Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDL9_LEIDO

TriTrypDb:

LdBPK_280060.1 , LdCL_280005500 , LDHU3_28.0080

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.659
CLV_NRD_NRD_1	2	4	PF00675	0.592
CLV_NRD_NRD_1	400	402	PF00675	0.624
CLV_NRD_NRD_1	45	47	PF00675	0.583
CLV_NRD_NRD_1	52	54	PF00675	0.612
CLV_NRD_NRD_1	6	8	PF00675	0.605
CLV_PCSK_KEX2_1	18	20	PF00082	0.659
CLV_PCSK_KEX2_1	2	4	PF00082	0.595
CLV_PCSK_KEX2_1	382	384	PF00082	0.555
CLV_PCSK_KEX2_1	400	402	PF00082	0.645
CLV_PCSK_KEX2_1	45	47	PF00082	0.623
CLV_PCSK_KEX2_1	6	8	PF00082	0.600
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.555
CLV_PCSK_PC7_1	2	8	PF00082	0.713
CLV_PCSK_SKI1_1	259	263	PF00082	0.567
CLV_PCSK_SKI1_1	318	322	PF00082	0.456
CLV_PCSK_SKI1_1	33	37	PF00082	0.656
CLV_PCSK_SKI1_1	54	58	PF00082	0.661
CLV_PCSK_SKI1_1	7	11	PF00082	0.600
DEG_APCC_DBOX_1	5	13	PF00400	0.732
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DEG_ODPH_VHL_1	384	395	PF01847	0.692
DEG_SCF_TRCP1_1	339	344	PF00400	0.503
DEG_SPOP_SBC_1	404	408	PF00917	0.666
DEG_SPOP_SBC_1	473	477	PF00917	0.463
DOC_CDC14_PxL_1	148	156	PF14671	0.525
DOC_CYCLIN_RxL_1	30	40	PF00134	0.614
DOC_MAPK_DCC_7	423	431	PF00069	0.714
DOC_MAPK_gen_1	315	323	PF00069	0.481
DOC_MAPK_gen_1	382	389	PF00069	0.617
DOC_MAPK_gen_1	6	14	PF00069	0.706
DOC_MAPK_MEF2A_6	175	182	PF00069	0.483
DOC_MAPK_MEF2A_6	315	323	PF00069	0.460
DOC_MAPK_MEF2A_6	324	332	PF00069	0.475
DOC_MAPK_MEF2A_6	423	431	PF00069	0.623
DOC_PP1_RVXF_1	51	58	PF00149	0.596
DOC_PP2B_LxvP_1	218	221	PF13499	0.616
DOC_PP4_FxxP_1	456	459	PF00568	0.577
DOC_USP7_MATH_1	221	225	PF00917	0.705
DOC_USP7_MATH_1	427	431	PF00917	0.708
DOC_USP7_MATH_1	473	477	PF00917	0.463
DOC_USP7_MATH_1	59	63	PF00917	0.647
DOC_WW_Pin1_4	115	120	PF00397	0.612
DOC_WW_Pin1_4	455	460	PF00397	0.648
LIG_14-3-3_CanoR_1	474	479	PF00244	0.462
LIG_14-3-3_CanoR_1	6	14	PF00244	0.706
LIG_BIR_III_2	162	166	PF00653	0.527
LIG_BRCT_BRCA1_1	157	161	PF00533	0.554
LIG_BRCT_BRCA1_1	237	241	PF00533	0.546
LIG_BRCT_BRCA1_1	316	320	PF00533	0.497
LIG_BRCT_BRCA1_1	93	97	PF00533	0.693
LIG_Clathr_ClatBox_1	377	381	PF01394	0.586
LIG_EVH1_1	82	86	PF00568	0.596
LIG_FHA_1	72	78	PF00498	0.684
LIG_FHA_2	462	468	PF00498	0.511
LIG_LIR_Apic_2	305	310	PF02991	0.550
LIG_LIR_Gen_1	158	165	PF02991	0.519
LIG_LIR_Gen_1	190	201	PF02991	0.489
LIG_LIR_Gen_1	475	485	PF02991	0.481
LIG_LIR_Gen_1	94	104	PF02991	0.572
LIG_LIR_Nem_3	158	164	PF02991	0.526
LIG_LIR_Nem_3	190	196	PF02991	0.505
LIG_LIR_Nem_3	317	323	PF02991	0.457
LIG_LYPXL_S_1	218	222	PF13949	0.553
LIG_LYPXL_yS_3	219	222	PF13949	0.564
LIG_MLH1_MIPbox_1	237	241	PF16413	0.566
LIG_SH2_CRK	90	94	PF00017	0.606
LIG_SH2_GRB2like	90	93	PF00017	0.621
LIG_SH2_NCK_1	307	311	PF00017	0.602
LIG_SH2_PTP2	143	146	PF00017	0.576
