Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDN2_LEIDO

TriTrypDb:

LdBPK_160770.1 , LdCL_160013000 , LDHU3_16.0920

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.735
CLV_C14_Caspase3-7	246	250	PF00656	0.633
CLV_C14_Caspase3-7	455	459	PF00656	0.499
CLV_NRD_NRD_1	188	190	PF00675	0.660
CLV_NRD_NRD_1	281	283	PF00675	0.697
CLV_NRD_NRD_1	327	329	PF00675	0.831
CLV_NRD_NRD_1	355	357	PF00675	0.746
CLV_NRD_NRD_1	42	44	PF00675	0.535
CLV_NRD_NRD_1	464	466	PF00675	0.443
CLV_NRD_NRD_1	467	469	PF00675	0.454
CLV_PCSK_FUR_1	465	469	PF00082	0.606
CLV_PCSK_KEX2_1	188	190	PF00082	0.662
CLV_PCSK_KEX2_1	327	329	PF00082	0.831
CLV_PCSK_KEX2_1	41	43	PF00082	0.554
CLV_PCSK_KEX2_1	464	466	PF00082	0.448
CLV_PCSK_KEX2_1	467	469	PF00082	0.454
CLV_PCSK_KEX2_1	545	547	PF00082	0.643
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.575
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.660
CLV_PCSK_PC7_1	184	190	PF00082	0.667
CLV_PCSK_SKI1_1	386	390	PF00082	0.597
CLV_PCSK_SKI1_1	42	46	PF00082	0.526
DEG_APCC_DBOX_1	530	538	PF00400	0.596
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DEG_SCF_FBW7_1	314	321	PF00400	0.602
DEG_SPOP_SBC_1	145	149	PF00917	0.693
DEG_SPOP_SBC_1	183	187	PF00917	0.671
DEG_SPOP_SBC_1	67	71	PF00917	0.731
DOC_CDC14_PxL_1	534	542	PF14671	0.655
DOC_MAPK_gen_1	436	445	PF00069	0.422
DOC_PP2B_LxvP_1	107	110	PF13499	0.701
DOC_PP2B_LxvP_1	539	542	PF13499	0.650
DOC_USP7_MATH_1	102	106	PF00917	0.665
DOC_USP7_MATH_1	182	186	PF00917	0.749
DOC_USP7_MATH_1	332	336	PF00917	0.730
DOC_USP7_MATH_1	388	392	PF00917	0.631
DOC_USP7_MATH_1	5	9	PF00917	0.676
DOC_USP7_MATH_1	548	552	PF00917	0.723
DOC_USP7_MATH_1	576	580	PF00917	0.738
DOC_USP7_MATH_1	83	87	PF00917	0.718
DOC_USP7_MATH_1	96	100	PF00917	0.679
DOC_WW_Pin1_4	178	183	PF00397	0.768
DOC_WW_Pin1_4	198	203	PF00397	0.639
DOC_WW_Pin1_4	205	210	PF00397	0.738
DOC_WW_Pin1_4	281	286	PF00397	0.555
DOC_WW_Pin1_4	314	319	PF00397	0.812
DOC_WW_Pin1_4	69	74	PF00397	0.720
DOC_WW_Pin1_4	98	103	PF00397	0.716
LIG_14-3-3_CanoR_1	184	191	PF00244	0.746
LIG_14-3-3_CanoR_1	567	573	PF00244	0.652
LIG_14-3-3_CanoR_1	574	583	PF00244	0.561
LIG_14-3-3_CanoR_1	77	82	PF00244	0.781
LIG_BRCT_BRCA1_1	458	462	PF00533	0.630
LIG_Clathr_ClatBox_1	484	488	PF01394	0.462
LIG_FHA_1	14	20	PF00498	0.524
LIG_FHA_1	154	160	PF00498	0.746
LIG_FHA_1	199	205	PF00498	0.736
LIG_FHA_1	224	230	PF00498	0.620
LIG_FHA_1	270	276	PF00498	0.610
LIG_FHA_1	319	325	PF00498	0.748
LIG_FHA_1	451	457	PF00498	0.479
