LeishMANIAdb
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G1 cyclin CycE4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
G1 cyclin CycE4, putative
Gene product:
G1 cyclin CycE4, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDM6_LEIDO
TriTrypDb:
LdBPK_330830.1 * , LdCL_330013800 , LDHU3_33.1200
Length:
881

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IDM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDM6

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 6
GO:0001932 regulation of protein phosphorylation 7 6
GO:0019220 regulation of phosphate metabolic process 6 6
GO:0019222 regulation of metabolic process 3 6
GO:0031323 regulation of cellular metabolic process 4 6
GO:0031399 regulation of protein modification process 6 6
GO:0042325 regulation of phosphorylation 7 6
GO:0043549 regulation of kinase activity 5 6
GO:0045859 regulation of protein kinase activity 6 6
GO:0050789 regulation of biological process 2 6
GO:0050790 regulation of catalytic activity 3 6
GO:0050794 regulation of cellular process 3 6
GO:0051171 regulation of nitrogen compound metabolic process 4 6
GO:0051174 regulation of phosphorus metabolic process 5 6
GO:0051246 regulation of protein metabolic process 5 6
GO:0051338 regulation of transferase activity 4 6
GO:0051726 regulation of cell cycle 4 6
GO:0060255 regulation of macromolecule metabolic process 4 6
GO:0065007 biological regulation 1 6
GO:0065009 regulation of molecular function 2 6
GO:0071900 regulation of protein serine/threonine kinase activity 7 6
GO:0080090 regulation of primary metabolic process 4 6
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 6
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0019899 enzyme binding 3 6
GO:0019900 kinase binding 4 6
GO:0019901 protein kinase binding 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 449 453 PF00656 0.705
CLV_NRD_NRD_1 304 306 PF00675 0.616
CLV_NRD_NRD_1 474 476 PF00675 0.806
CLV_NRD_NRD_1 496 498 PF00675 0.684
CLV_NRD_NRD_1 579 581 PF00675 0.763
CLV_NRD_NRD_1 60 62 PF00675 0.399
CLV_NRD_NRD_1 610 612 PF00675 0.708
CLV_NRD_NRD_1 692 694 PF00675 0.739
CLV_NRD_NRD_1 710 712 PF00675 0.602
CLV_NRD_NRD_1 727 729 PF00675 0.582
CLV_NRD_NRD_1 756 758 PF00675 0.857
CLV_PCSK_KEX2_1 304 306 PF00082 0.653
CLV_PCSK_KEX2_1 474 476 PF00082 0.654
CLV_PCSK_KEX2_1 495 497 PF00082 0.739
CLV_PCSK_KEX2_1 579 581 PF00082 0.771
CLV_PCSK_KEX2_1 60 62 PF00082 0.475
CLV_PCSK_KEX2_1 609 611 PF00082 0.808
CLV_PCSK_KEX2_1 692 694 PF00082 0.734
CLV_PCSK_KEX2_1 727 729 PF00082 0.694
