Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDR1_LEIDO

TriTrypDb:

LdBPK_161250.1 , LdCL_160017700 , LDHU3_16.1520

Length:

286

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IDR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDR1

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0018193	peptidyl-amino acid modification	5	25
GO:0018208	peptidyl-proline modification	6	25
GO:0019538	protein metabolic process	3	25
GO:0036211	protein modification process	4	25
GO:0043170	macromolecule metabolic process	3	25
GO:0043412	macromolecule modification	4	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	25
GO:0003824	catalytic activity	1	25
GO:0016853	isomerase activity	2	25
GO:0016859	cis-trans isomerase activity	3	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0005488	binding	1	3
GO:0016018	cyclosporin A binding	4	3
GO:0033218	amide binding	2	3
GO:0042277	peptide binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.232
CLV_NRD_NRD_1	7	9	PF00675	0.484
CLV_NRD_NRD_1	97	99	PF00675	0.303
CLV_PCSK_KEX2_1	166	168	PF00082	0.234
CLV_PCSK_KEX2_1	7	9	PF00082	0.485
CLV_PCSK_KEX2_1	97	99	PF00082	0.368
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.226
CLV_PCSK_SKI1_1	281	285	PF00082	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DOC_CDC14_PxL_1	46	54	PF14671	0.408
DOC_CKS1_1	12	17	PF01111	0.412
DOC_MAPK_gen_1	165	174	PF00069	0.260
DOC_MAPK_gen_1	30	40	PF00069	0.416
DOC_MAPK_MEF2A_6	33	42	PF00069	0.450
DOC_PP2B_LxvP_1	221	224	PF13499	0.364
DOC_USP7_MATH_1	257	261	PF00917	0.487
DOC_WW_Pin1_4	11	16	PF00397	0.563
DOC_WW_Pin1_4	115	120	PF00397	0.270
DOC_WW_Pin1_4	252	257	PF00397	0.595
DOC_WW_Pin1_4	272	277	PF00397	0.640
DOC_WW_Pin1_4	69	74	PF00397	0.444
LIG_14-3-3_CanoR_1	281	286	PF00244	0.511
LIG_14-3-3_CanoR_1	30	36	PF00244	0.405
LIG_APCC_ABBA_1	82	87	PF00400	0.305
LIG_BRCT_BRCA1_1	186	190	PF00533	0.305
LIG_CSL_BTD_1	158	161	PF09270	0.190
LIG_FHA_1	139	145	PF00498	0.232
LIG_FHA_1	20	26	PF00498	0.424
LIG_FHA_1	4	10	PF00498	0.535
LIG_FHA_2	70	76	PF00498	0.506
LIG_Integrin_isoDGR_2	202	204	PF01839	0.232
LIG_LIR_Gen_1	124	133	PF02991	0.266
LIG_LIR_Gen_1	216	225	PF02991	0.382
LIG_LIR_Gen_1	233	239	PF02991	0.160
LIG_LIR_Gen_1	34	43	PF02991	0.259
LIG_LIR_Gen_1	76	85	PF02991	0.203
LIG_LIR_Nem_3	124	129	PF02991	0.321
LIG_LIR_Nem_3	216	221	PF02991	0.382
LIG_LIR_Nem_3	233	238	PF02991	0.160
LIG_LIR_Nem_3	34	40	PF02991	0.312
LIG_LIR_Nem_3	44	49	PF02991	0.386
LIG_LIR_Nem_3	76	82	PF02991	0.287
LIG_MLH1_MIPbox_1	186	190	PF16413	0.305
LIG_SH2_CRK	114	118	PF00017	0.243
LIG_SH2_CRK	235	239	PF00017	0.253
LIG_SH2_NCK_1	152	156	PF00017	0.364
LIG_SH2_STAP1	235	239	PF00017	0.218
LIG_SH2_STAT3	112	115	PF00017	0.234
LIG_SH2_STAT3	133	136	PF00017	0.396
LIG_SH2_STAT5	112	115	PF00017	0.250
LIG_SH2_STAT5	121	124	PF00017	0.272
LIG_SH2_STAT5	125	128	PF00017	0.284
LIG_SH2_STAT5	133	136	PF00017	0.265
LIG_SH2_STAT5	24	27	PF00017	0.634
LIG_SH3_3	44	50	PF00018	0.359
LIG_TRAF2_1	72	75	PF00917	0.571
MOD_CK1_1	151	157	PF00069	0.364
MOD_CK1_1	17	23	PF00069	0.499
MOD_CK1_1	184	190	PF00069	0.241
MOD_CK1_1	251	257	PF00069	0.709
MOD_CK1_1	26	32	PF00069	0.554
MOD_CK1_1	260	266	PF00069	0.596
MOD_CK2_1	264	270	PF00069	0.543
MOD_CK2_1	69	75	PF00069	0.511
MOD_GlcNHglycan	153	156	PF01048	0.378
MOD_GlcNHglycan	16	19	PF01048	0.464
MOD_GlcNHglycan	193	196	PF01048	0.299
MOD_GlcNHglycan	250	253	PF01048	0.467
MOD_GlcNHglycan	281	284	PF01048	0.648
MOD_GSK3_1	117	124	PF00069	0.284
MOD_GSK3_1	146	153	PF00069	0.359
MOD_GSK3_1	19	26	PF00069	0.524
MOD_GSK3_1	248	255	PF00069	0.499
MOD_GSK3_1	260	267	PF00069	0.489
MOD_GSK3_1	268	275	PF00069	0.628
MOD_GSK3_1	277	284	PF00069	0.680
MOD_GSK3_1	48	55	PF00069	0.420
MOD_GSK3_1	69	76	PF00069	0.441
MOD_N-GLC_1	184	189	PF02516	0.308
MOD_NEK2_1	189	194	PF00069	0.306
MOD_NEK2_1	19	24	PF00069	0.584
MOD_NEK2_1	250	255	PF00069	0.489
MOD_NEK2_1	52	57	PF00069	0.428
MOD_NEK2_1	63	68	PF00069	0.420
MOD_NEK2_2	138	143	PF00069	0.287
MOD_PIKK_1	184	190	PF00454	0.309
MOD_PIKK_1	257	263	PF00454	0.478
MOD_PIKK_1	41	47	PF00454	0.367
MOD_PIKK_1	52	58	PF00454	0.570
MOD_Plk_1	138	144	PF00069	0.238
MOD_Plk_1	73	79	PF00069	0.501
MOD_Plk_4	121	127	PF00069	0.246
MOD_Plk_4	245	251	PF00069	0.522
MOD_Plk_4	74	80	PF00069	0.469
MOD_ProDKin_1	11	17	PF00069	0.559
MOD_ProDKin_1	115	121	PF00069	0.270
MOD_ProDKin_1	252	258	PF00069	0.599
MOD_ProDKin_1	272	278	PF00069	0.640
MOD_ProDKin_1	69	75	PF00069	0.453
TRG_DiLeu_BaEn_1	245	250	PF01217	0.354
TRG_DiLeu_BaEn_3	74	80	PF01217	0.469
TRG_ENDOCYTIC_2	114	117	PF00928	0.243
TRG_ENDOCYTIC_2	235	238	PF00928	0.330
TRG_ER_diArg_1	7	9	PF00400	0.485
TRG_ER_diArg_1	96	98	PF00400	0.366
TRG_NLS_MonoCore_2	164	169	PF00514	0.223
TRG_NLS_MonoExtC_3	165	171	PF00514	0.354
TRG_NLS_MonoExtN_4	165	170	PF00514	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P523	Leptomonas seymouri	35%	100%
A0A0N1IJB8	Leptomonas seymouri	79%	78%
A0A0S4KGS8	Bodo saltans	40%	100%
A0A1X0NTS4	Trypanosomatidae	32%	100%
A0A1X0P0F8	Trypanosomatidae	58%	84%
A0A3Q8ICB3	Leishmania donovani	33%	100%
A0A3R7MER6	Trypanosoma rangeli	57%	86%
A0A3R7RE54	Trypanosoma rangeli	33%	100%
A0A3S7WXF4	Leishmania donovani	36%	97%
A0A3S7X410	Leishmania donovani	39%	100%
A0A422N490	Trypanosoma rangeli	31%	100%
A4H8P7	Leishmania braziliensis	87%	100%
A4HCI8	Leishmania braziliensis	32%	100%
A4HHU7	Leishmania braziliensis	30%	100%
A4HIW9	Leishmania braziliensis	40%	100%
A4HLM4	Leishmania braziliensis	39%	100%
A4HPH9	Leishmania braziliensis	36%	100%
A4HX17	Leishmania infantum	100%	100%
A4I004	Leishmania infantum	33%	100%
A4I042	Leishmania infantum	36%	97%
A4I698	Leishmania infantum	39%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZYI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	81%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	99%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
G5EEW6	Caenorhabditis elegans	28%	67%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P26882	Bos taurus	32%	77%
P34791	Arabidopsis thaliana	30%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q08752	Homo sapiens	32%	77%
Q09637	Caenorhabditis elegans	33%	93%
Q4Q424	Leishmania major	39%	100%
Q4Q6Q9	Leishmania major	39%	100%
Q4QBK2	Leishmania major	33%	100%
Q4QEP7	Leishmania major	95%	100%
Q6DGG0	Rattus norvegicus	34%	77%
Q9CR16	Mus musculus	34%	77%
Q9TW32	Dictyostelium discoideum	35%	100%
Q9UUE4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	66%
V5B2A0	Trypanosoma cruzi	32%	100%
V5DJ29	Trypanosoma cruzi	59%	89%