Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDS7_LEIDO

TriTrypDb:

LdBPK_281440.1 , LdCL_280019000 , LDHU3_28.1800

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A0A3Q8IDS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.573
CLV_NRD_NRD_1	289	291	PF00675	0.542
CLV_NRD_NRD_1	324	326	PF00675	0.587
CLV_NRD_NRD_1	50	52	PF00675	0.787
CLV_NRD_NRD_1	91	93	PF00675	0.707
CLV_PCSK_KEX2_1	183	185	PF00082	0.573
CLV_PCSK_KEX2_1	289	291	PF00082	0.542
CLV_PCSK_KEX2_1	324	326	PF00082	0.481
CLV_PCSK_KEX2_1	50	52	PF00082	0.787
CLV_PCSK_KEX2_1	91	93	PF00082	0.690
CLV_PCSK_SKI1_1	289	293	PF00082	0.411
CLV_PCSK_SKI1_1	35	39	PF00082	0.636
DEG_APCC_DBOX_1	165	173	PF00400	0.608
DOC_MAPK_gen_1	286	294	PF00069	0.535
DOC_MAPK_gen_1	328	336	PF00069	0.563
DOC_MAPK_MEF2A_6	218	227	PF00069	0.568
DOC_MAPK_MEF2A_6	328	336	PF00069	0.660
DOC_USP7_MATH_1	129	133	PF00917	0.840
DOC_USP7_MATH_1	154	158	PF00917	0.804
DOC_USP7_MATH_1	264	268	PF00917	0.602
DOC_USP7_MATH_1	42	46	PF00917	0.837
DOC_WW_Pin1_4	11	16	PF00397	0.762
DOC_WW_Pin1_4	119	124	PF00397	0.705
DOC_WW_Pin1_4	150	155	PF00397	0.787
DOC_WW_Pin1_4	18	23	PF00397	0.687
DOC_WW_Pin1_4	260	265	PF00397	0.426
DOC_WW_Pin1_4	328	333	PF00397	0.643
DOC_WW_Pin1_4	58	63	PF00397	0.789
LIG_14-3-3_CanoR_1	128	134	PF00244	0.672
LIG_14-3-3_CanoR_1	166	170	PF00244	0.538
LIG_14-3-3_CanoR_1	176	181	PF00244	0.440
LIG_14-3-3_CanoR_1	43	47	PF00244	0.682
LIG_Actin_WH2_2	287	304	PF00022	0.619
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_deltaCOP1_diTrp_1	72	77	PF00928	0.760
LIG_FHA_1	222	228	PF00498	0.572
LIG_FHA_1	273	279	PF00498	0.582
LIG_FHA_1	329	335	PF00498	0.666
LIG_FHA_1	77	83	PF00498	0.790
LIG_FHA_2	229	235	PF00498	0.577
LIG_FHA_2	36	42	PF00498	0.677
LIG_LIR_Gen_1	234	243	PF02991	0.573
LIG_LIR_Nem_3	234	238	PF02991	0.565
LIG_PDZ_Class_1	345	350	PF00595	0.713
LIG_SH2_GRB2like	235	238	PF00017	0.442
LIG_SH2_PTP2	235	238	PF00017	0.559
LIG_SH2_SRC	214	217	PF00017	0.603
LIG_SH2_STAT5	173	176	PF00017	0.583
LIG_SH2_STAT5	214	217	PF00017	0.603
LIG_SH2_STAT5	229	232	PF00017	0.265
LIG_SH2_STAT5	235	238	PF00017	0.460
LIG_SH3_3	117	123	PF00018	0.831
LIG_SH3_3	12	18	PF00018	0.647
LIG_SH3_3	131	137	PF00018	0.590
LIG_SH3_3	222	228	PF00018	0.572
LIG_SH3_3	77	83	PF00018	0.650
LIG_SUMO_SIM_par_1	274	279	PF11976	0.585
LIG_SUMO_SIM_par_1	331	338	PF11976	0.692
LIG_SUMO_SIM_par_1	78	84	PF11976	0.614
LIG_TRAF2_1	339	342	PF00917	0.574
LIG_TYR_ITIM	233	238	PF00017	0.563
LIG_WW_3	66	70	PF00397	0.753
MOD_CDC14_SPxK_1	155	158	PF00782	0.686
MOD_CDK_SPK_2	119	124	PF00069	0.705
MOD_CDK_SPK_2	18	23	PF00069	0.678
MOD_CDK_SPxK_1	152	158	PF00069	0.684
MOD_CDK_SPxxK_3	62	69	PF00069	0.630
MOD_CK1_1	122	128	PF00069	0.712
MOD_CK1_1	159	165	PF00069	0.625
MOD_CK1_1	168	174	PF00069	0.516
MOD_CK1_1	21	27	PF00069	0.772
MOD_CK1_1	28	34	PF00069	0.765
MOD_CK1_1	61	67	PF00069	0.655
MOD_CK1_1	84	90	PF00069	0.777
MOD_CK2_1	228	234	PF00069	0.582
MOD_CK2_1	35	41	PF00069	0.641
MOD_Cter_Amidation	287	290	PF01082	0.530
MOD_GlcNHglycan	131	134	PF01048	0.760
MOD_GlcNHglycan	158	161	PF01048	0.667
MOD_GlcNHglycan	246	249	PF01048	0.725
MOD_GlcNHglycan	266	269	PF01048	0.319
MOD_GlcNHglycan	30	33	PF01048	0.747
MOD_GlcNHglycan	52	55	PF01048	0.669
MOD_GSK3_1	115	122	PF00069	0.788
MOD_GSK3_1	123	130	PF00069	0.663
MOD_GSK3_1	150	157	PF00069	0.788
MOD_GSK3_1	168	175	PF00069	0.280
MOD_GSK3_1	21	28	PF00069	0.754
MOD_GSK3_1	244	251	PF00069	0.678
MOD_GSK3_1	260	267	PF00069	0.385
MOD_GSK3_1	272	279	PF00069	0.547
MOD_GSK3_1	324	331	PF00069	0.481
MOD_GSK3_1	341	348	PF00069	0.752
MOD_GSK3_1	58	65	PF00069	0.727
MOD_GSK3_1	81	88	PF00069	0.733
MOD_N-GLC_2	237	239	PF02516	0.437
MOD_NEK2_1	172	177	PF00069	0.577
MOD_NEK2_1	76	81	PF00069	0.725
MOD_PIKK_1	93	99	PF00454	0.688
MOD_PKA_1	324	330	PF00069	0.512
MOD_PKA_1	50	56	PF00069	0.787
MOD_PKA_2	127	133	PF00069	0.670
MOD_PKA_2	165	171	PF00069	0.622
MOD_PKA_2	210	216	PF00069	0.605
MOD_PKA_2	324	330	PF00069	0.512
MOD_PKA_2	42	48	PF00069	0.704
MOD_PKA_2	50	56	PF00069	0.744
MOD_PKA_2	85	91	PF00069	0.827
MOD_PKB_1	312	320	PF00069	0.429
MOD_Plk_1	115	121	PF00069	0.717
MOD_Plk_1	276	282	PF00069	0.565
MOD_Plk_4	107	113	PF00069	0.614
MOD_Plk_4	137	143	PF00069	0.718
MOD_Plk_4	210	216	PF00069	0.605
MOD_Plk_4	221	227	PF00069	0.525
MOD_Plk_4	4	10	PF00069	0.731
MOD_Plk_4	76	82	PF00069	0.710
MOD_ProDKin_1	11	17	PF00069	0.760
MOD_ProDKin_1	119	125	PF00069	0.705
MOD_ProDKin_1	150	156	PF00069	0.789
MOD_ProDKin_1	18	24	PF00069	0.688
MOD_ProDKin_1	260	266	PF00069	0.436
MOD_ProDKin_1	328	334	PF00069	0.651
MOD_ProDKin_1	58	64	PF00069	0.789
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.438
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.389
TRG_ENDOCYTIC_2	235	238	PF00928	0.559
TRG_ER_diArg_1	182	184	PF00400	0.568
TRG_ER_diArg_1	289	291	PF00400	0.542
TRG_ER_diArg_1	323	325	PF00400	0.479
TRG_ER_diArg_1	90	92	PF00400	0.771
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGI0	Leishmania braziliensis	64%	96%
A4I3L2	Leishmania infantum	100%	100%
E9AZV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8D3	Leishmania major	88%	100%