LIG_SH2_STAP1	193	197	PF00017	0.498
LIG_SH2_STAT5	143	146	PF00017	0.576
LIG_SH2_STAT5	478	481	PF00017	0.485
LIG_SH3_3	325	331	PF00018	0.496
LIG_SH3_3	332	338	PF00018	0.498
LIG_SH3_3	418	424	PF00018	0.646
LIG_SH3_3	80	86	PF00018	0.578
LIG_SH3_3	98	104	PF00018	0.554
LIG_TYR_ITIM	191	196	PF00017	0.540
LIG_UBA3_1	376	382	PF00899	0.519
MOD_CK1_1	202	208	PF00069	0.582
MOD_CK1_1	273	279	PF00069	0.480
MOD_CK1_1	430	436	PF00069	0.731
MOD_CK2_1	305	311	PF00069	0.578
MOD_Cter_Amidation	4	7	PF01082	0.708
MOD_GlcNHglycan	197	200	PF01048	0.514
MOD_GlcNHglycan	230	234	PF01048	0.715
MOD_GlcNHglycan	249	252	PF01048	0.370
MOD_GlcNHglycan	275	278	PF01048	0.499
MOD_GlcNHglycan	339	342	PF01048	0.460
MOD_GlcNHglycan	432	435	PF01048	0.652
MOD_GlcNHglycan	61	64	PF01048	0.565
MOD_GSK3_1	153	160	PF00069	0.551
MOD_GSK3_1	195	202	PF00069	0.602
MOD_GSK3_1	264	271	PF00069	0.485
MOD_GSK3_1	273	280	PF00069	0.403
MOD_GSK3_1	337	344	PF00069	0.574
MOD_GSK3_1	349	356	PF00069	0.567
MOD_GSK3_1	55	62	PF00069	0.663
MOD_GSK3_1	8	15	PF00069	0.699
MOD_N-GLC_1	91	96	PF02516	0.578
MOD_N-GLC_2	110	112	PF02516	0.572
MOD_N-GLC_2	87	89	PF02516	0.544
MOD_NEK2_1	12	17	PF00069	0.604
MOD_NEK2_1	204	209	PF00069	0.495
MOD_NEK2_1	235	240	PF00069	0.551
MOD_NEK2_1	343	348	PF00069	0.440
MOD_NEK2_1	372	377	PF00069	0.635
MOD_NEK2_1	411	416	PF00069	0.531
MOD_NEK2_2	287	292	PF00069	0.568
MOD_OFUCOSY	446	451	PF10250	0.701
MOD_PIKK_1	20	26	PF00454	0.724
MOD_PK_1	123	129	PF00069	0.523
MOD_PKA_2	247	253	PF00069	0.560
MOD_PKA_2	473	479	PF00069	0.463
MOD_PKA_2	5	11	PF00069	0.668
MOD_Plk_1	235	241	PF00069	0.598
MOD_Plk_1	466	472	PF00069	0.555
MOD_Plk_1	91	97	PF00069	0.559
MOD_Plk_2-3	157	163	PF00069	0.548
MOD_Plk_2-3	305	311	PF00069	0.549
MOD_Plk_4	221	227	PF00069	0.679
MOD_Plk_4	235	241	PF00069	0.582
MOD_Plk_4	264	270	PF00069	0.505
MOD_Plk_4	330	336	PF00069	0.458
MOD_Plk_4	372	378	PF00069	0.555
MOD_Plk_4	438	444	PF00069	0.574
MOD_Plk_4	467	473	PF00069	0.489
MOD_ProDKin_1	115	121	PF00069	0.616
MOD_ProDKin_1	455	461	PF00069	0.635
MOD_SUMO_for_1	422	425	PF00179	0.674
TRG_ENDOCYTIC_2	143	146	PF00928	0.576
TRG_ENDOCYTIC_2	193	196	PF00928	0.520
TRG_ENDOCYTIC_2	219	222	PF00928	0.564
TRG_ENDOCYTIC_2	478	481	PF00928	0.485
TRG_ENDOCYTIC_2	90	93	PF00928	0.536
TRG_ER_diArg_1	1	3	PF00400	0.588
TRG_ER_diArg_1	18	20	PF00400	0.659
TRG_NES_CRM1_1	367	381	PF08389	0.598
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN6	Leptomonas seymouri	76%	99%
A0A0S4J200	Bodo saltans	42%	95%
A0A1X0NVX9	Trypanosomatidae	56%	98%
A0A3R7NQD0	Trypanosoma rangeli	54%	96%
A4HG49	Leishmania braziliensis	84%	100%
A4I379	Leishmania infantum	99%	100%
D0A7Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AZG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8R4	Leishmania major	94%	100%