Transcription elongation regulator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation regulator-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDN1_LEIDO

TriTrypDb:

LdBPK_272220.1 , LdCL_270029600 , LDHU3_27.3370

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0008023	transcription elongation factor complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032044	DSIF complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IDN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDN1

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0032784	regulation of DNA-templated transcription elongation	7	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006354	DNA-templated transcription elongation	6	1
GO:0006368	transcription elongation by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.515
CLV_C14_Caspase3-7	81	85	PF00656	0.642
CLV_NRD_NRD_1	159	161	PF00675	0.597
CLV_NRD_NRD_1	205	207	PF00675	0.291
CLV_NRD_NRD_1	231	233	PF00675	0.273
CLV_NRD_NRD_1	37	39	PF00675	0.597
CLV_NRD_NRD_1	646	648	PF00675	0.548
CLV_NRD_NRD_1	651	653	PF00675	0.636
CLV_PCSK_KEX2_1	159	161	PF00082	0.582
CLV_PCSK_KEX2_1	233	235	PF00082	0.393
CLV_PCSK_KEX2_1	322	324	PF00082	0.494
CLV_PCSK_KEX2_1	50	52	PF00082	0.638
CLV_PCSK_KEX2_1	54	56	PF00082	0.675
CLV_PCSK_KEX2_1	651	653	PF00082	0.648
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.393
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.494
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.637
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.655
CLV_PCSK_PC7_1	647	653	PF00082	0.626
CLV_PCSK_SKI1_1	114	118	PF00082	0.628
CLV_PCSK_SKI1_1	257	261	PF00082	0.393
CLV_PCSK_SKI1_1	327	331	PF00082	0.557
CLV_PCSK_SKI1_1	393	397	PF00082	0.567
CLV_PCSK_SKI1_1	618	622	PF00082	0.350
CLV_PCSK_SKI1_1	74	78	PF00082	0.701
DEG_APCC_DBOX_1	285	293	PF00400	0.351
DOC_CKS1_1	328	333	PF01111	0.459
DOC_CKS1_1	599	604	PF01111	0.448
DOC_CYCLIN_RxL_1	111	121	PF00134	0.517
DOC_MAPK_gen_1	180	188	PF00069	0.265
DOC_MAPK_gen_1	206	213	PF00069	0.251
DOC_MAPK_gen_1	271	280	PF00069	0.363
DOC_MAPK_gen_1	546	554	PF00069	0.355
DOC_MAPK_MEF2A_6	206	213	PF00069	0.262
DOC_MAPK_MEF2A_6	446	454	PF00069	0.393
DOC_MAPK_MEF2A_6	485	494	PF00069	0.475
DOC_PP2B_PxIxI_1	404	410	PF00149	0.421
DOC_PP4_FxxP_1	328	331	PF00568	0.411
DOC_SPAK_OSR1_1	248	252	PF12202	0.393
DOC_USP7_MATH_1	181	185	PF00917	0.393
DOC_USP7_MATH_1	19	23	PF00917	0.585
DOC_USP7_MATH_1	477	481	PF00917	0.379
DOC_USP7_MATH_1	63	67	PF00917	0.677
DOC_USP7_MATH_1	677	681	PF00917	0.610
