Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDP1_LEIDO

TriTrypDb:

LdBPK_272440.1 , LdCL_270032800 , LDHU3_27.3680

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDP1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016874	ligase activity	2	9
GO:0004835	tubulin-tyrosine ligase activity	3	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.500
CLV_NRD_NRD_1	214	216	PF00675	0.318
CLV_NRD_NRD_1	282	284	PF00675	0.299
CLV_NRD_NRD_1	492	494	PF00675	0.700
CLV_NRD_NRD_1	523	525	PF00675	0.484
CLV_NRD_NRD_1	57	59	PF00675	0.427
CLV_NRD_NRD_1	88	90	PF00675	0.789
CLV_PCSK_KEX2_1	125	127	PF00082	0.507
CLV_PCSK_KEX2_1	214	216	PF00082	0.272
CLV_PCSK_KEX2_1	491	493	PF00082	0.700
CLV_PCSK_KEX2_1	523	525	PF00082	0.518
CLV_PCSK_KEX2_1	57	59	PF00082	0.427
CLV_PCSK_SKI1_1	154	158	PF00082	0.488
CLV_PCSK_SKI1_1	214	218	PF00082	0.262
CLV_PCSK_SKI1_1	242	246	PF00082	0.314
CLV_PCSK_SKI1_1	275	279	PF00082	0.302
CLV_PCSK_SKI1_1	375	379	PF00082	0.325
CLV_PCSK_SKI1_1	380	384	PF00082	0.336
CLV_PCSK_SKI1_1	429	433	PF00082	0.458
CLV_PCSK_SKI1_1	439	443	PF00082	0.460
CLV_PCSK_SKI1_1	62	66	PF00082	0.649
DEG_APCC_DBOX_1	214	222	PF00400	0.533
DEG_APCC_DBOX_1	379	387	PF00400	0.509
DEG_SPOP_SBC_1	481	485	PF00917	0.582
DEG_SPOP_SBC_1	63	67	PF00917	0.580
DOC_CDC14_PxL_1	16	24	PF14671	0.407
DOC_CKS1_1	430	435	PF01111	0.462
DOC_CYCLIN_RxL_1	369	381	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.475
DOC_MAPK_gen_1	240	247	PF00069	0.510
DOC_MAPK_gen_1	283	289	PF00069	0.476
DOC_PP2B_LxvP_1	48	51	PF13499	0.412
DOC_PP4_FxxP_1	143	146	PF00568	0.405
DOC_PP4_FxxP_1	430	433	PF00568	0.475
DOC_SPAK_OSR1_1	142	146	PF12202	0.400
DOC_USP7_MATH_1	156	160	PF00917	0.446
DOC_USP7_MATH_1	260	264	PF00917	0.516
DOC_USP7_MATH_1	456	460	PF00917	0.637
DOC_USP7_MATH_1	482	486	PF00917	0.635
DOC_USP7_MATH_1	63	67	PF00917	0.603
DOC_USP7_MATH_1	78	82	PF00917	0.690
DOC_USP7_MATH_1	91	95	PF00917	0.559
DOC_WW_Pin1_4	24	29	PF00397	0.412
DOC_WW_Pin1_4	292	297	PF00397	0.499
DOC_WW_Pin1_4	420	425	PF00397	0.475
DOC_WW_Pin1_4	429	434	PF00397	0.411
DOC_WW_Pin1_4	477	482	PF00397	0.761
DOC_WW_Pin1_4	499	504	PF00397	0.651
DOC_WW_Pin1_4	67	72	PF00397	0.696
DOC_WW_Pin1_4	7	12	PF00397	0.446
DOC_WW_Pin1_4	81	86	PF00397	0.597
LIG_14-3-3_CanoR_1	125	132	PF00244	0.459
LIG_14-3-3_CanoR_1	175	179	PF00244	0.519
LIG_14-3-3_CanoR_1	248	256	PF00244	0.571
LIG_14-3-3_CanoR_1	308	313	PF00244	0.475
LIG_14-3-3_CanoR_1	491	498	PF00244	0.748
LIG_14-3-3_CanoR_1	62	71	PF00244	0.536
LIG_Actin_WH2_2	43	59	PF00022	0.415
LIG_APCC_ABBA_1	109	114	PF00400	0.383
LIG_BIR_III_2	526	530	PF00653	0.510
LIG_BRCT_BRCA1_1	105	109	PF00533	0.504
LIG_BRCT_BRCA1_1	157	161	PF00533	0.485
LIG_BRCT_BRCA1_1	48	52	PF00533	0.413
LIG_BRCT_BRCA1_1	494	498	PF00533	0.660
