Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDR2_LEIDO

TriTrypDb:

LdBPK_281090.1 , LdCL_280015500 , LDHU3_28.1340 , LDHU3_34.5130

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	859	863	PF00656	0.720
CLV_NRD_NRD_1	193	195	PF00675	0.678
CLV_NRD_NRD_1	197	199	PF00675	0.585
CLV_NRD_NRD_1	362	364	PF00675	0.427
CLV_NRD_NRD_1	496	498	PF00675	0.471
CLV_NRD_NRD_1	749	751	PF00675	0.642
CLV_NRD_NRD_1	769	771	PF00675	0.303
CLV_NRD_NRD_1	788	790	PF00675	0.307
CLV_NRD_NRD_1	797	799	PF00675	0.433
CLV_PCSK_FUR_1	494	498	PF00082	0.563
CLV_PCSK_KEX2_1	193	195	PF00082	0.642
CLV_PCSK_KEX2_1	197	199	PF00082	0.589
CLV_PCSK_KEX2_1	362	364	PF00082	0.396
CLV_PCSK_KEX2_1	496	498	PF00082	0.462
CLV_PCSK_KEX2_1	646	648	PF00082	0.473
CLV_PCSK_KEX2_1	719	721	PF00082	0.515
CLV_PCSK_KEX2_1	749	751	PF00082	0.642
CLV_PCSK_KEX2_1	769	771	PF00082	0.303
CLV_PCSK_KEX2_1	788	790	PF00082	0.307
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.515
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.515
CLV_PCSK_PC7_1	193	199	PF00082	0.681
CLV_PCSK_PC7_1	358	364	PF00082	0.355
CLV_PCSK_PC7_1	745	751	PF00082	0.631
CLV_PCSK_PC7_1	765	771	PF00082	0.319
CLV_PCSK_SKI1_1	189	193	PF00082	0.734
CLV_PCSK_SKI1_1	213	217	PF00082	0.674
CLV_PCSK_SKI1_1	231	235	PF00082	0.533
CLV_PCSK_SKI1_1	303	307	PF00082	0.660
CLV_PCSK_SKI1_1	481	485	PF00082	0.375
CLV_PCSK_SKI1_1	533	537	PF00082	0.464
CLV_PCSK_SKI1_1	724	728	PF00082	0.453
CLV_PCSK_SKI1_1	789	793	PF00082	0.411
CLV_PCSK_SKI1_1	794	798	PF00082	0.446
CLV_PCSK_SKI1_1	920	924	PF00082	0.630
DEG_APCC_DBOX_1	212	220	PF00400	0.652
DEG_APCC_DBOX_1	517	525	PF00400	0.412
DEG_APCC_DBOX_1	630	638	PF00400	0.490
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SCF_FBW7_1	589	596	PF00400	0.423
DEG_SCF_FBW7_1	816	823	PF00400	0.526
DOC_CDC14_PxL_1	677	685	PF14671	0.457
DOC_CDC14_PxL_1	705	713	PF14671	0.546
DOC_CKS1_1	442	447	PF01111	0.533
DOC_CYCLIN_RxL_1	186	195	PF00134	0.542
DOC_CYCLIN_RxL_1	228	238	PF00134	0.653
DOC_CYCLIN_RxL_1	297	310	PF00134	0.585
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.520
DOC_MAPK_gen_1	394	403	PF00069	0.467
DOC_MAPK_gen_1	57	65	PF00069	0.561
DOC_MAPK_HePTP_8	393	405	PF00069	0.510
DOC_MAPK_MEF2A_6	396	405	PF00069	0.445
DOC_MAPK_MEF2A_6	518	526	PF00069	0.400
DOC_MAPK_MEF2A_6	570	577	PF00069	0.382
DOC_MAPK_MEF2A_6	631	638	PF00069	0.551
DOC_MAPK_MEF2A_6	85	94	PF00069	0.414
DOC_MAPK_NFAT4_5	631	639	PF00069	0.503
DOC_MAPK_RevD_3	634	647	PF00069	0.406
DOC_PP2B_LxvP_1	403	406	PF13499	0.503
DOC_PP2B_LxvP_1	575	578	PF13499	0.419
DOC_PP2B_LxvP_1	636	639	PF13499	0.383
DOC_PP2B_LxvP_1	660	663	PF13499	0.635
DOC_PP2B_LxvP_1	90	93	PF13499	0.421
DOC_PP4_FxxP_1	46	49	PF00568	0.517
DOC_PP4_FxxP_1	884	887	PF00568	0.644
DOC_USP7_MATH_1	138	142	PF00917	0.610
DOC_USP7_MATH_1	275	279	PF00917	0.676
DOC_USP7_MATH_1	354	358	PF00917	0.526
DOC_USP7_MATH_1	495	499	PF00917	0.572
DOC_USP7_MATH_1	553	557	PF00917	0.394
DOC_USP7_MATH_1	593	597	PF00917	0.418
DOC_USP7_MATH_1	898	902	PF00917	0.710
DOC_USP7_MATH_1	907	911	PF00917	0.614
DOC_USP7_MATH_1	927	931	PF00917	0.634
DOC_USP7_MATH_2	122	128	PF00917	0.584
DOC_USP7_UBL2_3	390	394	PF12436	0.567
DOC_WW_Pin1_4	172	177	PF00397	0.597
DOC_WW_Pin1_4	338	343	PF00397	0.567
DOC_WW_Pin1_4	441	446	PF00397	0.512
DOC_WW_Pin1_4	589	594	PF00397	0.376
DOC_WW_Pin1_4	670	675	PF00397	0.441
DOC_WW_Pin1_4	816	821	PF00397	0.568
DOC_WW_Pin1_4	900	905	PF00397	0.747
DOC_WW_Pin1_4	921	926	PF00397	0.616
LIG_14-3-3_CanoR_1	193	201	PF00244	0.524
LIG_14-3-3_CanoR_1	494	503	PF00244	0.548
LIG_14-3-3_CanoR_1	570	574	PF00244	0.493
LIG_14-3-3_CanoR_1	60	66	PF00244	0.505
LIG_14-3-3_CanoR_1	650	660	PF00244	0.617
LIG_APCC_ABBA_1	688	693	PF00400	0.418
LIG_BRCT_BRCA1_1	555	559	PF00533	0.492
LIG_Clathr_ClatBox_1	521	525	PF01394	0.372
LIG_CtBP_PxDLS_1	122	126	PF00389	0.589
LIG_FHA_1	398	404	PF00498	0.367
LIG_FHA_1	469	475	PF00498	0.547
LIG_FHA_1	570	576	PF00498	0.490
LIG_FHA_1	821	827	PF00498	0.492
LIG_FHA_2	112	118	PF00498	0.585
LIG_FHA_2	138	144	PF00498	0.621
LIG_FHA_2	362	368	PF00498	0.533
LIG_FHA_2	415	421	PF00498	0.540
LIG_FHA_2	442	448	PF00498	0.525
LIG_FHA_2	652	658	PF00498	0.522
LIG_FHA_2	698	704	PF00498	0.566
LIG_FHA_2	817	823	PF00498	0.526
LIG_FHA_2	852	858	PF00498	0.567
LIG_LIR_Apic_2	44	49	PF02991	0.505
LIG_LIR_Apic_2	883	887	PF02991	0.645
LIG_LIR_Gen_1	209	219	PF02991	0.661
LIG_LIR_Gen_1	400	410	PF02991	0.512
LIG_LIR_Gen_1	556	563	PF02991	0.432
LIG_LIR_Gen_1	693	702	PF02991	0.421
LIG_LIR_Gen_1	819	829	PF02991	0.529
LIG_LIR_Nem_3	151	157	PF02991	0.723
LIG_LIR_Nem_3	209	214	PF02991	0.668
LIG_LIR_Nem_3	400	405	PF02991	0.495
LIG_LIR_Nem_3	485	490	PF02991	0.562
LIG_LIR_Nem_3	529	535	PF02991	0.443
LIG_LIR_Nem_3	556	562	PF02991	0.395
LIG_LIR_Nem_3	571	577	PF02991	0.407
LIG_LIR_Nem_3	735	740	PF02991	0.421
LIG_LIR_Nem_3	819	824	PF02991	0.538
LIG_Pex14_1	42	46	PF04695	0.490
LIG_PTB_Apo_2	278	285	PF02174	0.742
LIG_PTB_Phospho_1	278	284	PF10480	0.740
LIG_SH2_CRK	442	446	PF00017	0.536
LIG_SH2_CRK	758	762	PF00017	0.453
LIG_SH2_NCK_1	587	591	PF00017	0.460
LIG_SH2_SRC	29	32	PF00017	0.435
LIG_SH2_SRC	691	694	PF00017	0.453
LIG_SH2_SRC	806	809	PF00017	0.483
LIG_SH2_STAP1	29	33	PF00017	0.568
LIG_SH2_STAP1	301	305	PF00017	0.677
LIG_SH2_STAP1	399	403	PF00017	0.353
LIG_SH2_STAP1	452	456	PF00017	0.406
LIG_SH2_STAP1	554	558	PF00017	0.385
LIG_SH2_STAT5	359	362	PF00017	0.520
LIG_SH2_STAT5	399	402	PF00017	0.362
LIG_SH2_STAT5	561	564	PF00017	0.396
LIG_SH2_STAT5	574	577	PF00017	0.443
LIG_SH2_STAT5	642	645	PF00017	0.488
LIG_SH2_STAT5	754	757	PF00017	0.498
LIG_SH2_STAT5	806	809	PF00017	0.483
LIG_SH3_3	125	131	PF00018	0.487
LIG_SH3_3	290	296	PF00018	0.747
LIG_SH3_3	403	409	PF00018	0.425
LIG_SH3_3	463	469	PF00018	0.569
LIG_SH3_3	570	576	PF00018	0.503
LIG_SH3_3	659	665	PF00018	0.622
LIG_SH3_3	919	925	PF00018	0.744
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.558
LIG_SUMO_SIM_par_1	121	127	PF11976	0.590
LIG_SUMO_SIM_par_1	470	476	PF11976	0.515
LIG_SUMO_SIM_par_1	520	525	PF11976	0.435
LIG_TRAF2_1	376	379	PF00917	0.562
LIG_TRAF2_1	417	420	PF00917	0.565
LIG_TRAF2_1	690	693	PF00917	0.461
LIG_TYR_ITIM	530	535	PF00017	0.319
LIG_UBA3_1	304	311	PF00899	0.510
LIG_UBA3_1	526	533	PF00899	0.327
LIG_WRC_WIRS_1	43	48	PF05994	0.494
LIG_WRC_WIRS_1	514	519	PF05994	0.494
LIG_WRC_WIRS_1	543	548	PF05994	0.458
LIG_WW_1	674	677	PF00397	0.404
MOD_CDK_SPK_2	441	446	PF00069	0.474
MOD_CDK_SPxxK_3	338	345	PF00069	0.552
MOD_CK1_1	161	167	PF00069	0.760
MOD_CK1_1	307	313	PF00069	0.610
MOD_CK1_1	371	377	PF00069	0.584
MOD_CK1_1	5	11	PF00069	0.646
MOD_CK1_1	588	594	PF00069	0.394
MOD_CK1_1	903	909	PF00069	0.714
MOD_CK2_1	111	117	PF00069	0.594
MOD_CK2_1	137	143	PF00069	0.537
MOD_CK2_1	248	254	PF00069	0.727
MOD_CK2_1	414	420	PF00069	0.540
MOD_CK2_1	441	447	PF00069	0.525
MOD_CK2_1	588	594	PF00069	0.469
MOD_CK2_1	649	655	PF00069	0.589
MOD_Cter_Amidation	786	789	PF01082	0.410
MOD_GlcNHglycan	140	143	PF01048	0.568
MOD_GlcNHglycan	160	163	PF01048	0.468
MOD_GlcNHglycan	183	186	PF01048	0.687
MOD_GlcNHglycan	194	197	PF01048	0.578
MOD_GlcNHglycan	250	253	PF01048	0.730
MOD_GlcNHglycan	268	271	PF01048	0.553
MOD_GlcNHglycan	311	314	PF01048	0.630
MOD_GlcNHglycan	4	7	PF01048	0.602
MOD_GlcNHglycan	555	558	PF01048	0.428
MOD_GlcNHglycan	683	686	PF01048	0.555
MOD_GlcNHglycan	900	903	PF01048	0.789
MOD_GlcNHglycan	905	908	PF01048	0.770
MOD_GSK3_1	157	164	PF00069	0.805
MOD_GSK3_1	177	184	PF00069	0.676
MOD_GSK3_1	218	225	PF00069	0.721
MOD_GSK3_1	244	251	PF00069	0.616
MOD_GSK3_1	367	374	PF00069	0.529
MOD_GSK3_1	564	571	PF00069	0.498
MOD_GSK3_1	585	592	PF00069	0.429
MOD_GSK3_1	651	658	PF00069	0.609
MOD_GSK3_1	666	673	PF00069	0.510
MOD_GSK3_1	816	823	PF00069	0.512
MOD_GSK3_1	894	901	PF00069	0.732
MOD_GSK3_1	903	910	PF00069	0.770
MOD_NEK2_1	123	128	PF00069	0.583
MOD_NEK2_1	157	162	PF00069	0.746
MOD_NEK2_1	192	197	PF00069	0.527
MOD_NEK2_1	2	7	PF00069	0.717
MOD_NEK2_1	222	227	PF00069	0.684
MOD_NEK2_1	304	309	PF00069	0.588
MOD_NEK2_1	368	373	PF00069	0.488
MOD_NEK2_1	389	394	PF00069	0.591
MOD_NEK2_1	683	688	PF00069	0.519
MOD_NEK2_1	727	732	PF00069	0.410
MOD_NEK2_1	856	861	PF00069	0.592
MOD_NEK2_2	569	574	PF00069	0.424
MOD_PIKK_1	177	183	PF00454	0.735
MOD_PIKK_1	415	421	PF00454	0.526
MOD_PIKK_1	564	570	PF00454	0.504
MOD_PIKK_1	727	733	PF00454	0.421
MOD_PKA_2	181	187	PF00069	0.597
MOD_PKA_2	192	198	PF00069	0.579
MOD_PKA_2	354	360	PF00069	0.531
MOD_PKA_2	361	367	PF00069	0.506
MOD_PKA_2	495	501	PF00069	0.582
MOD_PKA_2	569	575	PF00069	0.368
MOD_PKA_2	630	636	PF00069	0.434
MOD_PKA_2	649	655	PF00069	0.344
MOD_Plk_1	123	129	PF00069	0.522
MOD_Plk_1	368	374	PF00069	0.508
MOD_Plk_1	593	599	PF00069	0.416
MOD_Plk_1	727	733	PF00069	0.398
MOD_Plk_1	856	862	PF00069	0.562
MOD_Plk_2-3	468	474	PF00069	0.582
MOD_Plk_4	222	228	PF00069	0.687
MOD_Plk_4	244	250	PF00069	0.673
MOD_Plk_4	331	337	PF00069	0.466
MOD_Plk_4	394	400	PF00069	0.509
MOD_Plk_4	569	575	PF00069	0.368
MOD_Plk_4	593	599	PF00069	0.416
MOD_Plk_4	638	644	PF00069	0.470
MOD_Plk_4	851	857	PF00069	0.553
MOD_ProDKin_1	172	178	PF00069	0.599
MOD_ProDKin_1	338	344	PF00069	0.561
MOD_ProDKin_1	441	447	PF00069	0.511
MOD_ProDKin_1	589	595	PF00069	0.373
MOD_ProDKin_1	670	676	PF00069	0.431
MOD_ProDKin_1	816	822	PF00069	0.574
MOD_ProDKin_1	900	906	PF00069	0.748
MOD_ProDKin_1	921	927	PF00069	0.608
MOD_SUMO_rev_2	468	477	PF00179	0.590
MOD_SUMO_rev_2	51	59	PF00179	0.498
MOD_SUMO_rev_2	525	535	PF00179	0.434
MOD_SUMO_rev_2	716	721	PF00179	0.507
TRG_DiLeu_BaEn_1	531	536	PF01217	0.428
TRG_DiLeu_BaEn_1	632	637	PF01217	0.516
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.577
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.648
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.531
TRG_ENDOCYTIC_2	301	304	PF00928	0.606
TRG_ENDOCYTIC_2	532	535	PF00928	0.365
TRG_ENDOCYTIC_2	574	577	PF00928	0.453
TRG_ENDOCYTIC_2	677	680	PF00928	0.462
TRG_ENDOCYTIC_2	691	694	PF00928	0.459
TRG_ER_diArg_1	192	194	PF00400	0.631
TRG_ER_diArg_1	197	199	PF00400	0.579
TRG_ER_diArg_1	493	496	PF00400	0.618
TRG_ER_diArg_1	749	751	PF00400	0.666
TRG_ER_diArg_1	769	771	PF00400	0.351
TRG_ER_diArg_1	788	790	PF00400	0.307
TRG_NES_CRM1_1	240	254	PF08389	0.637
TRG_NES_CRM1_1	31	47	PF08389	0.507
TRG_NES_CRM1_1	424	435	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W5	Leptomonas seymouri	48%	89%
A0A1X0NZW9	Trypanosomatidae	35%	95%
A0A3R7M3D8	Trypanosoma rangeli	35%	100%
A4HGE4	Leishmania braziliensis	77%	100%
A4I3H7	Leishmania infantum	100%	100%
E9AZR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8G7	Leishmania major	94%	100%
V5D1P8	Trypanosoma cruzi	36%	100%