LeishMANIAdb
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Pumillio protein 8, putative

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pumillio protein 8, putative
Gene product:
Pumilio homology domain family member 8
Species:
Leishmania donovani
UniProt:
A0A3Q8IDL8_LEIDO
TriTrypDb:
LdBPK_252470.1 * , LdCL_250030500 , LDHU3_25.2960
Length:
573

Annotations

Annotations by Jardim et al.

Nucleic acid binding, pumillio 8 PUF8

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IDL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDL8

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 237 239 PF00675 0.357
CLV_NRD_NRD_1 313 315 PF00675 0.313
CLV_NRD_NRD_1 351 353 PF00675 0.309
CLV_NRD_NRD_1 385 387 PF00675 0.311
CLV_NRD_NRD_1 541 543 PF00675 0.675
CLV_NRD_NRD_1 560 562 PF00675 0.686
CLV_PCSK_KEX2_1 217 219 PF00082 0.353
CLV_PCSK_KEX2_1 237 239 PF00082 0.288
CLV_PCSK_KEX2_1 313 315 PF00082 0.332
CLV_PCSK_KEX2_1 503 505 PF00082 0.547
CLV_PCSK_KEX2_1 525 527 PF00082 0.603
CLV_PCSK_KEX2_1 541 543 PF00082 0.601
CLV_PCSK_KEX2_1 560 562 PF00082 0.600
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.296
CLV_PCSK_PC1ET2_1 313 315 PF00082 0.332
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.547
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.635
CLV_PCSK_PC1ET2_1 541 543 PF00082 0.609
CLV_PCSK_SKI1_1 129 133 PF00082 0.397
CLV_PCSK_SKI1_1 165 169 PF00082 0.343
CLV_PCSK_SKI1_1 201 205 PF00082 0.290
CLV_PCSK_SKI1_1 237 241 PF00082 0.283
CLV_PCSK_SKI1_1 24 28 PF00082 0.337
CLV_PCSK_SKI1_1 315 319 PF00082 0.307
CLV_PCSK_SKI1_1 389 393 PF00082 0.320
CLV_PCSK_SKI1_1 44 48 PF00082 0.487
CLV_PCSK_SKI1_1 443 447 PF00082 0.318
CLV_PCSK_SKI1_1 468 472 PF00082 0.297
CLV_PCSK_SKI1_1 560 564 PF00082 0.680
CLV_Separin_Metazoa 55 59 PF03568 0.347
DEG_APCC_DBOX_1 236 244 PF00400 0.353
DEG_APCC_DBOX_1 467 475 PF00400 0.380
DEG_SCF_FBW7_1 105 112 PF00400 0.300
DEG_SCF_FBW7_2 379 385 PF00400 0.282
DOC_CDC14_PxL_1 171 179 PF14671 0.282
DOC_CDC14_PxL_1 435 443 PF14671 0.326
DOC_CKS1_1 106 111 PF01111 0.310
DOC_CKS1_1 379 384 PF01111 0.258
DOC_CKS1_1 413 418 PF01111 0.339
DOC_CYCLIN_RxL_1 234 241 PF00134 0.343
DOC_MAPK_MEF2A_6 201 208 PF00069 0.262
DOC_MAPK_NFAT4_5 201 209 PF00069 0.261
DOC_PP1_RVXF_1 127 134 PF00149 0.291
DOC_PP4_FxxP_1 390 393 PF00568 0.332
DOC_USP7_MATH_1 109 113 PF00917 0.287
DOC_USP7_MATH_1 199 203 PF00917 0.387
DOC_USP7_MATH_1 300 304 PF00917 0.306
DOC_USP7_MATH_1 430 434 PF00917 0.373
DOC_USP7_MATH_1 75 79 PF00917 0.598
DOC_USP7_MATH_2 159 165 PF00917 0.373
DOC_USP7_UBL2_3 132 136 PF12436 0.427
DOC_USP7_UBL2_3 44 48 PF12436 0.373
DOC_USP7_UBL2_3 563 567 PF12436 0.624
DOC_WW_Pin1_4 105 110 PF00397 0.299
DOC_WW_Pin1_4 194 199 PF00397 0.441
DOC_WW_Pin1_4 366 371 PF00397 0.263
DOC_WW_Pin1_4 378 383 PF00397 0.250