DOC_USP7_MATH_1	79	83	PF00917	0.495
DOC_USP7_UBL2_3	315	319	PF12436	0.396
DOC_USP7_UBL2_3	41	45	PF12436	0.584
DOC_USP7_UBL2_3	50	54	PF12436	0.527
DOC_WW_Pin1_4	327	332	PF00397	0.581
DOC_WW_Pin1_4	598	603	PF00397	0.427
DOC_WW_Pin1_4	624	629	PF00397	0.497
LIG_14-3-3_CanoR_1	159	167	PF00244	0.470
LIG_14-3-3_CanoR_1	266	274	PF00244	0.499
LIG_14-3-3_CanoR_1	414	420	PF00244	0.481
LIG_14-3-3_CanoR_1	562	567	PF00244	0.417
LIG_14-3-3_CanoR_1	577	583	PF00244	0.304
LIG_14-3-3_CanoR_1	64	71	PF00244	0.579
LIG_14-3-3_CanoR_1	647	655	PF00244	0.556
LIG_Actin_WH2_2	406	423	PF00022	0.451
LIG_APCC_ABBA_1	165	170	PF00400	0.356
LIG_APCC_ABBA_1	491	496	PF00400	0.335
LIG_APCC_ABBAyCdc20_2	223	229	PF00400	0.250
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_CSL_BTD_1	599	602	PF09270	0.476
LIG_FHA_1	187	193	PF00498	0.395
LIG_FHA_1	267	273	PF00498	0.589
LIG_FHA_1	301	307	PF00498	0.328
LIG_FHA_1	319	325	PF00498	0.490
LIG_FHA_1	361	367	PF00498	0.455
LIG_FHA_1	375	381	PF00498	0.519
LIG_FHA_1	415	421	PF00498	0.436
LIG_FHA_1	434	440	PF00498	0.226
LIG_FHA_1	578	584	PF00498	0.509
LIG_FHA_1	607	613	PF00498	0.347
LIG_FHA_1	617	623	PF00498	0.322
LIG_FHA_1	92	98	PF00498	0.564
LIG_FHA_2	123	129	PF00498	0.453
LIG_FHA_2	150	156	PF00498	0.624
LIG_Integrin_RGD_1	286	288	PF01839	0.483
LIG_KLC1_Yacidic_2	224	229	PF13176	0.250
LIG_LIR_Apic_2	325	331	PF02991	0.576
LIG_LIR_Gen_1	224	230	PF02991	0.252
LIG_LIR_Gen_1	276	285	PF02991	0.323
LIG_LIR_Gen_1	4	15	PF02991	0.663
LIG_LIR_Gen_1	563	572	PF02991	0.511
LIG_LIR_Nem_3	224	228	PF02991	0.252
LIG_LIR_Nem_3	276	280	PF02991	0.305
LIG_LIR_Nem_3	343	349	PF02991	0.433
LIG_LIR_Nem_3	4	10	PF02991	0.659
LIG_LIR_Nem_3	486	490	PF02991	0.484
LIG_LIR_Nem_3	563	569	PF02991	0.505
LIG_NRBOX	9	15	PF00104	0.540
LIG_PTB_Apo_2	190	197	PF02174	0.250
LIG_PTB_Phospho_1	190	196	PF10480	0.250
LIG_SH2_CRK	566	570	PF00017	0.517
LIG_SH2_NCK_1	133	137	PF00017	0.566
LIG_SH2_NCK_1	566	570	PF00017	0.450
LIG_SH2_NCK_1	668	672	PF00017	0.598
LIG_SH2_PTP2	225	228	PF00017	0.250
LIG_SH2_PTP2	277	280	PF00017	0.373
LIG_SH2_SRC	133	136	PF00017	0.562
LIG_SH2_SRC	225	228	PF00017	0.250
LIG_SH2_STAP1	196	200	PF00017	0.265
LIG_SH2_STAP1	668	672	PF00017	0.598
LIG_SH2_STAP1	7	11	PF00017	0.660
LIG_SH2_STAT3	384	387	PF00017	0.528
LIG_SH2_STAT5	115	118	PF00017	0.551
LIG_SH2_STAT5	225	228	PF00017	0.250
LIG_SH2_STAT5	277	280	PF00017	0.373
LIG_SH2_STAT5	344	347	PF00017	0.365
LIG_SH2_STAT5	356	359	PF00017	0.251
LIG_SH2_STAT5	75	78	PF00017	0.576
LIG_SH3_3	250	256	PF00018	0.393
LIG_SH3_3	310	316	PF00018	0.482
LIG_SH3_3	596	602	PF00018	0.432
LIG_SH3_4	315	322	PF00018	0.458
LIG_SUMO_SIM_anti_2	489	494	PF11976	0.460
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.411
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.396
LIG_SUMO_SIM_par_1	531	537	PF11976	0.350
LIG_TRAF2_1	125	128	PF00917	0.439
LIG_TRAF2_1	376	379	PF00917	0.402
LIG_TRAF2_1	655	658	PF00917	0.623
LIG_TYR_ITIM	5	10	PF00017	0.654
LIG_TYR_ITIM	564	569	PF00017	0.506
MOD_CDK_SPK_2	327	332	PF00069	0.461
MOD_CK1_1	154	160	PF00069	0.566
MOD_CK1_1	457	463	PF00069	0.393
MOD_CK1_1	486	492	PF00069	0.471
MOD_CK1_1	520	526	PF00069	0.500
MOD_CK1_1	680	686	PF00069	0.669
MOD_CK1_1	82	88	PF00069	0.570
MOD_CK2_1	122	128	PF00069	0.452
MOD_CK2_1	373	379	PF00069	0.410
MOD_CK2_1	531	537	PF00069	0.459
MOD_CK2_1	63	69	PF00069	0.768
MOD_CK2_1	82	88	PF00069	0.525
MOD_Cter_Amidation	645	648	PF01082	0.555
MOD_GlcNHglycan	367	370	PF01048	0.434
MOD_GlcNHglycan	455	459	PF01048	0.537
MOD_GlcNHglycan	479	482	PF01048	0.382
MOD_GlcNHglycan	663	666	PF01048	0.673
MOD_GlcNHglycan	675	678	PF01048	0.673
MOD_GlcNHglycan	679	682	PF01048	0.683
MOD_GlcNHglycan	696	699	PF01048	0.503
MOD_GlcNHglycan	81	84	PF01048	0.587
MOD_GSK3_1	151	158	PF00069	0.646
MOD_GSK3_1	262	269	PF00069	0.609
MOD_GSK3_1	405	412	PF00069	0.511
MOD_GSK3_1	429	436	PF00069	0.422
MOD_GSK3_1	457	464	PF00069	0.477
MOD_GSK3_1	479	486	PF00069	0.404
MOD_GSK3_1	511	518	PF00069	0.501
MOD_GSK3_1	573	580	PF00069	0.528
MOD_GSK3_1	673	680	PF00069	0.653
MOD_N-GLC_1	405	410	PF02516	0.327
MOD_N-GLC_1	694	699	PF02516	0.644
MOD_N-GLC_2	193	195	PF02516	0.250
MOD_N-GLC_2	509	511	PF02516	0.472
MOD_NEK2_1	340	345	PF00069	0.477
MOD_NEK2_1	357	362	PF00069	0.246
MOD_NEK2_1	365	370	PF00069	0.403
MOD_NEK2_1	420	425	PF00069	0.384
MOD_NEK2_1	431	436	PF00069	0.406
MOD_NEK2_1	439	444	PF00069	0.457
MOD_NEK2_1	583	588	PF00069	0.431
MOD_NEK2_1	616	621	PF00069	0.328
MOD_NEK2_2	212	217	PF00069	0.250
MOD_NEK2_2	517	522	PF00069	0.540
MOD_PIKK_1	160	166	PF00454	0.624
MOD_PIKK_1	266	272	PF00454	0.598
MOD_PIKK_1	653	659	PF00454	0.616
MOD_PK_1	515	521	PF00069	0.612
MOD_PKA_1	647	653	PF00069	0.559
MOD_PKA_2	181	187	PF00069	0.361
MOD_PKA_2	265	271	PF00069	0.517
MOD_PKA_2	413	419	PF00069	0.435
MOD_PKA_2	420	426	PF00069	0.354
MOD_PKA_2	573	579	PF00069	0.436
MOD_PKA_2	63	69	PF00069	0.584
MOD_PKA_2	646	652	PF00069	0.493
MOD_PKA_2	673	679	PF00069	0.616
MOD_Plk_1	340	346	PF00069	0.457
MOD_Plk_1	405	411	PF00069	0.320
MOD_Plk_1	583	589	PF00069	0.513
MOD_Plk_1	686	692	PF00069	0.620
MOD_Plk_1	694	700	PF00069	0.645