CLV_PCSK_KEX2_1 756 758 PF00082 0.857
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.739
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.808
CLV_PCSK_SKI1_1 496 500 PF00082 0.735
CLV_PCSK_SKI1_1 540 544 PF00082 0.838
CLV_PCSK_SKI1_1 622 626 PF00082 0.756
CLV_PCSK_SKI1_1 727 731 PF00082 0.688
DEG_APCC_DBOX_1 270 278 PF00400 0.524
DEG_APCC_DBOX_1 632 640 PF00400 0.810
DEG_SCF_FBW7_1 307 313 PF00400 0.681
DEG_SCF_FBW7_1 327 334 PF00400 0.487
DEG_SPOP_SBC_1 403 407 PF00917 0.625
DEG_SPOP_SBC_1 778 782 PF00917 0.732
DOC_CDC14_PxL_1 429 437 PF14671 0.632
DOC_CKS1_1 307 312 PF01111 0.676
DOC_CKS1_1 748 753 PF01111 0.745
DOC_CYCLIN_RxL_1 490 500 PF00134 0.729
DOC_MAPK_DCC_7 474 483 PF00069 0.734
DOC_MAPK_HePTP_8 471 483 PF00069 0.754
DOC_MAPK_MEF2A_6 199 206 PF00069 0.524
DOC_MAPK_MEF2A_6 474 483 PF00069 0.734
DOC_PP2B_LxvP_1 153 156 PF13499 0.449
DOC_PP2B_LxvP_1 18 21 PF13499 0.780
DOC_PP2B_LxvP_1 425 428 PF13499 0.760
DOC_PP2B_LxvP_1 489 492 PF13499 0.800
DOC_PP2B_LxvP_1 528 531 PF13499 0.844
DOC_PP2B_LxvP_1 651 654 PF13499 0.866
DOC_PP4_FxxP_1 123 126 PF00568 0.524
DOC_PP4_FxxP_1 477 480 PF00568 0.730
DOC_PP4_FxxP_1 92 95 PF00568 0.524
DOC_USP7_MATH_1 126 130 PF00917 0.404
DOC_USP7_MATH_1 259 263 PF00917 0.524
DOC_USP7_MATH_1 28 32 PF00917 0.737
DOC_USP7_MATH_1 331 335 PF00917 0.791
DOC_USP7_MATH_1 403 407 PF00917 0.735
DOC_USP7_MATH_1 437 441 PF00917 0.792
DOC_USP7_MATH_1 602 606 PF00917 0.742
DOC_USP7_MATH_1 684 688 PF00917 0.724
DOC_USP7_MATH_1 723 727 PF00917 0.772
DOC_USP7_MATH_1 770 774 PF00917 0.769
DOC_USP7_MATH_1 778 782 PF00917 0.697
DOC_USP7_MATH_1 95 99 PF00917 0.524
DOC_WW_Pin1_4 113 118 PF00397 0.318
DOC_WW_Pin1_4 148 153 PF00397 0.517
DOC_WW_Pin1_4 306 311 PF00397 0.672
DOC_WW_Pin1_4 319 324 PF00397 0.580
DOC_WW_Pin1_4 327 332 PF00397 0.680
DOC_WW_Pin1_4 356 361 PF00397 0.805
DOC_WW_Pin1_4 507 512 PF00397 0.803
DOC_WW_Pin1_4 521 526 PF00397 0.598
DOC_WW_Pin1_4 747 752 PF00397 0.719
DOC_WW_Pin1_4 755 760 PF00397 0.742
DOC_WW_Pin1_4 761 766 PF00397 0.648
DOC_WW_Pin1_4 874 879 PF00397 0.799
DOC_WW_Pin1_4 91 96 PF00397 0.524
DOC_WW_Pin1_4 98 103 PF00397 0.411
LIG_14-3-3_CanoR_1 122 126 PF00244 0.361
LIG_14-3-3_CanoR_1 13 19 PF00244 0.706
LIG_14-3-3_CanoR_1 148 152 PF00244 0.449
LIG_14-3-3_CanoR_1 233 241 PF00244 0.453
LIG_14-3-3_CanoR_1 4 10 PF00244 0.760
LIG_14-3-3_CanoR_1 438 448 PF00244 0.797
LIG_14-3-3_CanoR_1 474 478 PF00244 0.641
LIG_14-3-3_CanoR_1 496 502 PF00244 0.813
LIG_14-3-3_CanoR_1 579 586 PF00244 0.721
LIG_14-3-3_CanoR_1 676 684 PF00244 0.754
LIG_14-3-3_CanoR_1 711 720 PF00244 0.691
