LeishMANIAdb
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WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD domain, G-beta repeat family protein
Gene product:
protein transport protein SEC13, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDS6_LEIDO
TriTrypDb:
LdBPK_280690.1 , LdCL_280011500 , LDHU3_28.0860
Length:
359

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005643 nuclear pore 3 11
GO:0030117 membrane coat 3 12
GO:0030120 vesicle coat 4 12
GO:0030127 COPII vesicle coat 5 12
GO:0032991 protein-containing complex 1 12
GO:0098796 membrane protein complex 2 12
GO:0140513 nuclear protein-containing complex 2 12
GO:0005794 Golgi apparatus 5 1
GO:0031080 nuclear pore outer ring 3 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0005840 ribosome 5 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A0A3Q8IDS6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDS6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006900 vesicle budding from membrane 5 12
GO:0006996 organelle organization 4 12
GO:0008104 protein localization 4 12
GO:0009966 regulation of signal transduction 4 12
GO:0009967 positive regulation of signal transduction 5 12
GO:0009987 cellular process 1 12
GO:0010646 regulation of cell communication 4 12
GO:0010647 positive regulation of cell communication 5 12
GO:0015031 protein transport 4 12
GO:0015931 nucleobase-containing compound transport 5 12
GO:0016043 cellular component organization 3 12
GO:0016050 vesicle organization 5 12
GO:0023051 regulation of signaling 3 12
GO:0023056 positive regulation of signaling 4 12
GO:0032006 regulation of TOR signaling 6 12
GO:0032008 positive regulation of TOR signaling 7 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0048518 positive regulation of biological process 3 12
GO:0048522 positive regulation of cellular process 4 12
GO:0048583 regulation of response to stimulus 3 12
GO:0048584 positive regulation of response to stimulus 4 12
GO:0050657 nucleic acid transport 6 12
GO:0050658 RNA transport 4 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0051028 mRNA transport 5 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051236 establishment of RNA localization 3 12
GO:0051641 cellular localization 2 12
GO:0061024 membrane organization 4 12
GO:0065007 biological regulation 1 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0090114 COPII-coated vesicle budding 6 12
GO:1902531 regulation of intracellular signal transduction 5 12
GO:1902533 positive regulation of intracellular signal transduction 6 12
GO:1903432 regulation of TORC1 signaling 7 12
GO:1904263 positive regulation of TORC1 signaling 8 12
GO:0006606 protein import into nucleus 5 1
GO:0006886 intracellular protein transport 4 1
GO:0006913 nucleocytoplasmic transport 5 1
GO:0033365 protein localization to organelle 5 1
GO:0034504 protein localization to nucleus 6 1
GO:0046907 intracellular transport 3 1
GO:0051169 nuclear transport 4 1
GO:0051170 import into nucleus 6 1
GO:0051649 establishment of localization in cell 3 1
GO:0072594 establishment of protein localization to organelle 4 1
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 330 334 PF00656 0.467
