LeishMANIAdb
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Glycerol-3-phosphate dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycerol-3-phosphate dehydrogenase
Gene product:
glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial
Species:
Leishmania donovani
UniProt:
A0A3Q8IDM8_LEIDO
TriTrypDb:
LdBPK_280240.1 , LdCL_280007300 , LDHU3_28.0330
Length:
608

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, Glycerol-3-phosphate dehydrogenase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0009331 glycerol-3-phosphate dehydrogenase complex 4 12
GO:0032991 protein-containing complex 1 12
GO:1902494 catalytic complex 2 12
GO:1990204 oxidoreductase complex 3 12
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IDM8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDM8

Function

Biological processes
Term Name Level Count
GO:0006072 glycerol-3-phosphate metabolic process 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0019637 organophosphate metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0052646 alditol phosphate metabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901135 carbohydrate derivative metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 12
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor 4 12
GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity 6 12
GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity 7 12
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 82 86 PF00656 0.440
CLV_NRD_NRD_1 207 209 PF00675 0.313
CLV_NRD_NRD_1 278 280 PF00675 0.296
CLV_NRD_NRD_1 324 326 PF00675 0.264
CLV_NRD_NRD_1 33 35 PF00675 0.306
CLV_NRD_NRD_1 446 448 PF00675 0.245
CLV_NRD_NRD_1 557 559 PF00675 0.202
CLV_PCSK_KEX2_1 33 35 PF00082 0.299
CLV_PCSK_KEX2_1 557 559 PF00082 0.202
CLV_PCSK_KEX2_1 590 592 PF00082 0.346
CLV_PCSK_PC1ET2_1 590 592 PF00082 0.346
CLV_PCSK_SKI1_1 122 126 PF00082 0.202
CLV_PCSK_SKI1_1 302 306 PF00082 0.262
CLV_PCSK_SKI1_1 343 347 PF00082 0.213
CLV_PCSK_SKI1_1 527 531 PF00082 0.217
CLV_PCSK_SKI1_1 560 564 PF00082 0.245
CLV_Separin_Metazoa 267 271 PF03568 0.449
DOC_CDC14_PxL_1 146 154 PF14671 0.413
DOC_CDC14_PxL_1 201 209 PF14671 0.506
DOC_MAPK_FxFP_2 194 197 PF00069 0.506
DOC_MAPK_gen_1 330 337 PF00069 0.449
DOC_MAPK_gen_1 557 563 PF00069 0.413
DOC_MAPK_MEF2A_6 469 478 PF00069 0.363
DOC_PP1_RVXF_1 341 347 PF00149 0.402
DOC_PP1_RVXF_1 558 564 PF00149 0.404
DOC_PP2B_LxvP_1 405 408 PF13499 0.469
DOC_PP2B_LxvP_1 493 496 PF13499 0.449
DOC_PP4_FxxP_1 194 197 PF00568 0.413
DOC_PP4_FxxP_1 346 349 PF00568 0.469
DOC_USP7_MATH_1 394 398 PF00917 0.504
DOC_USP7_MATH_1 60 64 PF00917 0.469
DOC_USP7_MATH_1 601 605 PF00917 0.488
DOC_USP7_UBL2_3 202 206 PF12436 0.469
DOC_USP7_UBL2_3 465 469 PF12436 0.494
DOC_WW_Pin1_4 529 534 PF00397 0.506
LIG_14-3-3_CanoR_1 232 238 PF00244 0.445
LIG_14-3-3_CanoR_1 575 583 PF00244 0.527
LIG_14-3-3_CanoR_1 89 94 PF00244 0.413
LIG_Actin_WH2_2 117 135 PF00022 0.445
LIG_BIR_II_1 1 5 PF00653 0.386
LIG_BRCT_BRCA1_1 192 196 PF00533 0.363
LIG_FHA_1 108 114 PF00498 0.412
LIG_FHA_1 141 147 PF00498 0.459
LIG_FHA_1 279 285 PF00498 0.449
LIG_FHA_1 317 323 PF00498 0.419
LIG_FHA_1 360 366 PF00498 0.406
LIG_FHA_1 416 422 PF00498 0.427
LIG_FHA_1 471 477 PF00498 0.393
LIG_FHA_1 488 494 PF00498 0.461
LIG_FHA_1 63 69 PF00498 0.438
LIG_FHA_1 86 92 PF00498 0.416