LIG_FHA_1	487	493	PF00498	0.488
LIG_FHA_1	558	564	PF00498	0.696
LIG_FHA_1	70	76	PF00498	0.709
LIG_FHA_2	145	151	PF00498	0.796
LIG_FHA_2	379	385	PF00498	0.640
LIG_FHA_2	43	49	PF00498	0.630
LIG_FHA_2	495	501	PF00498	0.482
LIG_Integrin_RGD_1	361	363	PF01839	0.716
LIG_LIR_Apic_2	103	109	PF02991	0.711
LIG_LIR_Gen_1	494	501	PF02991	0.398
LIG_LIR_Nem_3	132	138	PF02991	0.766
LIG_LIR_Nem_3	395	401	PF02991	0.627
LIG_LIR_Nem_3	494	498	PF02991	0.392
LIG_MLH1_MIPbox_1	458	462	PF16413	0.630
LIG_MYND_1	538	542	PF01753	0.669
LIG_PTB_Apo_2	439	446	PF02174	0.442
LIG_REV1ctd_RIR_1	459	469	PF16727	0.514
LIG_SH2_NCK_1	470	474	PF00017	0.420
LIG_SH2_SRC	106	109	PF00017	0.704
LIG_SH2_STAT3	10	13	PF00017	0.539
LIG_SH2_STAT3	527	530	PF00017	0.424
LIG_SH2_STAT5	106	109	PF00017	0.704
LIG_SH2_STAT5	191	194	PF00017	0.669
LIG_SH2_STAT5	342	345	PF00017	0.667
LIG_SH2_STAT5	368	371	PF00017	0.702
LIG_SH2_STAT5	37	40	PF00017	0.503
LIG_SH2_STAT5	470	473	PF00017	0.528
LIG_SH2_STAT5	52	55	PF00017	0.536
LIG_SH3_1	328	334	PF00018	0.591
LIG_SH3_3	107	113	PF00018	0.683
LIG_SH3_3	197	203	PF00018	0.832
LIG_SH3_3	272	278	PF00018	0.685
LIG_SH3_3	326	332	PF00018	0.817
LIG_SH3_3	367	373	PF00018	0.568
LIG_SH3_3	477	483	PF00018	0.486
LIG_SH3_3	551	557	PF00018	0.704
LIG_SH3_3	85	91	PF00018	0.802
LIG_SUMO_SIM_par_1	452	460	PF11976	0.499
LIG_TRAF2_1	381	384	PF00917	0.632
LIG_TRAF2_1	497	500	PF00917	0.487
LIG_UBA3_1	439	447	PF00899	0.480
MOD_CDC14_SPxK_1	101	104	PF00782	0.728
MOD_CDK_SPxK_1	178	184	PF00069	0.704
MOD_CDK_SPxK_1	98	104	PF00069	0.724
MOD_CK1_1	140	146	PF00069	0.764
MOD_CK1_1	196	202	PF00069	0.758
MOD_CK1_1	208	214	PF00069	0.703
MOD_CK1_1	222	228	PF00069	0.593
MOD_CK1_1	284	290	PF00069	0.742
MOD_CK1_1	320	326	PF00069	0.820
MOD_CK1_1	95	101	PF00069	0.808
MOD_CK2_1	144	150	PF00069	0.793
MOD_CK2_1	378	384	PF00069	0.620
MOD_CK2_1	42	48	PF00069	0.637
MOD_CK2_1	494	500	PF00069	0.482
MOD_GlcNHglycan	139	142	PF01048	0.648
MOD_GlcNHglycan	161	164	PF01048	0.797
MOD_GlcNHglycan	195	198	PF01048	0.762
MOD_GlcNHglycan	231	234	PF01048	0.663
MOD_GlcNHglycan	257	261	PF01048	0.744
MOD_GlcNHglycan	286	289	PF01048	0.787
MOD_GlcNHglycan	334	337	PF01048	0.724
MOD_GlcNHglycan	471	474	PF01048	0.527
MOD_GlcNHglycan	546	549	PF01048	0.707
MOD_GlcNHglycan	578	581	PF01048	0.651
MOD_GlcNHglycan	81	84	PF01048	0.721
MOD_GlcNHglycan	85	88	PF01048	0.723
MOD_GlcNHglycan	94	97	PF01048	0.785
MOD_GSK3_1	140	147	PF00069	0.720
MOD_GSK3_1	149	156	PF00069	0.738
MOD_GSK3_1	159	166	PF00069	0.724
