Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDR9_LEIDO

TriTrypDb:

LdBPK_281270.1 , LdCL_280017300 , LDHU3_28.1600

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A0A3Q8IDR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.555
CLV_C14_Caspase3-7	359	363	PF00656	0.632
CLV_C14_Caspase3-7	889	893	PF00656	0.674
CLV_C14_Caspase3-7	922	926	PF00656	0.599
CLV_NRD_NRD_1	316	318	PF00675	0.659
CLV_NRD_NRD_1	347	349	PF00675	0.710
CLV_NRD_NRD_1	693	695	PF00675	0.613
CLV_NRD_NRD_1	88	90	PF00675	0.677
CLV_PCSK_KEX2_1	247	249	PF00082	0.672
CLV_PCSK_KEX2_1	316	318	PF00082	0.606
CLV_PCSK_KEX2_1	347	349	PF00082	0.710
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.672
CLV_PCSK_SKI1_1	248	252	PF00082	0.640
CLV_PCSK_SKI1_1	317	321	PF00082	0.646
CLV_PCSK_SKI1_1	396	400	PF00082	0.706
CLV_PCSK_SKI1_1	424	428	PF00082	0.471
CLV_PCSK_SKI1_1	513	517	PF00082	0.723
CLV_PCSK_SKI1_1	694	698	PF00082	0.672
CLV_PCSK_SKI1_1	906	910	PF00082	0.638
CLV_Separin_Metazoa	689	693	PF03568	0.394
DEG_APCC_DBOX_1	193	201	PF00400	0.640
DEG_APCC_DBOX_1	247	255	PF00400	0.635
DEG_APCC_DBOX_1	257	265	PF00400	0.477
DEG_APCC_DBOX_1	316	324	PF00400	0.638
DEG_APCC_DBOX_1	423	431	PF00400	0.559
DEG_SPOP_SBC_1	701	705	PF00917	0.540
DOC_CDC14_PxL_1	954	962	PF14671	0.642
DOC_CYCLIN_RxL_1	245	255	PF00134	0.559
DOC_CYCLIN_RxL_1	510	518	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	399	402	PF00134	0.690
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.557
DOC_MAPK_DCC_7	396	405	PF00069	0.687
DOC_MAPK_DCC_7	544	553	PF00069	0.550
DOC_MAPK_gen_1	316	323	PF00069	0.641
DOC_MAPK_gen_1	347	353	PF00069	0.692
DOC_MAPK_gen_1	66	75	PF00069	0.499
DOC_MAPK_gen_1	810	819	PF00069	0.639
DOC_MAPK_gen_1	936	944	PF00069	0.615
DOC_MAPK_MEF2A_6	316	323	PF00069	0.641
DOC_MAPK_MEF2A_6	396	405	PF00069	0.687
DOC_MAPK_MEF2A_6	544	553	PF00069	0.550
DOC_MAPK_MEF2A_6	702	710	PF00069	0.595
DOC_MAPK_MEF2A_6	936	944	PF00069	0.615
DOC_PP1_RVXF_1	61	68	PF00149	0.536
DOC_PP1_RVXF_1	791	797	PF00149	0.655
DOC_PP2B_LxvP_1	23	26	PF13499	0.523
DOC_PP2B_LxvP_1	399	402	PF13499	0.690
DOC_PP2B_LxvP_1	633	636	PF13499	0.556
DOC_PP2B_LxvP_1	860	863	PF13499	0.721
DOC_PP2B_LxvP_1	960	963	PF13499	0.638
DOC_PP4_FxxP_1	658	661	PF00568	0.637
DOC_PP4_FxxP_1	789	792	PF00568	0.681
DOC_USP7_MATH_1	106	110	PF00917	0.552
DOC_USP7_MATH_1	33	37	PF00917	0.611
DOC_USP7_MATH_1	337	341	PF00917	0.674
DOC_USP7_MATH_1	346	350	PF00917	0.680
DOC_USP7_MATH_1	446	450	PF00917	0.693
DOC_USP7_MATH_1	585	589	PF00917	0.723
DOC_USP7_MATH_1	772	776	PF00917	0.745
DOC_USP7_MATH_1	792	796	PF00917	0.426
DOC_USP7_MATH_1	820	824	PF00917	0.701
DOC_USP7_MATH_1	840	844	PF00917	0.558
DOC_WW_Pin1_4	176	181	PF00397	0.648
DOC_WW_Pin1_4	241	246	PF00397	0.621
DOC_WW_Pin1_4	341	346	PF00397	0.770
DOC_WW_Pin1_4	390	395	PF00397	0.786
DOC_WW_Pin1_4	911	916	PF00397	0.670
DOC_WW_Pin1_4	936	941	PF00397	0.672
DOC_WW_Pin1_4	958	963	PF00397	0.701
LIG_14-3-3_CanoR_1	186	192	PF00244	0.668
LIG_14-3-3_CanoR_1	258	262	PF00244	0.606
LIG_14-3-3_CanoR_1	329	337	PF00244	0.712
LIG_14-3-3_CanoR_1	347	352	PF00244	0.535
LIG_14-3-3_CanoR_1	364	373	PF00244	0.544
LIG_14-3-3_CanoR_1	424	433	PF00244	0.603
LIG_14-3-3_CanoR_1	52	59	PF00244	0.615
LIG_14-3-3_CanoR_1	544	548	PF00244	0.591
LIG_14-3-3_CanoR_1	577	581	PF00244	0.665
LIG_14-3-3_CanoR_1	584	590	PF00244	0.686
LIG_14-3-3_CanoR_1	675	679	PF00244	0.643
LIG_14-3-3_CanoR_1	702	707	PF00244	0.622
LIG_14-3-3_CanoR_1	709	714	PF00244	0.439
LIG_14-3-3_CanoR_1	793	797	PF00244	0.696
LIG_14-3-3_CanoR_1	89	96	PF00244	0.602
LIG_14-3-3_CanoR_1	946	954	PF00244	0.605
LIG_Actin_WH2_2	450	465	PF00022	0.580
LIG_Actin_WH2_2	563	579	PF00022	0.635
LIG_Actin_WH2_2	628	645	PF00022	0.571
LIG_BIR_III_2	231	235	PF00653	0.697
LIG_BIR_III_4	746	750	PF00653	0.626
LIG_BRCT_BRCA1_1	654	658	PF00533	0.600
LIG_Clathr_ClatBox_1	430	434	PF01394	0.543
LIG_CSL_BTD_1	443	446	PF09270	0.660
LIG_deltaCOP1_diTrp_1	895	902	PF00928	0.647
LIG_eIF4E_1	367	373	PF01652	0.604
LIG_FHA_1	135	141	PF00498	0.566
LIG_FHA_1	217	223	PF00498	0.633
LIG_FHA_1	251	257	PF00498	0.609
LIG_FHA_1	329	335	PF00498	0.605
LIG_FHA_1	366	372	PF00498	0.631
LIG_FHA_1	434	440	PF00498	0.668
LIG_FHA_1	466	472	PF00498	0.675
LIG_FHA_1	675	681	PF00498	0.554
LIG_FHA_1	695	701	PF00498	0.579
LIG_FHA_1	918	924	PF00498	0.645
LIG_FHA_2	122	128	PF00498	0.527
LIG_FHA_2	406	412	PF00498	0.406
LIG_FHA_2	512	518	PF00498	0.690
LIG_FHA_2	610	616	PF00498	0.658
LIG_FHA_2	684	690	PF00498	0.477
LIG_FHA_2	726	732	PF00498	0.823
LIG_FHA_2	859	865	PF00498	0.774
LIG_FHA_2	887	893	PF00498	0.779
LIG_FHA_2	89	95	PF00498	0.616
LIG_IRF3_LxIS_1	750	756	PF10401	0.577
LIG_LIR_Apic_2	655	661	PF02991	0.626
LIG_LIR_Apic_2	788	792	PF02991	0.686
LIG_LIR_Gen_1	292	302	PF02991	0.688
LIG_LIR_Gen_1	795	803	PF02991	0.758
LIG_LIR_Gen_1	907	918	PF02991	0.597
LIG_LIR_Gen_1	939	949	PF02991	0.618
LIG_LIR_LC3C_4	109	114	PF02991	0.470
LIG_LIR_Nem_3	292	298	PF02991	0.681
LIG_LIR_Nem_3	442	447	PF02991	0.708
LIG_LIR_Nem_3	453	457	PF02991	0.556
LIG_LIR_Nem_3	751	755	PF02991	0.666
LIG_LIR_Nem_3	795	799	PF02991	0.746
LIG_LIR_Nem_3	907	913	PF02991	0.642
LIG_LIR_Nem_3	939	944	PF02991	0.773
LIG_LIR_Nem_3	964	969	PF02991	0.698
LIG_MYND_1	27	31	PF01753	0.591
LIG_MYND_1	958	962	PF01753	0.644
LIG_MYND_3	197	201	PF01753	0.595
LIG_NRBOX	426	432	PF00104	0.641
LIG_Pex14_1	217	221	PF04695	0.575
LIG_Pex14_2	375	379	PF04695	0.658
LIG_Pex14_2	654	658	PF04695	0.600
LIG_Rb_LxCxE_1	428	442	PF01857	0.579
LIG_SH2_NCK_1	803	807	PF00017	0.677
LIG_SH2_SRC	547	550	PF00017	0.682
LIG_SH2_SRC	580	583	PF00017	0.718
LIG_SH2_SRC	649	652	PF00017	0.632
LIG_SH2_STAP1	562	566	PF00017	0.574
LIG_SH2_STAT5	221	224	PF00017	0.580
LIG_SH2_STAT5	28	31	PF00017	0.585
LIG_SH2_STAT5	367	370	PF00017	0.619
LIG_SH2_STAT5	547	550	PF00017	0.594
LIG_SH2_STAT5	679	682	PF00017	0.579
LIG_SH2_STAT5	716	719	PF00017	0.628
LIG_SH3_2	391	396	PF14604	0.645
LIG_SH3_3	141	147	PF00018	0.650
LIG_SH3_3	186	192	PF00018	0.668
LIG_SH3_3	27	33	PF00018	0.675
LIG_SH3_3	388	394	PF00018	0.658
LIG_SH3_3	395	401	PF00018	0.582
LIG_SH3_3	659	665	PF00018	0.774
LIG_SH3_3	956	962	PF00018	0.643
LIG_SUMO_SIM_par_1	552	558	PF11976	0.543
LIG_UBA3_1	690	695	PF00899	0.678
LIG_WW_1	25	28	PF00397	0.571
LIG_WW_3	344	348	PF00397	0.658
MOD_CDC14_SPxK_1	244	247	PF00782	0.610
MOD_CDC14_SPxK_1	344	347	PF00782	0.714
MOD_CDC14_SPxK_1	393	396	PF00782	0.791
MOD_CDK_SPxK_1	241	247	PF00069	0.617
MOD_CDK_SPxK_1	341	347	PF00069	0.716
MOD_CDK_SPxK_1	390	396	PF00069	0.788
MOD_CDK_SPxxK_3	241	248	PF00069	0.616
MOD_CDK_SPxxK_3	341	348	PF00069	0.661
MOD_CK1_1	105	111	PF00069	0.565
MOD_CK1_1	121	127	PF00069	0.369
MOD_CK1_1	157	163	PF00069	0.558
MOD_CK1_1	176	182	PF00069	0.456
MOD_CK1_1	279	285	PF00069	0.663
MOD_CK1_1	294	300	PF00069	0.738
MOD_CK1_1	533	539	PF00069	0.665
MOD_CK1_1	557	563	PF00069	0.550
MOD_CK1_1	583	589	PF00069	0.775
MOD_CK1_1	748	754	PF00069	0.667
MOD_CK1_1	818	824	PF00069	0.724
MOD_CK1_1	875	881	PF00069	0.818
MOD_CK1_1	914	920	PF00069	0.681
MOD_CK2_1	327	333	PF00069	0.728
MOD_CK2_1	498	504	PF00069	0.758
MOD_CK2_1	609	615	PF00069	0.639
MOD_CK2_1	683	689	PF00069	0.471
MOD_CK2_1	725	731	PF00069	0.822
MOD_CK2_1	753	759	PF00069	0.744
MOD_CK2_1	763	769	PF00069	0.645
MOD_CK2_1	770	776	PF00069	0.520
MOD_CK2_1	858	864	PF00069	0.777
MOD_CK2_1	964	970	PF00069	0.824
MOD_CMANNOS	131	134	PF00535	0.513
MOD_Cter_Amidation	87	90	PF01082	0.668
MOD_GlcNHglycan	104	107	PF01048	0.558
MOD_GlcNHglycan	175	178	PF01048	0.586
MOD_GlcNHglycan	189	192	PF01048	0.747
MOD_GlcNHglycan	239	244	PF01048	0.625
MOD_GlcNHglycan	278	281	PF01048	0.682
MOD_GlcNHglycan	312	315	PF01048	0.695
MOD_GlcNHglycan	339	342	PF01048	0.689
MOD_GlcNHglycan	35	38	PF01048	0.646
MOD_GlcNHglycan	39	44	PF01048	0.553
MOD_GlcNHglycan	427	430	PF01048	0.611
MOD_GlcNHglycan	448	451	PF01048	0.648
MOD_GlcNHglycan	494	497	PF01048	0.666
MOD_GlcNHglycan	535	538	PF01048	0.754
MOD_GlcNHglycan	54	57	PF01048	0.370
MOD_GlcNHglycan	562	565	PF01048	0.668
MOD_GlcNHglycan	587	590	PF01048	0.742
MOD_GlcNHglycan	609	612	PF01048	0.691
MOD_GlcNHglycan	738	742	PF01048	0.674
MOD_GlcNHglycan	746	750	PF01048	0.565
MOD_GlcNHglycan	75	78	PF01048	0.542
MOD_GlcNHglycan	755	758	PF01048	0.613
MOD_GlcNHglycan	772	775	PF01048	0.617
MOD_GlcNHglycan	846	849	PF01048	0.758
MOD_GlcNHglycan	866	869	PF01048	0.663
MOD_GlcNHglycan	878	881	PF01048	0.661
MOD_GlcNHglycan	904	909	PF01048	0.671
MOD_GlcNHglycan	949	952	PF01048	0.702
MOD_GlcNHglycan	954	957	PF01048	0.736
MOD_GlcNHglycan	966	969	PF01048	0.540
MOD_GSK3_1	102	109	PF00069	0.567
MOD_GSK3_1	130	137	PF00069	0.598
MOD_GSK3_1	178	185	PF00069	0.706
MOD_GSK3_1	287	294	PF00069	0.752
MOD_GSK3_1	337	344	PF00069	0.823
MOD_GSK3_1	433	440	PF00069	0.663
MOD_GSK3_1	446	453	PF00069	0.534
MOD_GSK3_1	543	550	PF00069	0.678
MOD_GSK3_1	576	583	PF00069	0.624
MOD_GSK3_1	588	595	PF00069	0.604
MOD_GSK3_1	670	677	PF00069	0.648
MOD_GSK3_1	69	76	PF00069	0.561
MOD_GSK3_1	696	703	PF00069	0.611
MOD_GSK3_1	725	732	PF00069	0.658
MOD_GSK3_1	831	838	PF00069	0.745
MOD_GSK3_1	840	847	PF00069	0.624
MOD_GSK3_1	872	879	PF00069	0.726
MOD_GSK3_1	882	889	PF00069	0.818
MOD_GSK3_1	958	965	PF00069	0.744
MOD_N-GLC_1	154	159	PF02516	0.544
MOD_N-GLC_1	310	315	PF02516	0.736
MOD_N-GLC_1	831	836	PF02516	0.659
MOD_NEK2_1	199	204	PF00069	0.569
MOD_NEK2_1	250	255	PF00069	0.586
MOD_NEK2_1	270	275	PF00069	0.365
MOD_NEK2_1	327	332	PF00069	0.647
MOD_NEK2_1	405	410	PF00069	0.443
MOD_NEK2_1	478	483	PF00069	0.681
MOD_NEK2_1	576	581	PF00069	0.586
