Pyridoxal-dependent decarboxylase conserved domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pyridoxal-dependent decarboxylase conserved domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDL2_LEIDO

TriTrypDb:

LdBPK_160430.1 , LdCL_160009200 , LDHU3_16.0510

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDL2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016829	lyase activity	2	10
GO:0016830	carbon-carbon lyase activity	3	10
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016831	carboxy-lyase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.468
CLV_C14_Caspase3-7	56	60	PF00656	0.700
CLV_MEL_PAP_1	376	382	PF00089	0.704
CLV_NRD_NRD_1	299	301	PF00675	0.559
CLV_NRD_NRD_1	495	497	PF00675	0.535
CLV_PCSK_KEX2_1	140	142	PF00082	0.635
CLV_PCSK_KEX2_1	495	497	PF00082	0.535
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.635
CLV_PCSK_SKI1_1	106	110	PF00082	0.396
CLV_PCSK_SKI1_1	285	289	PF00082	0.719
CLV_PCSK_SKI1_1	388	392	PF00082	0.707
CLV_PCSK_SKI1_1	40	44	PF00082	0.650
CLV_PCSK_SKI1_1	415	419	PF00082	0.564
CLV_PCSK_SKI1_1	540	544	PF00082	0.706
DEG_APCC_DBOX_1	362	370	PF00400	0.763
DEG_APCC_DBOX_1	387	395	PF00400	0.692
DEG_COP1_1	258	269	PF00400	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DEG_SCF_FBW7_1	51	56	PF00400	0.724
DOC_CKS1_1	320	325	PF01111	0.630
DOC_MAPK_gen_1	495	503	PF00069	0.523
DOC_MAPK_MEF2A_6	479	488	PF00069	0.633
DOC_MAPK_MEF2A_6	495	503	PF00069	0.448
DOC_MAPK_RevD_3	126	141	PF00069	0.544
DOC_PP2B_LxvP_1	143	146	PF13499	0.676
DOC_PP2B_LxvP_1	507	510	PF13499	0.676
DOC_SPAK_OSR1_1	214	218	PF12202	0.295
DOC_USP7_MATH_1	255	259	PF00917	0.533
DOC_USP7_MATH_1	354	358	PF00917	0.679
DOC_USP7_MATH_1	44	48	PF00917	0.725
DOC_USP7_MATH_1	455	459	PF00917	0.741
DOC_USP7_MATH_1	466	470	PF00917	0.782
DOC_USP7_MATH_1	51	55	PF00917	0.468
DOC_USP7_MATH_1	93	97	PF00917	0.556
DOC_WW_Pin1_4	278	283	PF00397	0.724
DOC_WW_Pin1_4	319	324	PF00397	0.631
DOC_WW_Pin1_4	331	336	PF00397	0.626
DOC_WW_Pin1_4	438	443	PF00397	0.740
DOC_WW_Pin1_4	460	465	PF00397	0.760
DOC_WW_Pin1_4	49	54	PF00397	0.752
LIG_14-3-3_CanoR_1	132	138	PF00244	0.444
LIG_14-3-3_CanoR_1	17	23	PF00244	0.745
LIG_14-3-3_CanoR_1	285	294	PF00244	0.538
LIG_14-3-3_CanoR_1	313	318	PF00244	0.623
LIG_14-3-3_CanoR_1	379	387	PF00244	0.677
LIG_14-3-3_CanoR_1	540	545	PF00244	0.574
LIG_14-3-3_CanoR_1	551	556	PF00244	0.690
LIG_deltaCOP1_diTrp_1	340	344	PF00928	0.662
LIG_Dynein_DLC8_1	130	136	PF01221	0.494
LIG_FHA_1	132	138	PF00498	0.575
LIG_FHA_1	226	232	PF00498	0.352
LIG_FHA_1	320	326	PF00498	0.630
LIG_FHA_1	347	353	PF00498	0.713
LIG_FHA_1	422	428	PF00498	0.537
LIG_FHA_1	71	77	PF00498	0.571
LIG_FHA_1	79	85	PF00498	0.471
LIG_FHA_2	36	42	PF00498	0.695
LIG_FHA_2	416	422	PF00498	0.584
LIG_FHA_2	54	60	PF00498	0.711
LIG_FHA_2	65	71	PF00498	0.494
LIG_Integrin_RGD_1	395	397	PF01839	0.705
LIG_LIR_Gen_1	535	544	PF02991	0.525
LIG_LIR_Gen_1	70	79	PF02991	0.535
LIG_LIR_Nem_3	502	506	PF02991	0.658
LIG_LIR_Nem_3	70	75	PF02991	0.539
LIG_LYPXL_S_1	185	189	PF13949	0.343
LIG_LYPXL_yS_3	186	189	PF13949	0.343
LIG_Pex14_2	211	215	PF04695	0.295
LIG_RPA_C_Fungi	424	436	PF08784	0.629
LIG_SH2_CRK	275	279	PF00017	0.724
LIG_SH2_CRK	72	76	PF00017	0.525
LIG_SH2_NCK_1	254	258	PF00017	0.564
LIG_SH2_PTP2	130	133	PF00017	0.420
LIG_SH2_STAP1	166	170	PF00017	0.407
LIG_SH2_STAP1	65	69	PF00017	0.633
LIG_SH2_STAP1	72	76	PF00017	0.449
LIG_SH2_STAT5	110	113	PF00017	0.417
LIG_SH2_STAT5	130	133	PF00017	0.233
LIG_SH2_STAT5	365	368	PF00017	0.680
LIG_SH2_STAT5	544	547	PF00017	0.650
LIG_SH2_STAT5	72	75	PF00017	0.544
LIG_SH3_3	13	19	PF00018	0.750
LIG_SH3_3	235	241	PF00018	0.646
LIG_SH3_3	260	266	PF00018	0.511
LIG_SH3_3	276	282	PF00018	0.687
LIG_SH3_3	330	336	PF00018	0.667
LIG_SH3_3	367	373	PF00018	0.740
LIG_SUMO_SIM_anti_2	203	210	PF11976	0.412
LIG_SUMO_SIM_par_1	372	378	PF11976	0.652
LIG_SUMO_SIM_par_1	505	512	PF11976	0.673
LIG_SUMO_SIM_par_1	72	78	PF11976	0.462
LIG_TYR_ITIM	128	133	PF00017	0.421
LIG_TYR_ITIM	273	278	PF00017	0.672
LIG_WRC_WIRS_1	191	196	PF05994	0.443
MOD_CDK_SPxxK_3	278	285	PF00069	0.712
MOD_CK1_1	150	156	PF00069	0.687
MOD_CK1_1	196	202	PF00069	0.443
MOD_CK1_1	21	27	PF00069	0.613
MOD_CK1_1	281	287	PF00069	0.645
MOD_CK1_1	334	340	PF00069	0.735
MOD_CK1_1	460	466	PF00069	0.779
MOD_CK1_1	516	522	PF00069	0.585
MOD_CK1_1	96	102	PF00069	0.546
MOD_CK2_1	334	340	PF00069	0.665
MOD_CK2_1	35	41	PF00069	0.701
MOD_CK2_1	64	70	PF00069	0.520
MOD_DYRK1A_RPxSP_1	49	53	PF00069	0.726
MOD_GlcNHglycan	10	13	PF01048	0.799
MOD_GlcNHglycan	198	201	PF01048	0.445
MOD_GlcNHglycan	290	293	PF01048	0.412
MOD_GlcNHglycan	380	383	PF01048	0.645
MOD_GlcNHglycan	451	454	PF01048	0.747
MOD_GlcNHglycan	457	460	PF01048	0.705
MOD_GlcNHglycan	469	472	PF01048	0.569
MOD_GlcNHglycan	98	101	PF01048	0.581
MOD_GSK3_1	17	24	PF00069	0.609
MOD_GSK3_1	190	197	PF00069	0.202
MOD_GSK3_1	2	9	PF00069	0.757
MOD_GSK3_1	221	228	PF00069	0.384
MOD_GSK3_1	255	262	PF00069	0.413
MOD_GSK3_1	264	271	PF00069	0.457
MOD_GSK3_1	281	288	PF00069	0.569
MOD_GSK3_1	45	52	PF00069	0.665
MOD_GSK3_1	551	558	PF00069	0.612
MOD_GSK3_1	78	85	PF00069	0.516
MOD_N-GLC_2	23	25	PF02516	0.575
MOD_NEK2_1	194	199	PF00069	0.202
MOD_NEK2_1	259	264	PF00069	0.425
MOD_NEK2_1	555	560	PF00069	0.658
MOD_NEK2_1	64	69	PF00069	0.502
MOD_NEK2_1	75	80	PF00069	0.450
MOD_PIKK_1	131	137	PF00454	0.501
MOD_PIKK_1	248	254	PF00454	0.476
MOD_PIKK_1	78	84	PF00454	0.514
MOD_PKA_2	131	137	PF00069	0.545
MOD_PKA_2	378	384	PF00069	0.623
MOD_PKA_2	85	91	PF00069	0.572
MOD_PKB_1	538	546	PF00069	0.561
MOD_Plk_1	400	406	PF00069	0.558
MOD_Plk_1	421	427	PF00069	0.647
MOD_Plk_4	159	165	PF00069	0.594
MOD_Plk_4	259	265	PF00069	0.453
MOD_Plk_4	513	519	PF00069	0.707
MOD_Plk_4	540	546	PF00069	0.650
MOD_Plk_4	70	76	PF00069	0.467
MOD_ProDKin_1	278	284	PF00069	0.723
MOD_ProDKin_1	319	325	PF00069	0.631
MOD_ProDKin_1	331	337	PF00069	0.624
MOD_ProDKin_1	438	444	PF00069	0.743
MOD_ProDKin_1	460	466	PF00069	0.759
MOD_ProDKin_1	49	55	PF00069	0.751
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.478
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.700
TRG_ENDOCYTIC_2	130	133	PF00928	0.420
TRG_ENDOCYTIC_2	186	189	PF00928	0.343
TRG_ENDOCYTIC_2	275	278	PF00928	0.680
TRG_ENDOCYTIC_2	72	75	PF00928	0.530
TRG_ER_diArg_1	495	497	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL2	Leptomonas seymouri	45%	77%
A0A1X0P0L1	Trypanosomatidae	30%	83%
A0A3R7K963	Trypanosoma rangeli	36%	100%
A4H8G7	Leishmania braziliensis	76%	100%
A4HWU0	Leishmania infantum	99%	100%
C9ZW41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9AQJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEX8	Leishmania major	92%	100%