MOD_Plk_2-3	122	128	PF00069	0.587
MOD_Plk_2-3	531	537	PF00069	0.392
MOD_Plk_2-3	687	693	PF00069	0.660
MOD_Plk_2-3	84	90	PF00069	0.613
MOD_Plk_4	340	346	PF00069	0.508
MOD_Plk_4	479	485	PF00069	0.350
MOD_Plk_4	486	492	PF00069	0.328
MOD_Plk_4	687	693	PF00069	0.660
MOD_ProDKin_1	327	333	PF00069	0.581
MOD_ProDKin_1	598	604	PF00069	0.429
MOD_ProDKin_1	624	630	PF00069	0.497
MOD_SUMO_for_1	504	507	PF00179	0.498
MOD_SUMO_for_1	636	639	PF00179	0.387
MOD_SUMO_rev_2	119	126	PF00179	0.533
MOD_SUMO_rev_2	169	175	PF00179	0.400
TRG_DiLeu_BaEn_1	639	644	PF01217	0.414
TRG_DiLeu_BaEn_1	9	14	PF01217	0.540
TRG_ENDOCYTIC_2	139	142	PF00928	0.441
TRG_ENDOCYTIC_2	225	228	PF00928	0.250
TRG_ENDOCYTIC_2	277	280	PF00928	0.373
TRG_ENDOCYTIC_2	566	569	PF00928	0.514
TRG_ENDOCYTIC_2	7	10	PF00928	0.661
TRG_ER_diArg_1	159	161	PF00400	0.623
TRG_ER_diArg_1	180	183	PF00400	0.265
TRG_ER_diArg_1	232	235	PF00400	0.408
TRG_ER_diArg_1	278	281	PF00400	0.316
TRG_NES_CRM1_1	210	220	PF08389	0.265
TRG_NLS_Bipartite_1	38	58	PF00514	0.662
TRG_NLS_MonoCore_2	53	58	PF00514	0.672
TRG_NLS_MonoExtC_3	231	237	PF00514	0.393
TRG_NLS_MonoExtC_3	37	42	PF00514	0.602
TRG_NLS_MonoExtC_3	46	51	PF00514	0.560
TRG_NLS_MonoExtC_3	53	59	PF00514	0.481
TRG_NLS_MonoExtN_4	36	42	PF00514	0.603
TRG_NLS_MonoExtN_4	44	51	PF00514	0.555
TRG_NLS_MonoExtN_4	53	58	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I1	Leptomonas seymouri	81%	100%
A0A0S4IUW1	Bodo saltans	42%	95%
A0A1X0NRB9	Trypanosomatidae	50%	96%
A0A422NAL6	Trypanosoma rangeli	51%	99%
A4HG07	Leishmania braziliensis	90%	99%
A4I326	Leishmania infantum	100%	100%
C9ZJK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9ACU7	Leishmania major	97%	100%
E9AZD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O13936	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	71%
O80770	Arabidopsis thaliana	25%	71%
Q4I5I4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	67%
Q4PIC4	Ustilago maydis (strain 521 / FGSC 9021)	24%	73%
Q4WP96	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	66%
Q5ALX3	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	73%
Q5BCN2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	69%
Q6BZG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	72%
Q6CC84	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	71%
Q6CWW9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	68%
Q6FRZ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	69%
Q7S3C4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	66%
Q9STN3	Arabidopsis thaliana	25%	67%
V5D465	Trypanosoma cruzi	52%	97%