Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDS0_LEIDO

TriTrypDb:

LdBPK_261130.1 , LdCL_260016900 , LDHU3_26.1410

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.615
CLV_C14_Caspase3-7	193	197	PF00656	0.604
CLV_C14_Caspase3-7	700	704	PF00656	0.633
CLV_C14_Caspase3-7	712	716	PF00656	0.445
CLV_C14_Caspase3-7	730	734	PF00656	0.514
CLV_NRD_NRD_1	269	271	PF00675	0.697
CLV_NRD_NRD_1	310	312	PF00675	0.758
CLV_NRD_NRD_1	397	399	PF00675	0.443
CLV_NRD_NRD_1	4	6	PF00675	0.623
CLV_NRD_NRD_1	444	446	PF00675	0.610
CLV_NRD_NRD_1	503	505	PF00675	0.714
CLV_NRD_NRD_1	584	586	PF00675	0.678
CLV_NRD_NRD_1	587	589	PF00675	0.611
CLV_NRD_NRD_1	774	776	PF00675	0.676
CLV_PCSK_FUR_1	584	588	PF00082	0.658
CLV_PCSK_KEX2_1	268	270	PF00082	0.698
CLV_PCSK_KEX2_1	3	5	PF00082	0.625
CLV_PCSK_KEX2_1	310	312	PF00082	0.758
CLV_PCSK_KEX2_1	444	446	PF00082	0.610
CLV_PCSK_KEX2_1	503	505	PF00082	0.714
CLV_PCSK_KEX2_1	584	586	PF00082	0.678
CLV_PCSK_KEX2_1	587	589	PF00082	0.611
CLV_PCSK_KEX2_1	774	776	PF00082	0.676
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.698
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.781
CLV_PCSK_SKI1_1	103	107	PF00082	0.531
CLV_PCSK_SKI1_1	200	204	PF00082	0.468
CLV_PCSK_SKI1_1	310	314	PF00082	0.677
CLV_PCSK_SKI1_1	343	347	PF00082	0.593
CLV_PCSK_SKI1_1	504	508	PF00082	0.574
CLV_PCSK_SKI1_1	544	548	PF00082	0.590
CLV_PCSK_SKI1_1	775	779	PF00082	0.550
CLV_Separin_Metazoa	331	335	PF03568	0.505
DEG_APCC_DBOX_1	102	110	PF00400	0.517
DEG_APCC_DBOX_1	397	405	PF00400	0.479
DEG_SCF_FBW7_1	628	635	PF00400	0.709
DEG_SPOP_SBC_1	536	540	PF00917	0.661
DEG_SPOP_SBC_1	627	631	PF00917	0.704
DOC_CYCLIN_RxL_1	107	115	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.481
DOC_MAPK_MEF2A_6	234	242	PF00069	0.467
DOC_PP1_RVXF_1	652	658	PF00149	0.617
DOC_PP1_RVXF_1	733	740	PF00149	0.443
DOC_PP4_FxxP_1	225	228	PF00568	0.580
DOC_PP4_MxPP_1	323	326	PF00568	0.695
DOC_SPAK_OSR1_1	224	228	PF12202	0.587
DOC_USP7_MATH_1	132	136	PF00917	0.586
DOC_USP7_MATH_1	15	19	PF00917	0.598
DOC_USP7_MATH_1	353	357	PF00917	0.503
DOC_USP7_MATH_1	408	412	PF00917	0.660
DOC_USP7_MATH_1	451	455	PF00917	0.625
DOC_USP7_MATH_1	536	540	PF00917	0.785
DOC_USP7_MATH_1	621	625	PF00917	0.733
DOC_USP7_MATH_1	632	636	PF00917	0.600
DOC_USP7_MATH_1	644	648	PF00917	0.598
DOC_USP7_MATH_1	653	657	PF00917	0.463
DOC_USP7_MATH_1	768	772	PF00917	0.485
DOC_WW_Pin1_4	229	234	PF00397	0.518
DOC_WW_Pin1_4	459	464	PF00397	0.633
DOC_WW_Pin1_4	628	633	PF00397	0.674
LIG_14-3-3_CanoR_1	398	408	PF00244	0.638
LIG_14-3-3_CanoR_1	486	491	PF00244	0.584
LIG_14-3-3_CanoR_1	49	55	PF00244	0.710
LIG_14-3-3_CanoR_1	504	510	PF00244	0.444
LIG_14-3-3_CanoR_1	567	573	PF00244	0.665
LIG_14-3-3_CanoR_1	585	591	PF00244	0.731
LIG_14-3-3_CanoR_1	654	663	PF00244	0.611
LIG_14-3-3_CanoR_1	728	732	PF00244	0.569
LIG_14-3-3_CanoR_1	752	758	PF00244	0.438
LIG_14-3-3_CanoR_1	774	778	PF00244	0.686
