Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDR8_LEIDO

TriTrypDb:

LdBPK_331480.1 , LdCL_330021400 , LDHU3_33.2210

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDR8

PDB structure(s): 7aih_Y , 7ane_Y

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.370
CLV_NRD_NRD_1	129	131	PF00675	0.460
CLV_NRD_NRD_1	162	164	PF00675	0.522
CLV_NRD_NRD_1	225	227	PF00675	0.438
CLV_NRD_NRD_1	261	263	PF00675	0.448
CLV_NRD_NRD_1	58	60	PF00675	0.464
CLV_PCSK_KEX2_1	129	131	PF00082	0.476
CLV_PCSK_KEX2_1	162	164	PF00082	0.522
CLV_PCSK_KEX2_1	261	263	PF00082	0.504
CLV_PCSK_KEX2_1	60	62	PF00082	0.443
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.443
CLV_PCSK_SKI1_1	226	230	PF00082	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DOC_MAPK_gen_1	162	170	PF00069	0.550
DOC_MAPK_gen_1	261	269	PF00069	0.542
DOC_PP2B_LxvP_1	133	136	PF13499	0.439
DOC_PP2B_LxvP_1	146	149	PF13499	0.416
DOC_USP7_MATH_1	289	293	PF00917	0.544
DOC_USP7_MATH_1	95	99	PF00917	0.500
DOC_WW_Pin1_4	131	136	PF00397	0.442
LIG_14-3-3_CanoR_1	96	104	PF00244	0.402
LIG_APCC_ABBA_1	236	241	PF00400	0.526
LIG_deltaCOP1_diTrp_1	166	170	PF00928	0.486
LIG_FHA_1	13	19	PF00498	0.589
LIG_FHA_1	132	138	PF00498	0.459
LIG_FHA_1	163	169	PF00498	0.439
LIG_FHA_1	181	187	PF00498	0.263
LIG_FHA_2	209	215	PF00498	0.416
LIG_LIR_Gen_1	165	175	PF02991	0.491
LIG_LIR_Gen_1	219	229	PF02991	0.357
LIG_LIR_Gen_1	278	289	PF02991	0.549
LIG_LIR_Gen_1	76	86	PF02991	0.433
LIG_LIR_Nem_3	157	161	PF02991	0.451
LIG_LIR_Nem_3	165	170	PF02991	0.405
LIG_LIR_Nem_3	176	181	PF02991	0.372
LIG_LIR_Nem_3	216	221	PF02991	0.379
LIG_LIR_Nem_3	278	284	PF02991	0.487
LIG_LIR_Nem_3	76	81	PF02991	0.448
LIG_LYPXL_yS_3	158	161	PF13949	0.450
LIG_MYND_1	131	135	PF01753	0.446
LIG_SH2_CRK	128	132	PF00017	0.511
LIG_SH2_CRK	281	285	PF00017	0.567
LIG_SH2_CRK	78	82	PF00017	0.452
LIG_SH2_NCK_1	281	285	PF00017	0.549
LIG_SH2_NCK_1	78	82	PF00017	0.533
LIG_SH2_PTP2	221	224	PF00017	0.381
LIG_SH2_SRC	140	143	PF00017	0.407
LIG_SH2_STAT5	180	183	PF00017	0.496
LIG_SH2_STAT5	221	224	PF00017	0.366
LIG_SH2_STAT5	48	51	PF00017	0.466
LIG_TRAF2_1	100	103	PF00917	0.501
LIG_TRAF2_1	112	115	PF00917	0.364
LIG_TYR_ITIM	279	284	PF00017	0.446
MOD_CK1_1	79	85	PF00069	0.545
MOD_CK2_1	208	214	PF00069	0.428
MOD_GlcNHglycan	30	33	PF01048	0.571
MOD_GlcNHglycan	78	81	PF01048	0.545
MOD_LATS_1	127	133	PF00433	0.551
MOD_PIKK_1	150	156	PF00454	0.503
MOD_PKA_1	129	135	PF00069	0.449
MOD_PKA_1	162	168	PF00069	0.501
MOD_PKA_1	21	27	PF00069	0.517
MOD_PKA_2	129	135	PF00069	0.449
MOD_PKA_2	162	168	PF00069	0.407
MOD_PKA_2	76	82	PF00069	0.545
MOD_PKA_2	88	94	PF00069	0.426
MOD_PKA_2	95	101	PF00069	0.366
MOD_Plk_1	67	73	PF00069	0.481
MOD_ProDKin_1	131	137	PF00069	0.439
MOD_SUMO_for_1	191	194	PF00179	0.553
MOD_SUMO_rev_2	79	86	PF00179	0.528
TRG_DiLeu_BaEn_1	114	119	PF01217	0.466
TRG_DiLeu_BaEn_4	102	108	PF01217	0.497
TRG_DiLeu_BaEn_4	114	120	PF01217	0.379
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.500
TRG_ENDOCYTIC_2	158	161	PF00928	0.450
TRG_ENDOCYTIC_2	221	224	PF00928	0.366
TRG_ENDOCYTIC_2	281	284	PF00928	0.442
TRG_ENDOCYTIC_2	287	290	PF00928	0.360
TRG_ENDOCYTIC_2	78	81	PF00928	0.429
TRG_ER_diArg_1	128	130	PF00400	0.455
TRG_ER_diArg_1	161	163	PF00400	0.519
TRG_NES_CRM1_1	99	111	PF08389	0.436
TRG_NLS_MonoExtC_3	58	64	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q5	Leptomonas seymouri	82%	100%
A0A0S4JF52	Bodo saltans	53%	100%
A0A1X0P198	Trypanosomatidae	67%	100%
A0A3R7MCA1	Trypanosoma rangeli	68%	100%
A4HLK0	Leishmania braziliensis	92%	100%
A4I911	Leishmania infantum	100%	100%
D0A511	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B3X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q448	Leishmania major	98%	100%
V5BHC0	Trypanosoma cruzi	68%	100%