LIG_LIR_Apic_2 192 197 PF02991 0.427
LIG_LIR_Apic_2 24 28 PF02991 0.417
LIG_LIR_Gen_1 188 198 PF02991 0.388
LIG_LIR_Gen_1 248 259 PF02991 0.427
LIG_LIR_Nem_3 188 194 PF02991 0.403
LIG_LIR_Nem_3 248 254 PF02991 0.427
LIG_LIR_Nem_3 397 402 PF02991 0.411
LIG_LIR_Nem_3 509 514 PF02991 0.413
LIG_LYPXL_yS_3 204 207 PF13949 0.506
LIG_MYND_1 157 161 PF01753 0.506
LIG_Pex14_1 503 507 PF04695 0.402
LIG_Pex14_2 346 350 PF04695 0.402
LIG_SH2_CRK 25 29 PF00017 0.518
LIG_SH2_CRK 251 255 PF00017 0.528
LIG_SH2_CRK 599 603 PF00017 0.574
LIG_SH2_GRB2like 25 28 PF00017 0.518
LIG_SH2_NCK_1 25 29 PF00017 0.552
LIG_SH2_NCK_1 45 49 PF00017 0.618
LIG_SH2_SRC 8 11 PF00017 0.258
LIG_SH2_STAP1 178 182 PF00017 0.402
LIG_SH2_STAP1 191 195 PF00017 0.402
LIG_SH2_STAP1 235 239 PF00017 0.454
LIG_SH2_STAP1 285 289 PF00017 0.413
LIG_SH2_STAP1 599 603 PF00017 0.517
LIG_SH2_STAT3 224 227 PF00017 0.388
LIG_SH2_STAT3 541 544 PF00017 0.445
LIG_SH2_STAT5 119 122 PF00017 0.402
LIG_SH2_STAT5 25 28 PF00017 0.547
LIG_SH2_STAT5 327 330 PF00017 0.409
LIG_SH2_STAT5 8 11 PF00017 0.358
LIG_SH3_3 366 372 PF00018 0.493
LIG_SH3_3 61 67 PF00018 0.460
LIG_SUMO_SIM_anti_2 69 74 PF11976 0.402
LIG_SUMO_SIM_par_1 280 286 PF11976 0.402
LIG_SUMO_SIM_par_1 424 430 PF11976 0.407
LIG_TYR_ITIM 249 254 PF00017 0.445
LIG_TYR_ITIM 43 48 PF00017 0.525
LIG_UBA3_1 524 530 PF00899 0.484
LIG_WRC_WIRS_1 191 196 PF05994 0.363
LIG_WRC_WIRS_1 602 607 PF05994 0.471
MOD_CK1_1 106 112 PF00069 0.414
MOD_CK1_1 155 161 PF00069 0.469
MOD_CK1_1 397 403 PF00069 0.495
MOD_GlcNHglycan 296 299 PF01048 0.362
MOD_GlcNHglycan 396 399 PF01048 0.227
MOD_GlcNHglycan 599 602 PF01048 0.313
MOD_GlcNHglycan 81 84 PF01048 0.279
MOD_GSK3_1 102 109 PF00069 0.387
MOD_GSK3_1 185 192 PF00069 0.435
MOD_GSK3_1 233 240 PF00069 0.407
MOD_GSK3_1 355 362 PF00069 0.424
MOD_GSK3_1 597 604 PF00069 0.542
MOD_GSK3_1 85 92 PF00069 0.437
MOD_N-GLC_1 436 441 PF02516 0.233
MOD_NEK2_1 1 6 PF00069 0.456
MOD_NEK2_1 152 157 PF00069 0.496
MOD_NEK2_1 189 194 PF00069 0.427
MOD_NEK2_1 23 28 PF00069 0.418
MOD_NEK2_1 233 238 PF00069 0.461
MOD_NEK2_1 35 40 PF00069 0.540
MOD_NEK2_1 386 391 PF00069 0.511
MOD_NEK2_1 436 441 PF00069 0.468
MOD_NEK2_1 457 462 PF00069 0.486
MOD_PIKK_1 28 34 PF00454 0.499
MOD_PIKK_1 415 421 PF00454 0.427
MOD_PK_1 89 95 PF00069 0.427
MOD_PKA_2 107 113 PF00069 0.427
MOD_PKA_2 278 284 PF00069 0.435
MOD_PKA_2 556 562 PF00069 0.402
MOD_PKA_2 574 580 PF00069 0.402
MOD_Plk_1 140 146 PF00069 0.445
MOD_Plk_1 189 195 PF00069 0.363
MOD_Plk_1 273 279 PF00069 0.523
MOD_Plk_4 155 161 PF00069 0.402
MOD_Plk_4 190 196 PF00069 0.466
MOD_ProDKin_1 529 535 PF00069 0.506
MOD_SUMO_for_1 43 46 PF00179 0.585
MOD_SUMO_rev_2 424 433 PF00179 0.493
TRG_DiLeu_BaEn_2 189 195 PF01217 0.449
TRG_ENDOCYTIC_2 163 166 PF00928 0.402
TRG_ENDOCYTIC_2 178 181 PF00928 0.405
TRG_ENDOCYTIC_2 191 194 PF00928 0.411
TRG_ENDOCYTIC_2 198 201 PF00928 0.316
TRG_ENDOCYTIC_2 204 207 PF00928 0.402
TRG_ENDOCYTIC_2 251 254 PF00928 0.427
TRG_ENDOCYTIC_2 446 449 PF00928 0.444
TRG_ENDOCYTIC_2 45 48 PF00928 0.525
TRG_ENDOCYTIC_2 511 514 PF00928 0.413
TRG_ENDOCYTIC_2 599 602 PF00928 0.571
TRG_ER_diArg_1 33 35 PF00400 0.499
TRG_ER_diArg_1 557 560 PF00400 0.402
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.217

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDC6 Leptomonas seymouri 69% 100%
