Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDL0_LEIDO

TriTrypDb:

LdBPK_330450.1 , LdCL_330010000 , LDHU3_33.0700

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.595
CLV_C14_Caspase3-7	78	82	PF00656	0.565
CLV_NRD_NRD_1	196	198	PF00675	0.550
CLV_PCSK_FUR_1	194	198	PF00082	0.617
CLV_PCSK_KEX2_1	114	116	PF00082	0.601
CLV_PCSK_KEX2_1	196	198	PF00082	0.575
CLV_PCSK_KEX2_1	70	72	PF00082	0.478
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.601
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.435
CLV_PCSK_SKI1_1	156	160	PF00082	0.545
CLV_PCSK_SKI1_1	197	201	PF00082	0.582
CLV_PCSK_SKI1_1	41	45	PF00082	0.604
DEG_MDM2_SWIB_1	94	101	PF02201	0.479
DEG_SCF_FBW7_1	47	54	PF00400	0.564
DOC_CKS1_1	48	53	PF01111	0.615
DOC_CYCLIN_RxL_1	59	67	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.528
DOC_MAPK_gen_1	194	201	PF00069	0.587
DOC_MAPK_MEF2A_6	96	103	PF00069	0.454
DOC_MAPK_NFAT4_5	96	104	PF00069	0.514
DOC_PP1_RVXF_1	60	67	PF00149	0.486
DOC_PP2B_LxvP_1	99	102	PF13499	0.511
DOC_USP7_MATH_1	144	148	PF00917	0.705
DOC_USP7_MATH_1	51	55	PF00917	0.568
DOC_WW_Pin1_4	139	144	PF00397	0.666
DOC_WW_Pin1_4	47	52	PF00397	0.574
LIG_14-3-3_CanoR_1	196	202	PF00244	0.490
LIG_Clathr_ClatBox_1	63	67	PF01394	0.508
LIG_deltaCOP1_diTrp_1	202	209	PF00928	0.475
LIG_FHA_1	165	171	PF00498	0.482
LIG_FHA_1	42	48	PF00498	0.497
LIG_FHA_2	35	41	PF00498	0.489
LIG_FHA_2	48	54	PF00498	0.565
LIG_LIR_Apic_2	18	24	PF02991	0.450
LIG_LIR_Gen_1	18	26	PF02991	0.415
LIG_LIR_Gen_1	36	47	PF02991	0.419
LIG_LIR_Nem_3	18	22	PF02991	0.425
LIG_LIR_Nem_3	36	42	PF02991	0.400
LIG_MYND_1	139	143	PF01753	0.655
LIG_Pex14_1	90	94	PF04695	0.456
LIG_Pex14_2	94	98	PF04695	0.470
LIG_Rb_LxCxE_1	167	186	PF01857	0.534
LIG_SH2_STAP1	39	43	PF00017	0.518
LIG_SH2_STAT3	86	89	PF00017	0.478
LIG_SH2_STAT5	21	24	PF00017	0.423
LIG_SH2_STAT5	86	89	PF00017	0.439
LIG_SH3_3	116	122	PF00018	0.700
LIG_SH3_3	123	129	PF00018	0.609
LIG_SH3_3	140	146	PF00018	0.493
LIG_SH3_3	45	51	PF00018	0.626
MOD_CK1_1	142	148	PF00069	0.650
MOD_CK1_1	211	217	PF00069	0.499
MOD_CK2_1	34	40	PF00069	0.534
MOD_CK2_1	47	53	PF00069	0.521
MOD_GlcNHglycan	106	109	PF01048	0.679
MOD_GlcNHglycan	146	149	PF01048	0.530
MOD_GlcNHglycan	6	9	PF01048	0.672
MOD_GSK3_1	104	111	PF00069	0.571
MOD_GSK3_1	11	18	PF00069	0.518
MOD_GSK3_1	2	9	PF00069	0.713
MOD_GSK3_1	47	54	PF00069	0.538
MOD_LATS_1	2	8	PF00433	0.737
MOD_NEK2_1	6	11	PF00069	0.707
MOD_NEK2_1	75	80	PF00069	0.430
MOD_Plk_1	2	8	PF00069	0.744
MOD_Plk_1	75	81	PF00069	0.438
MOD_Plk_4	121	127	PF00069	0.646
MOD_Plk_4	208	214	PF00069	0.441
MOD_Plk_4	34	40	PF00069	0.531
MOD_ProDKin_1	139	145	PF00069	0.668
MOD_ProDKin_1	47	53	PF00069	0.569
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.512
TRG_ENDOCYTIC_2	39	42	PF00928	0.526
TRG_ER_diArg_1	193	196	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL76	Leptomonas seymouri	48%	68%
A0A1X0P0M0	Trypanosomatidae	33%	72%
A4HL79	Leishmania braziliensis	77%	100%
D0A4P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	70%
E9AHN1	Leishmania infantum	100%	100%
E9B3M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4G5	Leishmania major	94%	100%