Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDS9_LEIDO

TriTrypDb:

LdBPK_261340.1 , LdCL_260019000 , LDHU3_26.1650

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.572
CLV_C14_Caspase3-7	322	326	PF00656	0.479
CLV_C14_Caspase3-7	493	497	PF00656	0.369
CLV_C14_Caspase3-7	538	542	PF00656	0.763
CLV_NRD_NRD_1	31	33	PF00675	0.580
CLV_NRD_NRD_1	328	330	PF00675	0.437
CLV_NRD_NRD_1	354	356	PF00675	0.439
CLV_NRD_NRD_1	407	409	PF00675	0.389
CLV_NRD_NRD_1	421	423	PF00675	0.322
CLV_NRD_NRD_1	67	69	PF00675	0.618
CLV_NRD_NRD_1	7	9	PF00675	0.710
CLV_PCSK_KEX2_1	31	33	PF00082	0.600
CLV_PCSK_KEX2_1	328	330	PF00082	0.546
CLV_PCSK_KEX2_1	354	356	PF00082	0.439
CLV_PCSK_KEX2_1	421	423	PF00082	0.334
CLV_PCSK_KEX2_1	563	565	PF00082	0.548
CLV_PCSK_KEX2_1	67	69	PF00082	0.620
CLV_PCSK_KEX2_1	7	9	PF00082	0.710
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.548
CLV_PCSK_PC7_1	3	9	PF00082	0.602
CLV_PCSK_PC7_1	63	69	PF00082	0.584
CLV_PCSK_SKI1_1	421	425	PF00082	0.451
CLV_PCSK_SKI1_1	563	567	PF00082	0.425
DEG_APCC_DBOX_1	420	428	PF00400	0.444
DEG_APCC_DBOX_1	467	475	PF00400	0.420
DEG_APCC_DBOX_1	595	603	PF00400	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	141	145	PF00917	0.652
DOC_CYCLIN_RxL_1	419	428	PF00134	0.447
DOC_MAPK_gen_1	192	201	PF00069	0.543
DOC_MAPK_MEF2A_6	246	254	PF00069	0.546
DOC_PP4_FxxP_1	366	369	PF00568	0.481
DOC_USP7_MATH_1	140	144	PF00917	0.711
DOC_USP7_MATH_1	152	156	PF00917	0.514
DOC_USP7_MATH_1	176	180	PF00917	0.629
DOC_USP7_MATH_1	183	187	PF00917	0.584
DOC_USP7_MATH_1	283	287	PF00917	0.733
DOC_USP7_MATH_1	479	483	PF00917	0.413
DOC_USP7_MATH_1	504	508	PF00917	0.533
DOC_USP7_MATH_1	545	549	PF00917	0.717
DOC_USP7_UBL2_3	122	126	PF12436	0.508
DOC_USP7_UBL2_3	518	522	PF12436	0.440
DOC_WW_Pin1_4	179	184	PF00397	0.741
DOC_WW_Pin1_4	279	284	PF00397	0.621
LIG_14-3-3_CanoR_1	210	218	PF00244	0.404
LIG_14-3-3_CanoR_1	222	228	PF00244	0.331
LIG_14-3-3_CanoR_1	246	254	PF00244	0.480
LIG_14-3-3_CanoR_1	31	39	PF00244	0.646
LIG_14-3-3_CanoR_1	328	332	PF00244	0.532
LIG_14-3-3_CanoR_1	354	361	PF00244	0.463
LIG_14-3-3_CanoR_1	387	393	PF00244	0.477
LIG_14-3-3_CanoR_1	449	454	PF00244	0.433
LIG_14-3-3_CanoR_1	468	472	PF00244	0.467
LIG_14-3-3_CanoR_1	53	62	PF00244	0.629
LIG_14-3-3_CanoR_1	598	603	PF00244	0.395
LIG_14-3-3_CanoR_1	84	89	PF00244	0.652
LIG_Actin_WH2_2	407	423	PF00022	0.547
LIG_Actin_WH2_2	424	439	PF00022	0.357
LIG_Actin_WH2_2	506	524	PF00022	0.432
LIG_APCC_ABBA_1	549	554	PF00400	0.501
LIG_BIR_III_2	175	179	PF00653	0.645
LIG_BIR_III_4	541	545	PF00653	0.498
LIG_BRCT_BRCA1_1	296	300	PF00533	0.455
LIG_BRCT_MDC1_1	600	604	PF00533	0.420
LIG_CaM_IQ_9	39	55	PF13499	0.567
LIG_FHA_1	158	164	PF00498	0.650
LIG_FHA_1	224	230	PF00498	0.372
LIG_FHA_1	287	293	PF00498	0.541
LIG_FHA_1	296	302	PF00498	0.387
LIG_FHA_1	31	37	PF00498	0.628
LIG_FHA_1	436	442	PF00498	0.381
LIG_FHA_1	457	463	PF00498	0.573
LIG_FHA_2	134	140	PF00498	0.612
LIG_FHA_2	231	237	PF00498	0.394
LIG_FHA_2	328	334	PF00498	0.469
LIG_FHA_2	389	395	PF00498	0.446
LIG_FHA_2	468	474	PF00498	0.575
LIG_GBD_Chelix_1	509	517	PF00786	0.414
LIG_LIR_Gen_1	197	206	PF02991	0.489
LIG_LIR_Gen_1	410	419	PF02991	0.393
LIG_LIR_Gen_1	511	521	PF02991	0.346
LIG_LIR_Nem_3	197	201	PF02991	0.505
LIG_LIR_Nem_3	410	414	PF02991	0.389
LIG_LIR_Nem_3	511	517	PF02991	0.324
LIG_LYPXL_SIV_4	119	127	PF13949	0.403
LIG_NRBOX	512	518	PF00104	0.418
LIG_NRBOX	598	604	PF00104	0.455
LIG_Pex14_1	2	6	PF04695	0.596
LIG_SH2_STAT5	111	114	PF00017	0.419
LIG_SH2_STAT5	120	123	PF00017	0.375
LIG_SH2_STAT5	227	230	PF00017	0.377
LIG_SH2_STAT5	365	368	PF00017	0.398
LIG_SH2_STAT5	384	387	PF00017	0.272
LIG_SH2_STAT5	484	487	PF00017	0.413
LIG_SH2_STAT5	88	91	PF00017	0.462
LIG_SH3_3	584	590	PF00018	0.509
LIG_SUMO_SIM_par_1	422	428	PF11976	0.327
LIG_TRAF2_1	330	333	PF00917	0.513
LIG_UBA3_1	251	260	PF00899	0.423
LIG_UBA3_1	513	522	PF00899	0.390
MOD_CK1_1	157	163	PF00069	0.715
MOD_CK1_1	179	185	PF00069	0.737
MOD_CK1_1	214	220	PF00069	0.407
MOD_CK1_1	273	279	PF00069	0.635
MOD_CK1_1	286	292	PF00069	0.473
MOD_CK1_1	294	300	PF00069	0.396
MOD_CK1_1	388	394	PF00069	0.489
MOD_CK1_1	45	51	PF00069	0.748
MOD_CK1_1	529	535	PF00069	0.660
MOD_CK1_1	57	63	PF00069	0.750
MOD_CK1_1	87	93	PF00069	0.477
MOD_CK2_1	152	158	PF00069	0.706
MOD_CK2_1	327	333	PF00069	0.527
MOD_CK2_1	354	360	PF00069	0.452
MOD_CK2_1	467	473	PF00069	0.527
MOD_GlcNHglycan	117	120	PF01048	0.440
MOD_GlcNHglycan	144	147	PF01048	0.687
MOD_GlcNHglycan	185	188	PF01048	0.816
MOD_GlcNHglycan	213	216	PF01048	0.405
MOD_GlcNHglycan	279	282	PF01048	0.687
MOD_GlcNHglycan	285	288	PF01048	0.618
MOD_GlcNHglycan	293	296	PF01048	0.427
MOD_GlcNHglycan	501	505	PF01048	0.516
MOD_GlcNHglycan	506	509	PF01048	0.431
MOD_GlcNHglycan	57	60	PF01048	0.630
MOD_GlcNHglycan	74	77	PF01048	0.598
MOD_GlcNHglycan	80	83	PF01048	0.600
MOD_GSK3_1	140	147	PF00069	0.681
MOD_GSK3_1	179	186	PF00069	0.689
MOD_GSK3_1	273	280	PF00069	0.701
MOD_GSK3_1	291	298	PF00069	0.369
MOD_GSK3_1	30	37	PF00069	0.664
MOD_GSK3_1	38	45	PF00069	0.582
MOD_GSK3_1	500	507	PF00069	0.456
MOD_GSK3_1	53	60	PF00069	0.489
MOD_GSK3_1	574	581	PF00069	0.374
MOD_GSK3_1	585	592	PF00069	0.424
MOD_GSK3_1	594	601	PF00069	0.265
MOD_N-GLC_1	115	120	PF02516	0.498
MOD_N-GLC_1	163	168	PF02516	0.768
MOD_N-GLC_1	270	275	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	127	132	PF00069	0.515
MOD_NEK2_1	230	235	PF00069	0.405
MOD_NEK2_1	327	332	PF00069	0.439
MOD_NEK2_1	385	390	PF00069	0.451
MOD_NEK2_1	39	44	PF00069	0.673
MOD_NEK2_1	500	505	PF00069	0.594
MOD_NEK2_1	516	521	PF00069	0.313
MOD_NEK2_1	523	528	PF00069	0.517
MOD_NEK2_1	54	59	PF00069	0.669
MOD_NEK2_1	578	583	PF00069	0.545
MOD_NEK2_2	545	550	PF00069	0.522
MOD_PIKK_1	163	169	PF00454	0.618
MOD_PIKK_1	187	193	PF00454	0.653
MOD_PIKK_1	39	45	PF00454	0.546
MOD_PIKK_1	479	485	PF00454	0.398
MOD_PIKK_1	526	532	PF00454	0.572
MOD_PIKK_1	589	595	PF00454	0.439
MOD_PIKK_1	99	105	PF00454	0.372
MOD_PK_1	246	252	PF00069	0.398
MOD_PK_1	449	455	PF00069	0.439
MOD_PKA_1	354	360	PF00069	0.427
MOD_PKA_2	245	251	PF00069	0.532
MOD_PKA_2	30	36	PF00069	0.552
MOD_PKA_2	327	333	PF00069	0.438
MOD_PKA_2	354	360	PF00069	0.454
MOD_PKA_2	467	473	PF00069	0.427
MOD_PKB_1	596	604	PF00069	0.398
MOD_Plk_1	115	121	PF00069	0.404
MOD_Plk_1	152	158	PF00069	0.600
MOD_Plk_1	545	551	PF00069	0.546
MOD_Plk_4	230	236	PF00069	0.457
MOD_Plk_4	246	252	PF00069	0.534
MOD_Plk_4	449	455	PF00069	0.464
MOD_Plk_4	578	584	PF00069	0.470
MOD_Plk_4	598	604	PF00069	0.307
MOD_Plk_4	84	90	PF00069	0.575
MOD_ProDKin_1	179	185	PF00069	0.742
MOD_ProDKin_1	279	285	PF00069	0.614
MOD_SUMO_rev_2	548	558	PF00179	0.620
TRG_DiLeu_BaEn_1	473	478	PF01217	0.461
TRG_DiLeu_BaEn_4	319	325	PF01217	0.443
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.626
TRG_ENDOCYTIC_2	227	230	PF00928	0.382
TRG_ER_diArg_1	220	223	PF00400	0.434
TRG_ER_diArg_1	327	329	PF00400	0.512
TRG_ER_diArg_1	353	355	PF00400	0.470
TRG_ER_diArg_1	420	422	PF00400	0.364
TRG_ER_diArg_1	596	599	PF00400	0.393
TRG_ER_diArg_1	6	8	PF00400	0.621
TRG_ER_diArg_1	66	68	PF00400	0.608
TRG_NES_CRM1_1	341	352	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P9	Leptomonas seymouri	65%	100%
A0A0S4KJS0	Bodo saltans	33%	100%
A0A1X0NTU8	Trypanosomatidae	43%	100%
A4HEZ1	Leishmania braziliensis	79%	100%
A4I265	Leishmania infantum	100%	100%
C9ZRT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AYB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4Q958	Leishmania major	93%	100%
V5B9R8	Trypanosoma cruzi	44%	100%