A0A0S4IY53 Bodo saltans 43% 95%
A0A1X0NVE3 Trypanosomatidae 54% 99%
A0A422N0G9 Trypanosoma rangeli 56% 100%
A4HG65 Leishmania braziliensis 86% 100%
A4I397 Leishmania infantum 100% 100%
A6QLU1 Bos taurus 37% 84%
A7DZP8 Mesocricetus auratus 39% 84%
D0A7S4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
D4GQU6 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 25% 100%
E9AZI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O14400 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 94%
O83004 Pseudomonas tolaasii 25% 100%
O86963 Enterococcus casseliflavus 29% 100%
P0A9C0 Escherichia coli (strain K12) 24% 100%
P0A9C1 Escherichia coli O157:H7 24% 100%
P0A9C2 Shigella flexneri 24% 100%
P0DB20 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 28% 99%
P0DB21 Streptococcus pyogenes serotype M3 (strain SSI-1) 28% 99%
P13035 Escherichia coli (strain K12) 26% 100%
P18158 Bacillus subtilis (strain 168) 31% 100%
P32191 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 94%
P35571 Rattus norvegicus 38% 84%
P35596 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 28% 100%
P43304 Homo sapiens 38% 84%
P43799 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 23% 100%
P52111 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 26% 100%
P53435 Mycobacterium leprae (strain TN) 29% 100%
P64183 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31% 100%
P64185 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 29% 100%
P74257 Synechocystis sp. (strain PCC 6803 / Kazusa) 30% 100%
P90795 Caenorhabditis elegans 37% 84%
P9WN78 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 29% 100%
P9WN79 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 100%
P9WN80 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 100%
P9WN81 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
Q2FHD8 Staphylococcus aureus (strain USA300) 31% 100%
Q2FYZ4 Staphylococcus aureus (strain NCTC 8325 / PS 47) 31% 100%
Q2YIQ2 Brucella abortus (strain 2308) 27% 100%
Q2YXR5 Staphylococcus aureus (strain bovine RF122 / ET3-1) 31% 100%
Q49X94 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 31% 100%
Q4L608 Staphylococcus haemolyticus (strain JCSC1435) 31% 100%
Q4Q8P6 Leishmania major 95% 100%
Q4R755 Macaca fascicularis 38% 84%
Q54QC1 Dictyostelium discoideum 34% 95%
Q5HGD1 Staphylococcus aureus (strain COL) 31% 100%
Q5HPP0 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 32% 100%
Q5XAK0 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) 28% 99%
Q64521 Mus musculus 38% 84%
Q6G9R2 Staphylococcus aureus (strain MSSA476) 31% 100%
Q6GHD4 Staphylococcus aureus (strain MRSA252) 31% 100%
Q7A105 Staphylococcus aureus (strain MW2) 31% 100%
Q7A5V7 Staphylococcus aureus (strain N315) 31% 100%
Q8CPE6 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 32% 100%
Q8NZX0 Streptococcus pyogenes serotype M18 (strain MGAS8232) 28% 99%
Q8SR40 Encephalitozoon cuniculi (strain GB-M1) 33% 99%
Q99UH2 Staphylococcus aureus (strain Mu50 / ATCC 700699) 31% 100%
Q99YI8 Streptococcus pyogenes serotype M1 28% 99%
Q9CG65 Lactococcus lactis subsp. lactis (strain IL1403) 27% 100%
Q9SS48 Arabidopsis thaliana 39% 97%
V5AUH1 Trypanosoma cruzi 56% 88%
V5BVH7 Trypanosoma cruzi 25% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS