Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDQ2_LEIDO

TriTrypDb:

LdBPK_261700.1 , LdCL_260022600 , LDHU3_26.2130

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.601
CLV_C14_Caspase3-7	212	216	PF00656	0.667
CLV_C14_Caspase3-7	51	55	PF00656	0.713
CLV_C14_Caspase3-7	86	90	PF00656	0.758
CLV_MEL_PAP_1	502	508	PF00089	0.707
CLV_NRD_NRD_1	111	113	PF00675	0.786
CLV_NRD_NRD_1	252	254	PF00675	0.496
CLV_NRD_NRD_1	284	286	PF00675	0.516
CLV_NRD_NRD_1	312	314	PF00675	0.472
CLV_NRD_NRD_1	450	452	PF00675	0.695
CLV_NRD_NRD_1	611	613	PF00675	0.723
CLV_NRD_NRD_1	625	627	PF00675	0.807
CLV_NRD_NRD_1	629	631	PF00675	0.845
CLV_NRD_NRD_1	649	651	PF00675	0.506
CLV_NRD_NRD_1	694	696	PF00675	0.771
CLV_PCSK_FUR_1	626	630	PF00082	0.769
CLV_PCSK_KEX2_1	111	113	PF00082	0.605
CLV_PCSK_KEX2_1	252	254	PF00082	0.496
CLV_PCSK_KEX2_1	284	286	PF00082	0.613
CLV_PCSK_KEX2_1	399	401	PF00082	0.701
CLV_PCSK_KEX2_1	450	452	PF00082	0.695
CLV_PCSK_KEX2_1	610	612	PF00082	0.863
CLV_PCSK_KEX2_1	625	627	PF00082	0.760
CLV_PCSK_KEX2_1	628	630	PF00082	0.793
CLV_PCSK_KEX2_1	634	636	PF00082	0.801
CLV_PCSK_KEX2_1	681	683	PF00082	0.688
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.701
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.755
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.716
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.688
CLV_PCSK_PC7_1	625	631	PF00082	0.768
CLV_PCSK_SKI1_1	231	235	PF00082	0.667
CLV_PCSK_SKI1_1	277	281	PF00082	0.510
CLV_PCSK_SKI1_1	335	339	PF00082	0.579
CLV_PCSK_SKI1_1	41	45	PF00082	0.769
CLV_PCSK_SKI1_1	665	669	PF00082	0.663
CLV_PCSK_SKI1_1	96	100	PF00082	0.732
DEG_SCF_FBW7_1	299	306	PF00400	0.491
DEG_SCF_TRCP1_1	224	230	PF00400	0.606
DEG_SPOP_SBC_1	286	290	PF00917	0.549
DEG_SPOP_SBC_1	599	603	PF00917	0.616
DEG_SPOP_SBC_1	82	86	PF00917	0.653
DOC_CKS1_1	300	305	PF01111	0.505
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.530
DOC_MAPK_gen_1	10	20	PF00069	0.509
DOC_MAPK_gen_1	284	294	PF00069	0.615
DOC_MAPK_gen_1	335	344	PF00069	0.597
DOC_MAPK_gen_1	662	670	PF00069	0.615
DOC_MAPK_HePTP_8	332	344	PF00069	0.522
DOC_MAPK_MEF2A_6	335	344	PF00069	0.538
DOC_PP1_SILK_1	101	106	PF00149	0.725
DOC_PP2B_LxvP_1	546	549	PF13499	0.741
DOC_PP2B_LxvP_1	668	671	PF13499	0.605
DOC_USP7_MATH_1	127	131	PF00917	0.608
DOC_USP7_MATH_1	14	18	PF00917	0.505
DOC_USP7_MATH_1	232	236	PF00917	0.424
DOC_USP7_MATH_1	286	290	PF00917	0.549
DOC_USP7_MATH_1	303	307	PF00917	0.470
DOC_USP7_MATH_1	394	398	PF00917	0.768
DOC_USP7_MATH_1	43	47	PF00917	0.766
DOC_USP7_MATH_1	488	492	PF00917	0.627
DOC_USP7_MATH_1	551	555	PF00917	0.743
DOC_USP7_MATH_1	569	573	PF00917	0.493
DOC_USP7_MATH_1	599	603	PF00917	0.625
DOC_USP7_MATH_1	639	643	PF00917	0.738
DOC_USP7_MATH_1	676	680	PF00917	0.825
DOC_USP7_MATH_1	82	86	PF00917	0.667
DOC_USP7_UBL2_3	652	656	PF12436	0.808
DOC_WW_Pin1_4	287	292	PF00397	0.532
DOC_WW_Pin1_4	299	304	PF00397	0.522
DOC_WW_Pin1_4	53	58	PF00397	0.693
LIG_14-3-3_CanoR_1	174	182	PF00244	0.555
LIG_14-3-3_CanoR_1	231	239	PF00244	0.676
LIG_14-3-3_CanoR_1	284	294	PF00244	0.513
LIG_14-3-3_CanoR_1	385	392	PF00244	0.620
LIG_14-3-3_CanoR_1	400	404	PF00244	0.671
LIG_14-3-3_CanoR_1	415	419	PF00244	0.723
LIG_14-3-3_CanoR_1	430	436	PF00244	0.600
LIG_14-3-3_CanoR_1	550	560	PF00244	0.807
LIG_14-3-3_CanoR_1	662	671	PF00244	0.760
LIG_14-3-3_CanoR_1	682	692	PF00244	0.678
LIG_AP_GAE_1	218	224	PF02883	0.706
LIG_APCC_ABBA_1	157	162	PF00400	0.458
LIG_APCC_ABBA_1	315	320	PF00400	0.569
LIG_APCC_ABBAyCdc20_2	314	320	PF00400	0.632
LIG_BIR_III_2	89	93	PF00653	0.750
LIG_BIR_III_4	113	117	PF00653	0.645
LIG_BRCT_BRCA1_1	23	27	PF00533	0.615
LIG_BRCT_BRCA1_1	401	405	PF00533	0.714
LIG_BRCT_BRCA1_1	431	435	PF00533	0.693
LIG_eIF4E_1	487	493	PF01652	0.625
LIG_FHA_1	320	326	PF00498	0.409
LIG_FHA_1	509	515	PF00498	0.565
LIG_FHA_1	517	523	PF00498	0.562
LIG_FHA_2	173	179	PF00498	0.652
LIG_FHA_2	319	325	PF00498	0.608
LIG_FHA_2	467	473	PF00498	0.643
LIG_FHA_2	585	591	PF00498	0.653
LIG_FHA_2	84	90	PF00498	0.832
LIG_LIR_Gen_1	197	208	PF02991	0.563
LIG_LIR_Gen_1	24	34	PF02991	0.619
LIG_LIR_Gen_1	320	331	PF02991	0.470
LIG_LIR_Gen_1	432	443	PF02991	0.732
LIG_LIR_Gen_1	99	109	PF02991	0.625
LIG_LIR_Nem_3	197	203	PF02991	0.546
LIG_LIR_Nem_3	24	30	PF02991	0.606
LIG_LIR_Nem_3	320	326	PF02991	0.434
LIG_LIR_Nem_3	432	438	PF02991	0.655
LIG_LIR_Nem_3	99	104	PF02991	0.630
LIG_PTB_Apo_2	494	501	PF02174	0.631
LIG_PTB_Phospho_1	494	500	PF10480	0.634
LIG_SH2_CRK	101	105	PF00017	0.709
LIG_SH2_CRK	300	304	PF00017	0.553
LIG_SH2_GRB2like	495	498	PF00017	0.683
LIG_SH2_NCK_1	487	491	PF00017	0.733
LIG_SH2_SRC	487	490	PF00017	0.677
LIG_SH2_SRC	495	498	PF00017	0.612
LIG_SH2_STAP1	161	165	PF00017	0.616
LIG_SH2_STAP1	359	363	PF00017	0.624
LIG_SH2_STAT5	169	172	PF00017	0.513
LIG_SH2_STAT5	200	203	PF00017	0.637
LIG_SH2_STAT5	513	516	PF00017	0.588
LIG_SH3_3	280	286	PF00018	0.556
LIG_SH3_3	325	331	PF00018	0.482
LIG_SH3_3	575	581	PF00018	0.688
LIG_SH3_3	8	14	PF00018	0.529
LIG_SUMO_SIM_anti_2	304	312	PF11976	0.431
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.727
LIG_SUMO_SIM_par_1	187	194	PF11976	0.628
LIG_SxIP_EBH_1	78	87	PF03271	0.648
LIG_TRAF2_1	469	472	PF00917	0.639
LIG_TRAF2_1	61	64	PF00917	0.794
LIG_TYR_ITIM	159	164	PF00017	0.509
MOD_CK1_1	21	27	PF00069	0.600
MOD_CK1_1	268	274	PF00069	0.500
MOD_CK1_1	306	312	PF00069	0.450
MOD_CK1_1	384	390	PF00069	0.684
MOD_CK1_1	410	416	PF00069	0.685
MOD_CK1_1	431	437	PF00069	0.751
MOD_CK1_1	62	68	PF00069	0.692
MOD_CK1_1	642	648	PF00069	0.854
MOD_CK1_1	677	683	PF00069	0.730
MOD_CK1_1	685	691	PF00069	0.726
MOD_CK1_1	699	705	PF00069	0.807
MOD_CK2_1	22	28	PF00069	0.527
MOD_CK2_1	318	324	PF00069	0.524
MOD_CK2_1	385	391	PF00069	0.697
MOD_CK2_1	466	472	PF00069	0.651
MOD_CK2_1	512	518	PF00069	0.609
MOD_CK2_1	535	541	PF00069	0.807
MOD_CK2_1	58	64	PF00069	0.734
MOD_Cter_Amidation	109	112	PF01082	0.591
MOD_Cter_Amidation	448	451	PF01082	0.682
MOD_Cter_Amidation	654	657	PF01082	0.824
MOD_DYRK1A_RPxSP_1	287	291	PF00069	0.538
MOD_GlcNHglycan	106	109	PF01048	0.663
MOD_GlcNHglycan	113	117	PF01048	0.669
MOD_GlcNHglycan	222	227	PF01048	0.704
MOD_GlcNHglycan	262	265	PF01048	0.463
MOD_GlcNHglycan	381	384	PF01048	0.797
MOD_GlcNHglycan	394	397	PF01048	0.585
MOD_GlcNHglycan	45	48	PF01048	0.768
MOD_GlcNHglycan	553	556	PF01048	0.802
MOD_GlcNHglycan	637	640	PF01048	0.727
MOD_GlcNHglycan	641	644	PF01048	0.729
MOD_GlcNHglycan	665	668	PF01048	0.791
MOD_GlcNHglycan	674	677	PF01048	0.822
MOD_GlcNHglycan	685	688	PF01048	0.639
MOD_GlcNHglycan	702	705	PF01048	0.638
MOD_GSK3_1	14	21	PF00069	0.616
MOD_GSK3_1	168	175	PF00069	0.544
MOD_GSK3_1	190	197	PF00069	0.635
MOD_GSK3_1	227	234	PF00069	0.623
MOD_GSK3_1	299	306	PF00069	0.492
MOD_GSK3_1	381	388	PF00069	0.696
MOD_GSK3_1	410	417	PF00069	0.788
MOD_GSK3_1	429	436	PF00069	0.465
MOD_GSK3_1	455	462	PF00069	0.692
MOD_GSK3_1	508	515	PF00069	0.611
MOD_GSK3_1	58	65	PF00069	0.680
MOD_GSK3_1	611	618	PF00069	0.746
MOD_GSK3_1	620	627	PF00069	0.709
MOD_GSK3_1	635	642	PF00069	0.750
MOD_GSK3_1	672	679	PF00069	0.760
MOD_GSK3_1	681	688	PF00069	0.686
MOD_GSK3_1	696	703	PF00069	0.649
MOD_GSK3_1	76	83	PF00069	0.736
MOD_N-GLC_1	203	208	PF02516	0.556
MOD_N-GLC_1	326	331	PF02516	0.497
MOD_N-GLC_1	428	433	PF02516	0.794
MOD_NEK2_1	152	157	PF00069	0.462
MOD_NEK2_1	203	208	PF00069	0.629
MOD_NEK2_1	260	265	PF00069	0.460
MOD_NEK2_1	381	386	PF00069	0.781
MOD_NEK2_1	392	397	PF00069	0.638
MOD_NEK2_1	584	589	PF00069	0.653
MOD_NEK2_1	624	629	PF00069	0.768
MOD_PIKK_1	523	529	PF00454	0.611
MOD_PIKK_1	59	65	PF00454	0.828
MOD_PIKK_1	644	650	PF00454	0.728
MOD_PKA_1	399	405	PF00069	0.692
MOD_PKA_1	610	616	PF00069	0.743
MOD_PKA_1	630	636	PF00069	0.500
MOD_PKA_1	681	687	PF00069	0.628
MOD_PKA_2	104	110	PF00069	0.758
MOD_PKA_2	173	179	PF00069	0.604
MOD_PKA_2	286	292	PF00069	0.531
MOD_PKA_2	384	390	PF00069	0.746
MOD_PKA_2	399	405	PF00069	0.667
MOD_PKA_2	414	420	PF00069	0.698
MOD_PKA_2	429	435	PF00069	0.517
MOD_PKA_2	516	522	PF00069	0.571
MOD_PKA_2	551	557	PF00069	0.806
MOD_PKA_2	610	616	PF00069	0.784
MOD_PKA_2	624	630	PF00069	0.743
MOD_PKA_2	639	645	PF00069	0.653
MOD_PKA_2	661	667	PF00069	0.719
MOD_PKA_2	681	687	PF00069	0.833
MOD_PKA_2	699	705	PF00069	0.666
MOD_PKB_1	628	636	PF00069	0.766
MOD_Plk_1	268	274	PF00069	0.403
MOD_Plk_1	319	325	PF00069	0.490
MOD_Plk_1	407	413	PF00069	0.748
MOD_Plk_1	488	494	PF00069	0.625
MOD_Plk_4	262	268	PF00069	0.455
MOD_Plk_4	306	312	PF00069	0.554
MOD_Plk_4	336	342	PF00069	0.415
MOD_Plk_4	434	440	PF00069	0.737
MOD_Plk_4	488	494	PF00069	0.625
MOD_Plk_4	556	562	PF00069	0.727
MOD_Plk_4	99	105	PF00069	0.728
MOD_ProDKin_1	287	293	PF00069	0.522
MOD_ProDKin_1	299	305	PF00069	0.514
MOD_ProDKin_1	53	59	PF00069	0.695
MOD_SUMO_for_1	48	51	PF00179	0.694
MOD_SUMO_rev_2	330	340	PF00179	0.502
MOD_SUMO_rev_2	358	364	PF00179	0.561
MOD_SUMO_rev_2	89	98	PF00179	0.741
TRG_DiLeu_BaEn_4	471	477	PF01217	0.633
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.513
TRG_ENDOCYTIC_2	101	104	PF00928	0.709
TRG_ENDOCYTIC_2	161	164	PF00928	0.538
TRG_ENDOCYTIC_2	200	203	PF00928	0.651
TRG_ER_diArg_1	251	253	PF00400	0.497
TRG_ER_diArg_1	283	285	PF00400	0.594
TRG_ER_diArg_1	32	35	PF00400	0.658
TRG_ER_diArg_1	549	552	PF00400	0.810
TRG_ER_diArg_1	624	626	PF00400	0.757
TRG_ER_diArg_1	628	630	PF00400	0.768
TRG_NLS_Bipartite_1	634	654	PF00514	0.827
TRG_NLS_MonoCore_2	608	613	PF00514	0.670
TRG_NLS_MonoExtN_4	609	614	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM04	Leptomonas seymouri	54%	98%
A4HD56	Leishmania braziliensis	74%	100%
A4I2A4	Leishmania infantum	99%	100%
E9AYF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q921	Leishmania major	92%	100%