MOD_NEK2_1	609	614	PF00069	0.702
MOD_NEK2_1	696	701	PF00069	0.542
MOD_NEK2_1	737	742	PF00069	0.761
MOD_NEK2_1	753	758	PF00069	0.622
MOD_NEK2_1	846	851	PF00069	0.650
MOD_NEK2_1	909	914	PF00069	0.759
MOD_NEK2_1	916	921	PF00069	0.674
MOD_NEK2_2	725	730	PF00069	0.653
MOD_NEK2_2	840	845	PF00069	0.649
MOD_PK_1	702	708	PF00069	0.554
MOD_PK_1	709	715	PF00069	0.411
MOD_PK_1	763	769	PF00069	0.659
MOD_PKA_1	347	353	PF00069	0.634
MOD_PKA_1	694	700	PF00069	0.596
MOD_PKA_2	257	263	PF00069	0.609
MOD_PKA_2	328	334	PF00069	0.590
MOD_PKA_2	346	352	PF00069	0.517
MOD_PKA_2	543	549	PF00069	0.586
MOD_PKA_2	576	582	PF00069	0.672
MOD_PKA_2	583	589	PF00069	0.805
MOD_PKA_2	674	680	PF00069	0.588
MOD_PKA_2	701	707	PF00069	0.543
MOD_PKA_2	792	798	PF00069	0.651
MOD_PKA_2	844	850	PF00069	0.725
MOD_PKA_2	875	881	PF00069	0.789
MOD_PKA_2	88	94	PF00069	0.634
MOD_PKB_1	605	613	PF00069	0.642
MOD_PKB_1	692	700	PF00069	0.572
MOD_Plk_1	157	163	PF00069	0.568
MOD_Plk_1	557	563	PF00069	0.514
MOD_Plk_1	614	620	PF00069	0.524
MOD_Plk_1	904	910	PF00069	0.640
MOD_Plk_4	130	136	PF00069	0.588
MOD_Plk_4	168	174	PF00069	0.550
MOD_Plk_4	199	205	PF00069	0.565
MOD_Plk_4	217	223	PF00069	0.370
MOD_Plk_4	347	353	PF00069	0.634
MOD_Plk_4	450	456	PF00069	0.643
MOD_Plk_4	543	549	PF00069	0.706
MOD_Plk_4	557	563	PF00069	0.477
MOD_Plk_4	674	680	PF00069	0.645
MOD_Plk_4	748	754	PF00069	0.690
MOD_Plk_4	798	804	PF00069	0.769
MOD_ProDKin_1	176	182	PF00069	0.655
MOD_ProDKin_1	241	247	PF00069	0.621
MOD_ProDKin_1	341	347	PF00069	0.771
MOD_ProDKin_1	390	396	PF00069	0.788
MOD_ProDKin_1	911	917	PF00069	0.668
MOD_ProDKin_1	936	942	PF00069	0.673
MOD_ProDKin_1	958	964	PF00069	0.702
MOD_SUMO_for_1	647	650	PF00179	0.641
TRG_DiLeu_BaEn_2	936	942	PF01217	0.673
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.586
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.678
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.561
TRG_ENDOCYTIC_2	966	969	PF00928	0.698
TRG_ER_diArg_1	227	230	PF00400	0.557
TRG_ER_diArg_1	346	348	PF00400	0.753
TRG_ER_diArg_1	604	607	PF00400	0.663
TRG_ER_diArg_1	691	694	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.696
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV9	Leptomonas seymouri	29%	100%
A4HGG3	Leishmania braziliensis	61%	100%
A4I3J5	Leishmania infantum	100%	100%
E9AZT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%