Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDS4_LEIDO

TriTrypDb:

LdBPK_262030.1 , LdCL_260025900 , LDHU3_26.2660

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.724
CLV_NRD_NRD_1	3	5	PF00675	0.543
CLV_NRD_NRD_1	320	322	PF00675	0.480
CLV_NRD_NRD_1	454	456	PF00675	0.432
CLV_NRD_NRD_1	528	530	PF00675	0.548
CLV_NRD_NRD_1	548	550	PF00675	0.597
CLV_PCSK_KEX2_1	3	5	PF00082	0.560
CLV_PCSK_KEX2_1	320	322	PF00082	0.482
CLV_PCSK_KEX2_1	528	530	PF00082	0.548
CLV_PCSK_KEX2_1	548	550	PF00082	0.508
CLV_PCSK_SKI1_1	294	298	PF00082	0.399
CLV_PCSK_SKI1_1	456	460	PF00082	0.544
CLV_PCSK_SKI1_1	54	58	PF00082	0.376
CLV_PCSK_SKI1_1	558	562	PF00082	0.446
CLV_PCSK_SKI1_1	714	718	PF00082	0.710
CLV_PCSK_SKI1_1	731	735	PF00082	0.495
CLV_Separin_Metazoa	111	115	PF03568	0.488
DEG_APCC_DBOX_1	3	11	PF00400	0.598
DEG_APCC_DBOX_1	30	38	PF00400	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SPOP_SBC_1	156	160	PF00917	0.453
DOC_CKS1_1	117	122	PF01111	0.378
DOC_CKS1_1	25	30	PF01111	0.432
DOC_CKS1_1	551	556	PF01111	0.375
DOC_CYCLIN_RxL_1	291	300	PF00134	0.417
DOC_CYCLIN_RxL_1	728	738	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.456
DOC_MAPK_gen_1	3	9	PF00069	0.558
DOC_MAPK_gen_1	320	327	PF00069	0.439
DOC_PP1_RVXF_1	637	643	PF00149	0.472
DOC_PP2B_LxvP_1	78	81	PF13499	0.476
DOC_USP7_MATH_1	138	142	PF00917	0.626
DOC_USP7_MATH_1	150	154	PF00917	0.686
DOC_USP7_MATH_1	156	160	PF00917	0.605
DOC_USP7_MATH_1	351	355	PF00917	0.368
DOC_USP7_MATH_1	464	468	PF00917	0.759
DOC_USP7_MATH_1	481	485	PF00917	0.618
DOC_USP7_MATH_1	497	501	PF00917	0.309
DOC_USP7_MATH_1	580	584	PF00917	0.366
DOC_USP7_MATH_1	618	622	PF00917	0.560
DOC_USP7_MATH_1	667	671	PF00917	0.525
DOC_USP7_MATH_1	716	720	PF00917	0.529
DOC_USP7_MATH_1	8	12	PF00917	0.519
DOC_WW_Pin1_4	116	121	PF00397	0.336
DOC_WW_Pin1_4	152	157	PF00397	0.559
DOC_WW_Pin1_4	24	29	PF00397	0.495
DOC_WW_Pin1_4	487	492	PF00397	0.467
DOC_WW_Pin1_4	550	555	PF00397	0.386
DOC_WW_Pin1_4	750	755	PF00397	0.648
LIG_14-3-3_CanoR_1	185	193	PF00244	0.355
LIG_14-3-3_CanoR_1	211	218	PF00244	0.470
LIG_14-3-3_CanoR_1	3	7	PF00244	0.516
LIG_14-3-3_CanoR_1	639	643	PF00244	0.467
LIG_Actin_WH2_2	645	663	PF00022	0.451
LIG_APCC_ABBA_1	519	524	PF00400	0.489
LIG_BIR_III_4	21	25	PF00653	0.525
LIG_BRCT_BRCA1_1	275	279	PF00533	0.342
LIG_Clathr_ClatBox_1	226	230	PF01394	0.445
LIG_CSL_BTD_1	5	8	PF09270	0.434
LIG_FHA_1	108	114	PF00498	0.420
LIG_FHA_1	117	123	PF00498	0.404
LIG_FHA_1	156	162	PF00498	0.500
LIG_FHA_1	177	183	PF00498	0.305
LIG_FHA_1	250	256	PF00498	0.402
LIG_FHA_1	261	267	PF00498	0.327
LIG_FHA_1	388	394	PF00498	0.581
LIG_FHA_1	417	423	PF00498	0.444
LIG_FHA_1	428	434	PF00498	0.522