DOC_WW_Pin1_4 412 417 PF00397 0.344
DOC_WW_Pin1_4 534 539 PF00397 0.597
LIG_14-3-3_CanoR_1 113 119 PF00244 0.304
LIG_14-3-3_CanoR_1 286 294 PF00244 0.250
LIG_14-3-3_CanoR_1 560 566 PF00244 0.591
LIG_Actin_WH2_2 431 449 PF00022 0.262
LIG_APCC_ABBA_1 206 211 PF00400 0.322
LIG_APCC_ABBA_1 380 385 PF00400 0.331
LIG_BIR_III_4 508 512 PF00653 0.535
LIG_BRCT_BRCA1_1 134 138 PF00533 0.319
LIG_BRCT_BRCA1_1 240 244 PF00533 0.343
LIG_BRCT_BRCA1_1 302 306 PF00533 0.300
LIG_Clathr_ClatBox_1 400 404 PF01394 0.350
LIG_deltaCOP1_diTrp_1 384 395 PF00928 0.264
LIG_deltaCOP1_diTrp_1 407 413 PF00928 0.361
LIG_EH1_1 148 156 PF00400 0.247
LIG_eIF4E_1 371 377 PF01652 0.345
LIG_FHA_1 106 112 PF00498 0.339
LIG_FHA_1 166 172 PF00498 0.393
LIG_FHA_1 420 426 PF00498 0.366
LIG_FHA_1 430 436 PF00498 0.322
LIG_FHA_2 272 278 PF00498 0.310
LIG_FHA_2 379 385 PF00498 0.302
LIG_FHA_2 535 541 PF00498 0.616
LIG_FHA_2 63 69 PF00498 0.440
LIG_LIR_Apic_2 192 198 PF02991 0.432
LIG_LIR_Apic_2 330 336 PF02991 0.274
LIG_LIR_Apic_2 412 416 PF02991 0.336
LIG_LIR_Gen_1 143 154 PF02991 0.337
LIG_LIR_Gen_1 161 171 PF02991 0.234
LIG_LIR_Gen_1 99 109 PF02991 0.465
LIG_LIR_Nem_3 135 141 PF02991 0.312
LIG_LIR_Nem_3 143 149 PF02991 0.237
LIG_LIR_Nem_3 161 166 PF02991 0.288
LIG_LIR_Nem_3 385 391 PF02991 0.268
LIG_LIR_Nem_3 99 105 PF02991 0.352
LIG_LYPXL_yS_3 222 225 PF13949 0.300
LIG_LYPXL_yS_3 259 262 PF13949 0.341
LIG_LYPXL_yS_3 88 91 PF13949 0.307
LIG_NRBOX 340 346 PF00104 0.377
LIG_NRBOX 375 381 PF00104 0.279
LIG_PCNA_yPIPBox_3 263 275 PF02747 0.286
LIG_PTB_Apo_2 365 372 PF02174 0.266
LIG_PTB_Phospho_1 365 371 PF10480 0.363
LIG_Rb_pABgroove_1 238 246 PF01858 0.368
LIG_Rb_pABgroove_1 336 344 PF01858 0.231
LIG_RPA_C_Fungi 455 467 PF08784 0.462
LIG_SH2_CRK 163 167 PF00017 0.375
LIG_SH2_CRK 333 337 PF00017 0.236
LIG_SH2_CRK 373 377 PF00017 0.347
LIG_SH2_NCK_1 516 520 PF00017 0.536
LIG_SH2_STAP1 141 145 PF00017 0.318
LIG_SH2_STAP1 146 150 PF00017 0.306
LIG_SH2_STAP1 163 167 PF00017 0.425
LIG_SH2_STAP1 191 195 PF00017 0.283
LIG_SH2_STAP1 346 350 PF00017 0.303
LIG_SH2_STAP1 84 88 PF00017 0.379
LIG_SH2_STAT3 346 349 PF00017 0.309
LIG_SH2_STAT3 371 374 PF00017 0.397
LIG_SH2_STAT5 269 272 PF00017 0.288
LIG_SH2_STAT5 354 357 PF00017 0.256
LIG_SH2_STAT5 448 451 PF00017 0.328
LIG_SH3_1 217 223 PF00018 0.381
LIG_SH3_3 103 109 PF00018 0.336
LIG_SH3_3 169 175 PF00018 0.282
LIG_SH3_3 217 223 PF00018 0.381
LIG_SH3_3 364 370 PF00018 0.344
LIG_SUMO_SIM_anti_2 202 207 PF11976 0.299
LIG_SUMO_SIM_anti_2 211 217 PF11976 0.275
LIG_SUMO_SIM_par_1 421 427 PF11976 0.364
LIG_TRAF2_1 11 14 PF00917 0.508
LIG_TRAF2_1 382 385 PF00917 0.381
LIG_TRAF2_1 488 491 PF00917 0.470
LIG_TRAF2_1 65 68 PF00917 0.541
LIG_TYR_ITIM 257 262 PF00017 0.328
LIG_UBA3_1 203 210 PF00899 0.252
LIG_UBA3_1 243 249 PF00899 0.285
LIG_UBA3_1 400 406 PF00899 0.395