LIG_Clathr_ClatBox_1	149	153	PF01394	0.463
LIG_CSL_BTD_1	347	350	PF09270	0.499
LIG_deltaCOP1_diTrp_1	190	196	PF00928	0.506
LIG_eIF4E_1	272	278	PF01652	0.475
LIG_eIF4E_1	397	403	PF01652	0.499
LIG_FHA_1	106	112	PF00498	0.456
LIG_FHA_1	162	168	PF00498	0.411
LIG_FHA_1	366	372	PF00498	0.518
LIG_FHA_1	43	49	PF00498	0.561
LIG_FHA_1	430	436	PF00498	0.481
LIG_FHA_2	307	313	PF00498	0.558
LIG_FHA_2	460	466	PF00498	0.745
LIG_GBD_Chelix_1	378	386	PF00786	0.371
LIG_Integrin_isoDGR_2	281	283	PF01839	0.316
LIG_Integrin_RGD_1	524	526	PF01839	0.510
LIG_LIR_Apic_2	141	146	PF02991	0.394
LIG_LIR_Apic_2	428	433	PF02991	0.441
LIG_LIR_Gen_1	110	119	PF02991	0.385
LIG_LIR_Nem_3	106	112	PF02991	0.409
LIG_LIR_Nem_3	164	169	PF02991	0.400
LIG_LIR_Nem_3	295	300	PF02991	0.499
LIG_LIR_Nem_3	3	9	PF02991	0.445
LIG_LIR_Nem_3	394	400	PF02991	0.474
LIG_LIR_Nem_3	515	521	PF02991	0.554
LIG_MYND_1	7	11	PF01753	0.392
LIG_PCNA_PIPBox_1	186	195	PF02747	0.516
LIG_Pex14_1	166	170	PF04695	0.412
LIG_Pex14_2	518	522	PF04695	0.433
LIG_SH2_CRK	147	151	PF00017	0.391
LIG_SH2_CRK	302	306	PF00017	0.488
LIG_SH2_CRK	405	409	PF00017	0.475
LIG_SH2_NCK_1	302	306	PF00017	0.533
LIG_SH2_SRC	201	204	PF00017	0.517
LIG_SH2_STAP1	112	116	PF00017	0.413
LIG_SH2_STAP1	297	301	PF00017	0.475
LIG_SH2_STAP1	405	409	PF00017	0.475
LIG_SH2_STAT3	267	270	PF00017	0.533
LIG_SH2_STAT5	102	105	PF00017	0.454
LIG_SH2_STAT5	147	150	PF00017	0.535
LIG_SH2_STAT5	169	172	PF00017	0.459
LIG_SH2_STAT5	267	270	PF00017	0.486
LIG_SH2_STAT5	272	275	PF00017	0.462
LIG_SH2_STAT5	302	305	PF00017	0.537
LIG_SH2_STAT5	355	358	PF00017	0.499
LIG_SH3_3	270	276	PF00018	0.475
LIG_SH3_3	5	11	PF00018	0.448
LIG_SUMO_SIM_par_1	274	280	PF11976	0.533
LIG_TYR_ITIM	145	150	PF00017	0.383
MOD_CDK_SPxxK_3	429	436	PF00069	0.466
MOD_CK1_1	107	113	PF00069	0.392
MOD_CK1_1	295	301	PF00069	0.497
MOD_CK1_1	306	312	PF00069	0.442
MOD_CK1_1	317	323	PF00069	0.482
MOD_CK1_1	354	360	PF00069	0.516
MOD_CK1_1	459	465	PF00069	0.739
MOD_CK1_1	472	478	PF00069	0.546
MOD_CK1_1	480	486	PF00069	0.748
MOD_CK1_1	499	505	PF00069	0.593
MOD_CK1_1	80	86	PF00069	0.750
MOD_CK1_1	98	104	PF00069	0.416
MOD_CK2_1	107	113	PF00069	0.406
MOD_CK2_1	306	312	PF00069	0.488
MOD_CK2_1	434	440	PF00069	0.531
MOD_CK2_1	459	465	PF00069	0.743
MOD_CMANNOS	193	196	PF00535	0.333
MOD_Cter_Amidation	281	284	PF01082	0.300
MOD_Cter_Amidation	489	492	PF01082	0.688
MOD_GlcNHglycan	236	239	PF01048	0.276
MOD_GlcNHglycan	249	252	PF01048	0.236
MOD_GlcNHglycan	475	478	PF01048	0.743
MOD_GlcNHglycan	498	501	PF01048	0.722
MOD_GlcNHglycan	93	96	PF01048	0.680
MOD_GlcNHglycan	97	100	PF01048	0.505
MOD_GSK3_1	103	110	PF00069	0.430
MOD_GSK3_1	127	134	PF00069	0.524
MOD_GSK3_1	170	177	PF00069	0.463
MOD_GSK3_1	20	27	PF00069	0.448
MOD_GSK3_1	351	358	PF00069	0.516
MOD_GSK3_1	38	45	PF00069	0.450
MOD_GSK3_1	447	454	PF00069	0.731
MOD_GSK3_1	456	463	PF00069	0.683
MOD_GSK3_1	465	472	PF00069	0.566
MOD_GSK3_1	473	480	PF00069	0.737
MOD_GSK3_1	492	499	PF00069	0.520
MOD_GSK3_1	63	70	PF00069	0.645
MOD_GSK3_1	77	84	PF00069	0.583
MOD_GSK3_1	91	98	PF00069	0.657
MOD_N-GLC_1	420	425	PF02516	0.275
MOD_N-GLC_1	469	474	PF02516	0.711
MOD_N-GLC_2	328	330	PF02516	0.275
MOD_N-GLC_2	486	488	PF02516	0.556
MOD_NEK2_1	103	108	PF00069	0.415
MOD_NEK2_1	155	160	PF00069	0.461
MOD_NEK2_1	161	166	PF00069	0.378
MOD_NEK2_1	170	175	PF00069	0.403
MOD_NEK2_1	247	252	PF00069	0.506
MOD_NEK2_1	277	282	PF00069	0.579
MOD_NEK2_1	29	34	PF00069	0.474
MOD_NEK2_1	365	370	PF00069	0.535
MOD_NEK2_1	378	383	PF00069	0.526
MOD_NEK2_1	434	439	PF00069	0.470
MOD_NEK2_1	52	57	PF00069	0.512
MOD_NEK2_1	64	69	PF00069	0.666
MOD_NEK2_2	262	267	PF00069	0.446
MOD_PIKK_1	300	306	PF00454	0.571
MOD_PKA_1	125	131	PF00069	0.505
MOD_PKA_1	491	497	PF00069	0.659
MOD_PKA_2	125	131	PF00069	0.434
MOD_PKA_2	174	180	PF00069	0.470
MOD_PKA_2	247	253	PF00069	0.571
MOD_PKA_2	491	497	PF00069	0.752
MOD_Plk_4	145	151	PF00069	0.398
MOD_Plk_4	156	162	PF00069	0.357
MOD_Plk_4	295	301	PF00069	0.489
MOD_Plk_4	351	357	PF00069	0.516
MOD_Plk_4	98	104	PF00069	0.435
MOD_ProDKin_1	24	30	PF00069	0.415
MOD_ProDKin_1	292	298	PF00069	0.499
MOD_ProDKin_1	420	426	PF00069	0.475
MOD_ProDKin_1	429	435	PF00069	0.405
MOD_ProDKin_1	477	483	PF00069	0.760
MOD_ProDKin_1	499	505	PF00069	0.648
MOD_ProDKin_1	67	73	PF00069	0.697
MOD_ProDKin_1	7	13	PF00069	0.448
MOD_ProDKin_1	81	87	PF00069	0.597
TRG_DiLeu_BaEn_1	213	218	PF01217	0.533
TRG_DiLeu_BaEn_1	516	521	PF01217	0.554
TRG_DiLeu_BaEn_2	513	519	PF01217	0.576
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.475
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.558
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.400
TRG_ENDOCYTIC_2	112	115	PF00928	0.381
TRG_ENDOCYTIC_2	147	150	PF00928	0.386
TRG_ENDOCYTIC_2	302	305	PF00928	0.488
TRG_ENDOCYTIC_2	397	400	PF00928	0.482
TRG_ENDOCYTIC_2	405	408	PF00928	0.451
TRG_ER_diArg_1	124	126	PF00400	0.575
TRG_ER_diArg_1	491	493	PF00400	0.700
TRG_ER_diArg_1	522	524	PF00400	0.453
TRG_ER_diArg_1	56	58	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.219
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A1	Leptomonas seymouri	65%	100%
A0A0S4ISF0	Bodo saltans	25%	94%
A0A0S4J6I6	Bodo saltans	40%	100%
A0A422N932	Trypanosoma rangeli	24%	100%
A0A422NE52	Trypanosoma rangeli	48%	100%
A4H9E1	Leishmania braziliensis	23%	100%
A4HG29	Leishmania braziliensis	79%	100%
A4I351	Leishmania infantum	100%	100%
A4Q9E4	Mus musculus	27%	99%
E9ACW9	Leishmania major	94%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%