LIG_FHA_1	487	493	PF00498	0.662
LIG_FHA_1	500	506	PF00498	0.312
LIG_FHA_1	68	74	PF00498	0.449
LIG_FHA_1	728	734	PF00498	0.522
LIG_FHA_2	418	424	PF00498	0.421
LIG_FHA_2	457	463	PF00498	0.464
LIG_FHA_2	722	728	PF00498	0.516
LIG_LIR_Gen_1	223	232	PF02991	0.442
LIG_LIR_Gen_1	285	293	PF02991	0.374
LIG_LIR_Nem_3	223	227	PF02991	0.431
LIG_LIR_Nem_3	285	289	PF02991	0.349
LIG_LIR_Nem_3	5	9	PF02991	0.534
LIG_MYND_2	105	109	PF01753	0.412
LIG_PDZ_Class_1	750	755	PF00595	0.628
LIG_SH2_NCK_1	281	285	PF00017	0.369
LIG_SH2_NCK_1	370	374	PF00017	0.483
LIG_SH2_PTP2	286	289	PF00017	0.412
LIG_SH2_SRC	689	692	PF00017	0.418
LIG_SH2_STAP1	313	317	PF00017	0.588
LIG_SH2_STAP1	653	657	PF00017	0.312
LIG_SH2_STAT5	286	289	PF00017	0.375
LIG_SH2_STAT5	404	407	PF00017	0.511
LIG_SH2_STAT5	443	446	PF00017	0.348
LIG_SH2_STAT5	689	692	PF00017	0.418
LIG_SH3_1	114	120	PF00018	0.400
LIG_SH3_3	114	120	PF00018	0.282
LIG_SH3_3	27	33	PF00018	0.468
LIG_SH3_3	337	343	PF00018	0.490
LIG_SH3_3	488	494	PF00018	0.448
LIG_SH3_3	548	554	PF00018	0.537
LIG_SH3_3	78	84	PF00018	0.565
LIG_SH3_3	99	105	PF00018	0.628
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.418
LIG_SUMO_SIM_anti_2	559	564	PF11976	0.487
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.409
LIG_SUMO_SIM_par_1	249	256	PF11976	0.333
LIG_TRAF2_1	375	378	PF00917	0.594
LIG_TRAF2_1	477	480	PF00917	0.671
LIG_TRAF2_1	724	727	PF00917	0.563
LIG_UBA3_1	341	347	PF00899	0.374
LIG_WW_1	605	608	PF00397	0.345
MOD_CDK_SPK_2	26	31	PF00069	0.434
MOD_CDK_SPxxK_3	116	123	PF00069	0.373
MOD_CDK_SPxxK_3	24	31	PF00069	0.437
MOD_CK1_1	233	239	PF00069	0.623
MOD_CK1_1	275	281	PF00069	0.431
MOD_CK1_1	316	322	PF00069	0.614
MOD_CK1_1	328	334	PF00069	0.337
MOD_CK1_1	354	360	PF00069	0.369
MOD_CK1_1	460	466	PF00069	0.616
MOD_CK1_1	539	545	PF00069	0.562
MOD_CK1_1	670	676	PF00069	0.526
MOD_CK1_1	747	753	PF00069	0.606
MOD_CK2_1	326	332	PF00069	0.557
MOD_CK2_1	417	423	PF00069	0.412
MOD_CK2_1	527	533	PF00069	0.582
MOD_CK2_1	681	687	PF00069	0.388
MOD_CK2_1	721	727	PF00069	0.529
MOD_CK2_1	8	14	PF00069	0.438
MOD_GlcNHglycan	136	139	PF01048	0.457
MOD_GlcNHglycan	152	155	PF01048	0.616
MOD_GlcNHglycan	235	238	PF01048	0.527
MOD_GlcNHglycan	299	302	PF01048	0.360
MOD_GlcNHglycan	328	331	PF01048	0.479
MOD_GlcNHglycan	466	469	PF01048	0.735
MOD_GlcNHglycan	483	486	PF01048	0.604
MOD_GlcNHglycan	541	544	PF01048	0.540
MOD_GlcNHglycan	582	585	PF01048	0.472
MOD_GlcNHglycan	620	623	PF01048	0.724
MOD_GlcNHglycan	631	634	PF01048	0.652
MOD_GSK3_1	134	141	PF00069	0.382
MOD_GSK3_1	152	159	PF00069	0.526
MOD_GSK3_1	233	240	PF00069	0.530
MOD_GSK3_1	321	328	PF00069	0.462
MOD_GSK3_1	383	390	PF00069	0.683