LIG_UBA3_1 56 62 PF00899 0.380
LIG_UBA3_1 94 101 PF00899 0.354
LIG_WRC_WIRS_1 318 323 PF05994 0.451
MOD_CDK_SPxxK_3 194 201 PF00069 0.430
MOD_CDK_SPxxK_3 534 541 PF00069 0.667
MOD_CK1_1 189 195 PF00069 0.358
MOD_CK1_1 79 85 PF00069 0.544
MOD_CK2_1 249 255 PF00069 0.385
MOD_CK2_1 271 277 PF00069 0.313
MOD_CK2_1 304 310 PF00069 0.297
MOD_CK2_1 378 384 PF00069 0.315
MOD_CK2_1 484 490 PF00069 0.424
MOD_CK2_1 62 68 PF00069 0.509
MOD_Cter_Amidation 501 504 PF01082 0.617
MOD_Cter_Amidation 558 561 PF01082 0.670
MOD_GlcNHglycan 122 125 PF01048 0.486
MOD_GlcNHglycan 454 457 PF01048 0.455
MOD_GlcNHglycan 486 489 PF01048 0.473
MOD_GlcNHglycan 50 53 PF01048 0.415
MOD_GlcNHglycan 551 554 PF01048 0.637
MOD_GSK3_1 105 112 PF00069 0.293
MOD_GSK3_1 132 139 PF00069 0.432
MOD_GSK3_1 161 168 PF00069 0.361
MOD_GSK3_1 186 193 PF00069 0.302
MOD_GSK3_1 300 307 PF00069 0.310
MOD_GSK3_1 542 549 PF00069 0.692
MOD_GSK3_1 75 82 PF00069 0.673
MOD_NEK2_1 1 6 PF00069 0.484
MOD_NEK2_1 265 270 PF00069 0.372
MOD_NEK2_1 281 286 PF00069 0.196
MOD_NEK2_1 304 309 PF00069 0.306
MOD_NEK2_1 328 333 PF00069 0.357
MOD_NEK2_1 47 52 PF00069 0.326
MOD_PIKK_1 249 255 PF00454 0.328
MOD_PIKK_1 527 533 PF00454 0.739
MOD_PK_1 107 113 PF00069 0.366
MOD_PKA_1 542 548 PF00069 0.663
MOD_PKA_2 14 20 PF00069 0.563
MOD_Plk_1 136 142 PF00069 0.409
MOD_Plk_1 199 205 PF00069 0.419
MOD_Plk_2-3 67 73 PF00069 0.587
MOD_Plk_4 114 120 PF00069 0.345
MOD_Plk_4 186 192 PF00069 0.326
MOD_Plk_4 265 271 PF00069 0.459
MOD_Plk_4 409 415 PF00069 0.340
MOD_ProDKin_1 105 111 PF00069 0.293
MOD_ProDKin_1 194 200 PF00069 0.437
MOD_ProDKin_1 366 372 PF00069 0.259
MOD_ProDKin_1 378 384 PF00069 0.256
MOD_ProDKin_1 412 418 PF00069 0.342
MOD_ProDKin_1 534 540 PF00069 0.594
MOD_SUMO_for_1 524 527 PF00179 0.570
TRG_DiLeu_BaLyEn_6 126 131 PF01217 0.381
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.292
TRG_ENDOCYTIC_2 146 149 PF00928 0.268
TRG_ENDOCYTIC_2 163 166 PF00928 0.238
TRG_ENDOCYTIC_2 222 225 PF00928 0.308
TRG_ENDOCYTIC_2 259 262 PF00928 0.319
TRG_ENDOCYTIC_2 373 376 PF00928 0.348
TRG_ENDOCYTIC_2 88 91 PF00928 0.332
TRG_ER_diArg_1 237 239 PF00400 0.353
TRG_ER_diArg_1 560 562 PF00400 0.600
TRG_NLS_Bipartite_1 525 547 PF00514 0.677
TRG_NLS_MonoExtC_3 541 546 PF00514 0.685
TRG_NLS_MonoExtN_4 541 547 PF00514 0.681
TRG_Pf-PMV_PEXEL_1 64 68 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWV1 Leptomonas seymouri 82% 100%
A0A0S4IXV1 Bodo saltans 48% 82%
A0A1X0NZF1 Trypanosomatidae 60% 93%
A0A3R7MC19 Trypanosoma rangeli 59% 98%
A4HED9 Leishmania braziliensis 85% 100%
A4I1T6 Leishmania infantum 100% 100%
C9ZKE5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 94%
E9AXX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q9K0 Leishmania major 96% 100%
V5D8H4 Trypanosoma cruzi 56% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS