DNA polymerase sigma-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase sigma-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDQ5_LEIDO

TriTrypDb:

LdBPK_260480.1 , LdCL_260010300 , LDHU3_26.0620

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0031499	TRAMP complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0110165	cellular anatomical entity	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IDQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0031123	RNA 3'-end processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043631	RNA polyadenylation	6	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071076	RNA 3' uridylation	8	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	8
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050265	RNA uridylyltransferase activity	4	8
GO:0070566	adenylyltransferase activity	5	8
GO:0070569	uridylyltransferase activity	5	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.807
CLV_MEL_PAP_1	454	460	PF00089	0.590
CLV_NRD_NRD_1	110	112	PF00675	0.677
CLV_NRD_NRD_1	131	133	PF00675	0.622
CLV_NRD_NRD_1	175	177	PF00675	0.746
CLV_NRD_NRD_1	196	198	PF00675	0.801
CLV_NRD_NRD_1	355	357	PF00675	0.503
CLV_NRD_NRD_1	380	382	PF00675	0.549
CLV_NRD_NRD_1	484	486	PF00675	0.513
CLV_NRD_NRD_1	574	576	PF00675	0.584
CLV_NRD_NRD_1	85	87	PF00675	0.693
CLV_PCSK_FUR_1	173	177	PF00082	0.774
CLV_PCSK_FUR_1	378	382	PF00082	0.535
CLV_PCSK_KEX2_1	110	112	PF00082	0.651
CLV_PCSK_KEX2_1	131	133	PF00082	0.622
CLV_PCSK_KEX2_1	173	175	PF00082	0.723
CLV_PCSK_KEX2_1	196	198	PF00082	0.801
CLV_PCSK_KEX2_1	380	382	PF00082	0.549
CLV_PCSK_KEX2_1	484	486	PF00082	0.406
CLV_PCSK_KEX2_1	574	576	PF00082	0.602
CLV_PCSK_PC7_1	570	576	PF00082	0.601
CLV_PCSK_SKI1_1	20	24	PF00082	0.620
CLV_PCSK_SKI1_1	239	243	PF00082	0.482
CLV_PCSK_SKI1_1	338	342	PF00082	0.568
CLV_PCSK_SKI1_1	494	498	PF00082	0.462
CLV_PCSK_SKI1_1	518	522	PF00082	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SPOP_SBC_1	216	220	PF00917	0.654
DOC_CKS1_1	89	94	PF01111	0.675
DOC_CKS1_1	98	103	PF01111	0.597
DOC_CYCLIN_yCln2_LP_2	231	234	PF00134	0.686
DOC_MAPK_gen_1	354	364	PF00069	0.515
DOC_MAPK_gen_1	378	388	PF00069	0.492
DOC_MAPK_MEF2A_6	278	285	PF00069	0.472
DOC_MAPK_MEF2A_6	380	388	PF00069	0.495
DOC_PP2B_LxvP_1	231	234	PF13499	0.686
DOC_PP2B_LxvP_1	293	296	PF13499	0.400
DOC_PP2B_LxvP_1	405	408	PF13499	0.351
DOC_PP4_FxxP_1	30	33	PF00568	0.661
DOC_PP4_FxxP_1	496	499	PF00568	0.501
DOC_USP7_MATH_1	331	335	PF00917	0.650
DOC_USP7_MATH_1	49	53	PF00917	0.673
DOC_USP7_MATH_1	59	63	PF00917	0.582
DOC_USP7_UBL2_3	494	498	PF12436	0.430
DOC_WW_Pin1_4	105	110	PF00397	0.577
DOC_WW_Pin1_4	123	128	PF00397	0.784
DOC_WW_Pin1_4	142	147	PF00397	0.792
DOC_WW_Pin1_4	211	216	PF00397	0.651
DOC_WW_Pin1_4	253	258	PF00397	0.433
DOC_WW_Pin1_4	544	549	PF00397	0.557
DOC_WW_Pin1_4	88	93	PF00397	0.718
DOC_WW_Pin1_4	97	102	PF00397	0.675
LIG_14-3-3_CanoR_1	196	206	PF00244	0.819
LIG_14-3-3_CanoR_1	273	277	PF00244	0.496
LIG_14-3-3_CanoR_1	34	43	PF00244	0.726
LIG_14-3-3_CanoR_1	354	364	PF00244	0.456
LIG_14-3-3_CanoR_1	533	539	PF00244	0.541
LIG_BRCT_BRCA1_1	26	30	PF00533	0.638
LIG_BRCT_BRCA1_1	357	361	PF00533	0.496
LIG_BRCT_BRCA1_1	534	538	PF00533	0.544
LIG_CtBP_PxDLS_1	8	12	PF00389	0.581
LIG_EH1_1	439	447	PF00400	0.390
LIG_EVH1_2	70	74	PF00568	0.614
LIG_FHA_1	200	206	PF00498	0.800
LIG_FHA_1	21	27	PF00498	0.623
LIG_FHA_1	289	295	PF00498	0.429
LIG_FHA_1	330	336	PF00498	0.467
LIG_FHA_1	561	567	PF00498	0.579
LIG_FHA_2	198	204	PF00498	0.579
LIG_FHA_2	256	262	PF00498	0.494
LIG_FHA_2	477	483	PF00498	0.376
LIG_Integrin_isoDGR_2	148	150	PF01839	0.628
LIG_IRF3_LxIS_1	217	224	PF10401	0.653
LIG_LIR_Apic_2	27	33	PF02991	0.649
LIG_LIR_Apic_2	37	43	PF02991	0.598
LIG_LIR_Apic_2	4	8	PF02991	0.533
LIG_LIR_Apic_2	495	499	PF02991	0.501
LIG_LIR_Gen_1	358	368	PF02991	0.450
LIG_LIR_Nem_3	358	364	PF02991	0.443
LIG_LIR_Nem_3	480	486	PF02991	0.473
LIG_LIR_Nem_3	535	541	PF02991	0.503
LIG_NRBOX	247	253	PF00104	0.466
LIG_NRBOX	400	406	PF00104	0.520
LIG_PCNA_yPIPBox_3	457	470	PF02747	0.485
LIG_SH2_CRK	286	290	PF00017	0.404
LIG_SH2_NCK_1	40	44	PF00017	0.687
LIG_SH2_NCK_1	76	80	PF00017	0.621
LIG_SH2_SRC	40	43	PF00017	0.687
LIG_SH2_STAT3	449	452	PF00017	0.527
LIG_SH2_STAT3	490	493	PF00017	0.478
LIG_SH2_STAT5	253	256	PF00017	0.549
LIG_SH2_STAT5	400	403	PF00017	0.424
LIG_SH2_STAT5	449	452	PF00017	0.459
LIG_SH2_STAT5	490	493	PF00017	0.375
LIG_SH2_STAT5	505	508	PF00017	0.384
LIG_SH2_STAT5	558	561	PF00017	0.565
LIG_SH2_STAT5	594	597	PF00017	0.550
LIG_SH3_1	86	92	PF00018	0.679
LIG_SH3_3	140	146	PF00018	0.749
LIG_SH3_3	506	512	PF00018	0.445
LIG_SH3_3	53	59	PF00018	0.809
LIG_SH3_3	86	92	PF00018	0.823
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.434
LIG_SUMO_SIM_par_1	323	329	PF11976	0.497
LIG_TRFH_1	253	257	PF08558	0.482
LIG_UBA3_1	416	421	PF00899	0.389
MOD_CDK_SPK_2	105	110	PF00069	0.679
MOD_CDK_SPxK_1	105	111	PF00069	0.681
MOD_CK1_1	155	161	PF00069	0.803
MOD_CK1_1	177	183	PF00069	0.778
MOD_CK1_1	190	196	PF00069	0.723
MOD_CK1_1	256	262	PF00069	0.499
MOD_CK1_1	288	294	PF00069	0.396
MOD_CK1_1	314	320	PF00069	0.569
MOD_CK1_1	329	335	PF00069	0.446
MOD_CK1_1	547	553	PF00069	0.566
MOD_CK1_1	62	68	PF00069	0.749
MOD_CK2_1	304	310	PF00069	0.550
MOD_GlcNHglycan	179	183	PF01048	0.791
MOD_GlcNHglycan	192	195	PF01048	0.664
MOD_GlcNHglycan	306	309	PF01048	0.607
MOD_GlcNHglycan	313	316	PF01048	0.448
MOD_GlcNHglycan	328	331	PF01048	0.504
MOD_GlcNHglycan	391	395	PF01048	0.488
MOD_GlcNHglycan	458	461	PF01048	0.509
MOD_GlcNHglycan	534	537	PF01048	0.539
MOD_GlcNHglycan	64	67	PF01048	0.733
MOD_GSK3_1	148	155	PF00069	0.815
MOD_GSK3_1	174	181	PF00069	0.730
MOD_GSK3_1	197	204	PF00069	0.721
MOD_GSK3_1	20	27	PF00069	0.682
MOD_GSK3_1	211	218	PF00069	0.680
MOD_GSK3_1	314	321	PF00069	0.455
MOD_GSK3_1	32	39	PF00069	0.666
MOD_GSK3_1	386	393	PF00069	0.479
MOD_GSK3_1	436	443	PF00069	0.397
MOD_GSK3_1	47	54	PF00069	0.565
MOD_GSK3_1	518	525	PF00069	0.404
MOD_N-GLC_1	318	323	PF02516	0.508
MOD_N-GLC_1	544	549	PF02516	0.522
MOD_N-GLC_2	425	427	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	217	222	PF00069	0.721
MOD_NEK2_1	26	31	PF00069	0.640
MOD_NEK2_1	355	360	PF00069	0.459
MOD_NEK2_1	390	395	PF00069	0.491
MOD_NEK2_1	462	467	PF00069	0.486
MOD_NEK2_1	522	527	PF00069	0.414
MOD_PIKK_1	355	361	PF00454	0.564
MOD_PIKK_1	47	53	PF00454	0.620
MOD_PIKK_1	550	556	PF00454	0.509
MOD_PKA_1	174	180	PF00069	0.839
MOD_PKA_2	174	180	PF00069	0.839
MOD_PKA_2	261	267	PF00069	0.575
MOD_PKA_2	272	278	PF00069	0.418
MOD_PKA_2	35	41	PF00069	0.736
MOD_PKA_2	355	361	PF00069	0.439
MOD_PKA_2	456	462	PF00069	0.546
MOD_PKA_2	532	538	PF00069	0.474
MOD_PKB_1	173	181	PF00069	0.802
MOD_PKB_1	197	205	PF00069	0.707
MOD_PKB_1	34	42	PF00069	0.686
MOD_Plk_1	18	24	PF00069	0.652
MOD_Plk_1	386	392	PF00069	0.429
MOD_Plk_2-3	10	16	PF00069	0.583
MOD_Plk_4	201	207	PF00069	0.704
MOD_Plk_4	227	233	PF00069	0.642
MOD_Plk_4	357	363	PF00069	0.360
MOD_Plk_4	518	524	PF00069	0.422
MOD_Plk_4	534	540	PF00069	0.401
MOD_ProDKin_1	105	111	PF00069	0.579
MOD_ProDKin_1	123	129	PF00069	0.779
MOD_ProDKin_1	142	148	PF00069	0.795
MOD_ProDKin_1	211	217	PF00069	0.652
MOD_ProDKin_1	253	259	PF00069	0.444
MOD_ProDKin_1	544	550	PF00069	0.553
MOD_ProDKin_1	88	94	PF00069	0.720
MOD_ProDKin_1	97	103	PF00069	0.676
MOD_SUMO_rev_2	133	138	PF00179	0.623
MOD_SUMO_rev_2	259	266	PF00179	0.501
MOD_SUMO_rev_2	382	386	PF00179	0.563
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.445
TRG_ENDOCYTIC_2	286	289	PF00928	0.408
TRG_ER_diArg_1	109	111	PF00400	0.734
TRG_ER_diArg_1	173	176	PF00400	0.753
TRG_ER_diArg_1	196	199	PF00400	0.712
TRG_ER_diArg_1	33	36	PF00400	0.681
TRG_ER_diArg_1	378	381	PF00400	0.538
TRG_ER_diArg_1	454	457	PF00400	0.544
TRG_ER_diArg_1	483	485	PF00400	0.424
TRG_NES_CRM1_1	284	299	PF08389	0.463
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD64	Leptomonas seymouri	57%	100%
A4HEQ5	Leishmania braziliensis	70%	100%
A4I1Y4	Leishmania infantum	99%	100%
C9ZS34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AY31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9E2	Leishmania major	92%	100%