Protein YIF1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIF1

Gene product:

protein transport protein YIF1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDN8_LEIDO

TriTrypDb:

LdBPK_201160.1 , LdCL_200016300 , LDHU3_20.1430

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3Q8IDN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDN8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.273
CLV_NRD_NRD_1	96	98	PF00675	0.207
CLV_PCSK_KEX2_1	81	83	PF00082	0.272
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.278
CLV_PCSK_SKI1_1	241	245	PF00082	0.321
CLV_PCSK_SKI1_1	297	301	PF00082	0.368
DEG_Nend_UBRbox_3	1	3	PF02207	0.763
DOC_CKS1_1	1	6	PF01111	0.706
DOC_MAPK_gen_1	81	87	PF00069	0.443
DOC_MAPK_MEF2A_6	241	249	PF00069	0.334
DOC_MAPK_MEF2A_6	81	89	PF00069	0.464
DOC_MAPK_NFAT4_5	82	90	PF00069	0.558
DOC_PP2B_LxvP_1	166	169	PF13499	0.453
DOC_PP2B_LxvP_1	224	227	PF13499	0.502
DOC_PP2B_LxvP_1	87	90	PF13499	0.539
DOC_PP4_FxxP_1	122	125	PF00568	0.535
DOC_PP4_FxxP_1	151	154	PF00568	0.558
DOC_USP7_MATH_1	152	156	PF00917	0.528
DOC_USP7_MATH_1	169	173	PF00917	0.372
DOC_USP7_MATH_1	189	193	PF00917	0.122
DOC_USP7_UBL2_3	94	98	PF12436	0.539
DOC_WW_Pin1_4	125	130	PF00397	0.477
DOC_WW_Pin1_4	134	139	PF00397	0.491
DOC_WW_Pin1_4	16	21	PF00397	0.709
DOC_WW_Pin1_4	185	190	PF00397	0.339
DOC_WW_Pin1_4	3	8	PF00397	0.685
DOC_WW_Pin1_4	96	101	PF00397	0.534
LIG_14-3-3_CanoR_1	297	302	PF00244	0.545
LIG_Actin_WH2_2	204	219	PF00022	0.348
LIG_BRCT_BRCA1_1	261	265	PF00533	0.434
LIG_BRCT_BRCA1_1	295	299	PF00533	0.405
LIG_eIF4E_1	79	85	PF01652	0.514
LIG_FHA_1	173	179	PF00498	0.377
LIG_FHA_1	188	194	PF00498	0.264
LIG_FHA_1	199	205	PF00498	0.309
LIG_FHA_1	275	281	PF00498	0.438
LIG_FHA_1	4	10	PF00498	0.760
LIG_FHA_1	91	97	PF00498	0.523
LIG_LIR_Apic_2	119	125	PF02991	0.535
LIG_LIR_Apic_2	150	154	PF02991	0.546
LIG_LIR_Gen_1	175	184	PF02991	0.307
LIG_LIR_Gen_1	296	306	PF02991	0.433
LIG_LIR_Nem_3	131	136	PF02991	0.534
LIG_LIR_Nem_3	164	170	PF02991	0.457
LIG_LIR_Nem_3	175	179	PF02991	0.305
LIG_LIR_Nem_3	258	264	PF02991	0.295
LIG_LIR_Nem_3	274	278	PF02991	0.353
LIG_PCNA_yPIPBox_3	228	241	PF02747	0.538
LIG_REV1ctd_RIR_1	24	31	PF16727	0.739
LIG_REV1ctd_RIR_1	273	283	PF16727	0.362
LIG_REV1ctd_RIR_1	89	98	PF16727	0.461
LIG_SH2_CRK	221	225	PF00017	0.452
LIG_SH2_CRK	240	244	PF00017	0.203
LIG_SH2_CRK	261	265	PF00017	0.426
LIG_SH2_CRK	268	272	PF00017	0.426
LIG_SH2_CRK	62	66	PF00017	0.567
LIG_SH2_PTP2	167	170	PF00017	0.327
LIG_SH2_PTP2	176	179	PF00017	0.275
LIG_SH2_PTP2	242	245	PF00017	0.340
LIG_SH2_STAP1	221	225	PF00017	0.452
LIG_SH2_STAP1	268	272	PF00017	0.442
LIG_SH2_STAT5	167	170	PF00017	0.305
LIG_SH2_STAT5	176	179	PF00017	0.305
LIG_SH2_STAT5	182	185	PF00017	0.305
LIG_SH2_STAT5	242	245	PF00017	0.292
LIG_SH2_STAT5	72	75	PF00017	0.468
LIG_SH2_STAT5	79	82	PF00017	0.443
LIG_SH2_STAT5	95	98	PF00017	0.443
LIG_SH3_3	1	7	PF00018	0.672
LIG_SH3_3	151	157	PF00018	0.517
LIG_SH3_3	223	229	PF00018	0.553
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.390
LIG_SUMO_SIM_par_1	83	88	PF11976	0.539
LIG_TYR_ITIM	174	179	PF00017	0.305
LIG_TYR_ITIM	219	224	PF00017	0.336
LIG_UBA3_1	234	241	PF00899	0.378
LIG_UBA3_1	85	94	PF00899	0.536
MOD_CK1_1	128	134	PF00069	0.482
MOD_CK1_1	137	143	PF00069	0.482
MOD_CK1_1	172	178	PF00069	0.426
MOD_CK1_1	188	194	PF00069	0.264
MOD_CK1_1	197	203	PF00069	0.292
MOD_CK1_1	274	280	PF00069	0.405
MOD_GlcNHglycan	109	112	PF01048	0.254
MOD_GlcNHglycan	16	19	PF01048	0.511
MOD_GlcNHglycan	261	264	PF01048	0.384
MOD_GSK3_1	102	109	PF00069	0.515
MOD_GSK3_1	185	192	PF00069	0.329
MOD_GSK3_1	194	201	PF00069	0.265
MOD_GSK3_1	255	262	PF00069	0.345
MOD_GSK3_1	293	300	PF00069	0.502
MOD_NEK2_1	107	112	PF00069	0.536
MOD_NEK2_1	198	203	PF00069	0.297
MOD_NEK2_1	271	276	PF00069	0.341
MOD_NEK2_1	39	44	PF00069	0.514
MOD_PIKK_1	249	255	PF00454	0.452
MOD_PKB_1	295	303	PF00069	0.558
MOD_Plk_1	75	81	PF00069	0.539
MOD_Plk_4	128	134	PF00069	0.552
MOD_Plk_4	169	175	PF00069	0.370
MOD_Plk_4	194	200	PF00069	0.307
MOD_Plk_4	271	277	PF00069	0.359
MOD_Plk_4	75	81	PF00069	0.481
MOD_ProDKin_1	125	131	PF00069	0.477
MOD_ProDKin_1	134	140	PF00069	0.491
MOD_ProDKin_1	16	22	PF00069	0.710
MOD_ProDKin_1	185	191	PF00069	0.339
MOD_ProDKin_1	3	9	PF00069	0.685
MOD_ProDKin_1	96	102	PF00069	0.534
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.558
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.528
TRG_ENDOCYTIC_2	167	170	PF00928	0.305
TRG_ENDOCYTIC_2	176	179	PF00928	0.305
TRG_ENDOCYTIC_2	221	224	PF00928	0.452
TRG_ENDOCYTIC_2	240	243	PF00928	0.203
TRG_ENDOCYTIC_2	261	264	PF00928	0.337
TRG_ENDOCYTIC_2	268	271	PF00928	0.285
TRG_ENDOCYTIC_2	62	65	PF00928	0.465
TRG_ENDOCYTIC_2	72	75	PF00928	0.407
TRG_ER_diArg_1	294	297	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.233

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI6	Leptomonas seymouri	61%	99%
A0A0S4KG55	Bodo saltans	34%	100%
A0A1X0NW97	Trypanosomatidae	39%	100%
A0A3R7RL55	Trypanosoma rangeli	35%	100%
A4HYV6	Leishmania infantum	100%	100%
C9ZID7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIG3	Leishmania braziliensis	85%	100%
E9AUQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4FZQ0	Xenopus laevis	24%	100%
Q4QCT2	Leishmania major	93%	100%
Q5BJH7	Homo sapiens	26%	100%
Q5U3G6	Danio rerio	26%	100%
Q6GN58	Xenopus laevis	23%	100%
Q6P301	Xenopus tropicalis	24%	100%
Q6PC24	Danio rerio	26%	100%
V5C052	Trypanosoma cruzi	38%	100%