MOD_GSK3_1	456	463	PF00069	0.522
MOD_GSK3_1	483	490	PF00069	0.696
MOD_GSK3_1	499	506	PF00069	0.328
MOD_GSK3_1	63	70	PF00069	0.404
MOD_GSK3_1	655	662	PF00069	0.412
MOD_GSK3_1	670	677	PF00069	0.383
MOD_GSK3_1	681	688	PF00069	0.346
MOD_GSK3_1	721	728	PF00069	0.551
MOD_GSK3_1	746	753	PF00069	0.544
MOD_N-GLC_1	199	204	PF02516	0.434
MOD_N-GLC_1	272	277	PF02516	0.475
MOD_N-GLC_1	383	388	PF02516	0.490
MOD_N-GLC_2	132	134	PF02516	0.285
MOD_NEK2_1	199	204	PF00069	0.430
MOD_NEK2_1	2	7	PF00069	0.547
MOD_NEK2_1	297	302	PF00069	0.323
MOD_NEK2_1	394	399	PF00069	0.632
MOD_NEK2_1	451	456	PF00069	0.391
MOD_NEK2_1	563	568	PF00069	0.351
MOD_NEK2_1	656	661	PF00069	0.453
MOD_NEK2_1	685	690	PF00069	0.393
MOD_NEK2_1	746	751	PF00069	0.535
MOD_PIKK_1	330	336	PF00454	0.351
MOD_PIKK_1	542	548	PF00454	0.548
MOD_PIKK_1	667	673	PF00454	0.510
MOD_PIKK_1	747	753	PF00454	0.605
MOD_PKA_2	184	190	PF00069	0.370
MOD_PKA_2	2	8	PF00069	0.531
MOD_PKA_2	210	216	PF00069	0.428
MOD_PKA_2	233	239	PF00069	0.439
MOD_PKA_2	481	487	PF00069	0.577
MOD_PKA_2	527	533	PF00069	0.628
MOD_PKA_2	536	542	PF00069	0.602
MOD_PKA_2	616	622	PF00069	0.612
MOD_PKA_2	638	644	PF00069	0.460
MOD_PKA_2	685	691	PF00069	0.470
MOD_PKA_2	744	750	PF00069	0.558
MOD_Plk_1	199	205	PF00069	0.434
MOD_Plk_1	249	255	PF00069	0.457
MOD_Plk_1	272	278	PF00069	0.522
MOD_Plk_1	313	319	PF00069	0.614
MOD_Plk_1	558	564	PF00069	0.411
MOD_Plk_1	725	731	PF00069	0.479
MOD_Plk_2-3	387	393	PF00069	0.561
MOD_Plk_4	282	288	PF00069	0.422
MOD_Plk_4	313	319	PF00069	0.541
MOD_Plk_4	558	564	PF00069	0.420
MOD_Plk_4	638	644	PF00069	0.460
MOD_Plk_4	670	676	PF00069	0.510
MOD_Plk_4	685	691	PF00069	0.295
MOD_Plk_4	716	722	PF00069	0.633
MOD_ProDKin_1	116	122	PF00069	0.328
MOD_ProDKin_1	152	158	PF00069	0.558
MOD_ProDKin_1	24	30	PF00069	0.487
MOD_ProDKin_1	487	493	PF00069	0.459
MOD_ProDKin_1	550	556	PF00069	0.388
TRG_DiLeu_BaEn_1	14	19	PF01217	0.418
TRG_DiLeu_BaEn_2	222	228	PF01217	0.415
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.433
TRG_DiLeu_BaLyEn_6	728	733	PF01217	0.471
TRG_ENDOCYTIC_2	286	289	PF00928	0.301
TRG_ENDOCYTIC_2	653	656	PF00928	0.304
TRG_ER_diArg_1	2	4	PF00400	0.544
TRG_ER_diArg_1	528	531	PF00400	0.428
TRG_NES_CRM1_1	219	231	PF08389	0.354
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P479	Leptomonas seymouri	60%	98%
A0A1X0P8E3	Trypanosomatidae	31%	98%
A0A3R7LMQ0	Trypanosoma rangeli	34%	100%
A4HF47	Leishmania braziliensis	79%	100%
A4I2D1	Leishmania infantum	100%	100%
C9ZX77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	91%
E9AYI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8Y9	Leishmania major	92%	100%
V5BJ35	Trypanosoma cruzi	33%	96%