MOD_GSK3_1	178	185	PF00069	0.752
MOD_GSK3_1	189	196	PF00069	0.751
MOD_GSK3_1	204	211	PF00069	0.710
MOD_GSK3_1	219	226	PF00069	0.774
MOD_GSK3_1	234	241	PF00069	0.719
MOD_GSK3_1	310	317	PF00069	0.817
MOD_GSK3_1	332	339	PF00069	0.712
MOD_GSK3_1	5	12	PF00069	0.667
MOD_GSK3_1	544	551	PF00069	0.699
MOD_GSK3_1	59	66	PF00069	0.665
MOD_GSK3_1	67	74	PF00069	0.681
MOD_GSK3_1	77	84	PF00069	0.759
MOD_GSK3_1	92	99	PF00069	0.784
MOD_LATS_1	142	148	PF00433	0.615
MOD_N-GLC_1	178	183	PF02516	0.771
MOD_N-GLC_1	267	272	PF02516	0.717
MOD_N-GLC_1	568	573	PF02516	0.653
MOD_NEK2_1	267	272	PF00069	0.693
MOD_NEK2_1	340	345	PF00069	0.649
MOD_NEK2_1	4	9	PF00069	0.745
MOD_NEK2_1	422	427	PF00069	0.503
MOD_NEK2_1	469	474	PF00069	0.515
MOD_NEK2_1	486	491	PF00069	0.383
MOD_NEK2_1	81	86	PF00069	0.727
MOD_NEK2_2	5	10	PF00069	0.665
MOD_PIKK_1	189	195	PF00454	0.713
MOD_PIKK_1	388	394	PF00454	0.667
MOD_PIKK_1	9	15	PF00454	0.550
MOD_PKA_1	42	48	PF00069	0.637
MOD_PKA_2	143	149	PF00069	0.729
MOD_PKA_2	163	169	PF00069	0.591
MOD_PKA_2	183	189	PF00069	0.577
MOD_PKA_2	219	225	PF00069	0.725
MOD_PKA_2	373	379	PF00069	0.737
MOD_PKA_2	42	48	PF00069	0.616
MOD_PKA_2	76	82	PF00069	0.781
MOD_Plk_1	402	408	PF00069	0.550
MOD_Plk_1	568	574	PF00069	0.654
MOD_Plk_2-3	403	409	PF00069	0.511
MOD_Plk_2-3	494	500	PF00069	0.482
MOD_Plk_4	130	136	PF00069	0.740
MOD_Plk_4	208	214	PF00069	0.767
MOD_Plk_4	320	326	PF00069	0.785
MOD_Plk_4	403	409	PF00069	0.545
MOD_Plk_4	5	11	PF00069	0.650
MOD_ProDKin_1	178	184	PF00069	0.769
MOD_ProDKin_1	198	204	PF00069	0.692
MOD_ProDKin_1	205	211	PF00069	0.739
MOD_ProDKin_1	281	287	PF00069	0.555
MOD_ProDKin_1	314	320	PF00069	0.813
MOD_ProDKin_1	69	75	PF00069	0.721
MOD_ProDKin_1	98	104	PF00069	0.718
MOD_SUMO_for_1	53	56	PF00179	0.645
MOD_SUMO_rev_2	372	381	PF00179	0.775
MOD_SUMO_rev_2	502	512	PF00179	0.483
TRG_DiLeu_BaEn_2	440	446	PF01217	0.464
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.483
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.656
TRG_ER_diArg_1	113	116	PF00400	0.670
TRG_ER_diArg_1	239	242	PF00400	0.719
TRG_ER_diArg_1	327	329	PF00400	0.831
TRG_ER_diArg_1	42	44	PF00400	0.535
TRG_ER_diArg_1	436	439	PF00400	0.380
TRG_ER_diArg_1	464	467	PF00400	0.455
TRG_ER_diArg_1	519	522	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS0	Leptomonas seymouri	36%	76%
A4H8J9	Leishmania braziliensis	67%	96%
A4HWX4	Leishmania infantum	99%	100%
E9AQN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEU2	Leishmania major	88%	100%