CLV_NRD_NRD_1 114 116 PF00675 0.459
CLV_PCSK_SKI1_1 211 215 PF00082 0.288
CLV_PCSK_SKI1_1 219 223 PF00082 0.295
DEG_SPOP_SBC_1 41 45 PF00917 0.441
DOC_CYCLIN_yCln2_LP_2 270 276 PF00134 0.384
DOC_CYCLIN_yCln2_LP_2 303 306 PF00134 0.461
DOC_PP1_RVXF_1 260 267 PF00149 0.318
DOC_PP1_RVXF_1 315 321 PF00149 0.338
DOC_PP2B_LxvP_1 122 125 PF13499 0.360
DOC_PP2B_LxvP_1 187 190 PF13499 0.472
DOC_PP2B_LxvP_1 207 210 PF13499 0.389
DOC_PP2B_LxvP_1 270 273 PF13499 0.431
DOC_PP2B_LxvP_1 303 306 PF13499 0.528
DOC_PP4_FxxP_1 180 183 PF00568 0.424
DOC_USP7_MATH_1 240 244 PF00917 0.408
DOC_USP7_MATH_1 27 31 PF00917 0.468
DOC_USP7_MATH_1 278 282 PF00917 0.341
DOC_USP7_MATH_2 232 238 PF00917 0.459
DOC_WW_Pin1_4 307 312 PF00397 0.602
DOC_WW_Pin1_4 58 63 PF00397 0.388
LIG_14-3-3_CanoR_1 211 220 PF00244 0.392
LIG_14-3-3_CanoR_1 349 357 PF00244 0.529
LIG_BIR_II_1 1 5 PF00653 0.557
LIG_BIR_III_4 20 24 PF00653 0.417
LIG_CSL_BTD_1 59 62 PF09270 0.408
LIG_deltaCOP1_diTrp_1 157 165 PF00928 0.370
LIG_FHA_1 157 163 PF00498 0.454
LIG_FHA_1 32 38 PF00498 0.445
LIG_FHA_1 323 329 PF00498 0.304
LIG_FHA_1 87 93 PF00498 0.420
LIG_FHA_1 9 15 PF00498 0.458
LIG_FHA_2 2 8 PF00498 0.502
LIG_FHA_2 244 250 PF00498 0.473
LIG_FHA_2 308 314 PF00498 0.447
LIG_FHA_2 92 98 PF00498 0.431
LIG_Integrin_isoDGR_2 22 24 PF01839 0.310
LIG_LIR_Gen_1 243 253 PF02991 0.481
LIG_LIR_Gen_1 319 328 PF02991 0.323
LIG_LIR_Nem_3 111 117 PF02991 0.404
LIG_LIR_Nem_3 135 139 PF02991 0.444
LIG_LIR_Nem_3 176 180 PF02991 0.428
LIG_LIR_Nem_3 225 231 PF02991 0.541
LIG_LIR_Nem_3 243 248 PF02991 0.378
LIG_LIR_Nem_3 319 323 PF02991 0.361
LIG_LIR_Nem_3 325 329 PF02991 0.354
LIG_LIR_Nem_3 58 63 PF02991 0.429
LIG_MAD2 349 357 PF02301 0.529
LIG_Pex14_1 224 228 PF04695 0.473
LIG_Pex14_2 177 181 PF04695 0.390
LIG_Pex14_2 220 224 PF04695 0.364
LIG_SH2_CRK 114 118 PF00017 0.419
LIG_SH2_CRK 136 140 PF00017 0.427
LIG_SH2_NCK_1 120 124 PF00017 0.451
LIG_SH2_NCK_1 38 42 PF00017 0.422
LIG_SH2_SRC 331 334 PF00017 0.474
LIG_SH2_STAP1 120 124 PF00017 0.327
LIG_SH2_STAP1 88 92 PF00017 0.366
LIG_SH2_STAT5 118 121 PF00017 0.341
LIG_SH2_STAT5 276 279 PF00017 0.315
LIG_SH2_STAT5 88 91 PF00017 0.480
LIG_SH3_2 206 211 PF14604 0.392
LIG_SH3_3 176 182 PF00018 0.327
LIG_SH3_3 200 206 PF00018 0.513
LIG_SH3_CIN85_PxpxPR_1 206 211 PF14604 0.372
LIG_SUMO_SIM_anti_2 61 67 PF11976 0.435
LIG_TRAF2_1 232 235 PF00917 0.630
LIG_TRAF2_1 69 72 PF00917 0.492
LIG_UBA3_1 187 193 PF00899 0.375
LIG_WRC_WIRS_1 162 167 PF05994 0.478
LIG_WRC_WIRS_1 323 328 PF05994 0.310
LIG_WW_3 208 212 PF00397 0.355
MOD_CK1_1 164 170 PF00069 0.406
MOD_CK1_1 243 249 PF00069 0.481
MOD_CK1_1 31 37 PF00069 0.457
MOD_CK1_1 40 46 PF00069 0.333
MOD_CK2_1 243 249 PF00069 0.485
MOD_CK2_1 307 313 PF00069 0.526
MOD_CK2_1 349 355 PF00069 0.522
MOD_CK2_1 41 47 PF00069 0.632
MOD_CK2_1 66 72 PF00069 0.535
MOD_CK2_1 91 97 PF00069 0.337
MOD_GlcNHglycan 234 239 PF01048 0.429
MOD_GlcNHglycan 256 259 PF01048 0.462
MOD_GSK3_1 1 8 PF00069 0.498
MOD_GSK3_1 240 247 PF00069 0.575
MOD_GSK3_1 27 34 PF00069 0.473
MOD_GSK3_1 318 325 PF00069 0.346
MOD_GSK3_1 37 44 PF00069 0.568
MOD_N-GLC_1 313 318 PF02516 0.423
MOD_NEK2_1 1 6 PF00069 0.595
MOD_NEK2_1 318 323 PF00069 0.343