LIG_14-3-3_CanoR_1 727 736 PF00244 0.658
LIG_14-3-3_CanoR_1 871 881 PF00244 0.808
LIG_14-3-3_CanoR_1 96 103 PF00244 0.393
LIG_Actin_WH2_2 272 289 PF00022 0.524
LIG_Actin_WH2_2 371 387 PF00022 0.618
LIG_BRCT_BRCA1_1 119 123 PF00533 0.449
LIG_BRCT_BRCA1_1 376 380 PF00533 0.496
LIG_BRCT_BRCA1_1 537 541 PF00533 0.757
LIG_BRCT_BRCA1_1 725 729 PF00533 0.686
LIG_BRCT_BRCA1_2 537 543 PF00533 0.758
LIG_Clathr_ClatBox_1 279 283 PF01394 0.524
LIG_Clathr_ClatBox_1 295 299 PF01394 0.587
LIG_CtBP_PxDLS_1 645 649 PF00389 0.682
LIG_deltaCOP1_diTrp_1 292 297 PF00928 0.592
LIG_EVH1_1 700 704 PF00568 0.833
LIG_FHA_1 122 128 PF00498 0.474
LIG_FHA_1 234 240 PF00498 0.524
LIG_FHA_1 298 304 PF00498 0.569
LIG_FHA_1 311 317 PF00498 0.524
LIG_FHA_1 320 326 PF00498 0.610
LIG_FHA_1 357 363 PF00498 0.760
LIG_FHA_1 424 430 PF00498 0.702
LIG_FHA_1 626 632 PF00498 0.763
LIG_FHA_1 668 674 PF00498 0.773
LIG_FHA_1 778 784 PF00498 0.756
LIG_FHA_2 268 274 PF00498 0.524
LIG_FHA_2 338 344 PF00498 0.749
LIG_FXI_DFP_1 279 283 PF00024 0.524
LIG_LIR_Apic_2 120 126 PF02991 0.449
LIG_LIR_Apic_2 476 480 PF02991 0.564
LIG_LIR_Apic_2 89 95 PF02991 0.524
LIG_LIR_Gen_1 221 229 PF02991 0.524
LIG_LIR_Gen_1 273 284 PF02991 0.524
LIG_LIR_Gen_1 377 388 PF02991 0.573
LIG_LIR_Gen_1 41 51 PF02991 0.607
LIG_LIR_Gen_1 452 463 PF02991 0.748
LIG_LIR_Nem_3 221 226 PF02991 0.524
LIG_LIR_Nem_3 273 279 PF02991 0.524
LIG_LIR_Nem_3 281 285 PF02991 0.394
LIG_LIR_Nem_3 377 383 PF02991 0.579
LIG_LIR_Nem_3 41 46 PF02991 0.472
LIG_LIR_Nem_3 452 458 PF02991 0.790
LIG_LIR_Nem_3 699 703 PF02991 0.844
LIG_LIR_Nem_3 817 823 PF02991 0.753
LIG_LIR_Nem_3 825 831 PF02991 0.611
LIG_LIR_Nem_3 839 845 PF02991 0.609
LIG_MYND_1 433 437 PF01753 0.616
LIG_REV1ctd_RIR_1 539 547 PF16727 0.834
LIG_SH2_CRK 7 11 PF00017 0.720
LIG_SH2_NCK_1 7 11 PF00017 0.720
LIG_SH2_SRC 246 249 PF00017 0.524
LIG_SH2_SRC 801 804 PF00017 0.849
LIG_SH2_STAP1 47 51 PF00017 0.586
LIG_SH2_STAP1 779 783 PF00017 0.838
LIG_SH2_STAP1 842 846 PF00017 0.768
LIG_SH2_STAT5 211 214 PF00017 0.524
LIG_SH2_STAT5 278 281 PF00017 0.377
LIG_SH2_STAT5 314 317 PF00017 0.712
LIG_SH2_STAT5 779 782 PF00017 0.763
LIG_SH2_STAT5 828 831 PF00017 0.700
LIG_SH2_STAT5 866 869 PF00017 0.810
LIG_SH3_1 745 751 PF00018 0.652
LIG_SH3_2 433 438 PF14604 0.695
LIG_SH3_3 115 121 PF00018 0.477
LIG_SH3_3 149 155 PF00018 0.517
LIG_SH3_3 427 433 PF00018 0.734
LIG_SH3_3 441 447 PF00018 0.649
LIG_SH3_3 476 482 PF00018 0.611
LIG_SH3_3 485 491 PF00018 0.588
LIG_SH3_3 505 511 PF00018 0.481
LIG_SH3_3 524 530 PF00018 0.604
LIG_SH3_3 635 641 PF00018 0.823
LIG_SH3_3 698 704 PF00018 0.843
LIG_SH3_3 735 741 PF00018 0.817
LIG_SH3_3 745 751 PF00018 0.645
LIG_SUMO_SIM_anti_2 379 386 PF11976 0.613
LIG_SUMO_SIM_par_1 379 386 PF11976 0.613
LIG_SUMO_SIM_par_1 428 434 PF11976 0.638
LIG_SUMO_SIM_par_1 446 452 PF11976 0.467
LIG_TRAF2_1 174 177 PF00917 0.498
LIG_TRAF2_1 50 53 PF00917 0.596
LIG_WW_2 479 482 PF00397 0.682
LIG_WW_3 435 439 PF00397 0.720
LIG_WW_3 689 693 PF00397 0.842
MOD_CDC14_SPxK_1 526 529 PF00782 0.847
MOD_CDK_SPK_2 117 122 PF00069 0.449
MOD_CDK_SPK_2 327 332 PF00069 0.688
MOD_CDK_SPK_2 91 96 PF00069 0.524
MOD_CDK_SPxK_1 523 529 PF00069 0.840
MOD_CDK_SPxxK_3 755 762 PF00069 0.772
MOD_CK1_1 113 119 PF00069 0.318
MOD_CK1_1 157 163 PF00069 0.499
MOD_CK1_1 267 273 PF00069 0.449
MOD_CK1_1 319 325 PF00069 0.725
MOD_CK1_1 334 340 PF00069 0.617
MOD_CK1_1 439 445 PF00069 0.661
MOD_CK1_1 456 462 PF00069 0.511
MOD_CK1_1 510 516 PF00069 0.806
MOD_CK1_1 523 529 PF00069 0.629
MOD_CK1_1 544 550 PF00069 0.827
MOD_CK1_1 578 584 PF00069 0.763
MOD_CK1_1 669 675 PF00069 0.846
MOD_CK1_1 773 779 PF00069 0.826
MOD_CK1_1 88 94 PF00069 0.524
MOD_CK1_1 98 104 PF00069 0.362
MOD_CK2_1 267 273 PF00069 0.524
MOD_CK2_1 286 292 PF00069 0.598
MOD_CK2_1 337 343 PF00069 0.751
MOD_CK2_1 804 810 PF00069 0.842
MOD_CMANNOS 294 297 PF00535 0.581
MOD_GlcNHglycan 165 168 PF01048 0.449
MOD_GlcNHglycan 261 264 PF01048 0.524
MOD_GlcNHglycan 31 34 PF01048 0.810
MOD_GlcNHglycan 317 321 PF01048 0.758
MOD_GlcNHglycan 439 442 PF01048 0.793
MOD_GlcNHglycan 455 458 PF01048 0.518
MOD_GlcNHglycan 556 559 PF01048 0.766
MOD_GlcNHglycan 590 593 PF01048 0.777
MOD_GlcNHglycan 598 601 PF01048 0.767
MOD_GlcNHglycan 641 644 PF01048 0.778
MOD_GlcNHglycan 673 676 PF01048 0.795
MOD_GlcNHglycan 686 689 PF01048 0.629
MOD_GlcNHglycan 772 775 PF01048 0.737
MOD_GlcNHglycan 792 795 PF01048 0.558
MOD_GlcNHglycan 97 100 PF01048 0.474
MOD_GSK3_1 106 113 PF00069 0.359
MOD_GSK3_1 117 124 PF00069 0.312
MOD_GSK3_1 218 225 PF00069 0.524
MOD_GSK3_1 306 313 PF00069 0.682
MOD_GSK3_1 315 322 PF00069 0.613
MOD_GSK3_1 327 334 PF00069 0.639
MOD_GSK3_1 335 342 PF00069 0.555
MOD_GSK3_1 356 363 PF00069 0.772
MOD_GSK3_1 392 399 PF00069 0.632
MOD_GSK3_1 403 410 PF00069 0.663
MOD_GSK3_1 417 424 PF00069 0.635
MOD_GSK3_1 436 443 PF00069 0.592
MOD_GSK3_1 5 12 PF00069 0.778
MOD_GSK3_1 584 591 PF00069 0.767
MOD_GSK3_1 667 674 PF00069 0.833
MOD_GSK3_1 723 730 PF00069 0.836
MOD_GSK3_1 769 776 PF00069 0.773
MOD_GSK3_1 84 91 PF00069 0.524
MOD_GSK3_1 94 101 PF00069 0.362
MOD_LATS_1 134 140 PF00433 0.524
MOD_N-GLC_1 146 151 PF02516 0.399
MOD_N-GLC_2 255 257 PF02516 0.368
MOD_NEK2_1 127 132 PF00069 0.474
MOD_NEK2_1 224 229 PF00069 0.524
MOD_NEK2_1 234 239 PF00069 0.362
MOD_NEK2_1 258 263 PF00069 0.524
MOD_NEK2_1 316 321 PF00069 0.738
MOD_NEK2_1 335 340 PF00069 0.534
MOD_NEK2_1 451 456 PF00069 0.785
MOD_NEK2_1 520 525 PF00069 0.672
MOD_NEK2_1 541 546 PF00069 0.834
MOD_NEK2_1 625 630 PF00069 0.757
MOD_NEK2_1 729 734 PF00069 0.677
MOD_NEK2_1 85 90 PF00069 0.405
MOD_PIKK_1 21 27 PF00454 0.697
MOD_PIKK_1 541 547 PF00454 0.783
MOD_PIKK_1 660 666 PF00454 0.870
MOD_PIKK_1 69 75 PF00454 0.524
MOD_PIKK_1 773 779 PF00454 0.831
MOD_PK_1 497 503 PF00069 0.819
MOD_PK_1 529 535 PF00069 0.834
MOD_PKA_1 727 733 PF00069 0.685
MOD_PKA_2 121 127 PF00069 0.399
MOD_PKA_2 147 153 PF00069 0.449
MOD_PKA_2 213 219 PF00069 0.524
MOD_PKA_2 232 238 PF00069 0.216
MOD_PKA_2 437 443 PF00069 0.720
MOD_PKA_2 473 479 PF00069 0.631
MOD_PKA_2 578 584 PF00069 0.756
MOD_PKA_2 666 672 PF00069 0.797
MOD_PKA_2 69 75 PF00069 0.487
MOD_PKA_2 691 697 PF00069 0.739
MOD_PKA_2 727 733 PF00069 0.780
MOD_PKA_2 95 101 PF00069 0.524
MOD_Plk_1 176 182 PF00069 0.434
MOD_Plk_1 267 273 PF00069 0.524
MOD_Plk_1 646 652 PF00069 0.867
MOD_Plk_1 850 856 PF00069 0.678
MOD_Plk_2-3 36 42 PF00069 0.687
MOD_Plk_4 310 316 PF00069 0.599
MOD_Plk_4 376 382 PF00069 0.676
MOD_Plk_4 440 446 PF00069 0.701
MOD_Plk_4 627 633 PF00069 0.770
MOD_ProDKin_1 113 119 PF00069 0.318
MOD_ProDKin_1 148 154 PF00069 0.517
MOD_ProDKin_1 306 312 PF00069 0.678
MOD_ProDKin_1 319 325 PF00069 0.581
MOD_ProDKin_1 327 333 PF00069 0.677
MOD_ProDKin_1 356 362 PF00069 0.811
MOD_ProDKin_1 507 513 PF00069 0.800
MOD_ProDKin_1 521 527 PF00069 0.601
MOD_ProDKin_1 747 753 PF00069 0.720
MOD_ProDKin_1 755 761 PF00069 0.738
MOD_ProDKin_1 874 880 PF00069 0.802
MOD_ProDKin_1 91 97 PF00069 0.524
MOD_ProDKin_1 98 104 PF00069 0.411
MOD_SUMO_rev_2 705 713 PF00179 0.724
TRG_DiLeu_BaEn_4 646 652 PF01217 0.867
TRG_ENDOCYTIC_2 700 703 PF00928 0.837
TRG_ER_diArg_1 303 305 PF00400 0.640
TRG_ER_diArg_1 496 498 PF00400 0.807
TRG_ER_diArg_1 60 62 PF00400 0.463
TRG_ER_diArg_1 610 612 PF00400 0.708
TRG_ER_diArg_1 691 693 PF00400 0.720
TRG_ER_diArg_1 727 729 PF00400 0.694
TRG_ER_diArg_1 869 872 PF00400 0.808
TRG_NES_CRM1_1 275 290 PF08389 0.524
TRG_NES_CRM1_1 293 306 PF08389 0.606
TRG_NLS_MonoExtN_4 492 499 PF00514 0.730
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A4HLB8 Leishmania braziliensis 71% 100%
A4I8U4 Leishmania infantum 100% 100%
E9B3R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q4C8 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS