Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDQ0_LEIDO

TriTrypDb:

LdBPK_280880.1 , LdCL_280013400 , LDHU3_28.1050

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.486
CLV_C14_Caspase3-7	222	226	PF00656	0.747
CLV_C14_Caspase3-7	262	266	PF00656	0.600
CLV_NRD_NRD_1	123	125	PF00675	0.458
CLV_NRD_NRD_1	162	164	PF00675	0.454
CLV_NRD_NRD_1	275	277	PF00675	0.424
CLV_NRD_NRD_1	383	385	PF00675	0.747
CLV_NRD_NRD_1	433	435	PF00675	0.517
CLV_NRD_NRD_1	75	77	PF00675	0.566
CLV_NRD_NRD_1	90	92	PF00675	0.484
CLV_PCSK_FUR_1	273	277	PF00082	0.548
CLV_PCSK_FUR_1	72	76	PF00082	0.665
CLV_PCSK_KEX2_1	273	275	PF00082	0.430
CLV_PCSK_KEX2_1	383	385	PF00082	0.753
CLV_PCSK_KEX2_1	433	435	PF00082	0.518
CLV_PCSK_KEX2_1	74	76	PF00082	0.570
CLV_PCSK_KEX2_1	90	92	PF00082	0.495
CLV_PCSK_PC7_1	270	276	PF00082	0.511
CLV_PCSK_PC7_1	86	92	PF00082	0.629
CLV_PCSK_SKI1_1	107	111	PF00082	0.549
CLV_PCSK_SKI1_1	164	168	PF00082	0.504
CLV_PCSK_SKI1_1	314	318	PF00082	0.367
CLV_PCSK_SKI1_1	359	363	PF00082	0.811
CLV_PCSK_SKI1_1	94	98	PF00082	0.540
CLV_Separin_Metazoa	340	344	PF03568	0.599
DEG_APCC_DBOX_1	136	144	PF00400	0.400
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DEG_SCF_FBW7_2	215	222	PF00400	0.589
DEG_SPOP_SBC_1	60	64	PF00917	0.742
DOC_CKS1_1	80	85	PF01111	0.626
DOC_MAPK_gen_1	484	492	PF00069	0.460
DOC_PP4_FxxP_1	185	188	PF00568	0.492
DOC_PP4_FxxP_1	338	341	PF00568	0.470
DOC_PP4_FxxP_1	388	391	PF00568	0.700
DOC_USP7_MATH_1	178	182	PF00917	0.454
DOC_USP7_MATH_1	257	261	PF00917	0.601
DOC_USP7_MATH_1	396	400	PF00917	0.635
DOC_USP7_MATH_1	60	64	PF00917	0.732
DOC_USP7_UBL2_3	160	164	PF12436	0.556
DOC_WW_Pin1_4	18	23	PF00397	0.558
DOC_WW_Pin1_4	202	207	PF00397	0.726
DOC_WW_Pin1_4	215	220	PF00397	0.750
DOC_WW_Pin1_4	296	301	PF00397	0.599
DOC_WW_Pin1_4	369	374	PF00397	0.791
DOC_WW_Pin1_4	79	84	PF00397	0.622
LIG_14-3-3_CanoR_1	177	187	PF00244	0.469
LIG_14-3-3_CanoR_1	2	10	PF00244	0.724
LIG_14-3-3_CanoR_1	202	206	PF00244	0.654
LIG_14-3-3_CanoR_1	398	403	PF00244	0.577
LIG_14-3-3_CanoR_1	407	413	PF00244	0.479
LIG_14-3-3_CanoR_1	418	424	PF00244	0.380
LIG_14-3-3_CanoR_1	449	456	PF00244	0.620
LIG_14-3-3_CanoR_1	74	80	PF00244	0.558
LIG_Actin_WH2_2	133	151	PF00022	0.484
LIG_BIR_III_2	40	44	PF00653	0.601
LIG_BIR_III_4	424	428	PF00653	0.449
LIG_BRCT_BRCA1_1	181	185	PF00533	0.561
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.373
LIG_FHA_1	24	30	PF00498	0.739
LIG_FHA_1	390	396	PF00498	0.711
LIG_FHA_1	5	11	PF00498	0.569
LIG_FHA_2	111	117	PF00498	0.451
LIG_FHA_2	128	134	PF00498	0.553
LIG_FHA_2	215	221	PF00498	0.756
LIG_FHA_2	335	341	PF00498	0.554
LIG_FHA_2	409	415	PF00498	0.648
LIG_FHA_2	491	497	PF00498	0.539
LIG_FHA_2	80	86	PF00498	0.490
LIG_GBD_Chelix_1	140	148	PF00786	0.413
LIG_LIR_Apic_2	182	188	PF02991	0.521
LIG_LIR_Apic_2	336	341	PF02991	0.461
LIG_LIR_Apic_2	386	391	PF02991	0.686
LIG_LIR_Gen_1	126	136	PF02991	0.411
LIG_LIR_Nem_3	103	109	PF02991	0.657
LIG_LIR_Nem_3	126	131	PF02991	0.425
LIG_LIR_Nem_3	302	307	PF02991	0.472
LIG_LIR_Nem_3	426	432	PF02991	0.424
LIG_Pex14_1	325	329	PF04695	0.374
LIG_RPA_C_Fungi	151	163	PF08784	0.536
LIG_SH2_CRK	165	169	PF00017	0.427
LIG_SH2_STAP1	30	34	PF00017	0.624
LIG_SH2_STAT5	114	117	PF00017	0.508
LIG_SH2_STAT5	147	150	PF00017	0.410
LIG_SH2_STAT5	30	33	PF00017	0.699
LIG_SH2_STAT5	329	332	PF00017	0.397
LIG_SH3_1	99	105	PF00018	0.521
LIG_SH3_2	102	107	PF14604	0.650
LIG_SH3_3	388	394	PF00018	0.590
LIG_SH3_3	460	466	PF00018	0.462
LIG_SH3_3	63	69	PF00018	0.777
LIG_SH3_3	77	83	PF00018	0.578
LIG_SH3_3	99	105	PF00018	0.521
LIG_TRAF2_1	259	262	PF00917	0.578
LIG_WW_3	340	344	PF00397	0.599
MOD_CDK_SPK_2	79	84	PF00069	0.637
MOD_CDK_SPxxK_3	79	86	PF00069	0.631
MOD_CK1_1	20	26	PF00069	0.598
MOD_CK1_1	204	210	PF00069	0.656
MOD_CK1_1	296	302	PF00069	0.660
MOD_CK1_1	4	10	PF00069	0.664
MOD_CK1_1	479	485	PF00069	0.650
MOD_CK1_1	50	56	PF00069	0.753
MOD_CK1_1	64	70	PF00069	0.593
MOD_CK2_1	132	138	PF00069	0.577
MOD_CK2_1	214	220	PF00069	0.643
MOD_CK2_1	257	263	PF00069	0.639
MOD_CK2_1	334	340	PF00069	0.531
MOD_CK2_1	354	360	PF00069	0.477
MOD_CK2_1	433	439	PF00069	0.672
MOD_CK2_1	448	454	PF00069	0.622
MOD_CK2_1	490	496	PF00069	0.476
MOD_CK2_1	79	85	PF00069	0.498
MOD_Cter_Amidation	122	125	PF01082	0.414
MOD_Cter_Amidation	381	384	PF01082	0.588
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.529
MOD_GlcNHglycan	181	184	PF01048	0.500
MOD_GlcNHglycan	206	209	PF01048	0.563
MOD_GlcNHglycan	252	256	PF01048	0.728
MOD_GlcNHglycan	301	304	PF01048	0.512
MOD_GlcNHglycan	385	388	PF01048	0.658
MOD_GlcNHglycan	398	401	PF01048	0.551
MOD_GlcNHglycan	63	66	PF01048	0.691
MOD_GSK3_1	16	23	PF00069	0.656
MOD_GSK3_1	209	216	PF00069	0.619
MOD_GSK3_1	235	242	PF00069	0.677
MOD_GSK3_1	314	321	PF00069	0.447
MOD_GSK3_1	448	455	PF00069	0.512
MOD_GSK3_1	50	57	PF00069	0.712
MOD_GSK3_1	60	67	PF00069	0.607
MOD_GSK3_1	75	82	PF00069	0.457
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	10	15	PF00069	0.549
MOD_NEK2_1	148	153	PF00069	0.525
MOD_NEK2_1	167	172	PF00069	0.397
MOD_NEK2_1	211	216	PF00069	0.526
MOD_NEK2_1	282	287	PF00069	0.496
MOD_NEK2_1	29	34	PF00069	0.649
MOD_NEK2_1	408	413	PF00069	0.519
MOD_NEK2_1	61	66	PF00069	0.735
MOD_PIKK_1	257	263	PF00454	0.637
MOD_PIKK_1	64	70	PF00454	0.645
MOD_PKA_1	124	130	PF00069	0.494
MOD_PKA_1	383	389	PF00069	0.758
MOD_PKA_1	433	439	PF00069	0.626
MOD_PKA_1	74	80	PF00069	0.540
MOD_PKA_2	1	7	PF00069	0.621
MOD_PKA_2	148	154	PF00069	0.545
MOD_PKA_2	201	207	PF00069	0.649
MOD_PKA_2	383	389	PF00069	0.669
MOD_PKA_2	419	425	PF00069	0.505
MOD_PKA_2	433	439	PF00069	0.524
MOD_PKA_2	448	454	PF00069	0.483
MOD_PKA_2	490	496	PF00069	0.476
MOD_PKA_2	54	60	PF00069	0.712
MOD_PKA_2	74	80	PF00069	0.484
MOD_PKB_1	72	80	PF00069	0.643
MOD_Plk_1	132	138	PF00069	0.550
MOD_Plk_1	314	320	PF00069	0.442
MOD_Plk_1	333	339	PF00069	0.329
MOD_Plk_2-3	132	138	PF00069	0.535
MOD_Plk_2-3	334	340	PF00069	0.564
MOD_Plk_2-3	352	358	PF00069	0.550
MOD_Plk_4	10	16	PF00069	0.498
MOD_Plk_4	110	116	PF00069	0.571
MOD_Plk_4	318	324	PF00069	0.386
MOD_ProDKin_1	18	24	PF00069	0.560
MOD_ProDKin_1	202	208	PF00069	0.729
MOD_ProDKin_1	215	221	PF00069	0.751
MOD_ProDKin_1	296	302	PF00069	0.600
MOD_ProDKin_1	369	375	PF00069	0.790
MOD_ProDKin_1	79	85	PF00069	0.618
MOD_SUMO_rev_2	88	96	PF00179	0.602
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.483
TRG_ENDOCYTIC_2	165	168	PF00928	0.408
TRG_ENDOCYTIC_2	429	432	PF00928	0.565
TRG_ER_diArg_1	273	276	PF00400	0.449
TRG_ER_diArg_1	307	310	PF00400	0.409
TRG_ER_diArg_1	342	345	PF00400	0.622
TRG_ER_diArg_1	383	385	PF00400	0.570
TRG_ER_diArg_1	405	408	PF00400	0.532
TRG_ER_diArg_1	432	434	PF00400	0.496
TRG_ER_diArg_1	73	76	PF00400	0.600
TRG_ER_diArg_1	89	91	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G0	Leptomonas seymouri	59%	100%
A0A0S4IT28	Bodo saltans	35%	100%
A0A1X0NYF9	Trypanosomatidae	47%	100%
A0A3R7M5S0	Trypanosoma rangeli	46%	100%
A4HGC4	Leishmania braziliensis	81%	100%
A4I3F7	Leishmania infantum	100%	100%
D0A7Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AZP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q8I7	Leishmania major	95%	100%
V5BKT5	Trypanosoma cruzi	43%	100%