MOD_NEK2_1 327 332 PF00069 0.296
MOD_PIKK_1 46 52 PF00454 0.649
MOD_Plk_1 46 52 PF00069 0.565
MOD_Plk_2-3 161 167 PF00069 0.484
MOD_Plk_4 1 7 PF00069 0.515
MOD_Plk_4 240 246 PF00069 0.517
MOD_Plk_4 322 328 PF00069 0.358
MOD_ProDKin_1 307 313 PF00069 0.599
MOD_ProDKin_1 58 64 PF00069 0.382
TRG_DiLeu_BaLyEn_6 299 304 PF01217 0.510
TRG_ENDOCYTIC_2 114 117 PF00928 0.465
TRG_ENDOCYTIC_2 136 139 PF00928 0.331
TRG_ENDOCYTIC_2 38 41 PF00928 0.472

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEP1 Leptomonas seymouri 79% 100%
A0A0S4JEG3 Bodo saltans 34% 100%
A0A1X0NYI1 Trypanosomatidae 46% 100%
A0A422P1N5 Trypanosoma rangeli 46% 100%
A1CGS0 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 27% 100%
A2QHM1 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 27% 100%
A3LNW3 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 27% 100%
A4HGA5 Leishmania braziliensis 90% 100%
A4I3D9 Leishmania infantum 100% 100%
A4REK3 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 28% 100%
A5DHD9 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 26% 100%
A5DXE2 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 27% 100%
A8XJ40 Caenorhabditis briggsae 24% 100%
D0A808 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AZM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
G0SA60 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 28% 100%
O64740 Arabidopsis thaliana 31% 100%
O94319 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
P0CS50 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 29% 100%
P0CS51 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 29% 100%
P53024 Komagataella phaffii (strain GS115 / ATCC 20864) 25% 100%
P55735 Homo sapiens 29% 100%
Q04491 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q0CHM0 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 26% 100%
Q0UNA9 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 30% 100%
Q1DZQ0 Coccidioides immitis (strain RS) 27% 100%
Q2GSM6 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 28% 100%
Q2UG43 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 27% 100%
Q3ZCC9 Bos taurus 29% 100%
Q4PCB8 Ustilago maydis (strain 521 / FGSC 9021) 31% 99%
Q4Q8K5 Leishmania major 95% 100%
Q4WNK7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 100%
Q54DS8 Dictyostelium discoideum 26% 100%
Q5AEF2 Candida albicans (strain SC5314 / ATCC MYA-2876) 26% 100%
Q5B563 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 28% 100%
Q5XFW8 Rattus norvegicus 28% 100%
Q6BIR1 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 27% 100%
Q6BZX5 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 100%
Q6CSZ5 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 25% 100%
Q6FNV4 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 100%
Q6FQU6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 100%
Q75BS2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q7RZF5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 27% 100%
Q9D1M0 Mus musculus 28% 100%
Q9N4A7 Caenorhabditis elegans 26% 100%
Q9SRI1 Arabidopsis thaliana 30% 100%
Q9V3J4 Drosophila melanogaster 28% 100%
V5B0S9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS