LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IDL6_LEIDO
TriTrypDb:
LdBPK_260980.1 , LdCL_260015400 , LDHU3_26.1250
Length:
410

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 328, 331, 337

Expansion

Sequence features

A0A3Q8IDL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDL6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 153 155 PF00675 0.730
CLV_NRD_NRD_1 282 284 PF00675 0.740
CLV_PCSK_KEX2_1 217 219 PF00082 0.672
CLV_PCSK_KEX2_1 282 284 PF00082 0.740
CLV_PCSK_KEX2_1 5 7 PF00082 0.717
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.672
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.788
CLV_PCSK_SKI1_1 129 133 PF00082 0.608
CLV_PCSK_SKI1_1 161 165 PF00082 0.708
CLV_PCSK_SKI1_1 217 221 PF00082 0.708
DEG_APCC_DBOX_1 26 34 PF00400 0.652
DEG_SCF_FBW7_1 374 381 PF00400 0.765
DEG_SPOP_SBC_1 378 382 PF00917 0.862
DOC_CYCLIN_RxL_1 129 140 PF00134 0.549
DOC_CYCLIN_yCln2_LP_2 329 335 PF00134 0.826
DOC_MAPK_gen_1 217 225 PF00069 0.599
DOC_MAPK_gen_1 5 13 PF00069 0.706
DOC_MAPK_MEF2A_6 5 13 PF00069 0.725
DOC_PP1_RVXF_1 132 139 PF00149 0.626
DOC_PP1_RVXF_1 192 198 PF00149 0.700
DOC_PP2B_LxvP_1 11 14 PF13499 0.750
DOC_USP7_MATH_1 361 365 PF00917 0.722
DOC_USP7_MATH_1 396 400 PF00917 0.776
DOC_WW_Pin1_4 122 127 PF00397 0.744
DOC_WW_Pin1_4 328 333 PF00397 0.733
DOC_WW_Pin1_4 334 339 PF00397 0.674
DOC_WW_Pin1_4 374 379 PF00397 0.745
DOC_WW_Pin1_4 383 388 PF00397 0.739
LIG_14-3-3_CanoR_1 129 138 PF00244 0.654
LIG_14-3-3_CanoR_1 344 348 PF00244 0.670
LIG_14-3-3_CanoR_1 6 12 PF00244 0.775
LIG_BIR_II_1 1 5 PF00653 0.768
LIG_BRCT_BRCA1_1 221 225 PF00533 0.582
LIG_FHA_1 130 136 PF00498 0.583
LIG_FHA_1 286 292 PF00498 0.787
LIG_FHA_1 337 343 PF00498 0.780
LIG_FHA_1 384 390 PF00498 0.737
LIG_FHA_1 57 63 PF00498 0.572
LIG_FHA_1 78 84 PF00498 0.643
LIG_FHA_1 8 14 PF00498 0.731
LIG_FHA_2 29 35 PF00498 0.759
LIG_FHA_2 344 350 PF00498 0.664
LIG_FHA_2 366 372 PF00498 0.740
LIG_LIR_Gen_1 85 94 PF02991 0.564
LIG_LIR_Nem_3 222 228 PF02991 0.579
LIG_LIR_Nem_3 25 29 PF02991 0.626
LIG_LIR_Nem_3 85 89 PF02991 0.557
LIG_MLH1_MIPbox_1 221 225 PF16413 0.583
LIG_PAM2_1 334 346 PF00658 0.784
LIG_Pex14_1 240 244 PF04695 0.644
LIG_Pex14_1 82 86 PF04695 0.531
LIG_PTB_Apo_2 391 398 PF02174 0.853
LIG_REV1ctd_RIR_1 222 231 PF16727 0.615
LIG_REV1ctd_RIR_1 241 249 PF16727 0.444
LIG_SH2_CRK 86 90 PF00017 0.596
LIG_SH2_NCK_1 108 112 PF00017 0.631
LIG_SH2_NCK_1 86 90 PF00017 0.523
LIG_SH2_STAP1 108 112 PF00017 0.562
LIG_SH2_STAT3 262 265 PF00017 0.713
LIG_SH2_STAT3 350 353 PF00017 0.681
LIG_SH2_STAT3 93 96 PF00017 0.687
LIG_SH2_STAT5 248 251 PF00017 0.638
LIG_SH2_STAT5 29 32 PF00017 0.643
LIG_SH2_STAT5 350 353 PF00017 0.681
LIG_SH2_STAT5 93 96 PF00017 0.594
LIG_SH3_1 154 160 PF00018 0.723
LIG_SH3_1 318 324 PF00018 0.806
LIG_SH3_3 120 126 PF00018 0.660
LIG_SH3_3 145 151 PF00018 0.720
LIG_SH3_3 154 160 PF00018 0.688
LIG_SH3_3 318 324 PF00018 0.770
LIG_SH3_3 332 338 PF00018 0.781
LIG_SUMO_SIM_anti_2 331 337 PF11976 0.845
LIG_SUMO_SIM_par_1 331 337 PF11976 0.786
LIG_SUMO_SIM_par_1 9 16 PF11976 0.686
LIG_UBA3_1 365 373 PF00899 0.796
MOD_CDK_SPxxK_3 122 129 PF00069 0.735
MOD_CK1_1 28 34 PF00069 0.653
MOD_CK1_1 328 334 PF00069 0.781
MOD_CK1_1 399 405 PF00069 0.824
MOD_CK1_1 75 81 PF00069 0.610
MOD_CK2_1 309 315 PF00069 0.706
MOD_CK2_1 316 322 PF00069 0.636
MOD_CK2_1 377 383 PF00069 0.861
MOD_GlcNHglycan 142 145 PF01048 0.583
MOD_GlcNHglycan 311 314 PF01048 0.679
MOD_GlcNHglycan 318 321 PF01048 0.722
MOD_GlcNHglycan 34 38 PF01048 0.783
MOD_GlcNHglycan 353 356 PF01048 0.807
MOD_GlcNHglycan 72 75 PF01048 0.624
MOD_GlcNHglycan 77 80 PF01048 0.580
MOD_GSK3_1 256 263 PF00069 0.748
MOD_GSK3_1 361 368 PF00069 0.726
MOD_GSK3_1 374 381 PF00069 0.734
MOD_GSK3_1 396 403 PF00069 0.761
MOD_GSK3_1 68 75 PF00069 0.602
MOD_N-GLC_1 397 402 PF02516 0.793
MOD_NEK2_1 115 120 PF00069 0.598
MOD_NEK2_1 243 248 PF00069 0.626
MOD_NEK2_1 365 370 PF00069 0.730
MOD_NEK2_1 397 402 PF00069 0.763
MOD_NEK2_1 62 67 PF00069 0.517
MOD_NEK2_1 70 75 PF00069 0.550
MOD_NEK2_2 343 348 PF00069 0.663
MOD_OFUCOSY 174 180 PF10250 0.769
MOD_PIKK_1 115 121 PF00454 0.670
MOD_PIKK_1 149 155 PF00454 0.727
MOD_PIKK_1 397 403 PF00454 0.832
MOD_PIKK_1 68 74 PF00454 0.635
MOD_PKA_2 343 349 PF00069 0.673
MOD_PKA_2 351 357 PF00069 0.705
MOD_Plk_1 361 367 PF00069 0.725
MOD_Plk_4 219 225 PF00069 0.555
MOD_Plk_4 243 249 PF00069 0.646
MOD_Plk_4 331 337 PF00069 0.812
MOD_Plk_4 361 367 PF00069 0.725
MOD_Plk_4 62 68 PF00069 0.537
MOD_Plk_4 77 83 PF00069 0.627
MOD_ProDKin_1 122 128 PF00069 0.735
MOD_ProDKin_1 328 334 PF00069 0.729
MOD_ProDKin_1 374 380 PF00069 0.747
MOD_ProDKin_1 383 389 PF00069 0.736
TRG_DiLeu_BaLyEn_6 131 136 PF01217 0.632
TRG_DiLeu_BaLyEn_6 384 389 PF01217 0.731
TRG_ENDOCYTIC_2 175 178 PF00928 0.684
TRG_ENDOCYTIC_2 86 89 PF00928 0.527
TRG_ER_diArg_1 191 194 PF00400 0.676
TRG_ER_diArg_1 282 284 PF00400 0.763
TRG_Pf-PMV_PEXEL_1 129 133 PF00026 0.659
TRG_Pf-PMV_PEXEL_1 367 371 PF00026 0.741

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDL9 Leptomonas seymouri 84% 100%
A0A0S4II62 Bodo saltans 51% 100%
A0A1X0NSZ7 Trypanosomatidae 63% 100%
A0A3R7NVU2 Trypanosoma rangeli 60% 100%
A4HEV6 Leishmania braziliensis 95% 100%
A4I230 Leishmania infantum 100% 100%
C9ZRX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 93%
E9AY79 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q993 Leishmania major 99% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS