LeishMANIAdb
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Small myristoylated protein 4, putative

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small myristoylated protein 4, putative
Gene product:
calpain-like cysteine peptidase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDP8_LEIDO
TriTrypDb:
LdBPK_201320.1 , LdCL_200017800 , LDHU3_20.1670
Length:
151

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Proteases, calpain-like cysteine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 2
Forrest at al. (metacyclic) yes yes: 5
Forrest at al. (procyclic) yes yes: 7
Silverman et al. no yes: 1
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 46
NetGPI no yes: 0, no: 46
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 2
GO:0020018 ciliary pocket membrane 6 1
GO:0031090 organelle membrane 3 2
GO:0031253 cell projection membrane 4 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
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Phosphorylation

Promastigote: 148, 149

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IDP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDP8

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
TermNameLevelCount
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044000 movement in host 4 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044409 entry into host 5 1
Previous12Next
Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 81 85 PF00656 0.232
CLV_NRD_NRD_1 125 127 PF00675 0.388
CLV_PCSK_KEX2_1 125 127 PF00082 0.404
CLV_PCSK_KEX2_1 130 132 PF00082 0.447
CLV_PCSK_KEX2_1 54 56 PF00082 0.391
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.468
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.347
CLV_PCSK_PC7_1 126 132 PF00082 0.429
CLV_PCSK_SKI1_1 131 135 PF00082 0.600
DOC_MAPK_gen_1 54 62 PF00069 0.397
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P6Y3 Leptomonas seymouri 44% 100%
A0A0N1HYV4 Leptomonas seymouri 43% 100%
A0A0N1I5S6 Leptomonas seymouri 71% 98%
A0A0N1PCZ0 Leptomonas seymouri 42% 100%
A0A0N1PE11 Leptomonas seymouri 35% 100%
A0A1X0NW79 Trypanosomatidae 47% 76%
A0A1X0NW95 Trypanosomatidae 45% 100%
A0A1X0NWH2 Trypanosomatidae 32% 100%
A0A1X0NWV3 Trypanosomatidae 49% 100%
A0A1X0NXT9 Trypanosomatidae 35% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS