Protein FYV4, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDM0_LEIDO

TriTrypDb:

LdBPK_330640.1 , LdCL_330011900 , LDHU3_33.0920

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IDM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDM0

PDB structure(s): 7ane_w

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.452
CLV_NRD_NRD_1	26	28	PF00675	0.405
CLV_PCSK_KEX2_1	101	103	PF00082	0.349
CLV_PCSK_KEX2_1	179	181	PF00082	0.497
CLV_PCSK_KEX2_1	88	90	PF00082	0.390
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.549
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.390
CLV_PCSK_SKI1_1	130	134	PF00082	0.342
DEG_COP1_1	136	145	PF00400	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DOC_CDC14_PxL_1	139	147	PF14671	0.414
DOC_MAPK_DCC_7	37	45	PF00069	0.434
DOC_MAPK_gen_1	101	111	PF00069	0.490
DOC_MAPK_gen_1	88	98	PF00069	0.521
DOC_MAPK_MEF2A_6	37	45	PF00069	0.434
DOC_USP7_UBL2_3	74	78	PF12436	0.361
LIG_14-3-3_CanoR_1	2	8	PF00244	0.551
LIG_14-3-3_CanoR_1	46	52	PF00244	0.367
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.359
LIG_EVH1_2	116	120	PF00568	0.383
LIG_FHA_1	47	53	PF00498	0.430
LIG_FHA_1	91	97	PF00498	0.481
LIG_FHA_2	120	126	PF00498	0.374
LIG_FHA_2	74	80	PF00498	0.409
LIG_LIR_Gen_1	79	84	PF02991	0.350
LIG_LIR_Nem_3	124	129	PF02991	0.388
LIG_LIR_Nem_3	136	142	PF02991	0.463
LIG_LIR_Nem_3	79	83	PF02991	0.339
LIG_Pex14_2	73	77	PF04695	0.347
LIG_SH2_CRK	139	143	PF00017	0.403
LIG_SH2_NCK_1	164	168	PF00017	0.535
LIG_SH2_STAP1	137	141	PF00017	0.406
LIG_SH2_STAP1	3	7	PF00017	0.555
LIG_SH2_STAT3	128	131	PF00017	0.356
LIG_SH2_STAT5	20	23	PF00017	0.318
LIG_SH2_STAT5	3	6	PF00017	0.665
LIG_SH2_STAT5	51	54	PF00017	0.365
LIG_SH3_1	140	146	PF00018	0.398
LIG_SH3_2	143	148	PF14604	0.409
LIG_SH3_3	140	146	PF00018	0.398
LIG_SH3_3	41	47	PF00018	0.498
LIG_TRAF2_1	122	125	PF00917	0.383
LIG_TRAF2_1	174	177	PF00917	0.511
MOD_CK1_1	35	41	PF00069	0.441
MOD_CK2_1	119	125	PF00069	0.383
MOD_CK2_1	84	90	PF00069	0.457
MOD_GlcNHglycan	185	188	PF01048	0.511
MOD_GSK3_1	131	138	PF00069	0.400
MOD_GSK3_1	31	38	PF00069	0.449
MOD_N-GLC_1	162	167	PF02516	0.375
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	73	78	PF00069	0.356
MOD_NEK2_1	8	13	PF00069	0.449
MOD_NEK2_1	84	89	PF00069	0.361
MOD_PKA_2	1	7	PF00069	0.593
MOD_Plk_1	135	141	PF00069	0.391
MOD_Plk_1	32	38	PF00069	0.553
MOD_Plk_4	18	24	PF00069	0.453
MOD_Plk_4	47	53	PF00069	0.368
MOD_SUMO_rev_2	176	181	PF00179	0.503
MOD_SUMO_rev_2	71	76	PF00179	0.358
TRG_DiLeu_BaEn_4	176	182	PF01217	0.425
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.433
TRG_ENDOCYTIC_2	129	132	PF00928	0.358
TRG_ENDOCYTIC_2	139	142	PF00928	0.399
TRG_ENDOCYTIC_2	164	167	PF00928	0.411
TRG_ENDOCYTIC_2	20	23	PF00928	0.435
TRG_ER_diArg_1	91	94	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ6	Leptomonas seymouri	91%	100%
A0A0S4JIZ9	Bodo saltans	72%	99%
A0A1X0P0P2	Trypanosomatidae	82%	100%
A0A3R7N7M2	Trypanosoma rangeli	80%	100%
A4HL99	Leishmania braziliensis	94%	100%
A4I8S5	Leishmania infantum	99%	100%
D0A4R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9B3P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q4E6	Leishmania major	97%	100%
V5DGB2	Trypanosoma cruzi	81%	100%