR_Nem_3	484	488	PF02991	0.557
LIG_LIR_Nem_3	611	617	PF02991	0.803
LIG_LIR_Nem_3	86	90	PF02991	0.378
LIG_NRBOX	369	375	PF00104	0.541
LIG_PTB_Apo_2	2	9	PF02174	0.645
LIG_SH2_CRK	425	429	PF00017	0.655
LIG_SH2_CRK	614	618	PF00017	0.814
LIG_SH2_STAT5	128	131	PF00017	0.434
LIG_SH2_STAT5	191	194	PF00017	0.520
LIG_SH2_STAT5	407	410	PF00017	0.497
LIG_SH2_STAT5	48	51	PF00017	0.376
LIG_SH2_STAT5	505	508	PF00017	0.592
LIG_SH2_STAT5	522	525	PF00017	0.449
LIG_SH3_3	21	27	PF00018	0.430
LIG_SH3_3	268	274	PF00018	0.532
LIG_SH3_3	328	334	PF00018	0.562
LIG_SH3_3	434	440	PF00018	0.570
LIG_SH3_3	59	65	PF00018	0.482
LIG_SUMO_SIM_anti_2	516	521	PF11976	0.636
LIG_SUMO_SIM_par_1	16	23	PF11976	0.534
LIG_SUMO_SIM_par_1	315	321	PF11976	0.588
LIG_SUMO_SIM_par_1	369	375	PF11976	0.541
LIG_SUMO_SIM_par_1	434	441	PF11976	0.610
LIG_SUMO_SIM_par_1	511	518	PF11976	0.600
LIG_UBA3_1	126	134	PF00899	0.469
LIG_UBA3_1	90	97	PF00899	0.424
LIG_WRC_WIRS_1	439	444	PF05994	0.641
MOD_CDK_SPK_2	570	575	PF00069	0.711
MOD_CDK_SPxK_1	418	424	PF00069	0.569
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	205	211	PF00069	0.682
MOD_CK1_1	215	221	PF00069	0.587
MOD_CK1_1	266	272	PF00069	0.647
MOD_CK1_1	329	335	PF00069	0.713
MOD_CK1_1	4	10	PF00069	0.658
MOD_CK1_1	490	496	PF00069	0.678
MOD_CK1_1	569	575	PF00069	0.705
MOD_CK1_1	616	622	PF00069	0.825
MOD_CK1_1	68	74	PF00069	0.462
MOD_CK2_1	26	32	PF00069	0.462
MOD_CK2_1	266	272	PF00069	0.566
MOD_CK2_1	4	10	PF00069	0.645
MOD_CK2_1	441	447	PF00069	0.744
MOD_CK2_1	453	459	PF00069	0.466
MOD_GlcNHglycan	129	132	PF01048	0.517
MOD_GlcNHglycan	13	16	PF01048	0.716
MOD_GlcNHglycan	172	177	PF01048	0.569
MOD_GlcNHglycan	232	235	PF01048	0.711
MOD_GlcNHglycan	268	271	PF01048	0.540
MOD_GlcNHglycan	276	279	PF01048	0.646
MOD_GlcNHglycan	330	334	PF01048	0.709
MOD_GlcNHglycan	425	428	PF01048	0.647
MOD_GlcNHglycan	453	456	PF01048	0.784
MOD_GlcNHglycan	478	481	PF01048	0.724
MOD_GlcNHglycan	538	541	PF01048	0.594
MOD_GlcNHglycan	583	586	PF01048	0.730
MOD_GlcNHglycan	596	599	PF01048	0.790
MOD_GlcNHglycan	94	97	PF01048	0.462
MOD_GSK3_1	101	108	PF00069	0.390
MOD_GSK3_1	137	144	PF00069	0.562
MOD_GSK3_1	230	237	PF00069	0.666
MOD_GSK3_1	262	269	PF00069	0.574
MOD_GSK3_1	274	281	PF00069	0.616
MOD_GSK3_1	441	448	PF00069	0.650
MOD_GSK3_1	453	460	PF00069	0.803
MOD_GSK3_1	483	490	PF00069	0.727
MOD_GSK3_1	549	556	PF00069	0.656
MOD_GSK3_1	566	573	PF00069	0.675
MOD_GSK3_1	576	583	PF00069	0.800
MOD_GSK3_1	609	616	PF00069	0.651
MOD_GSK3_1	9	16	PF00069	0.594
MOD_N-GLC_1	4	9	PF02516	0.643
MOD_N-GLC_1	542	547	PF02516	0.633
MOD_N-GLC_1	594	599	PF02516	0.771
MOD_NEK2_1	1	6	PF00069	0.604
MOD_NEK2_1	111	116	PF00069	0.436
MOD_NEK2_1	127	132	PF00069	0.420
MOD_NEK2_1	141	146	PF00069	0.488
MOD_NEK2_1	152	157	PF00069	0.495
MOD_NEK2_1	183	188	PF00069	0.469
MOD_NEK2_1	249	254	PF00069	0.465
MOD_NEK2_1	262	267	PF00069	0.357
MOD_NEK2_1	374	379	PF00069	0.491
MOD_NEK2_1	423	428	PF00069	0.637
MOD_NEK2_1	469	474	PF00069	0.756
MOD_NEK2_1	498	503	PF00069	0.685
MOD_NEK2_1	547	552	PF00069	0.686
MOD_NEK2_1	567	572	PF00069	0.478
MOD_NEK2_1	617	622	PF00069	0.779
MOD_NEK2_1	9	14	PF00069	0.773
MOD_PIKK_1	263	269	PF00454	0.579
MOD_PK_1	445	451	PF00069	0.513
MOD_PKA_1	386	392	PF00069	0.616
MOD_PKA_1	536	542	PF00069	0.580
MOD_PKA_2	152	158	PF00069	0.482
MOD_PKA_2	263	269	PF00069	0.656
MOD_PKA_2	312	318	PF00069	0.492
MOD_PKA_2	423	429	PF00069	0.605
MOD_PKA_2	536	542	PF00069	0.659
MOD_PKA_2	547	553	PF00069	0.745
MOD_Plk_1	20	26	PF00069	0.420
MOD_Plk_1	202	208	PF00069	0.731
MOD_Plk_1	4	10	PF00069	0.645
MOD_Plk_1	542	548	PF00069	0.636
MOD_Plk_4	111	117	PF00069	0.447
MOD_Plk_4	183	189	PF00069	0.471
MOD_Plk_4	249	255	PF00069	0.451
MOD_Plk_4	369	375	PF00069	0.491
MOD_Plk_4	4	10	PF00069	0.725
MOD_Plk_4	542	548	PF00069	0.600
MOD_ProDKin_1	221	227	PF00069	0.637
MOD_ProDKin_1	313	319	PF00069	0.594
MOD_ProDKin_1	387	393	PF00069	0.515
MOD_ProDKin_1	418	424	PF00069	0.536
MOD_ProDKin_1	487	493	PF00069	0.712
MOD_ProDKin_1	549	555	PF00069	0.676
MOD_ProDKin_1	570	576	PF00069	0.721
MOD_ProDKin_1	60	66	PF00069	0.440
MOD_ProDKin_1	609	615	PF00069	0.739
MOD_SUMO_rev_2	392	401	PF00179	0.549
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.501
TRG_ENDOCYTIC_2	544	547	PF00928	0.675
TRG_ENDOCYTIC_2	614	617	PF00928	0.816
TRG_ER_diArg_1	78	81	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G4	Leptomonas seymouri	46%	96%
A4HGL7	Leishmania braziliensis	73%	100%
A4I3P2	Leishmania infantum	100%	100%
D0A8C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AZY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8A2	Leishmania major	90%	100%