LIG_Actin_WH2_2	470	488	PF00022	0.718
LIG_BIR_III_4	715	719	PF00653	0.627
LIG_deltaCOP1_diTrp_1	680	690	PF00928	0.503
LIG_FHA_1	197	203	PF00498	0.448
LIG_FHA_1	244	250	PF00498	0.756
LIG_FHA_1	486	492	PF00498	0.551
LIG_FHA_1	650	656	PF00498	0.610
LIG_FHA_2	342	348	PF00498	0.451
LIG_FHA_2	506	512	PF00498	0.655
LIG_FHA_2	558	564	PF00498	0.571
LIG_FHA_2	569	575	PF00498	0.622
LIG_FHA_2	587	593	PF00498	0.688
LIG_FHA_2	629	635	PF00498	0.709
LIG_FHA_2	675	681	PF00498	0.692
LIG_FHA_2	728	734	PF00498	0.529
LIG_Integrin_RGD_1	673	675	PF01839	0.674
LIG_LIR_Gen_1	42	51	PF02991	0.572
LIG_LIR_Gen_1	656	663	PF02991	0.567
LIG_LIR_Gen_1	747	758	PF02991	0.425
LIG_LIR_Nem_3	361	366	PF02991	0.444
LIG_LIR_Nem_3	42	47	PF02991	0.569
LIG_LIR_Nem_3	429	434	PF02991	0.559
LIG_LIR_Nem_3	6	11	PF02991	0.555
LIG_LIR_Nem_3	656	660	PF02991	0.569
LIG_LIR_Nem_3	747	753	PF02991	0.429
LIG_NRBOX	210	216	PF00104	0.546
LIG_Pex14_1	113	117	PF04695	0.436
LIG_SH2_CRK	363	367	PF00017	0.451
LIG_SH2_CRK	44	48	PF00017	0.574
LIG_SH2_CRK	750	754	PF00017	0.395
LIG_SH2_NCK_1	44	48	PF00017	0.574
LIG_SH2_SRC	418	421	PF00017	0.592
LIG_SH2_STAP1	510	514	PF00017	0.541
LIG_SH2_STAP1	750	754	PF00017	0.428
LIG_SH2_STAT5	746	749	PF00017	0.576
LIG_SH3_3	322	328	PF00018	0.544
LIG_SH3_3	345	351	PF00018	0.492
LIG_SUMO_SIM_par_1	334	340	PF11976	0.437
LIG_SUMO_SIM_par_1	344	349	PF11976	0.455
LIG_SUMO_SIM_par_1	557	563	PF11976	0.552
LIG_TRAF2_1	328	331	PF00917	0.601
LIG_TRAF2_1	560	563	PF00917	0.599
LIG_TRAF2_1	678	681	PF00917	0.559
LIG_UBA3_1	558	565	PF00899	0.585
LIG_WW_2	325	328	PF00397	0.526
MOD_CDK_SPK_2	229	234	PF00069	0.461
MOD_CK1_1	256	262	PF00069	0.704
MOD_CK1_1	275	281	PF00069	0.495
MOD_CK1_1	377	383	PF00069	0.500
MOD_CK1_1	454	460	PF00069	0.668
MOD_CK1_1	52	58	PF00069	0.732
MOD_CK1_1	647	653	PF00069	0.617
MOD_CK2_1	173	179	PF00069	0.554
MOD_CK2_1	461	467	PF00069	0.568
MOD_CK2_1	505	511	PF00069	0.538
MOD_CK2_1	557	563	PF00069	0.549
MOD_CK2_1	586	592	PF00069	0.675
MOD_CK2_1	674	680	PF00069	0.572
MOD_GlcNHglycan	114	117	PF01048	0.469
MOD_GlcNHglycan	13	16	PF01048	0.599
MOD_GlcNHglycan	134	137	PF01048	0.735
MOD_GlcNHglycan	253	256	PF01048	0.716
MOD_GlcNHglycan	292	295	PF01048	0.650
MOD_GlcNHglycan	355	358	PF01048	0.619
MOD_GlcNHglycan	401	404	PF01048	0.619
MOD_GlcNHglycan	410	413	PF01048	0.580
MOD_GlcNHglycan	435	438	PF01048	0.658
MOD_GlcNHglycan	439	442	PF01048	0.635
MOD_GlcNHglycan	453	456	PF01048	0.515
MOD_GlcNHglycan	5	8	PF01048	0.567
MOD_GlcNHglycan	55	58	PF01048	0.696
MOD_GlcNHglycan	607	610	PF01048	0.699
MOD_GlcNHglycan	623	626	PF01048	0.671
MOD_GlcNHglycan	63	66	PF01048	0.495
MOD_GlcNHglycan	645	649	PF01048	0.675
MOD_GlcNHglycan	664	667	PF01048	0.429
MOD_GlcNHglycan	770	773	PF01048	0.508
MOD_GlcNHglycan	79	82	PF01048	0.479
MOD_GSK3_1	11	18	PF00069	0.605
MOD_GSK3_1	173	180	PF00069	0.417
MOD_GSK3_1	229	236	PF00069	0.623
MOD_GSK3_1	259	266	PF00069	0.650
MOD_GSK3_1	272	279	PF00069	0.521
MOD_GSK3_1	35	42	PF00069	0.649
MOD_GSK3_1	365	372	PF00069	0.485
MOD_GSK3_1	376	383	PF00069	0.461
MOD_GSK3_1	433	440	PF00069	0.474
MOD_GSK3_1	451	458	PF00069	0.581
MOD_GSK3_1	49	56	PF00069	0.697
MOD_GSK3_1	568	575	PF00069	0.773
MOD_GSK3_1	628	635	PF00069	0.741
MOD_GSK3_1	649	656	PF00069	0.685
MOD_GSK3_1	73	80	PF00069	0.532
MOD_GSK3_1	82	89	PF00069	0.489
MOD_N-GLC_1	251	256	PF02516	0.601
MOD_N-GLC_1	289	294	PF02516	0.661
MOD_N-GLC_1	605	610	PF02516	0.762
MOD_NEK2_1	11	16	PF00069	0.665
MOD_NEK2_1	112	117	PF00069	0.482
MOD_NEK2_1	173	178	PF00069	0.459
MOD_NEK2_1	238	243	PF00069	0.521
MOD_NEK2_1	24	29	PF00069	0.562
MOD_NEK2_1	346	351	PF00069	0.502
MOD_NEK2_1	376	381	PF00069	0.499
MOD_NEK2_1	505	510	PF00069	0.635
MOD_NEK2_1	572	577	PF00069	0.672
MOD_NEK2_1	88	93	PF00069	0.676
MOD_NEK2_2	305	310	PF00069	0.643
MOD_PIKK_1	17	23	PF00454	0.718
MOD_PIKK_1	269	275	PF00454	0.690
MOD_PIKK_1	578	584	PF00454	0.785
MOD_PK_1	486	492	PF00069	0.629
MOD_PKA_1	269	275	PF00069	0.690
MOD_PKA_1	3	9	PF00069	0.624
MOD_PKA_1	444	450	PF00069	0.660
MOD_PKA_1	586	592	PF00069	0.766
MOD_PKA_2	24	30	PF00069	0.613
MOD_PKA_2	269	275	PF00069	0.690
MOD_PKA_2	3	9	PF00069	0.658
MOD_PKA_2	444	450	PF00069	0.664
MOD_PKA_2	485	491	PF00069	0.553
MOD_PKA_2	586	592	PF00069	0.734
MOD_PKA_2	653	659	PF00069	0.648
MOD_PKA_2	727	733	PF00069	0.535
MOD_PKA_2	773	779	PF00069	0.687
MOD_PKB_1	484	492	PF00069	0.635
MOD_Plk_1	275	281	PF00069	0.669
MOD_Plk_2-3	245	251	PF00069	0.617
MOD_Plk_4	238	244	PF00069	0.608
MOD_Plk_4	365	371	PF00069	0.490
MOD_Plk_4	486	492	PF00069	0.567
MOD_Plk_4	505	511	PF00069	0.606
MOD_Plk_4	727	733	PF00069	0.535
MOD_Plk_4	753	759	PF00069	0.487
MOD_ProDKin_1	229	235	PF00069	0.521
MOD_ProDKin_1	459	465	PF00069	0.638
MOD_ProDKin_1	628	634	PF00069	0.674
MOD_SUMO_rev_2	562	566	PF00179	0.516
TRG_DiLeu_BaEn_1	210	215	PF01217	0.409
TRG_DiLeu_BaEn_3	157	163	PF01217	0.444
TRG_DiLeu_BaEn_4	154	160	PF01217	0.486
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.590
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.500
TRG_ENDOCYTIC_2	363	366	PF00928	0.441
TRG_ENDOCYTIC_2	44	47	PF00928	0.608
TRG_ENDOCYTIC_2	750	753	PF00928	0.425
TRG_ER_diArg_1	2	5	PF00400	0.618
TRG_ER_diArg_1	309	311	PF00400	0.754
TRG_ER_diArg_1	443	445	PF00400	0.634
TRG_ER_diArg_1	484	487	PF00400	0.723
TRG_ER_diArg_1	503	505	PF00400	0.431
TRG_ER_diArg_1	583	585	PF00400	0.671
TRG_ER_diArg_1	599	602	PF00400	0.573
TRG_ER_diArg_1	773	775	PF00400	0.553
TRG_NES_CRM1_1	206	220	PF08389	0.451
TRG_NLS_MonoCore_2	584	589	PF00514	0.781
TRG_NLS_MonoExtN_4	583	590	PF00514	0.777
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC42	Leptomonas seymouri	39%	96%
A4HEX0	Leishmania braziliensis	68%	100%
A4I244	Leishmania infantum	99%	100%
E9AY94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q979	Leishmania major	86%	98%