Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDQ8_LEIDO

TriTrypDb:

LdBPK_280420.1 , LdCL_280007700 , LDHU3_28.0370

Length:

216

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0008023	transcription elongation factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0070449	elongin complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IDQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.597
CLV_NRD_NRD_1	57	59	PF00675	0.566
CLV_PCSK_KEX2_1	188	190	PF00082	0.629
CLV_PCSK_KEX2_1	59	61	PF00082	0.621
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.619
CLV_PCSK_SKI1_1	162	166	PF00082	0.634
CLV_PCSK_SKI1_1	194	198	PF00082	0.688
CLV_PCSK_SKI1_1	54	58	PF00082	0.687
CLV_Separin_Metazoa	206	210	PF03568	0.570
DEG_APCC_KENBOX_2	116	120	PF00400	0.687
DOC_MAPK_gen_1	167	175	PF00069	0.468
DOC_MAPK_MEF2A_6	156	165	PF00069	0.712
DOC_MAPK_MEF2A_6	169	177	PF00069	0.459
DOC_PP1_RVXF_1	160	166	PF00149	0.630
DOC_PP1_RVXF_1	52	58	PF00149	0.688
DOC_PP4_FxxP_1	197	200	PF00568	0.539
DOC_USP7_MATH_1	33	37	PF00917	0.703
DOC_USP7_MATH_1	94	98	PF00917	0.638
DOC_WW_Pin1_4	47	52	PF00397	0.537
DOC_WW_Pin1_4	82	87	PF00397	0.607
LIG_14-3-3_CanoR_1	188	197	PF00244	0.650
LIG_APCC_ABBA_1	61	66	PF00400	0.522
LIG_APCC_ABBAyCdc20_2	60	66	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_FHA_1	200	206	PF00498	0.613
LIG_FHA_1	63	69	PF00498	0.565
LIG_FHA_2	133	139	PF00498	0.751
LIG_FHA_2	148	154	PF00498	0.623
LIG_LIR_Apic_2	20	26	PF02991	0.527
LIG_LIR_Apic_2	7	13	PF02991	0.718
LIG_LIR_Gen_1	178	186	PF02991	0.634
LIG_LIR_Gen_1	28	33	PF02991	0.615
LIG_LIR_Nem_3	178	182	PF02991	0.623
LIG_LIR_Nem_3	28	32	PF02991	0.553
LIG_PDZ_Class_2	211	216	PF00595	0.513
LIG_Pex14_2	6	10	PF04695	0.609
LIG_REV1ctd_RIR_1	70	77	PF16727	0.522
LIG_SH2_CRK	23	27	PF00017	0.646
LIG_SH2_GRB2like	23	26	PF00017	0.706
LIG_SH2_PTP2	29	32	PF00017	0.552
LIG_SH2_STAT5	179	182	PF00017	0.492
LIG_SH2_STAT5	18	21	PF00017	0.613
LIG_SH2_STAT5	29	32	PF00017	0.520
LIG_SH3_3	10	16	PF00018	0.556
LIG_SH3_3	142	148	PF00018	0.759
LIG_SH3_3	160	166	PF00018	0.468
LIG_TRAF2_1	36	39	PF00917	0.637
LIG_UBA3_1	164	169	PF00899	0.490
LIG_WW_1	15	18	PF00397	0.566
MOD_CDK_SPxxK_3	47	54	PF00069	0.534
MOD_CK1_1	84	90	PF00069	0.643
MOD_CK2_1	132	138	PF00069	0.751
MOD_CK2_1	147	153	PF00069	0.625
MOD_CK2_1	32	38	PF00069	0.703
MOD_GlcNHglycan	1	4	PF01048	0.560
MOD_GlcNHglycan	35	38	PF01048	0.700
MOD_GlcNHglycan	96	99	PF01048	0.650
MOD_GSK3_1	14	21	PF00069	0.627
MOD_GSK3_1	147	154	PF00069	0.683
MOD_GSK3_1	78	85	PF00069	0.695
MOD_NEK2_1	151	156	PF00069	0.664
MOD_NEK2_1	32	37	PF00069	0.627
MOD_NEK2_2	18	23	PF00069	0.715
MOD_PKA_1	188	194	PF00069	0.601
MOD_PKA_2	188	194	PF00069	0.616
MOD_Plk_1	157	163	PF00069	0.637
MOD_Plk_4	14	20	PF00069	0.704
MOD_Plk_4	175	181	PF00069	0.608
MOD_ProDKin_1	47	53	PF00069	0.534
MOD_ProDKin_1	82	88	PF00069	0.608
TRG_ENDOCYTIC_2	179	182	PF00928	0.620
TRG_ENDOCYTIC_2	29	32	PF00928	0.559
TRG_ER_diArg_1	188	190	PF00400	0.597
TRG_ER_diArg_1	57	60	PF00400	0.621
TRG_NLS_MonoExtC_3	57	62	PF00514	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P728	Leptomonas seymouri	47%	96%
A0A1X0NVU1	Trypanosomatidae	29%	100%
A4HG69	Leishmania braziliensis	75%	100%
A4I3B2	Leishmania infantum	100%	100%
E9AZI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8P2	Leishmania major	91%	100%